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Search Results for " torin "

5

抑制剂 & 化合物

23

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6100	Torin 2	Apoptosis; ATM/ATR; DNA-PK; mTOR; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	Torin 2 是一种特异性 mTOR 抑制剂，IC50值为0.25 nM，并改善了药代动力学特性。它抑制 ATM/ATR/DNA-PK 的 EC50 分别为 28 nM/35 nM/118 nM。
T6045	Torin 1	DNA-PK; PI3K; mTOR; Autophagy	Autophagy; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	Torin 1 是一种有效的 mTOR 抑制剂，IC50为 3 nM。它抑制 mTORC1/2复合物的 IC50值在 2 和 10 nM 之间，还诱导自噬。
T130965	Neosartorin
	Neosartorin 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T130965。
T23183	(+)- Praeruptorin C	Others	Others
	(+)- Praeruptorin C extracted from Peucedanum praeruptorum Dunn roots.
T33623	Necatorin Necatorine
	Necatorin is a mutagenic compound from edible mushroom Lactarius necator.

化合物

Cat.No: T6100

Target: Apoptosis, ATM/ATR, DNA-PK, mTOR, Autophagy

Cat.No: T6045

Target: DNA-PK, PI3K, mTOR, Autophagy

Cat.No: T130965

(+)- Praeruptorin C

Cat.No: T23183

Target: Others

Cat.No: T33623

Synonym: Necatorine

Cat. No.	Product Name	Target	Signaling Pathways
T6S1423	Praeruptorin B	Others	Others
	Praeruptorin B 在体外能抑制促癌因子诱导的现象。
T2845	Imperatorin Ammidin,8-Isoamylenoxypsoralen,欧前胡素,8-Isopentenyloxypsoralene,Marmelosin,Pentosalen	TRP/TRPV Channel; AChR; AChE; NOD	Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; NF-κB
	Imperatorin (8-Isopentenyloxypsoralene) 是NO synthesis 和BChE 的抑制剂，IC50分别为 9.2 μmol 和 31.4 μmol。它也是TRPV1的微弱激动剂，EC50为 12.6±3.2 μM。
T4S1419	(±)-Praeruptorin A Praeruptorin A,(±)-白花前胡甲素,白花前胡甲素,(-)-Praeruptorin A	p38 MAPK; Calcium Channel; Akt	Cytoskeletal Signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling
	(±)-Praeruptorin A 是来自白花前胡的干燥根中的一种主要成分，用于研究伴有厚痰和呼吸困难的咳嗽，非天生性咳嗽和上呼吸道感染。它是顺式-内酯 (CKL) 的二酯化产物，可作为 Ca2+-反流阻滞剂，用于高血压的研究。
T21165	Pellitorine AI3-19560,墙草碱,Pellitorin	TRP/TRPV Channel	Membrane transporter/Ion channel
	Pellitorine (Pellitorin) 是提取自 Piper nigrum 的根的一种化合物。它对 HL60 和 MCT-7 细胞系表现出显著的细胞毒活性。它可用于癌症疾病的研究。
TN1369	Alloimperatorin Prangenidin,别欧前胡素	Others	Others
	Alloimperatorin (Prangenidin) 是一种从Angelica dahurica 的提取得到的香豆素类化合物，具有抗肿瘤作用。
TN2024	Oxyimperatorin	Others	Others
	Oxyimperatorin 是一种香豆素，分离自当归。
T20604L	Litorin acetate(55749-97-8 Free base)	Bombesin Receptor	GPCR/G Protein
	Litorin acetate 是一种两栖类铃蟾肽衍生物，是一种铃蟾肽受体激动剂。它刺激平滑肌收缩，刺激胃泌素、胃酸和胰腺分泌，抑制体内营养。
T2846	Isoimperatorin	Antibacterial; AChE	Microbiology/Virology; Neuroscience
	Isoimperatorin 是 Angelica dahurica 根的甲醇提取物，是一种抗炎剂，有效抑制乙酰胆碱酯酶，IC50为 74.6 μM。
T4S1422	Praeruptorin E 白花前胡素 E,白花前胡素E	Others; Calcium Channel	Membrane transporter/Ion channel; Metabolism; Others
	Praeruptorin E 是白花前胡中的一种主要成分，是钙拮抗剂，pD2′值为 5.2。
T7032	Eupatorin	Others; P450	Metabolism; Others
	Eupatorin 是天然存在的黄酮，可捕获 G2-M 细胞周期，激活多个 caspase、细胞色素 C 的释放、多聚 (ADP-核糖) 聚合酶的裂解，促使凋亡细胞死亡。
TN1513	Clitorin 碟豆宁,碟豆素	PKC; Antifection	Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology
	Clitorin 是一种山奈酚糖苷，分离自 Acalypha indica 的花和叶，表现出抗氧化活性。
T6S1418	Praeruptorin C	Antioxidant; Calcium Channel	Membrane transporter/Ion channel; Metabolism; oxidation-reduction
	Praeruptorin C 是白花前胡中的一种主要成分，是钙拮抗剂，pD2′值为 5.7。
T3777	Praeruptorin A (+)-Praeruptorin A,白花前胡甲素	CaMK; NF-κB	Neuroscience; NF-κB
	Praeruptorin A ((+)-Praeruptorin A) 是一种白花前胡的主要生物活性成分。它能够抑制 NF-κB 活化，发挥抗炎作用。
T8626	Transtorine 1,4-DIHYDRO-4-OXOQUINOLINE-2-CARBOXYLIC ACID,1,4-二氢-4-氧代喹啉-2-羧酸	GluR; NMDAR	Neuroscience
	Transtorine (1,4-DIHYDRO-4-OXOQUINOLINE-2-CARBOXYLIC ACID) 是一种 GluR 和 NMDA 抑制剂。
TN4039	Eupatorin-5-methylether	Others	Others
	Eupatorin-5-methylether 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4039，CAS号为 21764-09-0。
T4S1421	Praeruptorin B Praeruptorin D,(+)-川白芷内酯	NPC1L1; Fatty Acid Synthase	Membrane transporter/Ion channel; Metabolism
	Praeruptorin B 是一种固醇调控元件结合蛋白(SREBPs)的抑制剂。
TN4819	(-)-Praeruptorin A	ATPase; IL Receptor; Calcium Channel; P-gp	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
	(-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis;it also can significantly suppress airway inflammation and airway remodeling induced by ovalbumin challenge, and is a potential candidate for the treatment of asthma. (-)-Praeruptorin A resensitizes Pgp-mediated MDR (Pgp-MDR) cancer cells to cancer drugs.
TN1769	Iristectorin A 鸢尾甲苷 A,鸢尾甲苷A	Others	Others
	Iristectorin A is a natural product from Iris tectorum.
T13933	Toringin	Others	Others
	Toringin is a bioflavonoid isolated from the bark of Docyniopsis tschonoski, and have various biological activities and beneficial actions against cancers, coronary heart disease, among other pathologies.
T32800	Littorine (R)-(-)-Littorine
	Littorine is a tropane alkaloid found in a variety of plants including Datura and Atropa belladonna. It is closely related in chemical structure to atropine, hyoscyamine, and scopolamine, which all share a common biosynthetic pathway.
TN3380	Alloisoimperatorin	AChR	Neuroscience
	Alloisoimperatorin is a candidate of AChE inhibitors, it displays potent antioxidant effects against the DPPH radical and against renal epithelial cell injury by using AAPH to generate peroxyl radicals in vitro. Alloisoimperatorin has estrogenic activity
T20604	Litorin
	Litorin, an amphibian bombesin peptide derivative, is found to suppress the nutriment, to stimulate the contraction of smooth muscle, to stimulate gastrin, gastric acid, and pancreatic secretion.
T11678	Iristectorin B	Others	Others
	Iristectorin B has anti-cancer activities in breast cancer.is an isoflavone from Iris tectorum.

天然产物

Cat.No: T6S1423

Target: Others

Cat.No: T2845

Synonym: Ammidin,8-Isoamylenoxypsoralen,欧前胡素,8-Isopentenyloxypsoralene,Marmelosin,Pentosalen

Target: TRP/TRPV Channel, AChR, AChE, NOD

(±)-Praeruptorin A

Cat.No: T4S1419

Synonym: Praeruptorin A,(±)-白花前胡甲素,白花前胡甲素,(-)-Praeruptorin A

Target: p38 MAPK, Calcium Channel, Akt

Cat.No: T21165

Synonym: AI3-19560,墙草碱,Pellitorin

Target: TRP/TRPV Channel

Alloimperatorin

Cat.No: TN1369

Synonym: Prangenidin,别欧前胡素

Target: Others

Cat.No: TN2024

Target: Others

Litorin acetate(55749-97-8 Free base)

Cat.No: T20604L

Target: Bombesin Receptor

Cat.No: T2846

Target: Antibacterial, AChE

Cat.No: T4S1422

Synonym: 白花前胡素 E,白花前胡素E

Target: Others, Calcium Channel

Cat.No: T7032

Target: Others, P450

Cat.No: TN1513

Synonym: 碟豆宁,碟豆素

Target: PKC, Antifection

Cat.No: T6S1418

Target: Antioxidant, Calcium Channel

Cat.No: T3777

Synonym: (+)-Praeruptorin A,白花前胡甲素

Target: CaMK, NF-κB

Cat.No: T8626

Synonym: 1,4-DIHYDRO-4-OXOQUINOLINE-2-CARBOXYLIC ACID,1,4-二氢-4-氧代喹啉-2-羧酸

Target: GluR, NMDAR

Eupatorin-5-methylether

Cat.No: TN4039

Target: Others

Cat.No: T4S1421

Synonym: Praeruptorin D,(+)-川白芷内酯

Target: NPC1L1, Fatty Acid Synthase

(-)-Praeruptorin A

Cat.No: TN4819

Target: ATPase, IL Receptor, Calcium Channel, P-gp

Cat.No: TN1769

Synonym: 鸢尾甲苷 A,鸢尾甲苷A

Target: Others

Cat.No: T13933

Target: Others

Cat.No: T32800

Synonym: (R)-(-)-Littorine

Alloisoimperatorin

Cat.No: TN3380

Target: AChR

Cat.No: T20604

Cat.No: T11678

Target: Others

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