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Search Results for " xanthine "

87

抑制剂 & 化合物

40

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T23535L	Xanthine amine congener trihydrochloride Xanthine amine congener trihydrochloride (96865-92-8 Free base)	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Xanthine amine congener trihydrochloride 是一种有效的腺苷拮抗剂，可逆转由腺苷激动剂 N6-环己基腺苷产生的尿流量、钠排泄和心率的减少。
T10509	Xanthine oxidase-IN-1 4-(3-Cyano-5,6-difluoroindol-1-yl)-2-hydroxybenzoic acid	Xanthine Oxidase	Metabolism
	Xanthine oxidase-IN-1是一种有效的黄嘌呤氧化酶抑制剂(IC50值:6.5 nM),是一种利用核酸和核苷酸介质降解产生的生物活性核苷酸在嘌呤分解代谢中起核心作用的化合物，
T78984	Xanthine oxidase-IN-10 XO8 analog	ROS	Immunology/Inflammation
	Xanthine oxidase-IN-10 (XO8 analog) 是一种黄嘌呤氧化酶 (XO) 抑制剂，可用于研究痛风。
T39387	Xanthine amine congener dihydrochloride XAC dihydrochloride,Xanthine amine congener dihydrochloride
	Xanthine amine congener dihydrochloride (XAC dihydrochloride), a potent antagonist for both Adenosine A1 and A2 receptors, exhibits IC50 values of 1.8 nM for A1 and 114 nM for A2 receptors. Additionally, it functions as a convulsant agent in mouse models.
T72078	Xanthine oxidoreductase-IN-4	Xanthine Oxidase	Metabolism
	Xanthine oxidoreductase-IN-4 是一种具有有口服活性黄嘌呤氧化还原酶 (XOR) 抑制剂，对 XOR 具有抑制作用，IC50 值为 29.3 nM。Xanthine oxidoreductase-IN-4 可用于研究高尿酸血症。
T23535	Xanthine amine congener	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Xanthine amine congener 是非选择性的腺苷受体拮抗剂，在小鼠中具有诱发惊厥的作用。
T76104	Xanthine oxidase 黄嘌呤氧化酶
	Xanthine oxidase 是一种黄嘌呤氧化还原酶，可产生活性氧 (ROS)，催化次黄嘌呤氧化为黄嘌呤，进一步催化黄嘌呤氧化为尿酸。
T72165	Xanthine oxidoreductase-IN-3	Xanthine Oxidase	Metabolism
	Xanthine oxidoreductase-IN-3 是一种具有口服活性的黄氨酸氧化还原酶 (XOR) 抑制剂（IC50 ： 26.3 nM）。Xanthine oxidoreductase-IN-3 可用急性高尿酸血症的研究。
T72166	Xanthine oxidoreductase-IN-5	Xanthine Oxidase	Metabolism
	Xanthine oxidoreductase-IN-5 是一种具有口服活性的黄氨酸氧化还原酶 (XOR) 抑制剂（IC50 ： 55 nM）。Xanthine oxidoreductase-IN-5 可用于急性高尿酸血症的研究。
T35156	Xanthine, 3-(3-methoxypropyl)-1-methyl-
	Xanthine, 3-(3-methoxypropyl)-1-methyl- is a bioactive chemical.
T131587	8-methyl-xanthine
	8-methyl-xanthine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131587。
T60890	Xanthine oxidoreductase-IN-1
	Xanthine oxidoreductase-IN-1 是黄嘌呤氧化还原酶（XOR）的抑制剂，IC50值为7.0 nM。
T72409	Xanthine oxidase-IN-6
	Xanthine oxidase-IN-6 是一种强效的、具有口服活性的黄嘌呤氧化酶 (XOD) 混合型抑制剂，其IC50值为1.37 µM。Xanthine oxidase-IN-6 具有很强的抗高尿酸血症 (anti-hyperuricemia) 和肾保护活性。
T62963	Xanthine amine congener hydrochloride
	Xanthine amine congener (XAC) hydrochloride 是一种非选择性腺苷受体拮抗剂，在小鼠中能够诱发惊厥。
T78985	Xanthine oxidase-IN-11	Xanthine Oxidase	Metabolism
	Xanthine oxidase-IN-11 (XO8 analog) 是一种有效的黄嘌呤氧化酶 (XO) 抑制剂。
T60632	Xanthine oxidase-IN-4
	Xanthine oxidase-IN-4 (化合物 19a) 是一种具有口服活性的有效黄嘌呤氧化酶 (XO) 抑制剂，IC50值为0.039 μM，可用于高尿酸血症和痛风的研究。Xanthine oxidase-IN-4 在氧嗪酸钾诱导的高尿酸血症大鼠中表现出降尿酸能力。
T61162	Xanthine oxidoreductase-IN-2
	Xanthine oxidoreductase-IN-2 (Compound IVa) is a potent inhibitor of xanthine oxidoreductase (XOR) with an IC50 value of 7.2 nM. Notably, Xanthine oxidoreductase-IN-2 demonstrates hypouricemic effects in mice, as evidenced by [1].
T60626	Xanthine oxidase-IN-7
	Xanthine oxidase-IN-7 (compound1h) 是一种口服的黄嘌呤氧化酶(XO)抑制剂 (IC50 = 0.36 μM)。Xanthine oxidase-IN-7 可有效降低血清尿酸水平，在高尿酸血症和痛风的研究中具有潜力。
T61092	Xanthine oxidase-IN-5
	Xanthine oxidase-IN-5, a powerful and orally active inhibitor of xanthine oxidase (XO), exhibits an IC50 value of 0.70 μM. It possesses favorable drug-like characteristics, with ligand efficiency (LE) and lipophilic ligand efficiency (LLE) values of 0.33 and 3.41, respectively. Moreover, Xanthine oxidase-IN-5 showcases significant hypouricemic effects in a hyperuricemic rat model [1].
T80767	Xanthine oxidase-IN-12	Xanthine Oxidase	Metabolism
	Xanthine oxidase-IN-12 (Compound 11), 作为一种高效的黄嘌呤氧化酶 (XO) 抑制剂，其IC50值达到91 nM。此外，Xanthine oxidase-IN-12 亦展现出抗氧化活性，能降低细胞内活性氧种 (ROS) 的水平。
T8337	Nequinate	Xanthine Oxidase; Parasite	Metabolism; Microbiology/Virology
	Nequinate 是一种喹啉化合物，是一种抗球虫剂，可预防球虫病。它抑制黄嘌呤氧化还原酶活性。
T1274	Benzbromarone Desuric,Normurat,苯溴马隆,Urinorm	Apoptosis; P450; Xanthine Oxidase	Apoptosis; Metabolism
	Benzbromarone (Desuric) 是一种高效的，耐受性良好的非竞争性黄嘌呤氧化酶抑制剂，用作排尿酸剂，研究痛风。
T2397	Topiroxostat 托匹司他,FYX-051	P450; ROS; Xanthine Oxidase	Immunology/Inflammation; Metabolism
	Topiroxostat (FYX-051) 是一种有效的口服黄嘌呤氧化还原酶 (XOR) 抑制剂，IC50=5.3 nM，Ki=5.7 nM。它还表现出弱的CYP3A4抑制活性 (18.6%)。它有用于高尿酸血症的研究潜力。
T22304	Desciclovir BW A515U,地昔洛韦,6-Deoxyacyclovir,DCV	Antifection	Microbiology/Virology
	Desciclovir (DCV) 是抗疱疹药物阿昔洛韦的前药，口服有活性，在体内被黄嘌呤氧化酶转化成为阿昔洛韦。
T0692	Allopurinol Zyloric,别嘌醇,Zyloprim,Lopurin,别嘌呤醇	ROS; Xanthine Oxidase	Immunology/Inflammation; Metabolism
	Allopurinol (Zyloric) 是一种黄嘌呤氧化酶(XO)抑制剂，IC50=7.82±0.12 μM。
T6376	Allopurinol Sodium 1H-吡唑并[3,4-D]嘧啶-4-醇单钠盐,Allopurinol sodium salt,Sodium allopurinol	ROS	Immunology/Inflammation
	Allopurinol Sodium 是黄嘌呤氧化酶抑制剂，其IC50= 0.2~50 μM。它能够抗利什曼原虫，也可用于研究痛风以及高尿酸血症。
T0773	Febuxostat 非布索坦,TMX 67,非布司他,TEI 6720	ROS; Xanthine Oxidase	Immunology/Inflammation; Metabolism
	Febuxostat (TEI 6720) 是一种选择性黄嘌呤氧化酶(XO)抑制剂，Ki=0.6 nM。
T20102	8-Azahypoxanthine NSC 22709,NSC-22709,阿扎次黄嘌呤,NSC22709	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	8-Azahypoxanthine (NSC-22709) 抑制次黄嘌呤-鸟嘌呤-黄嘌呤磷酸核糖基转移酶并具有抗疟特性。
T27076	8-Cyclopentyl-1,3-dimethylxanthine CPT,A1受体拮抗剂,CPT	Adenosine Receptor	GPCR/G Protein; Neuroscience
	8-Cyclopentyl-1,3-dimethylxanthine (CPT) 是一种选择性的腺苷A1受体拮抗剂，对 A1 受体和 A2 受体的Ki 值分别为 10.9 和 1440 nM。
T71327	Paraxanthine-d6
	Paraxanthine-d6 is intended for use as an internal standard for the quantification of paraxanthine by GC- or LC-MS. Paraxanthine is an active metabolite of caffeine. It is formed via N3-demethylation of caffeine by the cytochrome P450 (CYP) isoform CYP1A2. Paraxanthine is an adenosine A1 and A2 receptor antagonist. In vivo, paraxanthine increases striatal cGMP and extracellular striatal dopamine levels and locomotor activity, as well as inhibits motor depression induced by the adenosine A1 agoni...
T35739	Evoxanthine
	Evoxanthine is an alkaloid that has been found in O. renieri and has antimalarial and anticancer activities.1,2 It is active against P. falciparum with an IC50 value of 67.6 μg/ml.1 Evoxanthine decreases proliferation of nine sensitive and drug-resistant cancer cell lines (IC50s = 6.11-80.99 μM).2 \|1. Khalid, S.A., Farouk, A., Geary, T.G., et al. Potential antimalarial candidates from African plants: And in vitro approach using Plasmodium falciparum. J. Ethnopharmacol. 15(2), 201-209 (1986).\|2. ...
TNU1625	Arabinosylhypoxanthine
	Arabinosylhypoxanthine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 TNU1625，CAS号为 7013-16-3。
TNU1134	7-benzyl-3-methylxanthine
	7-benzyl-3-methylxanthine belongs to Heterocyclic Compounds - Purines.
T30905	Choline, compd. with 3-butyl-1-ethyl-6-thioxanthine
	Choline, compd. with 3-butyl-1-ethyl-6-thioxanthine is a bioactive chemical.
TNU1133	1,7-Dibenzyl-3-methylxanthine
	1,7-Dibenzyl-3-methylxanthine belongs to Heterocyclic Compounds - Purines.
T33676	Niraxostat Y 700,Y700,Y-700	Xanthine Oxidase	Metabolism
	Niraxostat (Y-700) 是作为黄嘌呤氧化酶抑制剂的异胞嘧啶衍生物之一。
T27323	FK-453 FK453,FK 453	Adenosine Receptor	GPCR/G Protein; Neuroscience
	FK-453 是一种有效的非黄嘌呤腺苷 A1 受体拮抗剂，具有利尿和肾血管扩张活性。
T8567	amflutizole	Xanthine Oxidase	Metabolism
	amflutizole 用于治疗痛风，是一种黄嘌呤氧化酶抑制剂。
T68145	Stacofylline
	Stacofylline 是一种黄嘌呤衍生物，可用于治疗偏头疼。
T9366	Pyrazoloadenine 4-Aminopyrazolo[3,4-d]pyrimidine	ROS	Immunology/Inflammation
	Pyrazoloadenine (4-Aminopyrazolo[3,4-d]pyrimidine) 是人黄嘌呤氧化酶的抑制剂。
T60625	Tigulixostat LR-19074,IBI-350,LC350189	Xanthine Oxidase	Metabolism
	Tigulixostat (LC350189) 是一种新型黄嘌呤氧化酶抑制剂（XOI），可降低尿酸生成，可用于研究痛风相关的疾病。
T20042	8-Azaadenine NSC 32797,NSC32797,NSC-32797	Xanthine Oxidase	Metabolism
	8-Azaadenine (NSC-32797) 是一种黄嘌呤氧化酶抑制剂，IC50 为 0.54 μM，Ki 为 0.66 μM。
T20347	Deoxybenzoin 二苯基乙酮,2-Phenylacetophenone,Benzyl phenyl ketone,NSC-131456,NSC131456,NSC 131456	Others	Others
	Deoxybenzoin (2-Phenylacetophenone) 用于靶向免疫传感器和黄嘌呤氧化酶。它用于治疗痛风。
T14944	CGS 15943	PI3K; Adenosine Receptor	GPCR/G Protein; Neuroscience; PI3K/Akt/mTOR signaling
	CGS 15943 是一种可口服的非黄嘌呤腺苷受体拮抗剂。在转染的 CHO 细胞中，其对人 A1、A2A、A2B 和 A3 腺苷受体的 Ki 分别为 3.5、4.2、16 和 50 nM。
T68090	Laprafylline	Others	Others
	Laprafylline 是一种黄嘌呤化合物，对体内支气管收缩有抑制作用，且具有抗肿瘤活性。Laprafylline在低浓度时可充当竞争性血清素能拮抗剂，在高难度时抑制由hist引起的收缩。
TP1886L1	NoxA1ds acetate(1435893-78-9 free base)	NADPH-oxidase	Immunology/Inflammation
	NoxA1ds acetate(1435893-78-9 free base) 是一种有效的选择性 NADPH 氧化酶 1 (NOX1) 抑制剂 (IC50 : 20 nM)。对 NOX1 的选择性优于对 NOX2、NOX4、NOX5 和黄嘌呤氧化酶的选择性。它抑制 HT-29 人结肠癌细胞中 NOX1 衍生的 O2 产生。在体外缺氧条件下减弱 VEGF 诱导的人肺动脉内皮细胞迁移。
T67965	Torbafylline	cAMP; PI3K; PDE	GPCR/G Protein; Metabolism; PI3K/Akt/mTOR signaling
	Torbafylline 是黄嘌呤衍生物，是磷酸二酯酶（PDE）抑制剂，通过激活 PDE4/cAMP/EPAC/PI3K/Akt 途径减弱烧伤诱导的大鼠骨骼肌蛋白水解，抑制癌症和败血症大鼠增强的骨骼肌泛素 - 蛋白酶体依赖性蛋白水解。
T3097	Mycophenolic Acid Impurity 马替麦考酚酸杂质,5,7-dihydroxy-4-methylphthalide	Others	Others
	Mycophenolic Acid Impurity (5,7-dihydroxy-4-methylphthalide) 是一种免疫抑制药物和有效的抗增殖剂，可用于代替旧的抗增殖剂 azathioprine。它通常用作三联疗法的一部分，包括钙调神经磷酸酶抑制剂（ciclosporin 或 tacrolimus）和prednisolone。它还可用于研究选择表达编码 XGPRT（黄嘌呤鸟嘌呤磷酸核糖基转移酶）的大肠杆菌基因的动物细胞。
T50059	6-ethenylquinoline	Others	Others
	6-ethenylquinoline 是一种结构独特的芳香杂环化合物，是生产其他芳香族化合物的重要中间体，并被用作合成各种药物的起始材料，包括抗真菌剂、抗寄生虫剂和抗病毒剂。它已被证明是多种参与药物代谢的酶的抑制剂，包括细胞色素P450、醛氧化酶和黄嘌呤氧化酶等。
T1083L	Theophylline monohydrate Quibron,茶碱一水合物	HDAC; PDE; Adenosine Receptor	Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience
	Theophylline monohydrate (Quibron) 似乎抑制磷酸二酯酶和前列腺素的产生，调节钙通量和细胞内钙分布，并拮抗腺苷。茶碱是黄嘌呤的天然生物碱衍生物，从植物山茶花和小粒咖啡中分离出来。在生理上，该药剂可放松支气管平滑肌，产生血管舒张（脑血管除外），刺激中枢神经系统，刺激心肌，利尿，增加胃酸分泌；它还可以抑制炎症并改善横膈膜的收缩性。

化合物

Xanthine amine congener trihydrochloride

Cat.No: T23535L

Synonym: Xanthine amine congener trihydrochloride (96865-92-8 Free base)

Target: Adenosine Receptor

Xanthine oxidase-IN-1

Cat.No: T10509

Synonym: 4-(3-Cyano-5,6-difluoroindol-1-yl)-2-hydroxybenzoic acid

Target: Xanthine Oxidase

Xanthine oxidase-IN-10

Cat.No: T78984

Synonym: XO8 analog

Target: ROS

Xanthine amine congener dihydrochloride

Cat.No: T39387

Synonym: XAC dihydrochloride,Xanthine amine congener dihydrochloride

Xanthine oxidoreductase-IN-4

Cat.No: T72078

Target: Xanthine Oxidase

Xanthine amine congener

Cat.No: T23535

Target: Adenosine Receptor

Xanthine oxidase

Cat.No: T76104

Synonym: 黄嘌呤氧化酶

Xanthine oxidoreductase-IN-3

Cat.No: T72165

Target: Xanthine Oxidase

Xanthine oxidoreductase-IN-5

Cat.No: T72166

Target: Xanthine Oxidase

Xanthine, 3-(3-methoxypropyl)-1-methyl-

Cat.No: T35156

8-methyl-xanthine

Cat.No: T131587

Xanthine oxidoreductase-IN-1

Cat.No: T60890

Xanthine oxidase-IN-6

Cat.No: T72409

Xanthine amine congener hydrochloride

Cat.No: T62963

Xanthine oxidase-IN-11

Cat.No: T78985

Target: Xanthine Oxidase

Xanthine oxidase-IN-4

Cat.No: T60632

Xanthine oxidoreductase-IN-2

Cat.No: T61162

Xanthine oxidase-IN-7

Cat.No: T60626

Xanthine oxidase-IN-5

Cat.No: T61092

Xanthine oxidase-IN-12

Cat.No: T80767

Target: Xanthine Oxidase

Cat.No: T8337

Target: Xanthine Oxidase, Parasite

Cat.No: T1274

Synonym: Desuric,Normurat,苯溴马隆,Urinorm

Target: Apoptosis, P450, Xanthine Oxidase

Cat.No: T2397

Synonym: 托匹司他,FYX-051

Target: P450, ROS, Xanthine Oxidase

Cat.No: T22304

Synonym: BW A515U,地昔洛韦,6-Deoxyacyclovir,DCV

Target: Antifection

Cat.No: T0692

Synonym: Zyloric,别嘌醇,Zyloprim,Lopurin,别嘌呤醇

Target: ROS, Xanthine Oxidase

Allopurinol Sodium

Cat.No: T6376

Synonym: 1H-吡唑并[3,4-D]嘧啶-4-醇单钠盐,Allopurinol sodium salt,Sodium allopurinol

Target: ROS

Cat.No: T0773

Synonym: 非布索坦,TMX 67,非布司他,TEI 6720

Target: ROS, Xanthine Oxidase

8-Azahypoxanthine

Cat.No: T20102

Synonym: NSC 22709,NSC-22709,阿扎次黄嘌呤,NSC22709

Target: Nucleoside Antimetabolite/Analog

8-Cyclopentyl-1,3-dimethylxanthine

Cat.No: T27076

Synonym: CPT,A1受体拮抗剂,CPT

Target: Adenosine Receptor

Paraxanthine-d6

Cat.No: T71327

Cat.No: T35739

Arabinosylhypoxanthine

Cat.No: TNU1625

7-benzyl-3-methylxanthine

Cat.No: TNU1134

Choline, compd. with 3-butyl-1-ethyl-6-thioxanthine

Cat.No: T30905

1,7-Dibenzyl-3-methylxanthine

Cat.No: TNU1133

Cat.No: T33676

Synonym: Y 700,Y700,Y-700

Target: Xanthine Oxidase

Cat.No: T27323

Synonym: FK453,FK 453

Target: Adenosine Receptor

Cat.No: T8567

Target: Xanthine Oxidase

Cat.No: T68145

Pyrazoloadenine

Cat.No: T9366

Synonym: 4-Aminopyrazolo[3,4-d]pyrimidine

Target: ROS

Cat.No: T60625

Synonym: LR-19074,IBI-350,LC350189

Target: Xanthine Oxidase

Cat.No: T20042

Synonym: NSC 32797,NSC32797,NSC-32797

Target: Xanthine Oxidase

Cat.No: T20347

Synonym: 二苯基乙酮,2-Phenylacetophenone,Benzyl phenyl ketone,NSC-131456,NSC131456,NSC 131456

Target: Others

Cat.No: T14944

Target: PI3K, Adenosine Receptor

Cat.No: T68090

Target: Others

NoxA1ds acetate(1435893-78-9 free base)

Cat.No: TP1886L1

Target: NADPH-oxidase

Cat.No: T67965

Target: cAMP, PI3K, PDE

Mycophenolic Acid Impurity

Cat.No: T3097

Synonym: 马替麦考酚酸杂质,5,7-dihydroxy-4-methylphthalide

Target: Others

6-ethenylquinoline

Cat.No: T50059

Target: Others

Theophylline monohydrate

Cat.No: T1083L

Synonym: Quibron,茶碱一水合物

Target: HDAC, PDE, Adenosine Receptor

Cat. No.	Product Name	Target	Signaling Pathways
T0665	Xanthine 2,6-Dihydroxypurine,海生丁（黄嘌呤）,黄嘌呤,Isoxanthine	Endogenous Metabolite; Adenosine Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Xanthine (Isoxanthine) 是一种植物生物碱，存在于茶、咖啡和可可中。Xanthine 是温和的中枢神经系统激活剂，也是嘌呤降解途径的中间产物。
TMO2681	Xanthosine 9-Beta-D-Ribofuranosylxanthine,黄嘌呤核苷,Xanthine riboside	Others; Endogenous Metabolite	Metabolism; Others
	Xanthosine (9-Beta-D-Ribofuranosylxanthine) 是黄嘌呤核苷，它能够提高山羊和牛的乳腺干细胞数量和产奶量。
T16685	Purpurogallin 红倍酚,红陪酚	Xanthine Oxidase	Metabolism
	Purpurogallin 是一种从栎属植物中提取的天然酚，具有显著的黄嘌呤氧化酶抑制作用，其IC50=0.2 µM，具有抗氧化和抗炎作用。
T75504	Xanthine oxidase-IN-8
	Xanthine oxidase-IN-8 (Icarisids J) (Compound 7) 是一种 XOD 抑制剂，IC50值为 29.71 μM。
T75505	Xanthine oxidase-IN-9
	Xanthine oxidase-IN-9 (Icarisids E) (Compound 2)，一种黄嘌呤氧化酶 (XOD) 高效抑制剂，具有31.81 μM 的 IC50 值。
T1694	Oxypurinol Oxipurinol,羟基嘌呤	ROS; Xanthine Oxidase; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	Oxypurinol 是一种黄嘌呤氧化酶 (xanthine oxidase) 抑制剂，是 Allopurinol 的主要特性代谢产物。它能够用于调节血尿酸水平，有潜力用于痛风的研究。
TMA0958	Forsythoside F 连翘酯苷F,Arenarioside,三糖苯丙素苷	Xanthine Oxidase	Metabolism
	Forsythoside F (Arenarioside) 是一种黄嘌呤氧化酶 (xanthine oxidase) 抑制剂，具有抗高尿酸活性。
T2858	Baicalein 5,6,7-Trihydroxyflavone,黄芩素,黄芩黄素	Ferroptosis; Influenza Virus; ROS; Xanthine Oxidase	Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology
	Baicalein (5,6,7-Trihydroxyflavone) 是一种黄嘌呤氧化酶抑制剂，其IC50值为 3.12 μM。
T12564	Prudomestin 3,5,7-Trihydroxy-4',8-dimethoxyflavone,3,5,7-三羟基-8,4'-二甲氧基黄酮	Xanthine Oxidase	Metabolism
	Prudomestin (3,5,7-Trihydroxy-4',8-dimethoxyflavone) 是一种分离自 Prunus domestica 心材中，具有很强的黄嘌呤氧化酶(XO)抑制活性(IC50≈6 µM)。
T2971	Phytic acid Inositol hexaphosphate,inositol hexakisphosphate,inositol polyphosphate,myo-Inositol, hexakis(dihydrogen phosphate),植酸,Fytic Acid	Xanthine Oxidase; Endogenous Metabolite	Metabolism
	Phytic acid (Fytic Acid) 是种子和谷粒的磷储存化合物。它被称为食品抑制剂，具有很强的螯合多价金属离子的能力，特别是钙，铁，锌和蛋白质残留物。它抑制超氧化物来源黄嘌呤氧化酶并具有抗氧化，抗炎以及神经保护作用。
T16527	Phytic acid dodecasodium salt hydrate 植酸十二钠盐,myo-Inositol, hexakis(dihydrogen phosphate) dodecasodium salt hydrate,Inositol hexaphosphate dodecasodium salt hydrate	Others; Xanthine Oxidase; Endogenous Metabolite	Metabolism; Others
	Phytic acid dodecasodium salt hydrate (myo-Inositol, hexakis(dihydrogen phosphate) dodecasodium salt hydrate) 是种子和谷物的磷储存化合物。 Phytic acid dodecasodium salt hydrate 抑制酶促超氧化物源黄嘌呤氧化酶，IC50 为 6 mM，并具有抗氧化、神经保护和抗炎作用。
T0070	Pentoxifylline Oxpentifylline,PTX,己酮可可碱,BL-191	HIV Protease; PDE; Adenosine Receptor; Autophagy	Autophagy; GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Pentoxifylline (PTX) 是一种具有口服活性的磷酸二酯酶非选择性抑制剂，具有免疫调节、抗炎、抗纤溶、抗增殖和血液流变学改善作用。它可研究周围血管疾病、脑血管疾病和其他一些涉及局部微循环缺陷的疾病。
PDK0014	3-Methylxanthine	Endogenous Metabolite	Metabolism
	3-Methylxanthine 是一种黄嘌呤衍生物和环磷酸鸟苷（GMP）抑制剂，在豚鼠分离的气管肌肉中测得其IC50值为 920 μM。
T0543	7-Methylxanthine Heteroxanthine,Heteroxanthin,7-甲基黄嘌呤	Nucleoside Antimetabolite/Analog; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	7-Methylxanthine (Heteroxanthine) 是一种黄嘌呤的甲基衍生物，是人尿结石的嘌呤成分。
T1362	Hypoxanthine 次黄嘌呤,6-羟基嘌呤,6-Hydroxypurine,Purin-6-ol,Sarcine,Sarkin	Others; Endogenous Metabolite	Metabolism; Others
	Hypoxanthine (Purin-6-ol)，也被称为 purine-6-ol 或 Hyp，是一种天然存在的嘌呤衍生物，是腺苷代谢和核苷酸补救途径形成核酸的反应中间体。在正常情况下，Hypoxanthine 很容易转化为尿酸。Hypoxanthine 首先被氧化为黄嘌呤，黄嘌呤再被黄嘌呤氧化酶氧化为尿酸。
T10021	1-Methylxanthine	Endogenous Metabolite	Metabolism
	1-Methylxanthine 是咖啡因衍生物，是咖啡因和茶碱 (1,3-二甲基黄嘌呤，TP) 在人体尿代谢产物，能够提高肿瘤细胞的放射敏感性。
T4973	Paraxanthine 1,7-二甲基黄嘌呤,1,7-DIMETHYLXANTHINE	Endogenous Metabolite	Metabolism
	Paraxanthine (1,7-dimethylxanthine) 是一种 caffeine 的代谢物，能够刺激Ryanodine 受体通道来抑制多巴胺能细胞的死亡。
T1363	N-Demethylricinine 4-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile,吉莫斯特中间体二	ROS	Immunology/Inflammation
	N-Demethylricinine (4-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile) 被报道为 xanthine oxidase 抑制剂。
T5S0281	Tubuloside A	NOS	Immunology/Inflammation
	Tubuloside A 是一种苯乙醇苷，具有抗氧化活性和保肝活性。
TN1002	Blumeatin	ROS	Immunology/Inflammation
	Blumeatin 是从Blumea balsamiferaDC 中分离得到，对 CCl4 和硫代乙酰胺 (TAA) 所致的肝损伤表现出保护活性。
T3750	4-Hydroxyacetophenone 对羟基苯乙酮,4-Acetylphenol,Piceol,p-Acetylphenol,4'-Hydroxyacetophenone	HBV; Xanthine Oxidase	Metabolism; Microbiology/Virology
	4-Hydroxyacetophenone (4-Acetylphenol) 是蒿属植物和木香属植物中的一种黄嘌呤氧化酶抑制剂，具有保肝促胆、抗乙型肝炎病毒和抗炎作用。
T0625	Theobromine 3, 7-Dimethylxanthine,可可碱,3,7-Dimethylxanthine	Endogenous Metabolite; PDE; Adenosine Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Theobromine (3,7-Dimethylxanthine) 是在可可豆中发现的一种甲基黄嘌呤，抑制腺苷受体 A1 信号传导，用作支气管扩张剂和血管扩张剂。
TN1962	Myricetin 3-O-galactoside Myricetin 3-O-beta-D-galactopyranoside	NOS; Xanthine Oxidase	Immunology/Inflammation; Metabolism
	Myricetin 3-O-galactoside (Myricetin 3-O-beta-D-galactopyranoside) 可抑制黄嘌呤氧化酶 (xanthine oxidase; XO) 活性，脂质过氧化并清除自由基。杨梅素3- o -半乳糖苷具有很多作用包括细胞毒性、抗氧化、抗基因毒性、抗感染性、抗炎作用和抗氧化活性，其主要作用是抑制诱导型一氧化氮合酶(iNOS)的合成。Myricetin 3-O-galactoside 抑制脂质过氧化的 IC50 为 160 μg/mL。
T2205	Acefylline Theophylline-7-acetic acid,茶碱乙酸,Carboxymethyltheophylline,acetyloxytheophylline,Theophyllineacetic acid	TNF; PAD; PKA; HDAC; PDE; Adenosine Receptor	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience; Tyrosine Kinase/Adaptors
	Acefylline (Theophylline-7-acetic acid) 是黄嘌呤衍生物，是一种腺苷受体拮抗剂。它是蛋白质精氨酸脱亚氨酶 (PAD) 激活剂，也是一种支气管扩张剂，可抑制大鼠肺 cAMP 磷酸二酯酶同工酶。
T0617	Nicotinamide N-oxide Nicotinamide-N-oxide,Nicotinamide 1-oxide,N-氧代烟酰胺,烟酰胺-N-氧化物,1-oxynicotinamide	c-Myc; Endogenous Metabolite; CXCR; Drug Metabolite	Autophagy; Cell Cycle/Checkpoint; GPCR/G Protein; Immunology/Inflammation; Metabolism
	Nicotinamide N-oxide (Nicotinamide 1-oxide) 是生物体内烟酰胺分解代谢物，是高效选择性CXCR2受体拮抗剂。
T0626	Uric Acid 尿酸,2,6,8-Trioxopurine,2,6,8-Trioxypurine,2,6,8-Trihydroxypurine,Lithic acid,Urate	Reactive Oxygen Species; Endogenous Metabolite; Phosphorylase	Immunology/Inflammation; Metabolism; NF-κB
	Uric Acid (Lithic acid) 是一种重要的抗氧化剂。Uric acid 能清除活性氧(ROS) ，如单线态氧和过氧亚硝酸盐，抑制脂质过氧化。Uric acid 有助于维持血压的稳定和抗氧化应激。
T1083	Theophylline Theo-24,1,3-Dimethylxanthine,茶碱	Endogenous Metabolite; HDAC; PDE; Adenosine Receptor; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience
	Theophylline (1,3-Dimethylxanthine) 是茶中的甲基黄嘌呤衍生物，具有利尿、平滑肌松弛、支气管扩张、心脏和中枢神经系统兴奋作用。
T4746	Purine 7H-Imidazo(4,5-d)pyrimidine,嘌呤	Others; Endogenous Metabolite	Metabolism; Others
	Purine (7H-Imidazo(4,5-d)pyrimidine) 是内源性代谢产物的一种。
T0892	Diphylline 二羟丙茶碱,Dyphylline,Diprophylline	PDE; Adenosine Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Diphylline (Diprophylline) 是一种A1/A2腺苷受体拮抗剂，也是环状核苷酸磷酸二酯酶抑制剂。它是一种黄嘌呤衍生物，具有支气管扩张和血管扩张作用，有用于治疗慢性支气管炎和肺气肿的潜力。
TN5670	Protosappanin A dimethyl acetal
	Protosappanin A dimethyl acetal shows significant xanthine oxidase inhibitory activity in a concentration-dependent manner.
TN2180	Sappanchalcone 苏木查耳酮	IL Receptor; BCL; TNF	Apoptosis; Immunology/Inflammation
	Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.
TN3208	7,3',4'-Trihydroxy-3-benzyl-2H-chromene	ROS	Immunology/Inflammation
	7,3',4'-Trihydroxy-3-benzyl-2H-chromene is a potential xanthine oxidase inhibitor.
TN4080	Fraxamoside	Xanthine Oxidase	Metabolism
	Fraxamoside is a xanthine oxidase inhibitor (XOI) comparable in potency in vitro to the standard antigout drug allopurinol. It shows significant free radical scavenging effect against DPPH(EC50=62.6 uM).
T38777	Ilexoside O
	Ilexoside O, a triterpene saponin derived from Ilex pubescens roots, demonstrates modest inhibition of xanthine oxidase (XOD) activity with an IC50 value of 53.05 μM.
TN1503	Cistanoside F 肉苁蓉苷F,肉苁蓉苷 F	NADPH-oxidase	Immunology/Inflammation
	Cistanoside F shows vasorelaxant, and antioxidative effects, it shows a strong free radical scavenging activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and xanthine/xanthine oxidase (XOD) generated superoxide anion radical (O2-.).
T75546	Ellagic acid 4-O-β-D-xylopyranoside
	Ellagic acid 4-O-β-D-xylopyranoside，天然鞣花单宁，展现抗菌活性。同时，作为黄嘌呤氧化酶 (xanthine oxidase) 抑制剂，其50为 2.1 μg/mL。
TN4433	Licoarylcoumarin	cAMP; HIV Protease; Antifection	GPCR/G Protein; Microbiology/Virology; Proteases/Proteasome
	Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE strains; it has anti-HIV activity, and it has inhibitory effects on xanthine oxidase.
TN3473	Axillarin
	Axillarin has antioxidant activity, it shows xanthine oxidase inhibitory activity ( IC(50) :36.0 uM). Axillarin can strongly protect primary cultured neurons against glutamate-induced oxidative stress.
T82649	Cyanidin
	Cyanidin，作为一种抗氧化剂，能够保护 DNA 免受裂解，有效清除自由基，并显著抑制 XO 活性。
T72594	Broussochalcone A
	Broussochalcone A 是一种具有抗氧化和抑制黄嘌呤氧化酶（IC50=2.21 μM）功能的化合物，能清除自由基，抑制铁诱导的脂质过氧化和脂多糖（LPS）激活的巨噬细胞中一氧化氮（NO）的合成。此外，Broussochalcone A 通过增加ROS水平和激活FOXO3信号通路，诱导人肾癌细胞的凋亡（Apoptosis）。

天然产物

Cat.No: T0665

Synonym: 2,6-Dihydroxypurine,海生丁（黄嘌呤）,黄嘌呤,Isoxanthine

Target: Endogenous Metabolite, Adenosine Receptor

Cat.No: TMO2681

Synonym: 9-Beta-D-Ribofuranosylxanthine,黄嘌呤核苷,Xanthine riboside

Target: Others, Endogenous Metabolite

Cat.No: T16685

Synonym: 红倍酚,红陪酚

Target: Xanthine Oxidase

Xanthine oxidase-IN-8

Cat.No: T75504

Xanthine oxidase-IN-9

Cat.No: T75505

Cat.No: T1694

Synonym: Oxipurinol,羟基嘌呤

Target: ROS, Xanthine Oxidase, Endogenous Metabolite

Cat.No: TMA0958

Synonym: 连翘酯苷F,Arenarioside,三糖苯丙素苷

Target: Xanthine Oxidase

Cat.No: T2858

Synonym: 5,6,7-Trihydroxyflavone,黄芩素,黄芩黄素

Target: Ferroptosis, Influenza Virus, ROS, Xanthine Oxidase

Cat.No: T12564

Synonym: 3,5,7-Trihydroxy-4',8-dimethoxyflavone,3,5,7-三羟基-8,4'-二甲氧基黄酮

Target: Xanthine Oxidase

Cat.No: T2971

Synonym: Inositol hexaphosphate,inositol hexakisphosphate,inositol polyphosphate,myo-Inositol, hexakis(dihydrogen phosphate),植酸,Fytic Acid

Target: Xanthine Oxidase, Endogenous Metabolite

Phytic acid dodecasodium salt hydrate

Cat.No: T16527

Synonym: 植酸十二钠盐,myo-Inositol, hexakis(dihydrogen phosphate) dodecasodium salt hydrate,Inositol hexaphosphate dodecasodium salt hydrate

Target: Others, Xanthine Oxidase, Endogenous Metabolite

Cat.No: T0070

Synonym: Oxpentifylline,PTX,己酮可可碱,BL-191

Target: HIV Protease, PDE, Adenosine Receptor, Autophagy

3-Methylxanthine

Cat.No: PDK0014

Target: Endogenous Metabolite

7-Methylxanthine

Cat.No: T0543

Synonym: Heteroxanthine,Heteroxanthin,7-甲基黄嘌呤

Target: Nucleoside Antimetabolite/Analog, Endogenous Metabolite

Cat.No: T1362

Synonym: 次黄嘌呤,6-羟基嘌呤,6-Hydroxypurine,Purin-6-ol,Sarcine,Sarkin

Target: Others, Endogenous Metabolite

1-Methylxanthine

Cat.No: T10021

Target: Endogenous Metabolite

Cat.No: T4973

Synonym: 1,7-二甲基黄嘌呤,1,7-DIMETHYLXANTHINE

Target: Endogenous Metabolite

N-Demethylricinine

Cat.No: T1363

Synonym: 4-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile,吉莫斯特中间体二

Target: ROS

Cat.No: T5S0281

Target: NOS

Cat.No: TN1002

Target: ROS

4-Hydroxyacetophenone

Cat.No: T3750

Synonym: 对羟基苯乙酮,4-Acetylphenol,Piceol,p-Acetylphenol,4'-Hydroxyacetophenone

Target: HBV, Xanthine Oxidase

Cat.No: T0625

Synonym: 3, 7-Dimethylxanthine,可可碱,3,7-Dimethylxanthine

Target: Endogenous Metabolite, PDE, Adenosine Receptor

Myricetin 3-O-galactoside

Cat.No: TN1962

Synonym: Myricetin 3-O-beta-D-galactopyranoside

Target: NOS, Xanthine Oxidase

Cat.No: T2205

Synonym: Theophylline-7-acetic acid,茶碱乙酸,Carboxymethyltheophylline,acetyloxytheophylline,Theophyllineacetic acid

Target: TNF, PAD, PKA, HDAC, PDE, Adenosine Receptor

Nicotinamide N-oxide

Cat.No: T0617

Synonym: Nicotinamide-N-oxide,Nicotinamide 1-oxide,N-氧代烟酰胺,烟酰胺-N-氧化物,1-oxynicotinamide

Target: c-Myc, Endogenous Metabolite, CXCR, Drug Metabolite

Cat.No: T0626

Synonym: 尿酸,2,6,8-Trioxopurine,2,6,8-Trioxypurine,2,6,8-Trihydroxypurine,Lithic acid,Urate

Target: Reactive Oxygen Species, Endogenous Metabolite, Phosphorylase

Cat.No: T1083

Synonym: Theo-24,1,3-Dimethylxanthine,茶碱

Target: Endogenous Metabolite, HDAC, PDE, Adenosine Receptor, Autophagy

Cat.No: T4746

Synonym: 7H-Imidazo(4,5-d)pyrimidine,嘌呤

Target: Others, Endogenous Metabolite

Cat.No: T0892

Synonym: 二羟丙茶碱,Dyphylline,Diprophylline

Target: PDE, Adenosine Receptor

Protosappanin A dimethyl acetal

Cat.No: TN5670

Cat.No: TN2180

Synonym: 苏木查耳酮

Target: IL Receptor, BCL, TNF

7,3',4'-Trihydroxy-3-benzyl-2H-chromene

Cat.No: TN3208

Target: ROS

Cat.No: TN4080

Target: Xanthine Oxidase

Cat.No: T38777

Cat.No: TN1503

Synonym: 肉苁蓉苷F,肉苁蓉苷 F

Target: NADPH-oxidase

Ellagic acid 4-O-β-D-xylopyranoside

Cat.No: T75546

Licoarylcoumarin

Cat.No: TN4433

Target: cAMP, HIV Protease, Antifection

Cat.No: TN3473

Cat.No: T82649

Broussochalcone A

Cat.No: T72594

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