Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sacubitrilat (LBQ-657) 是活性的脑啡肽酶 (NEP) 抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 433 | 现货 | ||
2 mg | ¥ 619 | 现货 | ||
5 mg | ¥ 990 | 现货 | ||
10 mg | ¥ 1,660 | 现货 | ||
25 mg | ¥ 3,660 | 现货 | ||
50 mg | ¥ 5,330 | 现货 | ||
100 mg | ¥ 7,520 | 现货 | ||
500 mg | ¥ 14,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,090 | 现货 |
产品描述 | Sacubitrilat (LBQ-657) (LBQ657) is an effective inhibitor of active neprilysin (NEP). |
体外活性 | Sacubitrilat is bound to the active site of NEP by an intricate network of interactions that involves all functional groups of the compound giving rise to the high inhibitory potency of 5?nM [1]. |
体内活性 | Pharmacokinetics of Sacubitril, Sacubitrilat, and valsartan following the administration of single oral doses of LCZ696 400 or 1200 mg under fasting conditions are summarized. The mean plasma concentrations of Sacubitril increases rapidly with a median Tmax of 0.52 h for the 400 mg dose and 1.05 h for the 1200 mg dose, followed by Sacubitrilat, with the corresponding Tmax values of 2.07 and 3.05 h, respectively. The median Tmax for valsartan is 2.07 h for both the LCZ696 400 mg and 1200 mg doses. The Cmax of Sacubitrilat shows a dose-proportional increase, while the Cmax of Sacubitril and Valsartan shows less than proportional increases between the doses [2]. |
别名 | LBQ-657 |
分子量 | 383.44 |
分子式 | C22H25NO5 |
CAS No. | 149709-44-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (260.80 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.608 mL | 13.0398 mL | 26.0797 mL | 65.1992 mL |
5 mM | 0.5216 mL | 2.608 mL | 5.2159 mL | 13.0398 mL | |
10 mM | 0.2608 mL | 1.304 mL | 2.608 mL | 6.5199 mL | |
20 mM | 0.1304 mL | 0.652 mL | 1.304 mL | 3.26 mL | |
50 mM | 0.0522 mL | 0.2608 mL | 0.5216 mL | 1.304 mL | |
100 mM | 0.0261 mL | 0.1304 mL | 0.2608 mL | 0.652 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Sacubitrilat 149709-44-4 Metabolism Neprilysin Desethyl Sacubitril NEP Neutral endopeptidase LBQ-657 Inhibitor inhibit LBQ657 LBQ 657 CD10 Cluster of differentiation 10 inhibitor