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Clitorin

Clitorin

产品编号 TN1513   CAS 55804-74-5
别名: 碟豆宁, 碟豆素

Clitorin 是一种山奈酚糖苷,分离自 Acalypha indica 的花和叶,表现出抗氧化活性。

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Clitorin Chemical Structure
Clitorin, CAS 55804-74-5
规格 价格/CNY 货期 数量
1 mg ¥ 497 现货
5 mg ¥ 1,200 现货
10 mg ¥ 1,770 现货
25 mg ¥ 2,990 现货
50 mg ¥ 4,420 现货
100 mg ¥ 6,280 现货
产品目录号及名称: Clitorin (TN1513)
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纯度: 99.63%
纯度: 99.55%
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天然产物信息
生物活性
化学信息
存储 & 溶解度
参考文献
植物来源
结构类型
产品描述 Clitorin has free radical scavenging property. It shows significant interactions with CD38, it may have anti-hyperglycemic potential.
体外活性 Antiplasmodial activity of extracts was confirmed and the active fractions in the extract were identified by HPLC-based activity profiling, a gradient HPLC fractionation of a single injection of the extract, followed by offline bioassay of the obtained microfractions. For preparative isolation of compounds, an alkaloidal fraction was obtained via adsorption on cationic ion exchange resin. Active compounds were purified by HPLC-MS and MPLC-ELSD. Structures were established by HR-ESI-MS and NMR spectroscopy. For compounds 5 and 7 absolute configuration was confirmed by comparison of experimental and calculated electronic circular dichroism (ECD) spectroscopy data, and by X-ray crystallography. Compounds were tested for bioactivity in vitro against four parasites (Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum), and in the Plasmodium berghei mouse model. Profiling indicated flavonoids and alkaloids in the active time windows. A total of nine compounds were isolated. Four were known flavonols--manghaslin, Clitorin, rutin, and nicotiflorin. Five compounds isolated from the alkaloidal fraction were piperidine alkaloids. Compounds 5 and 6 were inactive carpamic acid and methyl carpamate, while three alkaloids 7-9 showed high antiplasmodial activity and low cytotoxicity. When tested in the Plasmodium berghei mouse model, carpaine (7) did not increase the survival time of animals.
别名 碟豆宁, 碟豆素
分子量 740.66
分子式 C33H40O19
CAS No. 55804-74-5

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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参考文献

1. HPLC-based activity profiling for antiplasmodial compounds in the traditional Indonesian medicinal plant Carica papaya L.J Ethnopharmacol. 2014 Aug 8;155(1):426-34.
Mitoxantrone dihydrochloride Dequalinium chloride SB-218078 Bisindolylmaleimide I PKC ζ pseudosubstrate acetate PKCε Inhibitor Peptide acetate ML-7 hydrochloride K-252c

相关化合物库

该产品包含在如下化合物库中:
TGF-β/Smad靶点化合物库 烟草单体化合物库 抗感染天然产物库 表观遗传库 中国药典收录天然产物库 已知活性化合物库 细胞骨架化合物库 抗寄生虫天然产物库 高通量筛选天然产物库 中药单体化合物库

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请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

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您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Clitorin 55804-74-5 Chromatin/Epigenetic Cytoskeletal Signaling Microbiology/Virology PKC Antifection Inhibitor 碟豆宁 inhibit 碟豆素 inhibitor

 

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