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40

抑制剂 & 化合物

14

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T3316	Fluorometholone 氟米龙,Fluoromethalone,Cortilet,Oxylone,Delmeson	Glucocorticoid Receptor	Endocrinology/Hormones
	Fluorometholone (Fluoromethalone) 是合成糖皮质激素，具有抗炎和抗过敏作用。它可用作糖皮质激素受体激动剂，能够用于干眼症的研究。
T3977	Lifitegrast SHP-606,SAR 1118,立他司特,利非司特	Integrin	Cytoskeletal Signaling
	Lifitegrast (SAR 1118) 是一种整合素淋巴细胞功能相关抗原 1 拮抗剂，抑制 Jurkat T 细胞附着于ICAM-1的IC50为 2.98 nM。
T2390	Cevimeline hydrochloride hemihydrate	AChR	Neuroscience
	Cevimeline hydrochloride hemihydrate 是乙酰胆碱的奎尼丁衍生物，也是选择性的和口服活性的毒蕈碱型M1和M3受体激动剂。它可穿过血脑屏障，刺激唾液腺分泌，用作口干症的催涎剂。
T0977	Medrysone Gimeracil,6α-Methyl-11β-hydroxyprogesterone,6A-甲基-11B-羟孕酮,甲羟松	Glucocorticoid Receptor; Others	Endocrinology/Hormones; Others
	Medrysone (6α-Methyl-11β-hydroxyprogesterone) 是局部合成的糖皮质激素，具有代谢、抗炎和抗过敏特性，有潜力用于眼科的眼炎症研究。
T125559	Paradrymonoside
	Paradrymonoside 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125559，CAS号为 177413-34-2。
T125780	Drynachromoside A
	Drynachromoside A 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125780。
T64994	(2S,5R)-Benzhydryl 3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-oxide
	(2S,5R)-Benzhydryl 3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-oxide 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T64994，CAS号为 87579-78-0。
T27836	Linadryl hydrochloride A 446,A446,A-446
	Linadryl hydrochloride may have antihistamine activity.
T67365	2-(Benzhydrylsulfinyl)acetic acid
	2-(Benzhydrylsulfinyl)acetic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67365，CAS号为 63547-24-0。
TP2216	alpha-1 antitrypsin fragment 235-243 [Homo sapiens]/[Papio hamadryas]/[Cercopithecus aethiops]	Others	Others
	Protease inhibitor
T30373	Benzhydrylamine alpha-Phenylbenzylamine,Aminodiphenylmethane
	Benzhydrylamine is a biochemical that may be used in grafting and peptide synthesis.
T66344	(2S,5R,6S)-Benzhydryl 6-bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-oxide
	(2S,5R,6S)-Benzhydryl 6-bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-oxide 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66344，CAS号为 80353-26-0。
T126207	Dendryphiellic acid A
	Dendryphiellic acid A 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126207，CAS号为 121661-45-8。
T13571	JAK-IN-10	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK-IN-10 是一种 JAK 抑制剂，可用于干眼症的研究。
T67907	Nimucitinib	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Nimucitinib 是一种 Janus 激酶 (JAK) 抑制剂,可用来治疗干眼症，促进泪液分泌。
T33584	Namirotene CBS 211A,Cbs 211 A	Others	Others
	Namirotene (CBS 211A) 是一种蛋白质生物合成抑制剂，是一种人工合成的维甲酸类似物，可用于研究角膜疾病、角膜溃疡和干眼综合征。
T7099	Gefarnate	Others	Others
	Gefarnate 是一种胃炎和胃溃疡的研究药物，目前也用于研究干眼症。
TD0093	Oil Red O	Others	Others
	Oil Red O 用于制备染色溶液，可用于检测组织学冷冻切片中的脂质。
T16732	Reproxalap NS-2,ADX-102	Others	Others
	Reproxalap (NS-2) 是一种活性醛类隔离剂，可用于干眼症的研究。它能够与醛 (包括丙二醛和 4-羟基壬醛) 共价结合。
T40867	Simpinicline OC-02	AChE	Neuroscience
	Simpinicline (OC-02)（OC-02）是一种高选择性烟碱乙酰胆碱受体（nAChR）激动剂，可激活三叉神经副交感神经通路，可用于治疗干眼症。
T71704	Navamepent RX-10045	Others	Others
	Navamepent (RX-10045) 是 resolvin E1 (一种膳食-3多不饱和脂肪酸代谢物)的类似物，具有强大的抗炎活性，可减少角膜炎症、上皮损伤，加速角膜组织修复。Navamepent 可抑制角膜上皮细胞释放几种关键促炎介质。Navamepent 对干眼和杯状细胞损失非常有效，可加速泪液的产生。
T7423	Diquafosol tetrasodium 地夸磷索四钠,INS365	P2Y Receptor	GPCR/G Protein; Neuroscience
	Diquafosol tetrasodium (INS365) 是一种 P2Y2 受体激动剂，可刺激眼组织粘蛋白的分泌。它可改善泪膜稳定性和视觉功能，作为干眼症的局部治疗。
T12489L	Pimethixene maleate Pimetixene maleate	Dopamine Receptor; 5-HT Receptor; AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Pimethixene maleate (Pimetixene maleate) 是一种高效的 5-HT2B 受体拮抗剂，具有镇静和镇咳活性。Pimethixene maleate 抑制 5-HT1A，5-HT2A，5-HT2B，5-HT2C，组胺 H1，多巴胺 D2 和 D4.4 以及毒蕈碱 M1 和 M2，可用于研究儿童干咳和刺激性咳嗽。
T32133	Icomucret AL-12959,AL 12959,AL12959
	Icomucret can be used for the Treatment of Dry Eye.
T28496	R-932348 choline R-932348,R 348,R 932348,R932348,R-348,R348
	R-932348 choline, a dual JAK/SYK inhibitor, is used potentially for treatment of dry eye disease.
T34228	Quinethazone Quinethazon,Hydromox,Aquamox,Quinethazonum,Chinethazonum
	Quinethazone is a thiazide diuretic used to treat hypertension. Common side effects include dizziness, dry mouth, nausea, and low potassium levels.
T39293	Tivanisiran SYL1001,Tivanisiran
	Tivanisiran (SYL1001) is a siRNA developed specifically to inhibit the expression of transient receptor potential vanilloid 1 (TRPV1) to explore its implications in dry eye disease research.
T21372	Chlophedianol Hydrochloride clofedanol hydrochloride,clofedanol,chlophedianol
	Chlophedianol hydrochloride, a centrally acting cough suppressant, is used in the treatment of dry cough. It has antihistamine and local anesthetic properties, and may have anticholinergic effects at high doses.
T21119	Cevimeline AF-102B,西维美林,FKS 508,SNI 2011,HSDB 7286
	Cevimeline, a parasympathomimetic and muscarinic agonist, affects M1 and M3 receptors. Cevimeline has been shown to treat dry mouth and Sj gren's syndrome. It is also used to reduce Xerostomia symptoms and increase salivary flow in head and neck cancer survivors after radiotherapy.
T76988	Tanfanercept
	Tanfanercept (HL036337)，一种抗TNF-α单克隆抗体，在干眼症(DE)小鼠模型中能有效改善角膜糜烂。
T39128	Pro-Phe-Phe
	Pro-Phe-Phe, a highly aggregation-prone tripeptide composed of natural amino acids, exhibits the formation of distinctive helical-like sheets that engage in aromatic dry interfaces. This property makes Pro-Phe-Phe an excellent candidate for the development of modular super-helical self-assembling nanostructures.
TP1464	Risuteganib hydrochloride
	Risuteganib hydrochloride is an anti-integrin that downregulates oxidative stress and restores homeostasis, and targets three integrin receptors that are implicated in dry age-related macular degeneration (AMD) in order to restore homeostasis in the retin
T82074	Immune cell migration-IN-1
	Immune cell migration-IN-1（compound 2）是一种抑制免疫细胞迁移的有效化合物，适用于干眼病、湿疹、皮炎和牛皮癣等疾病研究。
T36005	1-Oleoyl-2-Palmitoyl-rac-glycerol
	1-Oleoyl-2-palmitoyl-rac-glycerol (1,2-OP) is a diacylglycerol containing oleic acid at the sn-1 position and palmitic acid at the sn-2 position. It enhances the inhibition of superoxide anion production by cytochalasin B when used at a concentration of 10 μM. The concentration of 1,2-OP decreases from 25.7 to 11.15% during the dry-curing process of Iberian ham.
T35445	1-Stearoyl-3-Oleoyl-rac-glycerol
	1-Stearoyl-3-oleoyl-rac-glycerol is a diacylglycerol that contains stearic acid at the sn-1 position and oleic acid at the sn-3 position. Intermittent fasting decreases skeletal muscle and hepatic levels of 1-stearoyl-3-oleoyl-rac-glycerol in New Zealand obese (NZO) mice.1 The concentration of 1-stearoyl-3-oleoyl-rac-glycerol decreases from 4.59 to 1.88% during the dry-curing process of Iberian ham.2References1. Baumeier, C., Kaiser, D., Heeren, J., et al. Caloric restriction and intermittent fa...
T70346	TOP1362
	TOP1362 is a Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders. TOP1362 strongly inhibited the kinase targets p38α, Syk, Src, and Lck, blocked the rise in p38α expression in hyperosmolar Chang cells, and potently reduced inflammatory cytokine release in cellular models of innate and adaptive immunities. In the EIU model, TOP1362 dose-dependently attenuated the LPS-induced rise in inflammatory cell infiltration and o...
T79235	JAK-IN-30	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK-IN-30（化合物31）是一种具有水溶性的JAK抑制剂，对JAK2、JAK1、JAK3及TYK2的IC50值分别为2、15、18及2 nM。该化合物作为研究干眼症（DED）的潜在药物而备受关注。
T62730	TDRL-X80
	TDRL-X80 是一种色素性干皮症蛋白 (XPA) 的有效抑制剂。TDRL-X80 能够抑制 XPA 的 DNA 结合活性。TDRL-X80 能够作用于单、双和顺铂损伤的 DNA，在荧光偏振 (FP) 分析中的 IC50 值为 18、20 和 29 μM，而 ELISA 分析中的 IC50为 21、39 和 28。
T82073	Immune cell migration-IN-2
	Immune cell migration-IN-2，例11的有效免疫细胞迁移抑制剂，在T细胞粘附试验中显示出13.5 nM的EC50，具有应用于干眼症与视网膜疾病研究的潜力。Immune cell migration-IN-2作为点击化学试剂，含有Alkyne基团，能够与含Azide基团的分子通过铜催化的叠氮-炔环加成反应(CuAAc)进行反应。
T66029	3,4-Dehydro-L-proline
	The leguminous shrub,Leucaena leucocephala(Leucaena) is wide‐spread in tropical and subtropical agricultural systems and provides a ready source of protein for livestock. However, the presence of mimosine, a non‐protein, amino acid comprising about 12% of the dry matter in growing tips ofLeucaena, is toxic to animals. Mimosine is degraded rapidly in the rumen to produce 3,4‐dihydroxypyridine (3,4‐DHP) and 2,3‐dihydroxypyridine (2,3‐DHP), both of which remain toxic to animals[1]. 3,4-DHP, as a de...

化合物

Fluorometholone

Cat.No: T3316

Synonym: 氟米龙,Fluoromethalone,Cortilet,Oxylone,Delmeson

Target: Glucocorticoid Receptor

Cat.No: T3977

Synonym: SHP-606,SAR 1118,立他司特,利非司特

Target: Integrin

Cevimeline hydrochloride hemihydrate

Cat.No: T2390

Target: AChR

Cat.No: T0977

Synonym: Gimeracil,6α-Methyl-11β-hydroxyprogesterone,6A-甲基-11B-羟孕酮,甲羟松

Target: Glucocorticoid Receptor, Others

Paradrymonoside

Cat.No: T125559

Drynachromoside A

Cat.No: T125780

(2S,5R)-Benzhydryl 3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-oxide

Cat.No: T64994

Linadryl hydrochloride

Cat.No: T27836

Synonym: A 446,A446,A-446

2-(Benzhydrylsulfinyl)acetic acid

Cat.No: T67365

alpha-1 antitrypsin fragment 235-243 [Homo sapiens]/[Papio hamadryas]/[Cercopithecus aethiops]

Cat.No: TP2216

Target: Others

Benzhydrylamine

Cat.No: T30373

Synonym: alpha-Phenylbenzylamine,Aminodiphenylmethane

(2S,5R,6S)-Benzhydryl 6-bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-oxide

Cat.No: T66344

Dendryphiellic acid A

Cat.No: T126207

Cat.No: T13571

Target: JAK

Cat.No: T67907

Target: JAK

Cat.No: T33584

Synonym: CBS 211A,Cbs 211 A

Target: Others

Cat.No: T7099

Target: Others

Cat.No: TD0093

Target: Others

Cat.No: T16732

Synonym: NS-2,ADX-102

Target: Others

Cat.No: T40867

Synonym: OC-02

Target: AChE

Cat.No: T71704

Synonym: RX-10045

Target: Others

Diquafosol tetrasodium

Cat.No: T7423

Synonym: 地夸磷索四钠,INS365

Target: P2Y Receptor

Pimethixene maleate

Cat.No: T12489L

Synonym: Pimetixene maleate

Target: Dopamine Receptor, 5-HT Receptor, AChR, Histamine Receptor

Cat.No: T32133

Synonym: AL-12959,AL 12959,AL12959

R-932348 choline

Cat.No: T28496

Synonym: R-932348,R 348,R 932348,R932348,R-348,R348

Cat.No: T34228

Synonym: Quinethazon,Hydromox,Aquamox,Quinethazonum,Chinethazonum

Cat.No: T39293

Synonym: SYL1001,Tivanisiran

Chlophedianol Hydrochloride

Cat.No: T21372

Synonym: clofedanol hydrochloride,clofedanol,chlophedianol

Cat.No: T21119

Synonym: AF-102B,西维美林,FKS 508,SNI 2011,HSDB 7286

Cat.No: T76988

Cat.No: T39128

Risuteganib hydrochloride

Cat.No: TP1464

Immune cell migration-IN-1

Cat.No: T82074

1-Oleoyl-2-Palmitoyl-rac-glycerol

Cat.No: T36005

1-Stearoyl-3-Oleoyl-rac-glycerol

Cat.No: T35445

Cat.No: T70346

Cat.No: T79235

Target: JAK

Cat.No: T62730

Immune cell migration-IN-2

Cat.No: T82073

3,4-Dehydro-L-proline

Cat.No: T66029

Cat. No.	Product Name	Target	Signaling Pathways
T1285	Anethole trithione 茴三硫,Anetholtrithion	Others; AChR	Neuroscience; Others
	Anethole trithione (Anetholtrithion) 是硫杂环胆碱，是一种胆汁分泌刺激剂，可增强唾液分泌并增加 mAChR 受体，用于口干症的研究。
T4S1114	Dryocrassin ABBA 东北贯众素,Dryocrassin	Influenza Virus; Antibacterial	Microbiology/Virology
	Dryocrassin ABBA (Dryocrassin) 是一种从苦参中提取的黄酮类天然产物，具有抗病毒和抗菌活性。它抑制树突状细胞的免疫刺激功能，延长同种异体皮肤移植成活率。
T2956	Cedryl acetate 乙酸柏木酯,Cedrol acetate,Cedranyl acetate	Antifungal	Microbiology/Virology
	Cedryl acetate (Cedranyl acetate) 是一种三环倍半萜烯，分离自草莓番石榴植物，能够表现出 α-葡萄糖苷酶的抑制活性。
T75456	Dendryphiellin D
	Dendryphiellin D，一种从Septoria rudbeckiae分离的化合物，后者为盐生植物Karelinia caspia中提取的植物病原真菌。该化合物显著抑制一氧化氮(NO)的生成。
T40815	δ-Decalactone	Others	Others
	δ-Decalactone 存在于脱脂奶粉和水果中，具有甜味。
T2980	Chondroitin sulfate Chonsurid,Chondroitin polysulfate,硫酸软骨素	MMP; Others; Endogenous Metabolite; NO Synthase	Immunology/Inflammation; Metabolism; Others; Proteases/Proteasome
	Chondroitin sulfate (Chonsurid) 是一种糖胺聚糖，被广泛用于骨关节炎的研究。它能够减少炎症介质和凋亡过程，并能够减少炎性细胞因子，iNOS 和MMPs 产生。
T3121	Betulin Trochol,betulinic alcohol,betuline,betulinol,桦木醇,Betulol,白桦脂醇	Apoptosis; Endogenous Metabolite; Lipid; Fatty Acid Synthase	Apoptosis; Metabolism
	Betulin (betulinol) 是从桦树树皮中分离出来的一种天然三萜，是 SREBP 抑制剂。
T2985	Gypenoside XLIX 绞股蓝皂苷 XLIX,绞股蓝皂苷XLIX	PPAR	DNA Damage/DNA Repair; Metabolism
	Gypenoside XLIX 是一种达玛烷型糖苷，是绞股蓝的主要成分。它是选择性过氧化物酶体增殖物激活受体 (PPAR)-α激活剂，可抑制细胞因子诱导的血管细胞粘附分子-1 (VCAM-1) 在人体内皮细胞中过度活跃和表达。
T2792	Glucosamine sulfate 硫酸葡萄糖胺,硫酸氨基葡萄糖,D-Glucosamine sulphate,D-Glucosaminesulfate	MMP; Reactive Oxygen Species; HIF/HIF Prolyl-Hydroxylase; Endogenous Metabolite; Autophagy	Autophagy; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; NF-κB; Proteases/Proteasome
	Glucosamine sulfate (D-Glucosaminesulfate) 是软骨基质和滑液中糖胺聚糖的天然成分，常用作骨关节炎的治疗方法。它也是一种氨基糖，是糖基化蛋白和脂质生化合成的突出前体，用作膳食补充剂。
TN1130	Yadanziolide A 鸦胆子素 H,鸦胆子内酯A	Antiviral	Immunology/Inflammation
	Yadanziolide A 来源于 Brucea javanica 干燥的种子。它具有强的抗病毒作用，能够抗烟草花叶病毒(IC50:5.5 μM)。它具有抗肿瘤活性。
T19278	Dicaprylyl carbonate 碳酸二辛酯,Dimethyl carbonate	Others	Others
	Dicaprylyl carbonate (Dimethyl carbonate) 是植物来源的固体脂肪，是干燥润肤剂。它具有强大的皮肤相容性和全面的性能，如防晒滤光片的增溶和分散能力。
T2P2923	Stearic acid 硬脂酸,Isostearic acid,Octadecanoic acid,Cetylacetic acid	Phosphatase; Endogenous Metabolite	Metabolism
	Stearic acid (Cetylacetic acid) 是长链饱和脂肪酸，存在于许多动植物油脂中。
TN1448	(-)-Bornyl acetate L-(-)-Bornyl acetate,左旋乙酸冰片酯,Bornyl acetate,(-)-乙酸龙脑酯	p38 MAPK; NF-κB; JNK; Antifungal	MAPK; Microbiology/Virology; NF-κB
	(-)-Bornyl acetate (L-(-)-Bornyl acetate) 是存在于牛膝草油中的一种具有抗真菌活性的 (+)-Bornyl acetate 低活性异构体。
T36348	Cerebroside C
	Cerebroside C is a fungal metabolite and glycosphingolipid that has been found in the rice pathogenic fungusM. grisea.1It induces production of the phytoalexin momilactone A when applied to wounded rice leaves, indicating that cerebroside C is an elicitor of the hypersensitive response in rice. Cerebroside C increases germination rate and reduces germination time in wheat seeds in a concentration-dependent manner at 4°C.2It also increases root length, fresh weight, and dry weight of wheat seedli...

天然产物

Anethole trithione

Cat.No: T1285

Synonym: 茴三硫,Anetholtrithion

Target: Others, AChR

Dryocrassin ABBA

Cat.No: T4S1114

Synonym: 东北贯众素,Dryocrassin

Target: Influenza Virus, Antibacterial

Cat.No: T2956

Synonym: 乙酸柏木酯,Cedrol acetate,Cedranyl acetate

Target: Antifungal

Dendryphiellin D

Cat.No: T75456

Cat.No: T40815

Target: Others

Chondroitin sulfate

Cat.No: T2980

Synonym: Chonsurid,Chondroitin polysulfate,硫酸软骨素

Target: MMP, Others, Endogenous Metabolite, NO Synthase

Cat.No: T3121

Synonym: Trochol,betulinic alcohol,betuline,betulinol,桦木醇,Betulol,白桦脂醇

Target: Apoptosis, Endogenous Metabolite, Lipid, Fatty Acid Synthase

Gypenoside XLIX

Cat.No: T2985

Synonym: 绞股蓝皂苷 XLIX,绞股蓝皂苷XLIX

Target: PPAR

Glucosamine sulfate

Cat.No: T2792

Synonym: 硫酸葡萄糖胺,硫酸氨基葡萄糖,D-Glucosamine sulphate,D-Glucosaminesulfate

Target: MMP, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite, Autophagy

Cat.No: TN1130

Synonym: 鸦胆子素 H,鸦胆子内酯A

Target: Antiviral

Dicaprylyl carbonate

Cat.No: T19278

Synonym: 碳酸二辛酯,Dimethyl carbonate

Target: Others

Cat.No: T2P2923

Synonym: 硬脂酸,Isostearic acid,Octadecanoic acid,Cetylacetic acid

Target: Phosphatase, Endogenous Metabolite

(-)-Bornyl acetate

Cat.No: TN1448

Synonym: L-(-)-Bornyl acetate,左旋乙酸冰片酯,Bornyl acetate,(-)-乙酸龙脑酯

Target: p38 MAPK, NF-κB, JNK, Antifungal

Cat.No: T36348

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