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114

抑制剂 & 化合物

45

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8536	Filastatin	Antifungal	Microbiology/Virology
	Filastatin 是一种长效的白色念珠菌丝状体抑制剂，具有强大的抗真菌作用。它抑制真菌与聚苯乙烯和人类细胞的粘附，从酵母到菌丝的形态转变，抑制菌丝特异性 HWP1 启动子。
T38240	2,6-Dichlorodiphenylamine	Antibacterial	Microbiology/Virology
	2,6-Dichlorodiphenylamine 是双氯芬酸钠的一种结构类似物，显示出抗白色念珠菌活性。2,6-Dichlorodiphenylamine 是非选择性抗炎剂，为COX 的抑制剂，在 CHO 细胞中，对人 COX-1 和 COX-2 的IC50分别为 4 和 1.3 nM。
T21678	3MB-PP1	PLK	Cell Cycle/Checkpoint
	3MB-PP1是嘌呤类似物，是一种 Polo 样激酶 1 (Plk1) 抑制剂。在表达类似物敏感的 Plk1 等位基因的细胞中，3MB-PP1 通过靶向 Plk1 阻断有丝分裂进程和细胞分裂。3MB-PP1 特异性抑制类似物敏感的 Ssn3 (Cdk8)。3MB-PP1 抑制 Leu93 突变 Zipper-interacting protein kinase(Leu93-ZIPK)，IC50为2 μM。3MB-PP1 可用于细胞分裂和白色念珠菌 (Candida albicans) 菌丝形成的研究。
T27617	Inz-1	P450	Metabolism
	Inz-1 是一种有效的真菌特异性线粒体细胞色素 bc1 抑制剂，对酵母和人类的 IC50 分别为 8.092 和 45.320 μM。 Inz-1 可逆转氟康唑或其他三唑类抗真菌药对致病性真菌白色念珠菌的耐药性。
T19717	Cyclo-L-Trp-L-Trp	Antifungal	Microbiology/Virology
	Cyclo-L-Trp-L-Trp 是一种广谱抗真菌剂。它还诱导组蛋白的高度乙酰化。
T17022	Tebuconazole	P450; Antifungal	Metabolism; Microbiology/Virology
	Tebuconazole 是一种农用唑类杀菌剂，可抑制 CYP51，对白色念珠菌 CYP51 和truncated Homo sapiens CYP51 的IC50分别为 0.9 和 1.3 μM。
T22387	NSC 55655 5-[(2-nitrophenyl)methylidene]thiazolidine-2,4-dione	Others	Others
	NSC 55655 (5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione) 具有抗菌和抗氧化活性，抑制 B. subtilis, S. aureus, K. pneumonia, E. coli, S. typhi ，A. niger 和 C. albicans 的增殖，可用于糖尿病。
T9602	Monocaprin	Anti-infection; Antibacterial	Microbiology/Virology
	Monocaprin 是癸酸的 1-单甘油酯，对包膜病毒、某些细菌和酵母白色念珠菌具有抗菌活性。
T16412	Oteseconazole VT-1161	P450; Antifungal	Metabolism; Microbiology/Virology
	Oteseconazole (VT-1161) 是一种口服有效的抗真菌剂，结合并抑制白色念球菌的 CYP51，Kd 值小于 39 nM。
T38137	3,5-Dimethylbenzaldehyde	Endogenous Metabolite; Antifungal	Metabolism; Microbiology/Virology
	3,5-Dimethylbenzaldehyde 具有广谱的抗菌活性，对枯草芽孢杆菌、白假丝酵母菌、大肠杆菌、铜绿假单胞菌、金黄色葡萄杆菌和肺炎链球菌具有抑制作用。
T77686	1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone	Antifungal	Microbiology/Virology
	1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 具有广谱的抗真菌活性，对白色念珠菌、黑曲霉、铜绿假单胞菌、金黄色葡萄球菌等具有抑制作用。
T2305	Isavuconazole 艾沙康唑,BAL-4815,RO-0094815	P450; Antibiotic; Antifungal	Metabolism; Microbiology/Virology
	Isavuconazole (RO-0094815) 是一种三唑类前药，对酵母、霉菌和二型真菌具有抗真菌活性。它抑制麦角固醇生物合成，导致真菌膜结构和功能的破坏。它是 CYP3A4抑制剂。
T77608	1H-Indole, 3,3'-(2-thienylmethylene)bis[2-methyl-	Antifungal	Microbiology/Virology
	1H-Indole, 3,3'-(2-thienylmethylene)bis[2-methyl- 可作为一种广谱抗菌剂，对黑曲霉枯草芽孢杆菌、白假丝酵母、大肠杆菌和金黄色葡萄球菌有抑制作用。1H-Indole, 3,3'-(2-thienylmethylene)bis[2-methyl- 在体外实验中显示出抗炎活性，可用于治疗细菌感染。
T4040	AN2718	Antifungal	Microbiology/Virology
	AN2718 通过 OBORT 机制抑制蛋白质合成，有抗真菌功效。
T61502	Antifungal agent 32
	Antifungal agent 32 (compound 1a) is a highly effective antifungal compound. It displays strong inhibitory activity against Candida albicans filamentation and biofilm formation, as well as inhibiting the morphological switching of Candida albicans and its adherence to epithelial cells. This makes Antifungal agent 32 a valuable tool for research on Candida albicans infections [1].
T13787	N-563	Others	Others
	N-563 promotes resistance to Candida albicans infection in mice
T35297	ZD 0870 D 0870,D0870,ZD0870
	ZD 0870, used to treat infections caused by fluconazole-resistant candida albicans.
T28596	RO-09-4609 RO 09-4609,RO09-4609,RO 094609,RO-094609
	RO-09-4609 is a potent and selective inhibitor of Candida albicans N-myristoyltransferase (CaNmt).
T71939	PS77
	PS77 is a Pkh inhibitor directed to the PIF-pocket with increased selectivity for C. albicans Pkh2.
T10311	Amphotericin X1 两性霉素 X1	Others	Others
	Amphotericin X1 is a derivative of Amphotericin B with good antifungal activity. Amphotericin X1 inhibits Candida albicans 33/079, Cryptococcus neoformans 451, C.parapsilosis 937A, Aspergillus niger 57A and A.fumigatus (MICs: 1 μg/mL, 1 μg/mL, 8 μg/mL, 2
T81496	PhD1
	PhD1是一种抗菌肽，源自猴血白细胞，对细菌和白色念珠菌(Candida albicans)具有抗菌活性。
T80629	2-Dodecanol
	2-Dodecanol有效抑制了C. albicans的菌丝形成和SIR2基因的表达。
T81494	PhD3
	PhD3是源自猴血白细胞的抗菌肽，具备针对细菌和（Candida albicans）的抗菌活性。
T81495	PhD2
	PhD2是一种源自猴血白细胞的抗菌肽，对细菌与(真菌)Candida albicans显示出抗生活性。
T35700	FR901379
	FR901379 is an echinocandin-like antifungal lipopeptide.1 It is active against C. albicans, C. krusei, C. tropicalis, C. utilis, A. fumigatus, and A. niger fungi (IC50s = <0.003-1.9 μg/ml). FR901379 is protective against C. albicans infection in mice (ED50 = 1.1 mg/kg). It also reduces the number of pulmonary cysts and trophozoites in a mouse model of P. carinii infection. \|1. Fujie, A., Iwamoto, T., Sato, B., et al. FR131535, a novel water-soluble echinocandin-like lipopeptide: Synthesis and bi...
T63802	Antifungal agent 35
	Antifungal agent 35 是一种使氟康唑对C. albicans 的抗真菌活性的有效增强剂，是有效的抗真菌剂。
T81493	PhD4
	PhD4，源自猴血白细胞的抗菌肽，对细菌和真菌(Candida albicans)均显示活性。
T64235	Antifungal agent 25
	Antifungal agent 25 是一种有效的、广谱的、体内具有代谢稳定性的抗真菌剂。Antifungal agent 25 对白色念珠菌和耐氟康唑的白色念珠菌都表现出抗真菌效果。
T80293	RP-1
	RP-1为一抗菌肽，具备针对S. aureus、S. typhimurium、E. coli及C. albicans的抗菌活性。
T76264	Nisin Z
	Nisin Z 是一种抗菌和抗炎肽。Nisin Z 可有效对抗革兰氏阳性菌和真菌 (fungi)，例如 C. albicans。
T36434	Sordarin sodium
	Sordarin is an inhibitor of fungal protein synthesis originally isolated from S. araneosa.[1] It binds to elongation factor 2 (EF-2) in the presence of ribosomes and inhibits the uncoupled GTPase activity of equimolar mixtures of EF-2 and ribosomes from C. albicans (IC50 = 0.1 μM). Sordarin inhibits protein synthesis in cell-free lysates of C. albicans, C. glabrata, and C. neoformans (IC50s = 0.01, 0.2, and 0.06 μg/ml, respectively) but not in rabbit reticulocytes (IC50 = >100 μg/ml).[1] [2] It...
T25342	Discobahamin A
	Discobahamin A is a bioactive peptide isolated from a new species of the Bahamian deep water marine sponge Discodermia. It is a growth of Candida albicans inhibitor.
T25343	Discobahamin B
	Discobahamin B is a bioactive peptide isolated from a new species of the Bahamian deep water marine sponge Discodermia. It is a growth of Candida albicans inhibitor.
T74272	Antifungal agent 84
	Antibacterial agent 84 是一种抗真菌化合物。Antibacterial agent 84 以 CNB1 依赖性方式抑制念珠菌。Antibacterial agent 84 抑制C. albicans 生物膜的活性。
T36533	SCH 725674
	SCH 725674 is an antifungal macrolide originally isolated from Aspergillus. It inhibits the growth of S. cerevisiae and C. albicans in vitro (MICs = 8 and 32 μg/ml, respectively).
T74273	Antifungal agent 52
	Antifungal agent 52 (compound 6c) 是四唑衍生物。Antifungal agent 52 抑制麦角固醇的合成。Antifungal agent 52 对白色念珠菌表现出显着的抗真菌活性 Antifungal agent 52 影响白色念珠菌基底细胞膜通透性。
T69051	Aculeacin A
	Aculeacin A is used to study mutations that lead to antibiotic resistance in Saccharomyces cerevisiae, the inhibition of Candida albicans and the morphogenetic transformation of Candida albicans when treated. Aculeacin A is a lipopeptide that inhibits β-glucan synthesis in yeasts. The inhibition is due to the selective blockage of glucan synthase. Aculeacin A, an amphophilic antibiotic, inhibits the biosynthesis of β−glucan by selective blockage of β(1→3) glucan synthase.
T62098	Antifungal agent 28
	Antifungal agent 28 (化合物 18) 是一种选择性的、有效的抗真菌剂。Antifungal agent 28 可以破坏成熟念珠菌生物膜，能够抑制白念珠菌和非白念珠菌的致病性菌株，包括耐氟康唑菌株。Antifungal agent 28 对隐球菌和曲霉菌株也具有抑制作用。
T80932	Tritrpticin
	Tritrpticin是一种来源于猪骨髓的抗菌肽，对Aspergillus fumigatus和Candida albicans表现出抗菌活性，其最小抑菌浓度（MIC）分别为250和1000 μg/ml。
T62159	Antifungal agent 24
	Antifungal agent 24 (Compound 6) 是一种抗真菌剂，能够抑制白色念珠菌 (MIC: 0.03 μg/ml)。
T61308	Antifungal agent 27
	Antifungal agent 27 (compound 7) is a chemical compound possessing antifungal properties. It exhibits moderate antibacterial activity and weak antifungal activity against MRSA and C. albicans SS5314, with minimal inhibitory concentration (MIC) values of 8 and 32 μg/mL, respectively [1].
T76470	GVLSNVIGYLKKLGTGALNAVLKQ
	GVLSNVIGYLKKLGTGALNAVLKQ 是一种具有 24 个氨基酸的抗菌肽。 GVLSNVIGYLKKLGTGALNAVLKQ 可能形成 α 螺旋。GVLSNVIGYLKKLGTGALNAVLKQ (PGQ) 对革兰氏阴性菌、革兰氏阳性菌和酵母Candida albicans 具有抗性。
T80407	Peptide 5g
	Peptide 5g 是一种具有广谱抗菌特性的化合物。它对 E. coli, S. aureus 和 C. albicans 的最小抑制浓度 (MIC) 值显著，分别为 30 μg/mL、10 μg/mL 和 12.5 μg/mL。
T83715	Histatin 3 TFA Hst-3
	Histatin 3, 一种唾液抗菌肽，对C. albicans具有活性（LC50 = 9.2 µM）。在12 µM浓度下，还能在无细胞测定中诱导肌动蛋白聚合。
T61398	Chitin synthase inhibitor 3
	Chitin synthase inhibitor 3 (compound 2d) 是一种高效的chitin synthase抑制剂，具有0.16 mM的IC50值，并对candida albicans显示出1 μg/mL的MIC，表现出抗真菌活性。
T63064	Antibacterial agent 100
	Antibacterial agent 100 (Compound 7c) 是一种抗细菌和真菌剂，能够作用于 Staphylococcus aureus (MIC: 4 μg/mL)、Candida albicans (MIC: 4 μg/mL) 和 Cryptococcus neoformans (MIC: 8 μg/mL)。
T82834	Bombinin-BO1
	Bombinin-BO1是一种蟾蜍皮肤分泌物中的抗菌肽，它对大肠杆菌(Escherichia coli)、金黄色葡萄球菌(Staphylococcus aureus)和白色念珠菌(Candida albicans)显示出抗生活性，其最小抑菌浓度(MIC)值分别为64 mg/L, 64 mg/L和128 mg/L。
T36437	Sphinganine (d17:0) Sphinganine (d17:0)
	Sphinganine is a synthetic bioactive sphingolipid that inhibits the growth of C. glabrata and C. albicans with a minimum fungicidal concentration (MFC) value of 0.5 μg/ml for both. More commonly, sphinganine is used as an internal standard in the analysis of sphingoid compounds by chromatographic or spectrometric methods.
TP1518	Lactoferrin (17-41) Lactoferrin 17-41
	Lactoferrin (17-41) is amino acids 17 to 41 fragment of lactoferrin, known as lactoferricin B. Lactoferrin (17-41) shows anti-fungal properties in combination of other anti-fungal agents.Candida Albicans is one of the targets of the lactoferricin B.
T80400	Peptide 5e
	Peptide 5e为一种具有抗菌特性的肽类化合物。其针对大肠杆菌(E. coli)、金黄色葡萄球菌(S. aureus)以及白色念珠菌(C. albicans)的最小抑制浓度(MIC)值依次为30、5及25 μg/mL。

化合物

Cat.No: T8536

Target: Antifungal

2,6-Dichlorodiphenylamine

Cat.No: T38240

Target: Antibacterial

Cat.No: T21678

Target: PLK

Cat.No: T27617

Target: P450

Cyclo-L-Trp-L-Trp

Cat.No: T19717

Target: Antifungal

Cat.No: T17022

Target: P450, Antifungal

Cat.No: T22387

Synonym: 5-[(2-nitrophenyl)methylidene]thiazolidine-2,4-dione

Target: Others

Cat.No: T9602

Target: Anti-infection, Antibacterial

Cat.No: T16412

Synonym: VT-1161

Target: P450, Antifungal

3,5-Dimethylbenzaldehyde

Cat.No: T38137

Target: Endogenous Metabolite, Antifungal

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone

Cat.No: T77686

Target: Antifungal

Cat.No: T2305

Synonym: 艾沙康唑,BAL-4815,RO-0094815

Target: P450, Antibiotic, Antifungal

1H-Indole, 3,3'-(2-thienylmethylene)bis[2-methyl-

Cat.No: T77608

Target: Antifungal

Cat.No: T4040

Target: Antifungal

Antifungal agent 32

Cat.No: T61502

Cat.No: T13787

Target: Others

Cat.No: T35297

Synonym: D 0870,D0870,ZD0870

Cat.No: T28596

Synonym: RO 09-4609,RO09-4609,RO 094609,RO-094609

Cat.No: T71939

Amphotericin X1

Cat.No: T10311

Synonym: 两性霉素 X1

Target: Others

Cat.No: T81496

Cat.No: T80629

Cat.No: T81494

Cat.No: T81495

Cat.No: T35700

Antifungal agent 35

Cat.No: T63802

Cat.No: T81493

Antifungal agent 25

Cat.No: T64235

Cat.No: T80293

Cat.No: T76264

Sordarin sodium

Cat.No: T36434

Cat.No: T25342

Cat.No: T25343

Antifungal agent 84

Cat.No: T74272

Cat.No: T36533

Antifungal agent 52

Cat.No: T74273

Cat.No: T69051

Antifungal agent 28

Cat.No: T62098

Cat.No: T80932

Antifungal agent 24

Cat.No: T62159

Antifungal agent 27

Cat.No: T61308

GVLSNVIGYLKKLGTGALNAVLKQ

Cat.No: T76470

Cat.No: T80407

Cat.No: T83715

Synonym: Hst-3

Chitin synthase inhibitor 3

Cat.No: T61398

Antibacterial agent 100

Cat.No: T63064

Cat.No: T82834

Sphinganine (d17:0)

Cat.No: T36437

Synonym: Sphinganine (d17:0)

Lactoferrin (17-41)

Cat.No: TP1518

Synonym: Lactoferrin 17-41

Cat.No: T80400

Cat. No.	Product Name	Target	Signaling Pathways
T1388	Fluconazole 氟康唑,UK-49858	Antibiotic; Antifection; Antifungal	Microbiology/Virology
	Fluconazole (UK-49858) 是一种对多种真菌具有活性的三唑类抗真菌剂，抑制 C. albicans 和 Candida kefyr 的 IC99为 0.20 μg/mL 至 0.39 μg/mL。
T14046	Anandamide 花生四烯酸乙醇胺,(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide	Cannabinoid Receptor; Endogenous Metabolite	GPCR/G Protein; Metabolism
	Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide) 是一种免疫调节剂，通过大麻素受体 CB1 和 CB2 起作用，还通过中枢神经系统中的其他靶点起作用，如 GPR18/GPR55。
T7029	Pseudolaric Acid C	Antifungal	Microbiology/Virology
	Pseudolaric Acid C 是一种从Pseudolarix kaempferiGorden 根皮部中分离的二萜酸，对白色念珠菌有较弱的抗真菌活性。
T37267	Pachybasin	Antibacterial	Microbiology/Virology
	Pachybasin 是一种蒽醌真菌代谢物。 Pachybasin 对大肠杆菌、枯草芽孢杆菌、M. luteus、S. cerevisiae、C. albicans、A. niger 和 A. flavus 具有抗菌活性，MIC 值为 64.0 μg/mL，对金黄色葡萄球菌具有抗菌活性和尖孢镰刀菌，MIC 值分别为 32.0 和 16.0 μg/mL。
TN1877	Lonicerin 忍冬苦苷,金银花	Apoptosis; Antibacterial	Apoptosis; Microbiology/Virology
	Lonicerin 是一种抗藻酸盐分泌蛋白的黄酮类化合物，对铜绿假单胞菌有抑制作用。它可预防脂多糖诱导的急性肺损伤的炎症和细胞凋亡。
TN1651	Furanodiene	Apoptosis; PARP; Reactive Oxygen Species; Caspase; CDK; P-gp	Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB; Proteases/Proteasome
	Furanodiene 是从姜黄中提取的一种萜类天然产物，可抑制外排转运蛋白Pgp 功能并降低 Pgp 蛋白水平。它通过抗血管生成和诱导ROS 产生，DNA 链断裂和细胞凋亡发挥抗癌作用。
T5S0636	Citric acid 柠檬酸,Citro,Citretten	Apoptosis; Others; Endogenous Metabolite; Antibacterial; Antibiotic	Apoptosis; Metabolism; Microbiology/Virology; Others
	Citric acid (Citro) 是柑橘类水果中发现的弱有机三羧酸。柠檬酸是食品添加剂和天然防腐剂。
T1678	Nystatin Stamycin,Fungicidin,制霉菌素,Nystavescent	Apoptosis; Antibiotic; Antifungal	Apoptosis; Microbiology/Virology
	Nystatin (Fungicidin) 是一种口服对酵母和支原体有效的多烯类抗真菌抗生素。它能增加质膜对包括氯离子等小单价离子的通透性。它可部分阻止 Oxaliplatin 诱导的脂筏聚集、DR4 和 DR5 聚集的胆固醇隔离试剂，减少细胞凋亡。
TN7224	2,2'-Dihydroxy chalcone	Antibacterial; Autophagy	Autophagy; Microbiology/Virology
	2,2'-Dihydroxy chalcone 是一种用 fMLP/CB 刺激的大鼠中性粒细胞释放β-葡糖醛酸酶（IC50=1.6±0.2μM）和溶菌酶（IC50=1.4±0.2μM）的有效抑制剂。2,2'-Dihydroxy chalcone 对大肠杆菌、福氏志贺氏菌、白葡萄球菌和金黄色葡萄球菌有抑菌活性。
T4S1321	(+)-Magnoflorine chloride Magnoflorine chloride,氯化木兰花碱,Corytuberine methochloride,Thalictrine chloride,Escholine chloride	Others; Antifungal	Microbiology/Virology; Others
	(+)-Magnoflorine chloride (Escholine chloride) 是从 Acoruscalamus 中分到的一种阿朴啡生物碱，具有抗炎、抗真菌、抗氧化和抗糖尿病的作用，可以减少 C. albicans 生物膜的形成。
T3S1320	(+)-Magnoflorine iodide Magnoflorine iodide,Thalictrine iodide,碘化木兰花碱,Corytuberine Methiodide	Others; Antifungal	Microbiology/Virology; Others
	(+)-Magnoflorine iodide (Thalictrine iodide) 是从 Acoruscalamus 中分到的一种阿朴啡生物碱，具有抗炎、抗真菌、抗氧化和抗糖尿病的作用，可以减少C. albicans 生物膜的形成。
T0011	2-Phenylethanol 苯乙醇,Phenethyl alcohol,2-Phenylethyl alcohol,Benzyl carbinol,Phenylethanol,Benzeneethanol	Others; Virus Protease; Antibacterial; Antibiotic	Microbiology/Virology; Others
	2-Phenylethanol (Phenylethanol) 是从玫瑰、风笛、阿勒颇松、桔子花等多种物种中提取得到的一种无色液体。它有一种使人感到愉悦的气味，也是一种从真菌Candida albicans 产生的自体抗生素。它可用作香皂中的防腐剂，也用作香烟添加剂。
T3S1319	(+)-Magnoflorine Escholin,Magnoflorine,Thalictrin,Escholine,木兰花碱	Others; Antifungal	Microbiology/Virology; Others
	(+)-Magnoflorine (Thalictrin) 是从 Acoruscalamus 中分到的一种阿朴啡生物碱，可以减少 C. albicans 生物膜的形成，具有抗真菌、抗氧化、抗糖尿病、镇静和抗焦虑的作用。
T25718	Lichesterol
	Lichesterol is extracted from polyene antibiotic-resistant Candida albicans.
T70891	Pyridoxatin
	Pyridoxatin is a fungal metabolite that inhibits production of thiobarbituric acid reactive substance (TBARS). Pyridoxatin inhibits hemolysis induced by the free radical generator AAPH and is active against C. albicans.
T79931	Mutanocyclin
	Mutanocyclin 作为一种效能显著的抗真菌剂，能够抑制白色念珠菌 (C. albicans) 的丝状形成，并下调 HWP1、ECE1、FLO8、TEC1 基因的 mRNA 表达水平。此外，Mutanocyclin 在体外小鼠模型中亦能有效抑制酵母形态的发展。
TN1561	Dehydroglaucine	Antifection	Microbiology/Virology
	Dehydroglaucine is an acetylcholinesterase inhibitor, it shows antimicrobial activity against Staphylococcus aureus, Mycobacterium smegmatis, Candida albicans, and Aspergillus niger.
T11895	Luteolin-7-rutinoside	Others	Others
	Luteolin-7-rutinoside has both antifungal activities and anti-arthritic, can result in a combination therapy for the treatment of fungal arthritis due to C. albicans infection.
TN2032	Pachypodol 霍香黃酮醇	Antifection	Microbiology/Virology
	Pachypodol has antibacterial and antifungal activities against Bacillus subtilis, Staphylococcus aureus, Staphylococcus faecalis, Echerichia coli, Pseudomonas aeruginosa, Candida albicans, Candida krusei and Candida galabrata.
TN3709	Coronarin D ethyl ether	NF-κB	NF-κB
	Coronarin D inhibits NF-KB activation pathway, which leads to inhibition of inflammation, invasion, and osteoclastogenesis, as well as potentiation of apoptosis.It shows promising antifungal activity against C. albicans in vitro.
TN3978	Epitaraxerol	Antifection	Microbiology/Virology
	Epitaraxerol shows moderate antifungal activity against C. albicans and low antimicrobial activity against T. mentagrophytes, A. niger, S. aureus, E. coli, P. aeruginosa, and B. subtilis.
TN2492	1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone	Others	Others
	1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone has moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines, but lacks antifungal activity against Candida albicans.
T28379	PF-1163B PF1163B,(-)-PF1163B,PF 1163B
	PF-1163B is an antifungal agent form Penicillium sp. II. PF-1163B inhibits ergosterol (ERG) synthesis with IC50 value of 34 ng/ml. PF-1163B showed potent growth inhibitory activity against pathogenic fungal strain Candida albicans but did not show cytotox
T37712	Fumiquinazoline D
	Fumiquinazoline D is a fungal metabolite originally isolated from A. fumigatus that has activity against Gram-positive and Gram-negative bacteria (MICs = 8-16 μg/ml) as well as F. solani and C. albicans fungi (MICs = 32 and 64 μg/ml, respectively).
TN3400	Altechromone A	Antifection	Microbiology/Virology
	Altechromone A has antimicrobial activity, it is active against Bacillus subtilis, Escherichia coli, Pseudomonas fluorescens and Candida albicans with the MICs of 3.9, 3.9, 1.8, and 3.9 ug/ml, respectively.
T37444	Aranorosin
	Aranorosin is a fungal metabolite originally isolated from P. roseus. It has antimicrobial activity against B. subtilis, A. niger, and C. albicans when used at a concentration of 1 mg/ml. Aranorosin also reduces viability in apoptosis-resistant HeLa/Bcl-2 cells.
T80335	Maximin H3
	Maximin H3，源自中华红腹蟾蜍Bombina maxima皮肤分泌，为一种抗菌肽。对Escherichia coli ATCC 25922、Staphylococcus aureus ATCC 2592、Bacillus pyocyaneus CMCC B1010 及Candida albicans ATCC 2002表现出显著抗性，其MIC值依次为20, 10, 20, 5 μg/ml。
TN3723	Cryptomeridiol	PAFR; Antifection	GPCR/G Protein; Microbiology/Virology
	Cryptomeridiol is a potential skin-whitening agent, exhibits melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells. Cryptomeridiol has low activity against A. niger, T. mentagrophytes, and C. albicans. (-)-Cryptomeridiol also exhibits a significant and concentration-dependent inhibitory effect on PAF receptor binding, with inhibitory concentration (IC)(50) values of 17.5 uM.
T80349	Maximin H4
	Maximin H4是一种来自中华红腹蟾蜍(Bombina maxima)皮肤分泌物的抗菌肽，具有针对Escherichia coli ATCC25922、Staphylococcus aureus ATCC2592、Bacillus pyocyaneus CMCCB1010和Candida albicans ATCC2002的抗菌活性。其最小抑菌浓度(MIC)值依次为12、6、12、6 μg/ml。
T38016	Hirsutide
	Hirsutide is a cyclotetrapeptide fungal metabolite produced by the entomopathogenic fungus Hirsutella. It has antibacterial activity against C. pyogenes, S. aureus, P. aeruginosa, and K. pneumonia (MICs = 25, 13, 6, and 21 μg/cm3, respectively). Hirsutide also has antifungal activity against C. albicans, M. audouinii, A. niger, and Ganoderma (MICs = 13, 6, 25, and 6 μg/cm3, respectively).
T80334	Maximin H2
	Maximin H2，源自中华红腹蟾蜍(Bombina maxima)皮肤分泌物的抗菌肽，对Escherichia coli ATCC25922、Staphylococcus aureus ATCC2592、Bacillus pyocyaneus CMCCB1010及Candida albicans ATCC2002展示了明显的抗菌活性。其最小抑菌浓度(MIC)值依序为20、2、4、2 μg/ml。
T80332	Maximin H1
	Maximin H1是一种抗菌肽，由中华红腹蟾蜍(Bombina maxima)皮肤分泌物提取得到。该化合物对Escherichia coli ATCC 25922、Staphylococcus aureus ATCC 25923、Bacillus pyocyaneus CMCC B1010和Candida albicans ATCC 2002表现出抗菌活性，其最小抑菌浓度(MIC)值分别为9、4.5、9、4.5 μg/ml。
T69225	Verrucarin J Muconomycin B
	Verrucarin J (Muconomycin B) 是Myrothecium 真菌家族的代谢物。Verrucarin J 诱导活性氧 (ROS) 生成和癌细胞系凋亡 (apoptosis)，例如 A549、HCT 116 和 SW-620 细胞。Verrucarin J 具有抗Candida albicans 和Mucor miehei 的活性。Verrucarin J 抑制沙粒病毒 Junin (JUNV) 产量，IC50为 1.2 ng/mL。
T36403	Methyl 3,4,5-trimethoxy-2-(2-(nicotinamido)benzamido)benzoate
	Preterramide C is a fungal metabolite that has been found inA. terreus.1It is active againstS. aureus(MIC = 52.4 μM) but notE. aerogenes,P. aeruginosa, orC. albicans(MICs = >100 μM for all).2Preterramide C inhibits the growth of L5178Y mouse lymphoma cells with an IC50value of 0.1 μg/ml.3It also inhibits nitric oxide (NO) production induced by LPS in RAW 264.7 cells (IC50= 5.48 μM).
T80330	XT-1
	XT-1是一种抗菌肽，源自热带爪蟾Xenopus tropicalis的皮肤分泌物，表现出对S.aureus、E.coli和C.albicans的强烈活性，其最小抑菌浓度(MIC)分别为5μM、6μM和50μM。
TN5014	Shoreic acid	Antifection; HSV	Microbiology/Virology
	Shoreic acid exhibits antibacterial activity against E. coli, P. aeruginosa, S. aureus, and B. subtilis with activity indices (AI) of 0.2, 0.3, 0.5 and 0.4, respectively, it also shows antifungal activity against C. albicans and T. mentagrophytes with AI
T79008	Ys-II
	Ys-II (Compound 1)为源于丝兰(Yucca elephantipe)茎部的螺甾烷醇糖苷，具备针对白色念珠菌和新型隐球菌(Cryptococcus neoformans)的抗真菌效力(IC50分别为5和6μg/mL)。
T72235	Antibacterial synergist 2
	Antibacterial synergist 2 是菌膜抑制剂。Antibacterial synergist 2 对肠球菌、金色葡萄球菌、铜绿假单胞菌和白色假单胞菌具有抑制效应。Antibacterial synergist 2 可用于与形成菌膜的病原体的相关研究。
T37008	Reveromycin A
	Reveromycin A is the major component of a complex of spiroketal antibiotics isolated from Streptomyces sp. It inhibits the mitogenic activity of epidermal growth factor in Balb/MK cells (IC50 = 0.7 μg/ml), displays antiproliferative activity against human KB and K562 tumor cell lines (IC50s = 1.9 and 1.6 μg/ml, respectively), and demonstrates antifungal activity against C. albicans (MIC = 2 μg/ml at pH 3). Reveromycin A also has been shown to inhibit bone resorption by inducing apoptosis in oste...
TN3708	Coronarin D	BCL; c-Myc; TNF; NF-κB; Caspase; COX; Antifection	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome
	Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were 2 and 4 mg/mL, respectively; it is active against tested Gram-positive bacteria, i
T36438	Sporogen-AO 1
	Sporogen-AO 1 is a fungal metabolite originally isolated fromA. oryzaethat has diverse biological activities.1,2,3,4,5It inhibits HIV-1 Tat transactivation in a cell-based assay with an IC50value of 15.8 μM.4Sporogen-AO 1 is cytotoxic to HeLa, KB, and NCI H187 cancer cells (IC50s = 8.3, 9, and 5.1 μM, respectively).2,5It is active againstC. albicans(MIC = 4 mM).3 1.Tanaka, S., Wada, K., Marumo, S., et al.Structure of sporogen-ao 1, a sporogenic substance of Aspergillus oryzaeTetrahedron Lett.25(...
T36329	Terpendole I
	Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 μg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 μg/ml for all) or the fungus C. albicans (MIC = 200 μg/ml).1,2 It is cytotoxic to HeLa cells with an IC50 value of 52.6 μM.3 \|1. Tomoda, H., Tabata, N., Yang, D.-J., et al. Ter...
T36886	Pestalotin
	Pestalotin is a fungal metabolite originally isolated from P. cryptomeriaecola with diverse biological activities. It induces reducing sugar release in embryoless rice endosperms when used at concentrations ranging from 3 to 100 mg/L and enhances growth of rice seedlings (O. sativa) when used in combination with gibberellin A3 at concentrations ranging from 30 to 500 mg/L. Pestalotin has antifungal activity, reducing the growth of C. albicans, C. neoformans, T. rubrum, and A. fumigatus (MICs = 1...
T83693	Magainin 2 TFA MG2
	Magainin 2是一种从非洲爪蟾（X. laevis）皮肤中分离出的阳离子肽，具有宿主防御和抗菌活性。该化合物对细菌E. coli、K. pneumoniae、S. epidermidis、S. aureus及真菌C. albicans表现出活性（MICs分别为5、10、10、50和80 µg/ml）。Magainin 2（20 µM）能降低猕猴桃花粉的萌发率和平均管长。在被单纯疱疹病毒1型（HSV-1）或2型（HSV-2）感染的Vero细胞中，它可减少病毒复制（EC50s分别为22.16和19.8 µM），同时不影响细胞活性，其50%细胞毒性浓度值（CC50）大于100 µM。
TN4471	Lysicamine	IL Receptor; Antifection	Immunology/Inflammation; Microbiology/Virology
	Lysicamine shows significant antioxidant capacity in the ORAC(FL) assay and it is active against S. epidermidis and C. dubliniensis, with MIC values in the range 12.5-100 microg mL(-1). Lysicamine has antimicrobial and anti-inflammation activity, the mini

天然产物

Cat.No: T1388

Synonym: 氟康唑,UK-49858

Target: Antibiotic, Antifection, Antifungal

Cat.No: T14046

Synonym: 花生四烯酸乙醇胺,(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide

Target: Cannabinoid Receptor, Endogenous Metabolite

Pseudolaric Acid C

Cat.No: T7029

Target: Antifungal

Cat.No: T37267

Target: Antibacterial

Cat.No: TN1877

Synonym: 忍冬苦苷,金银花

Target: Apoptosis, Antibacterial

Cat.No: TN1651

Target: Apoptosis, PARP, Reactive Oxygen Species, Caspase, CDK, P-gp

Cat.No: T5S0636

Synonym: 柠檬酸,Citro,Citretten

Target: Apoptosis, Others, Endogenous Metabolite, Antibacterial, Antibiotic

Cat.No: T1678

Synonym: Stamycin,Fungicidin,制霉菌素,Nystavescent

Target: Apoptosis, Antibiotic, Antifungal

2,2'-Dihydroxy chalcone

Cat.No: TN7224

Target: Antibacterial, Autophagy

(+)-Magnoflorine chloride

Cat.No: T4S1321

Synonym: Magnoflorine chloride,氯化木兰花碱,Corytuberine methochloride,Thalictrine chloride,Escholine chloride

Target: Others, Antifungal

(+)-Magnoflorine iodide

Cat.No: T3S1320

Synonym: Magnoflorine iodide,Thalictrine iodide,碘化木兰花碱,Corytuberine Methiodide

Target: Others, Antifungal

2-Phenylethanol

Cat.No: T0011

Synonym: 苯乙醇,Phenethyl alcohol,2-Phenylethyl alcohol,Benzyl carbinol,Phenylethanol,Benzeneethanol

Target: Others, Virus Protease, Antibacterial, Antibiotic

(+)-Magnoflorine

Cat.No: T3S1319

Synonym: Escholin,Magnoflorine,Thalictrin,Escholine,木兰花碱

Target: Others, Antifungal

Cat.No: T25718

Cat.No: T70891

Cat.No: T79931

Dehydroglaucine

Cat.No: TN1561

Target: Antifection

Luteolin-7-rutinoside

Cat.No: T11895

Target: Others

Cat.No: TN2032

Synonym: 霍香黃酮醇

Target: Antifection

Coronarin D ethyl ether

Cat.No: TN3709

Target: NF-κB

Cat.No: TN3978

Target: Antifection

1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone

Cat.No: TN2492

Target: Others

Cat.No: T28379

Synonym: PF1163B,(-)-PF1163B,PF 1163B

Fumiquinazoline D

Cat.No: T37712

Cat.No: TN3400

Target: Antifection

Cat.No: T37444

Cat.No: T80335

Cat.No: TN3723

Target: PAFR, Antifection

Cat.No: T80349

Cat.No: T38016

Cat.No: T80334

Cat.No: T80332

Cat.No: T69225

Synonym: Muconomycin B

Methyl 3,4,5-trimethoxy-2-(2-(nicotinamido)benzamido)benzoate

Cat.No: T36403

Cat.No: T80330

Cat.No: TN5014

Target: Antifection, HSV

Cat.No: T79008

Antibacterial synergist 2

Cat.No: T72235

Cat.No: T37008

Cat.No: TN3708

Target: BCL, c-Myc, TNF, NF-κB, Caspase, COX, Antifection

Cat.No: T36438

Cat.No: T36329

Cat.No: T36886

Cat.No: T83693

Synonym: MG2

Cat.No: TN4471

Target: IL Receptor, Antifection

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