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Search Results for " antileukemic "

24

抑制剂 & 化合物

14

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T31011	Coralyne chloride	Topoisomerase	DNA Damage/DNA Repair
	Coralyne chloride 是一种具有强抗癌活性的原小檗碱。它可用于制备 Coralyne 衍生物，是一种基于荧光 DNA 的分子整流剂，通过位点特异性插入构建成 DNA 双链体。它可作为一种拓扑异构酶 I 毒性分子，诱导拓扑异构酶 I 介导 DNA 裂解。
T7673	ATH686 ATH 686	Apoptosis; FLT	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	ATH686 是一种选择性的，ATP 竞争性的FLT3抑制剂，具有抗白血病作用。它靶向突变 FLT3 蛋白激酶活性，并通过诱导凋亡和抑制细胞周期来抑制具有 FLT3 突变的细胞的增殖。
T8308	NL-1	Mitochondrial Metabolism; Autophagy	Autophagy; Metabolism
	NL-1 是一种mitoNEET 抑制剂，具有抗白血病作用。它抑制 REH 和 REH/Ara-C 细胞生长，IC50分别为 47.35 µM 和 56.26 µM。
T24269	KPT-251 KPT251	Others	Others
	KPT-251 是一种选择性核输出抑制剂。
T16940	STAT5-IN-2	Apoptosis; STAT	Apoptosis; JAK/STAT signaling; Stem Cells
	STAT5-IN-2 是一种具有抗白血病作用的 STAT5 抑制剂（EC50：在 K562 和 KU812 细胞中分别为 9 μM 和 5 μM）。
T15235	Enocitabine	Nucleoside Antimetabolite/Analog; HCV Protease; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	Enocitabine 是一种核苷类似物，抑制 DNA 复制剂。Enocitabine 抑制人巨细胞病毒的复制，显示出抗白血病和抗病毒活性。
T27704	K00135 K-00135,Imidazol[1,2-b]pyridazine 1,K 00135,IMIDAZOPYRIDAZIN 1	Pim	Chromatin/Epigenetic; JAK/STAT signaling
	K00135 (IMIDAZOPYRIDAZIN 1) 是 Pim 激酶的选择性抑制剂，可用于胃癌和抗白血病治疗的研究。
T4409	Gilteritinib 吉列替尼,ASP2215	FLT; TAM Receptor; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	Gilteritinib (ASP2215) 是一种 FLT3 抑制剂 (IC50:0.29 nM)，也是一种 AXL 抑制剂 (IC50:0.73 nM)，具有 ATP 竞争性。
T24492	Moflomycin F 860191,F-860191,F860191
	Moflomycin is an anthracycline derivative. It exhibits a higher antileukemic activity compared to other anthracyclines.
T25503	Hisphen Synonyms Hisfen,MD 2
	Hisphen shows antileukemic activity.
T24978	5,10-Dideazaaminopterin
	5,10-Dideazaaminopterin is an antileukemic drug.
T76162	Stem bromelain
	茎型菠萝蛋白酶(EC 3.4.22.32)，主要自(Ananas comosus)茎中提取的半胱氨酸类蛋白酶，展现广泛纤溶、抗水肿、抗血栓及抗炎活性。此外，具备抗肿瘤、抗白血病及抗转移效能。
T24979	5,10-Dideazafolic acid
	5,10-Dideazafolic acid is an antileukemic drug.
T22132	PD 166326
	PD166326 是一种吡啶并嘧啶型受体酪氨酸激酶抑制剂，对于Src 和Abl 的IC50值分别为 6 nM 和 8 nM。PD166326 显示出抗白血病活性。
T40432	Mezerein
	Mezerein is a chemical compound with antileukemic properties and acts as a PKC activator. It effectively inhibits the growth of yeast expressing PKC alpha (IC 50 = 1190 nM), PKC beta1 (IC 50 = 908 nM), and PKC delta (IC 50 = 141 nM). However, it does not inhibit the growth of yeast expressing PKC.
T69829	GCN2iB acetate
	GCN2iB is a GCN2 inhibitor. GCN2iB may be useful for the treatment of cancer. The inhibition of GCN2 sensitizes cancer cells with low basal-level expression of asparagine synthetase (ASNS) to the antileukemic agent L-asparaginase (ASNase) in vitro and in vivo.
T15472	Hepsulfam NCI 329680,ZINC01574758	Others	Others
	Hepsulfam is an anticancer agent. It also displays excellent antileukemic activity (a median IC50: 0.91 μg/mL in a panel of different tumors).
T60559	S-(N-PhenethylthiocarbaMoyl)-L-cysteine
	S-(N-PhenethylthiocarbaMoyl)-L-cysteine (PEITC-Cys) 是一种抗癌剂。S-(N-PhenethylthiocarbaMoyl)-L-cysteine 具有抗白血病活性，可抑制 HL60 细胞中的 DNA 合成。S-(N-PhenethylthiocarbaMoyl)-L-cysteine 是P450的抑制剂。
T78733	ZLD115
	ZLD115（化合物44）为FB23衍生的FTO抑制剂，作为抗白血病药物，对白血病细胞系展示抗增殖效果。
T25170	Botryodiplodin Cytostipin,Antibiotic PSX 1
	Botryodiplodin, an antibiotic, has antileukemic activity from Botryodiplodia theobromae. It has the property of turning the skin of the individual in various shades of pink 2-3 hrs after application. It is a toxic metabolite of Penicillium carneo-lutescen
T73167	HDAC-IN-49
	HDAC-IN-49 是一种有效的非选择性 HDAC(HDAC) 抑制剂，对 HDAC1、HDAC2、HDAC3、HDAC4 和 HDAC6的 IC50分别为 13 nM、14 nM、21 nM、1880 nM 和 10 nM 。HDAC-IN-49 表现出显着的抗白血病活性，但对健康细胞具有低细胞毒性。
T73358	(-)SHIN2
	(-)SHIN2 是 (+)SHIN2 的异构体。(+)SHIN2 是丝氨酸羟甲基转移酶 (SHMT) 的抑制剂，具有抗白血病作用。(+)SHIN2 与 Methotrexate 在体内异种移植模型中具有协同作用。
T82774	Caspase-3 activator 3	Caspase	Apoptosis; Proteases/Proteasome
	Caspase-3 activator 3 (compound 2h) 通过激活caspase 3诱导HL-60和K562细胞apoptosis，表现出抗白血病活性。其对HL-60细胞的IC50值为42.89 μM，对K562细胞的IC50值为33.61 μM。
T4791	Idarubicin Demethoxydaunorubicin
	Idarubicin 是一种有效的、具有口服活性的蒽环类抗白血病剂。Idarubicin 抑制拓扑异构酶 II，干扰 DNA 复制和 RNA 转录。Idarubicin 可诱导 DNA 损伤。Idarubicin 抑制 DNA 合成和 c-myc 表达。Idarubicin 还抑制细菌和酵母菌的生长。

化合物

Coralyne chloride

Cat.No: T31011

Target: Topoisomerase

Cat.No: T7673

Synonym: ATH 686

Target: Apoptosis, FLT

Cat.No: T8308

Target: Mitochondrial Metabolism, Autophagy

Cat.No: T24269

Synonym: KPT251

Target: Others

Cat.No: T16940

Target: Apoptosis, STAT

Cat.No: T15235

Target: Nucleoside Antimetabolite/Analog, HCV Protease, DNA/RNA Synthesis

Cat.No: T27704

Synonym: K-00135,Imidazol[1,2-b]pyridazine 1,K 00135,IMIDAZOPYRIDAZIN 1

Target: Pim

Cat.No: T4409

Synonym: 吉列替尼,ASP2215

Target: FLT, TAM Receptor, c-Kit

Cat.No: T24492

Synonym: F 860191,F-860191,F860191

Cat.No: T25503

Synonym: Synonyms Hisfen,MD 2

5,10-Dideazaaminopterin

Cat.No: T24978

Cat.No: T76162

5,10-Dideazafolic acid

Cat.No: T24979

Cat.No: T22132

Cat.No: T40432

Cat.No: T69829

Cat.No: T15472

Synonym: NCI 329680,ZINC01574758

Target: Others

S-(N-PhenethylthiocarbaMoyl)-L-cysteine

Cat.No: T60559

Cat.No: T78733

Cat.No: T25170

Synonym: Cytostipin,Antibiotic PSX 1

Cat.No: T73167

Cat.No: T73358

Caspase-3 activator 3

Cat.No: T82774

Target: Caspase

Cat.No: T4791

Synonym: Demethoxydaunorubicin

Cat. No.	Product Name	Target	Signaling Pathways
TN1932	Microhelenin C	Others	Others
	Microhelenin C 是抑制从Helenium microcephalum 中提取的倍半萜内酯，具有抗肿瘤作用。
TN4673	(+)-Nortrachelogenin Wikstromol,荛花酚	Apoptosis; HIV Protease; PI3K; Antifection	Apoptosis; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	(+)-Nortrachelogenin 是一种从 Wikstroemia indica C.A. Meyer （百里香科）中分离出来的木脂素。 (+)-Nortrachelogenin 具有抗白血病活性。
T5S1058	Triptonide 雷公藤内酯酮,PG 492,NSC 165677	Apoptosis; Wnt/beta-catenin; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Stem Cells
	Triptonide (PG 492) 是从雷公藤中鉴定出的一种天然产物，是一种 Wnt 信号抑制剂，其 IC50约为 0.3 nM。它具有免疫抑制、抗炎、避育、神经保护和抗淋巴瘤作用。
TN2319	Yadanzioside A 鸦胆子苷A,鸦胆子内脂A	Others	Others
	Yadanzioside A has antileukemic activity.
TN5266	Yadanzioside F	Others	Others
	Yadanzioside F has antileukemic activity.
TN3780	Deacetyleupaserrin	Others	Others
	Deacetyleupaserrin is an antileukemic sesquiterpene lactone.
TN5265	Yadanzioside C	Others	Others
	Yadanzioside C has antileukemic activity.
TN2320	Yadanzioside G	Others	Others
	Yadanzioside G has antileukemic activity.
TN4027	Eucannabinolide	Others	Others
	Eucannabinolide exhibits in vivo antileukemic activity.
TN3796	Dehydrobruceantinol	Others	Others
	Dehydrobruceantinol shows bitter taste and has antileukemic activity.
TN3542	Bruceantinoside A	Others	Others
	Bruceantinoside A has antileukemic activity.
TN5092	Tagitinin F	Antifection	Microbiology/Virology
	Tagitinin F possesses antileukemic activity; it also shows in vitro leishmanicidal activities against Leishmania braziliensis promastigotes and amastigotes.
TN5270	Yadanzioside P	Others	Others
	Yadanzioside P has antileukemic and antitumor activities.
TL0014	Pinusolide	ERK; p38 MAPK; Calcium Channel; Lipoxygenase; PAFR; Caspase; JNK; AMPK	Apoptosis; Chromatin/Epigenetic; GPCR/G Protein; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, and could be used to treat neurodegenerative diseases. Pinusolide attenuates blockade of insulin signaling by enhancing IRS-1 tyrosine phosphorylation by the activating the AMPK pathway, indicates the targeting of AMPK represents a new therapeutic strategy for hyperglycemia-induced insulin resistance and type 2 diabetes.

天然产物

Cat.No: TN1932

Target: Others

(+)-Nortrachelogenin

Cat.No: TN4673

Synonym: Wikstromol,荛花酚

Target: Apoptosis, HIV Protease, PI3K, Antifection

Cat.No: T5S1058

Synonym: 雷公藤内酯酮,PG 492,NSC 165677

Target: Apoptosis, Wnt/beta-catenin, Autophagy

Cat.No: TN2319

Synonym: 鸦胆子苷A,鸦胆子内脂A

Target: Others

Cat.No: TN5266

Target: Others

Deacetyleupaserrin

Cat.No: TN3780

Target: Others

Cat.No: TN5265

Target: Others

Cat.No: TN2320

Target: Others

Eucannabinolide

Cat.No: TN4027

Target: Others

Dehydrobruceantinol

Cat.No: TN3796

Target: Others

Bruceantinoside A

Cat.No: TN3542

Target: Others

Cat.No: TN5092

Target: Antifection

Cat.No: TN5270

Target: Others

Cat.No: TL0014

Target: ERK, p38 MAPK, Calcium Channel, Lipoxygenase, PAFR, Caspase, JNK, AMPK

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