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Search Results for " endopeptidase "

68

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T12546	Prolyl Endopeptidase Inhibitor 1 (Boc)-Prolyl-prolinal,BPP,Boc-Pro-prolinal	Others	Others
	Prolyl Endopeptidase Inhibitor 1 is a potent inhibitor of prolyl endopeptidase (PEP; PE)(Ki : 15 nM) , has anti-amnesic effect.
T7693	Thiorphan	Neprilysin	Metabolism
	Thiorphan 是选择性neprilysin 抑制剂 (IC50:6.9 nM) 。
TQ0106	Sacubitrilat LBQ-657	Neprilysin	Metabolism
	Sacubitrilat (LBQ-657) 是活性的脑啡肽酶 (NEP) 抑制剂。
T8657	KYP-2047	Others	Others
	KYP-2047 是一种非常有效的选择性脯氨酰寡肽酶 (POP) 抑制剂。
T9713	δ-secretase inhibitor 11	Beta Amyloid; Caspase	Apoptosis; Neuroscience; Proteases/Proteasome
	δ-secretase inhibitor 11是一种分泌酶抑制剂，可用作阿尔茨海默病（AD）治疗转化开发的先导化合物。
T4574	Sacubitril AHU 377,AHU377,沙库必曲,AHU-377	Neprilysin	Metabolism
	Sacubitril (AHU-377) 是一种有效的NEP 抑制剂，IC50=5 nM。它是研究心力衰竭药物 LCZ696 的组分之一。
T4200	Sacubitril hemicalcium salt AHU-377 (hemicalcium salt),LCZ696中间体,AHU377 calcium salt	Neprilysin	Metabolism
	Sacubitril hemicalcium salt (AHU377 calcium salt) 是一种有效的 NEP 抑制剂，IC50=5 nM。它是研究心力衰竭药物 LCZ696 的组分之一。
T1176	Racecadotril Acetorphan,消旋卡多曲	Neprilysin; Proteasome	Metabolism; Proteases/Proteasome; Ubiquitination
	Racecadotril (Acetorphan) 是一种中性内肽酶 (NEP) 抑制剂，具有止泻作用。Racecadotril 及其活性代谢物 Thiorphan 抑制小鼠脑中纯化的NEP 活性，Ki 分别为 4500 和 6.1 nM。
T9855	BR102910 4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]-	Others	Others
	BR102910 (4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]-) 是一种选择性的成纤维细胞活化蛋白（FAP）的抑制剂。
T2318	Sacubitril/Valsartan Sacubitril mixture with Valsartan,沙库必曲/缬沙坦,Valsartan,Sacubitril,LCZ696	Apoptosis; RAAS; Neprilysin	Apoptosis; Endocrinology/Hormones; Metabolism
	Sacubitril/Valsartan (LCZ696)，以1:1摩尔比由Valsartan（一种ARB）和Sacubitril（AHU377）组成，为创新口服血管紧张素受体-脑啡肽酶（ARN）双重抑制剂，旨在治疗高血压与心力衰竭。其作用机制包括抑制炎症、氧化应激及细胞凋亡，有助于改善糖尿病心肌病。
T10671	Candoxatril UK 79300	Others	Others
	Candoxatril is an inhibitor neutral endopeptidase (NEP).
T41032	Lysostaphin	Antibacterial	Microbiology/Virology
	Lysostaphin是一种具有强大抗葡萄球菌活性的化合物，通过三种不同的酶展现其酶促活性：glycylglycine endopeptidase、endo-β-N-acetyl glucosamidase和N-acetyl muramyl-L-alanine amidase。
T10918	NEP-IN-1	Neprilysin	Metabolism
	NEP-IN-1 是中性肽链内切酶 (NEP) 的抑制剂 (IC50 = 2 nM)。
T27730	KGP94 KGP-94,KGP 94	Cysteine Protease	Proteases/Proteasome
	KGP94 是一种有效的、选择性的和竞争性的溶酶体内肽酶抑制剂。
T19626	LHW090-A7 (ALPHAS)-3'-氯-ALPHA-[[(1S)-2-乙氧基-1-甲基-2-氧代乙基]氨基][1,1'-联苯]-4-丙酸	Neprilysin	Metabolism
	LHW090-A7 是一种中性肽链内切酶 (NEP) 抑制剂，是一种负责脑啡肽代谢失活的酶。
T35233	Y-29794 Tosylate Y 29794,Y29794 tosylate,Y29794,Y-29794	Prolyl Endopeptidase (PREP)	Metabolism; Proteases/Proteasome
	Y-29794 Tosylate (Y-29794) 是一种具有口服活性、有效且特异性的非肽脯氨酰内肽酶 (PPCE) 抑制剂。
T12770	RR-11a analog aza-peptide Michael acceptor, 7a	Parasite	Microbiology/Virology
	RR-11a analog (aza-peptide Michael acceptor, 7a) 是一种天冬酰胺酰内肽酶抑制剂，对阴道毛滴虫中的 AE1、蓖麻硬蜱中的 AE 和曼氏血吸虫中的 AE 的 IC50 分别为 4.5 nM、4.5 nM 和 31 nM。
T27119L	(Rac)-Daglutril SLV 306 acetic acid,2-((3S)-3-(1-(2-(ethoxycarbonyl)-4-phenylbutyl)cyclopentane-1-carboxamido)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid	Others	Others
	(Rac)-Daglutril (SLV 306 acetic acid) 是 Daglutril 的消旋体。Daglutril 是一种口服活性的混合中性内肽酶/内皮素转化酶抑制剂，正在开发用于治疗原发性高血压和充血性心力衰竭。
TP1917L1	Sar-[D-Phe8]-des-Arg9-Bradykinin acetate Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base)	Bradykinin Receptor	GPCR/G Protein
	Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base) 是一种有效的选择性缓激肽 B1 受体激动剂（兔主动脉中的 EC50 = 9.02 nM），对氨肽酶、激肽酶 I 和 II (ACE) 以及中性内肽酶切割具有抗性。在体内表现出降血压和血管生成活性。
T27716	KC-12615 KC12615
	KC-12615 is an inhibitior of endopeptidase.
T26659	ARI-3531 ARI 3531
	ARI-3531 is a selective prolyl endopeptidase inhibitor.
T23698	Aladotril BP1137,BP 1137,BP-1137
	Aladotril is an inhibitor of neutral endopeptidase. Its prodrug is aladotrilat.
T12994	SQ28603 Squibb 28603,SQ28,603	Others	Others
	SQ28603 is a potent and selective neutral endopeptidase 3.4.24.11 (NEP) inhibitor.
T23541	Y-29794 oxalate	Others	Others
	Inhibitor of prolyl endopeptidase
T29053	UK-447841 UK 447841
	UK-447841, a neutral endopeptidase (NEP) inhibitor, is used potentially for the treatment of female sexual dysfunction.
T28715	Sch 34826 Sch34826,Sch-34826
	Sch 34826 is a potent, selective neutral endopeptidase inhibitor.
T27989	MDK0734 Cathepsin B Inhinitor-42
	MDK0734 is a selective inhibitor of cathepsin B endopeptidase and exopeptidase activities.
T25973	Poststatin
	Poststatin is a prolyl endopeptidase inhibitor produced by Streptomyces viridochromogenes MH534-30F3.
T70471	Cgs 26303
	Cgs 26303 is a potent non-peptidic inhibitor of neutral endopeptidase capable of protecting atrial natriuretic peptide from enzymatic degradation.
T70567	CGS 25462
	CGS 25462 is a neutral endopeptidase (NEP) inhibitor.
T17279	Z-321	Others	Others
	Z-321 is an inhibitor of prolyl endopeptidase.
T28246	ONO-1603 ONO1603
	ONO-1603, a prolyl endopeptidase inhibitor, is used potentially for the treatment of Alzheimer's disease.
T23699	Aladotrilat Fasidotrilat
	Aladotrilat is an inhibitor of neutral endopeptidase. Its prodrug is aladrotril.
T28003	MDK7677 Cathepsin B Inhinitor-17,MDK 7677
	MDK7677 is a selective inhibitor of cathepsin B endopeptidase and exopeptidase activities.
T31598	Ecadotril S.049,BAY-y 7432,BAY y 7432,BP 1.02,S049
	Ecadotril is a neutral endopeptidase (NEP) inhibitor, which plays an anti hypertensive role.
TP1900	Hemopressin (human, mouse)
	Bioactive endogenous peptide substrate for endopeptidase 24.15 (ep24.15), neurolysin (ep24.16) and ACE. Ki values are 27.76, 3.43 and 1.87 μM respectively. Potent hypotensive in vivo. Also acts as a selective CB1 receptor inverse agonist. Displays antinoc
T70698	MDL-100173
	MDL-100173 is a dual angiotensin-converting enzyme (ACE)/neutral endopeptidase (NEP) inhibitor.
T25955	Picromycin Antibiotic B 62169A,Amaromycin,Albomycetin,Pikromycin
	Picromycin is a 14-membered macrolide antibiotic and Prolyl endopeptidase (PREP) inhibitor. Pikromycin shows activity against gram-positive bacteria including mycobacteria.
T68601	Azidothiorphan
	Azidothiorphan is a photoaffinity ligand for the active site of the neutral endopeptidase 24.11. After ultraviolet irradiation the inhibitor binds irreversibly to the enzyme, and photolabeling occurs at the active site. The competitive inhibitor thiorphan protects the endopeptidase from inactivation.
T26048	RB 101 RB101,RB-101
	RB 101 suppresses enkephalinase and aminopeptidases; biologically cleaved at disulfide to produce inhibitors of both aminopeptidase N and neutral endopeptidase.
T25890	NSC-84096 CID 256758,CID-256758,CID256758
	NSC-84096 is an endopeptidase activity inhibitor of botulinum neurotoxin type A light chain (rBoNT/A-LC).
T29052	UK-414,495 UK 414495,UK414,495,UK414495,UK-414495
	UK-414,495 is a potent, selective inhibitor of the neutral endopeptidase, the enzyme normally serves to break down the neuropeptide VIP.
T30701	Candoxatrilat UK69578,UK 69578,U 73967,U-73967,U73967,UK-69578
	Candoxatrilat (U 73967, UK69578) is an active neutral endopeptidase inhibitor that reduces atrial natriuretic peptide degradation.
TP1210	Bradykinin (1-7) Bradykinin Fragment 1-7
	Bradykinin (1-7), an amino-truncated peptide derived from Bradykinin, is a metabolite formed through enzymatic cleavage by endopeptidase.
T15696	NEP-IN-2	Others	Others
	NEP-IN-2 is an inhibitor of neutral endopeptidase. It also is used in the research of proliferation in atherosclerosis, restenosis.
T74674	Z-Thioprolyl-Thiazolidine
	Z-Thioprolyl-Thiazolidine 是一种有效且特异的脯氨酰内肽酶 (prolyl endopeptidase) 抑制剂，对牛脑的脯氨酰内肽酶 Ki 为 0.36 nM。
T78363	Aspergillopepsin I Aspergillus acid protease
	Aspergillopepsin I (Aspergillus acid protease) 是一种属于天冬氨酸内肽酶类，能广泛特异性催化水解蛋白质中的肽键。
T38116	Fmoc-Ala-Glu-Asn-Lys-NH2 Fmoc-Ala-Glu-Asn-Lys-NH2
	Fmoc-Ala-Glu-Asn-Lys-NH2 is a peptide inhibitor that selectively targets asparagine endopeptidase (AEP) and inhibits the cleavage of amyloid precursor protein (APP). AEP, a pH-controlled cysteine proteinase, plays a crucial role in the proteolytic processing of APP, and its activity is enhanced during the aging process [1].
T70878	P516-0475
	P516-0475 is a novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO. This compound induces quorum sensing by stabilizing SHP pheromones in culture.
TP1901	Hemopressin(rat) Hemopressin (rat)
	Bioactive endogenous peptide substrate for endopeptidase 24.15 (ep24.15), neurolysin (ep24.16) and ACE. Ki values are 27.76, 3.43 and 1.87 μM respectively. Potent hypotensive in vivo. Also acts as a selective CB1 receptor inverse agonist. Displays antinoc

化合物

Prolyl Endopeptidase Inhibitor 1

Cat.No: T12546

Synonym: (Boc)-Prolyl-prolinal,BPP,Boc-Pro-prolinal

Target: Others

Cat.No: T7693

Target: Neprilysin

Cat.No: TQ0106

Synonym: LBQ-657

Target: Neprilysin

Cat.No: T8657

Target: Others

δ-secretase inhibitor 11

Cat.No: T9713

Target: Beta Amyloid, Caspase

Cat.No: T4574

Synonym: AHU 377,AHU377,沙库必曲,AHU-377

Target: Neprilysin

Sacubitril hemicalcium salt

Cat.No: T4200

Synonym: AHU-377 (hemicalcium salt),LCZ696中间体,AHU377 calcium salt

Target: Neprilysin

Cat.No: T1176

Synonym: Acetorphan,消旋卡多曲

Target: Neprilysin, Proteasome

Cat.No: T9855

Synonym: 4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]-

Target: Others

Sacubitril/Valsartan

Cat.No: T2318

Synonym: Sacubitril mixture with Valsartan,沙库必曲/缬沙坦,Valsartan,Sacubitril,LCZ696

Target: Apoptosis, RAAS, Neprilysin

Cat.No: T10671

Synonym: UK 79300

Target: Others

Cat.No: T41032

Target: Antibacterial

Cat.No: T10918

Target: Neprilysin

Cat.No: T27730

Synonym: KGP-94,KGP 94

Target: Cysteine Protease

Cat.No: T19626

Synonym: (ALPHAS)-3'-氯-ALPHA-[[(1S)-2-乙氧基-1-甲基-2-氧代乙基]氨基][1,1'-联苯]-4-丙酸

Target: Neprilysin

Y-29794 Tosylate

Cat.No: T35233

Synonym: Y 29794,Y29794 tosylate,Y29794,Y-29794

Target: Prolyl Endopeptidase (PREP)

Cat.No: T12770

Synonym: aza-peptide Michael acceptor, 7a

Target: Parasite

(Rac)-Daglutril

Cat.No: T27119L

Synonym: SLV 306 acetic acid,2-((3S)-3-(1-(2-(ethoxycarbonyl)-4-phenylbutyl)cyclopentane-1-carboxamido)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid

Target: Others

Sar-[D-Phe8]-des-Arg9-Bradykinin acetate

Cat.No: TP1917L1

Synonym: Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base)

Target: Bradykinin Receptor

Cat.No: T27716

Synonym: KC12615

Cat.No: T26659

Synonym: ARI 3531

Cat.No: T23698

Synonym: BP1137,BP 1137,BP-1137

Cat.No: T12994

Synonym: Squibb 28603,SQ28,603

Target: Others

Y-29794 oxalate

Cat.No: T23541

Target: Others

Cat.No: T29053

Synonym: UK 447841

Cat.No: T28715

Synonym: Sch34826,Sch-34826

Cat.No: T27989

Synonym: Cathepsin B Inhinitor-42

Cat.No: T25973

Cat.No: T70471

Cat.No: T70567

Cat.No: T17279

Target: Others

Cat.No: T28246

Synonym: ONO1603

Cat.No: T23699

Synonym: Fasidotrilat

Cat.No: T28003

Synonym: Cathepsin B Inhinitor-17,MDK 7677

Cat.No: T31598

Synonym: S.049,BAY-y 7432,BAY y 7432,BP 1.02,S049

Hemopressin (human, mouse)

Cat.No: TP1900

Cat.No: T70698

Cat.No: T25955

Synonym: Antibiotic B 62169A,Amaromycin,Albomycetin,Pikromycin

Cat.No: T68601

Cat.No: T26048

Synonym: RB101,RB-101

Cat.No: T25890

Synonym: CID 256758,CID-256758,CID256758

Cat.No: T29052

Synonym: UK 414495,UK414,495,UK414495,UK-414495

Cat.No: T30701

Synonym: UK69578,UK 69578,U 73967,U-73967,U73967,UK-69578

Bradykinin (1-7)

Cat.No: TP1210

Synonym: Bradykinin Fragment 1-7

Cat.No: T15696

Target: Others

Z-Thioprolyl-Thiazolidine

Cat.No: T74674

Aspergillopepsin I

Cat.No: T78363

Synonym: Aspergillus acid protease

Fmoc-Ala-Glu-Asn-Lys-NH2

Cat.No: T38116

Synonym: Fmoc-Ala-Glu-Asn-Lys-NH2

Cat.No: T70878

Hemopressin(rat)

Cat.No: TP1901

Synonym: Hemopressin (rat)

Cat. No.	Product Name	Target	Signaling Pathways
TN4442	Linderene acetate	Prolyl Endopeptidase (PREP)	Metabolism; Proteases/Proteasome
	Linderene acetate 是一种脯氨酸肽链内切酶抑制剂，分离自Lindera strychnifolia 中。
T2717	Salidroside 红景天苷,Rhodioloside	Apoptosis; mTOR	Apoptosis; PI3K/Akt/mTOR signaling
	Salidroside (Rhodioloside) 是一种从红景天中分离出来的具有生物活性的酚苷化合物，是一种脯氨酰内肽酶抑制剂。它能通过激活 mTOR 信号缓解肿瘤恶病质小鼠模型中的恶病质症状，还能通过增强 PINK1/Parkin 介导的线粒体自噬来保护多巴胺能神经元。
T2S0618	β-Elemonic Acid 3-oxo Tirucallic Acid,β-岚香酮酸,Beta-Elemonic acid,3-Oxotirucallenoic Acid,β-榄香酮酸,Elemadienonic Acid	Apoptosis; Reactive Oxygen Species; COX	Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
	β-Elemonic Acid (3-Oxotirucallenoic Acid) 是从乳香树中分离得到的一种三萜，具有抗癌和抗炎作用。它抑制脯氨酰内肽酶，诱导细胞凋亡，活性氧和COX-2表达。
T3891	Oroxylin A-7-O-glucuronide Oroxylin A Glucoronide,千层纸素A-7-0-Β-D-葡萄糖醛酸苷,Oroxyloside,Oroxylin A 7-O-beta-D-glucuronide	Others	Others
	Oroxylin A-7-O-glucuronide (Oroxylin A Glucoronide) 是一种类黄酮葡糖苷酸，提取自 Scutellaria baicalensis 干燥的根中，具有脯氨酰寡肽酶(POP)抑制作用。
T6627	Phosphoramidon Disodium Phosphoramidon Disodium Salt,磷酰胺二钠	RAAS; Neprilysin; Others	Endocrinology/Hormones; Metabolism; Others
	Phosphoramidon Disodium (Phosphoramidon Disodium Salt) Salt 是一种金属蛋白酶 (metalloprotease) 抑制剂。Phosphoramidon Disodium Salt 抑制内皮素转化酶 (ECE) ，中性肽内切酶 (NEP) 和血管紧张素转换酶 (ACE) 的IC50分别为 3.5 ，0.034 和 78 μM。
T2775	Baicalin 黄芩苷,黄岑苷,Baicalein 7-O-β-D-glucuronide	NF-κB; HIV Protease; GABA Receptor; Autophagy	Autophagy; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome
	Baicalin (Baicalein 7-O-β-D-glucuronide) 是一种从黄芩中分离出来的脯氨酰内肽酶抑制剂，具有抗氧化、抗肿瘤、抗 HIV 的特性。
T1168	Desonide Tridesilon,地索奈德,Locapred,Prednacinolone	Glucocorticoid Receptor	Endocrinology/Hormones
	Desonide (Prednacinolone) 是一种非氟化皮质类固醇抗炎剂，能够作用于糖皮质激素受体。
TN4917	Rosenonolactone	Others	Others
	Rosenonolactone shows inhibitory activity against prolyl endopeptidase and thrombin.
T20541	Phosphoramidon
	Phosphoramidon is a membrane metallo-endopeptidase & endothelin-converting enzyme inhibitor and thermolysin inhibitor, which is obtained from culture filtrate of Streptomyces tanashiensis.

天然产物

Linderene acetate

Cat.No: TN4442

Target: Prolyl Endopeptidase (PREP)

Cat.No: T2717

Synonym: 红景天苷,Rhodioloside

Target: Apoptosis, mTOR

β-Elemonic Acid

Cat.No: T2S0618

Synonym: 3-oxo Tirucallic Acid,β-岚香酮酸,Beta-Elemonic acid,3-Oxotirucallenoic Acid,β-榄香酮酸,Elemadienonic Acid

Target: Apoptosis, Reactive Oxygen Species, COX

Oroxylin A-7-O-glucuronide

Cat.No: T3891

Synonym: Oroxylin A Glucoronide,千层纸素A-7-0-Β-D-葡萄糖醛酸苷,Oroxyloside,Oroxylin A 7-O-beta-D-glucuronide

Target: Others

Phosphoramidon Disodium

Cat.No: T6627

Synonym: Phosphoramidon Disodium Salt,磷酰胺二钠

Target: RAAS, Neprilysin, Others

Cat.No: T2775

Synonym: 黄芩苷,黄岑苷,Baicalein 7-O-β-D-glucuronide

Target: NF-κB, HIV Protease, GABA Receptor, Autophagy

Cat.No: T1168

Synonym: Tridesilon,地索奈德,Locapred,Prednacinolone

Target: Glucocorticoid Receptor

Rosenonolactone

Cat.No: TN4917

Target: Others

Cat.No: T20541

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