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1592

抑制剂 & 化合物

10

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T28996	TP-064 TP 064	Histone Methyltransferase	Chromatin/Epigenetic
	TP-064 是选择性蛋白精氨酸甲基转移酶 4 抑制剂，IC50小于10 nM，具有抗癌活性。它抑制 BAF155 和 MED12 的二甲基化，IC50为 340 和 43 nM。它对于 PRMT6 的 IC50为 1.3 μM。
T9250	TP-4748	Others	Others
	TP-4748 是一种生化物质。
T22440	TP-353 EOS-61973	CDK	Cell Cycle/Checkpoint
	TP-353 (EOS-61973) 是一种 CDK7 抑制剂。
T4523	TP-3654	Pim	Chromatin/Epigenetic; JAK/STAT signaling
	TP3654是一种Pim 激酶抑制剂，对Pim-1和Pim-3的Ki 值分别为5和42 nM。
T9254	TP-2857 TAP2857	Antibacterial	Microbiology/Virology
	TP-2857 (TAP2857) 是一种有效的抗菌剂。
T13189	TP-10	PDE	Metabolism
	TP-10 是 PDE10A 对其他 PDE 的特异性抑制剂，IC50 为 0.8 nM。
T24897	TP0427736 TP427736,TP-0427736,TP-427736	TGF-beta/Smad	Stem Cells
	TP0427736 是一种有效的选择性 ALK5 抑制剂，IC50 为 2.72 nM，比对 ALK3 的抑制作用高 300 倍。 TP0427736 可降低人外根鞘细胞中 TGF-β 诱导的生长抑制，并延长小鼠毛囊中的生长期。
T2469	TP808 TP-808,TP 808	Others	Others
	TP808是一种高度通用的中间体，可用于多种四环素类抗生素的构建。
T11227L	Eravacycline dihydrochloride TP-434-046,TP-434 dihydrochloride	Antibacterial	Microbiology/Virology
	Eravacycline dihydrochloride (TP-434-046) 是一种有效的广谱抗菌剂，可对抗六种大肠杆菌(MIC：0.125-0.25 mg/L)。
T62525	TP-16	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	TP-16是一种新型高效且具有选择性的 EP4 拮抗剂，可阻断IMCs的功能，增强细胞毒性T细胞介导的体内肿瘤消除。
T34907	TP-238 TP 238
	TP-238 是一种有效的，选择性的CECR2/BPTF 双重探针，IC50值分别为 30 nM 和 350 nM。TP-238 还抑制BRD9，pIC50为 5.9，并且对其他 338 激酶的活性较低。
T28998	TP-680 TP 680
	TP-680 is a antagonist of cholecystokininA receptor.
T24896	TP 9201 TP-9201,TP9201
	TP 9201 is a platelet integrin alphaIIbbeta3 antagonist. It is a synthetic RGD-containing cyclic peptide.
T39486	TP-472N
	TP-472N serves as a negative control probe for TP-472, which is a specific and effective BRD7/9 probe.
TQ0120	CDDO-Im RTA-403,CDDO-Imidazolide,TP-235	Others; Ferroptosis; Nrf2; PPAR	Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Others
	CDDO-Im (TP-235) 是一种 Nrf2和 PPAR 的激活剂，对 PPARα 和 PPARγ 的 Ki 分别为232 nM 和 344 nM。
T23466	TP003	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	TP003是一种新型的非选择性GABAA 受体苯二氮卓位点激动剂，对α1β2γ2、α2β3γ2、α3β3γ2、α5β2γ2 的具有亲和力，其EC50 分别20.3、10.6、3.24、5.64 nM。 TP003 通过 α2GABAA 受体从而具有抗焦虑活性，也有部分抗惊厥活性。
T41110	EFdA-TP
	EFdA-TP, a highly potent nucleoside reverse transcriptase (RT) inhibitor, exerts its inhibitory effect on RT-catalyzed DNA synthesis through both immediate and delayed chain termination mechanisms, commonly referred to as ICT and DCT, respectively. Additionally, EFdA-TP demonstrates its efficacy in inhibiting HIV-1 RT through multiple pathways.
T68535	TP-051
	TP-051 is a FFAR1 agonist.
T34866	Thymocartin Thymocartinum,TP 4,Thymopoietin II (32-35),RGH 0206
	Thymocartin (RGH 0206) 是天然存在胸腺因子 (胸腺生成素) 的 32-35 片段。Thymocartin 可用于研究免疫缺陷病。
T68869	TP-110
	TP-110 is a new proteasome inhibitor, which shows potent growth inhibition in various tumor cell lines. Treatment with TP-110 for 24 h in vitro induced apoptosis in multiple myeloma cell line RPMI8226. TP-110 reduced the intrinsic inhibitor of apoptosis proteins (IAPs), cIAP-1 and XIAP, that suppress executioner caspases.
T5392	TP0463518	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	TP0463518 是缺氧诱导因子脯氨酰羟化酶抑制剂，能够作用于人 PHD2(Ki= 5.3 nM)。它还抑制人PHD1/PHD3，IC50分别为 18 和 63 nM，以及猴 PHD2(IC50=22 nM)。
T41202	TP 472N
	TP 472N is a negative control forTP 472. Inactive against other bromodomains (>20μM against BRD9).
T40120	FNC-TP
	FNC-TP, the intracellular active form of FNC, is a potent nucleoside reverse transcriptase inhibitor (NRTI) with broad-spectrum antiviral activity against HIV, HBV, and HCV.
T2005	Dubermatinib TP0903	Apoptosis; TAM Receptor	Apoptosis; Tyrosine Kinase/Adaptors
	Dubermatinib (TP0903) 是一种具有高效性和选择性的 Axl 受体酪氨酸激酶抑制剂，IC50值为27 nM。
T11227L1	Eravacycline HCl Eravacycline HCL(1207283-85-9 Free bse),TP-434 HCl	Antibiotic	Microbiology/Virology
	Eravacycline HCl (TP-434 HCl) 是一种具有广谱抗菌活性的强效抗生素。
T13190	TP-472	Epigenetic Reader Domain	Chromatin/Epigenetic
	TP-472 is a selective inhibitor of BRD9 (Kd: 33 nM).
T34908	TP-422 TP422
	TP-422 is a negative control for TP-238.
T28997	TP-271 TP271
	TP-271, a tetracyclines antibiotic, is used potentially for the treatment of community-acquired bacterial pneumonia (CABP).
T13188	TP-004	Others	Others
	TP-004 is a potent and reversible methionine aminopeptidase 2 (MetAP2) inhibitor (IC50: 6 nM).
T35649	EFdA-TP tetraammonium
	EFdA-TP tetraammonium is an influential nucleoside reverse transcriptase (RT) inhibitor that effectively prevents RT-mediated DNA synthesis by acting as an immediate or delayed chain terminator (ICT or DCT). Additionally, EFdA-TP tetraammonium exhibits multiple mechanisms of inhibiting HIV-1 RT[1].
T70429	TP-6076
	TP-6076 is a fluorocycline antibiotic, inhibiting bacterial protein synthesis, exhibiting great antimicrobial activity against carbapenem-resistant A. baumannii.
T40055	TP-238 hydrochloride
	TP-238 hydrochloride is a highly potent and selective dual CECR2/BPTF probe, demonstrating IC50 values of 30 nM and 350 nM, respectively. It additionally exerts inhibitory effects on BRD9, with a pIC50 value of 5.9, while displaying lower activity against 338 other kinases.
T6165	Bardoxolone Methyl RTA 402,CDDO Methyl ester,TP-155,甲基巴多索隆,NSC 713200	Apoptosis; IκB/IKK; Ferroptosis; Nrf2; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; NF-κB
	Bardoxolone Methyl (TP-155) 是一种合成的三萜类化合物，作为 Nrf2通路的激活剂和 NF-κB 途径的抑制剂，具有潜在的抗肿瘤和抗炎活性。
T13139	TP-008 TGFβRI-IN-2	Others	Others
	TGFβRI-IN-2 is a selective, potent and orally active inhibitor of (Activin-Like Kinase 5) ALK 5(pIC50 and pEC50 values of 7.6 and 6.63, respectively).
T71979	TP-S1-68
	TP-S1-68 is a Type-I inhibitor of TIE-2.
T20515	Selank TP-7,TP7,TP 7
	Selank is a synthetic analog of tuftsin.
T19588	TP748 2-苄氧基恶唑	Others	Others
	TP748 是一种异恶唑，也是合成四环素的关键中间体。
T26301	Tyropeptin A-4 TP 101,TP-101,TP101
	Tyropeptin A-4 is used as a proteasome inhibitor.
T11227	Eravacycline TP-434	Antibacterial	Microbiology/Virology
	Eravacycline (TP-434) 是一种有效的广谱抗菌剂。
T29431	4'-Azidothymidine 5'-triphosphate Adrt TP,Adrt-TP,AdrtTP
	4'-Azidothymidine 5'-triphosphate exerts selectively action on both reverse transcriptase of human immunodeficiency virus type 1 and human DNA polymerases alpha and beta.
T39104	Itacnosertib Itacnosertib,TP-0184
	Itacnosertib (TP-0184) is a chemical compound that acts as an inhibitor of JAK2, ACVR1 (ALK2), and ALK5, as indicated in WO2014151871.
T26209	Splenotritin TP 3,Thymopoietin tripeptide,TP3,TP-3
	Splenotritin is used as an antimicrobial peptide.
T73491	TP-050
	TP-050 是一种口服有效的选择性 NMDAR 激动剂，抑制 GluN2A 和 GluN2D 的 EC50值分别为 0.51 μM 和 9.6 µM。TP-050 可穿过血脑屏障 (BBB)。TP-050 诱导海马区的长期增益效应 (LTP)，增强神经元信号传输。
T6446L	Clevudine triphosphate L-FMAU-TP
	Clevudine triphosphate is a TTP analog that is able to inhibit protein priming independently of the deoxynucleoside triphosphate substrate.
T75351	TP-TRFS
	TP-TRFS 是高度选择性的一个硫氧还蛋白还原酶 (TrxR) 双光子荧光探针。
T63701	TP-5801
	TP-5801 是口服具有活力的非受体酪氨酸激酶 (TNK1) 抑制剂，IC50 值为 1.40 nM，具有抗肿瘤作用。
T77775	TP-1454
	TP-1454是一种针对PKM2的激活剂，其生化测定的AC50为10 Nm。它可通过作用于T调节细胞来调控肿瘤的免疫反应。
T73374	TP-030-1
	TP-030-1 是 RIPK1的抑制剂。TP-030-1 抑制 hRIPK1 的 Ki 值为 3.9 nM，抑制 mRIPK1 的 IC50值为 4.2 μM。TP-030-1 可用于炎症性疾病和神经退行性疾病的研究。
T78147	TP-5801 TFA	Others	Others
	TP-5801 TFA为口服活性非受体酪氨酸激酶（TNK1）抑制剂（IC50=1.40 nM），展现抗肿瘤活性。
T40088	TP0586352
	TP0586352 is a potent inhibitor of LpxC, exhibiting efficacy against carbapenem-resistant strains of Klebsiella pneumoniae without inducing cardiovascular risks.

化合物

Cat.No: T28996

Synonym: TP 064

Target: Histone Methyltransferase

Cat.No: T9250

Target: Others

Cat.No: T22440

Synonym: EOS-61973

Target: CDK

Cat.No: T4523

Target: Pim

Cat.No: T9254

Synonym: TAP2857

Target: Antibacterial

Cat.No: T13189

Target: PDE

Cat.No: T24897

Synonym: TP427736,TP-0427736,TP-427736

Target: TGF-beta/Smad

Cat.No: T2469

Synonym: TP-808,TP 808

Target: Others

Eravacycline dihydrochloride

Cat.No: T11227L

Synonym: TP-434-046,TP-434 dihydrochloride

Target: Antibacterial

Cat.No: T62525

Target: Prostaglandin Receptor

Cat.No: T34907

Synonym: TP 238

Cat.No: T28998

Synonym: TP 680

Cat.No: T24896

Synonym: TP-9201,TP9201

Cat.No: T39486

Cat.No: TQ0120

Synonym: RTA-403,CDDO-Imidazolide,TP-235

Target: Others, Ferroptosis, Nrf2, PPAR

Cat.No: T23466

Target: GABA Receptor

Cat.No: T41110

Cat.No: T68535

Cat.No: T34866

Synonym: Thymocartinum,TP 4,Thymopoietin II (32-35),RGH 0206

Cat.No: T68869

Cat.No: T5392

Target: HIF/HIF Prolyl-Hydroxylase

Cat.No: T41202

Cat.No: T40120

Cat.No: T2005

Synonym: TP0903

Target: Apoptosis, TAM Receptor

Eravacycline HCl

Cat.No: T11227L1

Synonym: Eravacycline HCL(1207283-85-9 Free bse),TP-434 HCl

Target: Antibiotic

Cat.No: T13190

Target: Epigenetic Reader Domain

Cat.No: T34908

Synonym: TP422

Cat.No: T28997

Synonym: TP271

Cat.No: T13188

Target: Others

EFdA-TP tetraammonium

Cat.No: T35649

Cat.No: T70429

TP-238 hydrochloride

Cat.No: T40055

Bardoxolone Methyl

Cat.No: T6165

Synonym: RTA 402,CDDO Methyl ester,TP-155,甲基巴多索隆,NSC 713200

Target: Apoptosis, IκB/IKK, Ferroptosis, Nrf2, Autophagy

Cat.No: T13139

Synonym: TGFβRI-IN-2

Target: Others

Cat.No: T71979

Cat.No: T20515

Synonym: TP-7,TP7,TP 7

Cat.No: T19588

Synonym: 2-苄氧基恶唑

Target: Others

Cat.No: T26301

Synonym: TP 101,TP-101,TP101

Cat.No: T11227

Synonym: TP-434

Target: Antibacterial

4'-Azidothymidine 5'-triphosphate

Cat.No: T29431

Synonym: Adrt TP,Adrt-TP,AdrtTP

Cat.No: T39104

Synonym: Itacnosertib,TP-0184

Cat.No: T26209

Synonym: TP 3,Thymopoietin tripeptide,TP3,TP-3

Cat.No: T73491

Clevudine triphosphate

Cat.No: T6446L

Synonym: L-FMAU-TP

Cat.No: T75351

Cat.No: T63701

Cat.No: T77775

Cat.No: T73374

Cat.No: T78147

Target: Others

Cat.No: T40088

Cat. No.	Product Name	Target	Signaling Pathways
T2598	Thymopentin TP5,胸腺五肽	Estrogen/progestogen Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Thymopentin (TP5) 是主要由胸腺皮质和髓质上皮细胞分泌的生物特性肽。它能促使自人类胚胎干细胞产生 T 细胞群。它是有效免疫调节剂，具有很短的血浆半衰期(30 秒)。
T1352	ATP disodium salt Adenosine 5'-triphosphate disodium salt,三磷酸腺苷二钠,ATP,ATP disodium,腺苷-5'-三磷酸二钠盐,Adetide,Adenosine-Triphosphate,Disodium adenosine triphosphate	P2X Receptor; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism; Neuroscience
	ATP disodium salt (Adenosine-Triphosphate) 是体内能量储存的重要物质，为代谢提供能量，同时在细胞中作为辅酶发挥作用。Adenosine 5'-triphosphate disodium salt 也是免疫和炎症中重要的内源性信号分子。
T38427	dUTP trisodium 2'-Deoxyuridine-5'-triphosphate trisodium salt,Deoxyuridine triphosphate	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	dUTP trisodium (Deoxyuridine triphosphate) 是在 5'-位具有三磷酸基团的脱氧尿苷磷酸盐，可用于 PCR。
T64980	ATP disodium trihydrate Adenosine-5'-triphosphate disodium trihydrate	Endogenous Metabolite	Metabolism
	ATP disodium trihydrate (Adenosine-5'-triphosphate disodium trihydrate) 是体内能量储存和代谢的重要物质，是免疫和炎症中重要的内源性信号分子，可为机体代谢提供能量，同时在细胞中作为辅酶发挥作用。
T2812	ATP disodium salt hydrate ATP disodium,ATP disodium salt,Adenosine disodium triphosphate,三磷酸腺苷二钠盐	Others; Endogenous Metabolite	Metabolism; Others
	ATP disodium salt hydrate (Adenosine disodium triphosphate) 是体内能量储存和代谢的重要物质，为代谢提供能量，同时在细胞中作为辅酶发挥作用。同时，它是也是免疫和炎症中重要的内源性信号分子。
T20089	ATP Atipi,ATP disodium salt hydrate,Triphosphoric acid adenosine ester,Ara-ATP,Triphosphaden,Adenosine triphosphate;Ara-ATP,Adenosine triphosphate	Endogenous Metabolite	Metabolism
	ATP (Adenosine triphosphate) 可为细胞提供能量，参与整体能量平衡，维持细胞内稳态。ATP 可以通过与特异性嘌呤能受体的相互作用充当细胞外信号分子，以介导神经传递、炎症、细胞凋亡和骨重塑等多种过程。
T73073	PTP1B-IN-21
	PTP1B-IN-21 是蛋白酪氨酸磷酸酶 1B (PTP1B) 的选择性抑制剂 (IC50=1.56 μM)，抑制力超出高度同源 T 细胞蛋白酪氨酸磷酸酶 (TCPTP；IC50>100 μM)，PTP1B 是抑制 2 型糖尿病的重要靶点。
T40526	ATP dipotassium 腺苷三磷酸二钾盐,Adenosine5'-triphosphatedipotassium
	ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a vital compound involved in energy storage and metabolism within living organisms. It plays a crucial role in supplying metabolic energy for driving pumps and acts as a coenzyme in cellular processes. Additionally, ATP dipotassium functions as a significant endogenous signaling molecule contributing to immunity and inflammation.
T73072	PTP1B-IN-20
	PTP1B-IN-20 是蛋白酪氨酸磷酸酶 1B (PTP1B) 的选择性抑制剂 (IC50=1.05 μM)，抑制力超出高度同源 T 细胞蛋白酪氨酸磷酸酶 (TCPTP；IC50=78.0 μM)，PTP1B 是抑制 2 型糖尿病的重要靶点。
T10021	1-Methylxanthine	Endogenous Metabolite	Metabolism
	1-Methylxanthine 是咖啡因衍生物，是咖啡因和茶碱 (1,3-二甲基黄嘌呤，TP) 在人体尿代谢产物，能够提高肿瘤细胞的放射敏感性。

天然产物

Cat.No: T2598

Synonym: TP5,胸腺五肽

Target: Estrogen/progestogen Receptor, Endogenous Metabolite

ATP disodium salt

Cat.No: T1352

Synonym: Adenosine 5'-triphosphate disodium salt,三磷酸腺苷二钠,ATP,ATP disodium,腺苷-5'-三磷酸二钠盐,Adetide,Adenosine-Triphosphate,Disodium adenosine triphosphate

Target: P2X Receptor, Endogenous Metabolite

Cat.No: T38427

Synonym: 2'-Deoxyuridine-5'-triphosphate trisodium salt,Deoxyuridine triphosphate

Target: DNA/RNA Synthesis

ATP disodium trihydrate

Cat.No: T64980

Synonym: Adenosine-5'-triphosphate disodium trihydrate

Target: Endogenous Metabolite

ATP disodium salt hydrate

Cat.No: T2812

Synonym: ATP disodium,ATP disodium salt,Adenosine disodium triphosphate,三磷酸腺苷二钠盐

Target: Others, Endogenous Metabolite

Cat.No: T20089

Synonym: Atipi,ATP disodium salt hydrate,Triphosphoric acid adenosine ester,Ara-ATP,Triphosphaden,Adenosine triphosphate;Ara-ATP,Adenosine triphosphate

Target: Endogenous Metabolite

Cat.No: T73073

ATP dipotassium

Cat.No: T40526

Synonym: 腺苷三磷酸二钾盐,Adenosine5'-triphosphatedipotassium

Cat.No: T73072

1-Methylxanthine

Cat.No: T10021

Target: Endogenous Metabolite

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