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111

抑制剂 & 化合物

10

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T13932	TLR1 N-[(1S)-2-甲基-1-(1-吡咯烷羰基)丙基]-苯丙酰胺	Others; MyD88	Immunology/Inflammation; Others
	TLR1 是细胞穿透 Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop 的小分子模拟物，能够阻碍 IL-1 受体介导的反应。
T8503	TLR4-IN-C34	TLR	Immunology/Inflammation
	TLR4-IN-C34 是 TLR4 的抑制剂，可减少内毒素血症和坏死性小肠结肠炎模型中的全身炎症
T39669	TLR7/8/9-IN-1 TLR7/8/9-IN-1	TLR	Immunology/Inflammation
	TLR7/8/9-IN-1 是具有口服活性的Toll 样受体7/8/9小分子拮抗剂，IC50为43 nM。
T13167	TLR7/8 agonist 3	TLR	Immunology/Inflammation
	TLR7/8 agonist 3 是TLR7/8激动剂。
T7672	MD2-TLR4-IN-1	TLR	Immunology/Inflammation
	MD2-TLR4-IN-1 是一种骨髓分化蛋白 2/toll 样受体 4 (MD2-TLR4) 复合物抑制剂，能够抑制巨噬细胞 LPS 诱导的 TNF-α 和 IL-6 的表达，IC50值分别为 0.89 和 0.53 μM。
T4258	TLR7 agonist 2 TLR7-agonist-1,TLR7-IN-1	TLR	Immunology/Inflammation
	TLR7 agonist 2 (TLR7-IN-1) 是选择性 Toll 样受体 7 激动剂，LEC 值为 0.4 μM。
T38078	TLR7/8-IN-1 TLR7/8-IN-1	TLR	Immunology/Inflammation
	TLR7/8-IN-1, a crystalline TLR7/TLR8 inhibitor, is a valuable compound for autoimmune disease research[1].
T5561	TLR7/8 agonist 1 dihydrochloride TLR7/8 agonist-5d,二盐酸TLR7/8 agonist 1	TLR	Immunology/Inflammation
	TLR7/8 agonist 1 dihydrochloride (TLR7/8 agonist-5d) 是 toll 样受体TLR7/TLR8的双重激动剂。
T38614	TLR7 agonist 3
	TLR7 agonist 3 (Compound 2), a potent activator of toll-like receptor 7 (TLR7), plays a critical role in initiating immune responses, positioning it as a promising target for immunomodulator development.
T40040	TLR8 agonist 2 hydrochloride
	TLR8 agonist 2 hydrochloride is a highly potent and selective agonist for human TLR8, exhibiting an EC50 of 3 nM. However, its activity towards human TLR7 is considerably weaker, with an EC50 of 33.33 μM.
T40039	TLR8 agonist 2 TLR8 agonist 2
	TLR8 agonist 2 is a highly effective and specific compound that activates TLR8, possessing an EC 50 of 3 nM in human TLR8. Notably, TLR8 agonist 2 demonstrates lower activity towards human TLR7, with an EC 50 of 33.33 μM.
T7317	CU-CPT-9a	TLR	Immunology/Inflammation
	CU-CPT-9a 是TLR8特异性拮抗剂，IC50值为 0.5 nM。
T10899	CU-CPT17e	TLR	Immunology/Inflammation
	CU-CPT17e 是多Toll 样受体激动剂，可激活TLR3、TLR8和TLR9。
T22698	TLR3-IN-1 CU CPT 4a	TLR	Immunology/Inflammation
	TLR3-IN-1 (CU CPT 4a) 是一种选择性的TLR3信号抑制剂，在 RAW 264.7 细胞中 IC50 为 3.44 μM。它可以抑制 TLR3/dsRNA 复合物介导的下游信号通路，并抑制全细胞中 TNF-α 和 IL-1β 的产生。
T15020	CU-CPT22	TLR	Immunology/Inflammation
	CU-CPT22 是 toll 样受体 1 和 2 蛋白复合物抑制剂，可阻断 Pam3CSK4诱导的 TLR1/2 激活，IC50值为 0.58 µM。它与 TLR1/2 结合的合成三酰脂蛋白竞争，Ki 值为 0.41 µM。
T39969	TLR7/8 agonist 4 TFA
	TLR7/8 agonist 4 TFA (compound 41) is a highly potent TLR7/8 agonist that exhibits significant anti-cancer activity.
T15777	Loxoribine RWJ 21757,7-Allyl-8-oxoguanosine,洛索立宾	Influenza Virus; TLR	Immunology/Inflammation; Microbiology/Virology
	Loxoribine (RWJ 21757) 是一种鸟苷类似物，是一种口服生物可利用的选择性 Toll 样受体 (TLR) 7 激动剂。具有抗病毒和抗肿瘤活性。它是一种新型的强效免疫刺激剂，具有较广谱的免疫生物学活性。
T9570	Enpatoran	TLR	Immunology/Inflammation
	Enpatoran (M5049) 是一种口服有效的TLR7/8选择性抑制剂，在HEK293 细胞中，IC50s 分别为 11.1 nM 和 24.1 nM。Enpatoran 可以阻断分子合成配体和天然内源性 RNA 配体。Enpatoran 在体内具有良好的药代动力学特性。Enpatoran 在先天性和适应性自身免疫阻断方面有研究的价值。
T11598	IAXO-102	TLR	Immunology/Inflammation
	IAXO-102 是一种 TLR4 拮抗剂，可负向调节 TLR4 信号传导，还可以防止实验性腹主动脉瘤的发展。它抑制 MAPK 和 p65 NF-κB 磷酸化和 TLR4 依赖性促炎蛋白的表达。
T39654	Afimetoran BMS-986256	TLR	Immunology/Inflammation
	Afimetoran (BMS-986256) 是一种有效的toll 样受体拮抗剂，在炎症和自身免疫性疾病中有研究的价值。
T4231	MD2-IN-1	TLR	Immunology/Inflammation
	MD2-IN-1 是骨髓分化蛋白 2 (MD2) 的抑制剂，对重组人 MD2 (rhMD2) 的 KD 为 189 μM。
T16506	PF-4878691 3M-852A	TLR	Immunology/Inflammation
	PF-4878691 (3M-852A) 是一种有效的选择性 Toll 样受体 7 激动剂，可将其抗病毒活性与其炎症活性解离。
T3502	C29	TLR	Immunology/Inflammation
	C29 是 Toll 样受体 2 抑制剂，可阻断 hTLR2/1 和 hTLR2/6 信号，IC50值分别为 19.7 和 37.6 μM。
T38547	TLR4-IN-C34-C2-COOH TLR4-IN-C34-C2-COOH
	TLR4-IN-C34-C2-COO is a linker compound that incorporates TLR4 inhibitor TLR4-IN-C34. It effectively inhibits TLR4 activity in enterocytes and macrophages. Moreover, it demonstrates a notable ability to mitigate systemic inflammation in murine models of endotoxemia and necrotizing enterocolitis.
T7347	CU-CPT-8m TLR8-specific antagonist	TLR	Immunology/Inflammation
	CU-CPT-8m (TLR8-specific antagonist) 是TLR8特异性拮抗剂，IC50值为 67 nM。
T40423	L48H37
	L48H37 is a chemically stable analog of Curcumin. It exhibits potent inhibitory properties against myeloid differentiation protein 2 (MD2), acting as a specific inhibitor. Its mechanism involves inhibiting the interaction and signaling transduction of LPS-TLR4/MD2. L48H37 is primarily utilized in sepsis and lung injury research [1].
T7860	SM-324405 SM 324405	TLR	Immunology/Inflammation
	SM-324405 是TLR7的激动剂，EC50 为 50 nM，对人和大鼠 TLR7 的 pEC50值分别为 7.3 和 6.6，可用于过敏性疾病的免疫治疗研究。
T17032	Telratolimod MEDI9197,3M-052	TLR	Immunology/Inflammation
	Telratolimod (MEDI9197) 是TLR7/8的激动剂，具有抗肿瘤活性。
T8727	TH1020	TLR; Antibacterial	Immunology/Inflammation; Microbiology/Virology
	TH1020 是一种选择性 Toll 样受体 5 /鞭毛蛋白复合拮抗剂，IC50为 0.85 μM。它抑制鞭毛蛋白诱导的TLR5信号传导。
T38423	CL097 CL097	Reactive Oxygen Species; TLR	Immunology/Inflammation; Metabolism; NF-κB
	CL097 是 TLR7 和 TLR8 的有效激动剂。 CL097 诱导巨噬细胞中的促炎细胞因子和 NADPH 氧化酶引发，从而增加 fMLF 刺激的 ROS 产生。
T15371	Gardiquimod	TLR; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Gardiquimod 可抑制巨噬细胞和活化的外周血单个核细胞的HIV-1感染。它是一种咪唑喹啉类似物，是一种 TLR7/8 激动剂。
T5521	Bropirimine U-54461,溴匹立明	TLR	Immunology/Inflammation
	Bropirimine (U-54461) 是 toll 样受体 7(TLR7)的合成激动剂，可通过 TLR7 介导 IFN-β 的产生抑制破骨细胞前体细胞向破骨细胞分化。它是一种生物反应调节剂，通过诱导淋巴因子起作用，在膀胱和上尿路的原位移行细胞癌中具有抗癌活性。
T23171	Polyinosinic-polycytidylic acid Poly(I:C),聚胞苷酸	TLR	Immunology/Inflammation
	Polyinosinic-polycytidylic acid (Poly(I:C)) 是一种双链 RNA (dsRNA)，是一种 TLR3 激动剂。Polyinosinic-polycytidylic acid 可以诱导哺乳动物天然免疫。
T15017	CU-T12-9	TLR	Immunology/Inflammation
	CU-T12-9 是特异性 TLR1/2激动剂，可激活先天免疫系统和适应性免疫系统。它选择性激活 TLR1/2 异二聚体，可通过促进 TLR1 和 TLR2 二聚而激活 NF-κB 信号，引起下游 TNF-α、IL-10 和 iNOS 增加。
T6898	Motolimod VTX-378,VTX-2337	TLR	Immunology/Inflammation
	Motolimod (VTX-378) 是一种有效且特异性的 Toll 样受体 8 (TLR8) 激动剂，EC50约为 100 nM。
T9765	TJ-M2010-5	MyD88	Immunology/Inflammation
	TJ-M2010-5 是一种 MyD88 抑制剂，可与 TIR 结构域结合以干扰其同源二聚化并抑制 MyD88 信号传导。 TJ-M2010-5 可用于心肌缺血/再灌注损伤研究。
T8316	1V209 TLR7 agonist T7	TLR	Immunology/Inflammation
	1V209 (TLR7 agonist T7) 是一种 Toll 样受体 7 (TLR7) 激动剂，可与各种多糖缀合，以改善其水溶性，增强功效并保持低毒性，具有抗肿瘤作用。
T39968	TLR7/8 agonist 4 hydroxy-PEG10-acid TLR7/8 agonist 4 hydroxy-PEG10-acid
	TLR7/8 agonist 4 hydroxy-PEG10-acid (compound 9) is a drug-linker conjugate employed in antibody-drug conjugates (ADC). This compound exhibits remarkable antitumor activity by utilizing TLR7/8 agonist 4, which acts as a potent activator of TLR7/8. The TLR7/8 agonist 4 is linked to hydroxy-PEG10-acid, the ADC linker, via a cleavable bond. Overall, it demonstrates promising pharmaceutical potential in the context of ADC-based therapeutics.
T12933	SM-276001	TLR; COX	Immunology/Inflammation; Neuroscience
	SM-276001 是可口服的干扰素诱导剂，是选择性TLR7激动剂，可以诱导抗肿瘤免疫反应。
T7302	CU-CPT9b CU-CPT-9b,TLR8-specific antagonist 1	TLR	Immunology/Inflammation
	CU-CPT9b (TLR8-specific antagonist 1) 是 toll 样受体 8 (TLR8) 的拮抗剂，Kd 为 21 nM。它抑制由 TLR8 激动剂 R-848 在过表达 TLR8 的 HEK-Blue 细胞中诱导的 NF-ĸB 活化，IC50 值为 0.7 nM。
T6964	Resiquimod R848,雷西莫特,S28463	HCV Protease; TLR	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Resiquimod (R848) 是一种 Toll 样受体7/8的激动剂，可诱导细胞因子上调。
T6846	Vesatolimod GS-9620,维沙莫德	Apoptosis; HCV Protease; HBV; TLR; HIV Protease	Apoptosis; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Vesatolimod (GS-9620) 是一种选择性 Toll 样受体 7 口服激动剂，EC50值为291 nM。
T9287	Hydroxychloroquine 2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol,羟氯喹	SARS-CoV; TLR; Parasite; Autophagy	Autophagy; Immunology/Inflammation; Microbiology/Virology
	Hydroxychloroquine (2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol) 是一种合成抗疟疾剂，有效抑制SARS-CoV-2感染，也抑制 Toll 样受体 7/9 信号传导。
T39970	TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride
	TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride (compound 9) is a drug-linker conjugate used in antibody-drug conjugates (ADCs) with high efficacy against tumors. It consists of TLR7/8 agonist 4, a potent TLR7/8 agonist, linked to the ADC linker hydroxy-PEG10-acid which can be cleaved.
T0951	Hydroxychloroquine sulfate Acidum iopanoicum,硫酸羟基氯喹,硫酸羟氯喹,HCQ sulfate	DNA; SARS-CoV; TLR; Parasite; Autophagy	Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology
	Hydroxychloroquine sulfate (Acidum iopanoicum) 抑制疟原虫血红素聚合酶。它还可抑制 Toll 样受体 7/9 信号传导和 SARS-CoV-2 感染。
T19675	SM360320 CL-087,SM 360320,CL 087,1V136,SM-360320,CL087	TLR	Immunology/Inflammation
	SM360320 (CL-087) 是一种有效的特异性 TLR7 激动剂。 SM360320 除了其 IFN 介导的活性外，还通过 I 型 IFN 非依赖性机制抑制肝细胞中的 HCV 复制。 SM360320 可用于研究作为治疗性 DNA 疫苗的免疫佐剂。
T13168	TLR7 agonist 1	TLR	Immunology/Inflammation
	TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).
T12516	Polyinosinic-polycytidylic acid sodium 双链聚肌胞,Poly(I:C) sodium	Apoptosis; Others; TLR	Apoptosis; Immunology/Inflammation; Others
	Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) 是双链 RNA 的合成类似物，是TLR3和视黄酸诱导型基因 I 受体激动剂。它可以用作疫苗佐剂，直接触发癌细胞发生凋亡，还增强先天性和适应性免疫反应，并改变肿瘤的微环境。
T70905	TLR9-IN-18
	TLR9-IN-18 is a potent and selective TLR9 antagonist. TLR9-IN-18 suppresses the production of the proinflammatory cytokine IL-6 in a CpG-induced mouse model.
TQ0181	Resatorvid CLI-095,TAK-242,瑞沙托维	TNF; TLR; Autophagy; Interleukin	Apoptosis; Autophagy; Immunology/Inflammation
	Resatorvid (TAK-242) 是一种 Toll 样受体 4 (TLR4) 的抑制剂，具有选择性。Resatorvid 直接与 Cys747 结合，阻止 TLR4 与 TIRAP 结合，从而阻止下游信号转导。Resatorvid 具有抗肿瘤活性、抗炎活性和神经保护作用。

化合物

Cat.No: T13932

Synonym: N-[(1S)-2-甲基-1-(1-吡咯烷羰基)丙基]-苯丙酰胺

Target: Others, MyD88

Cat.No: T8503

Target: TLR

TLR7/8/9-IN-1

Cat.No: T39669

Synonym: TLR7/8/9-IN-1

Target: TLR

TLR7/8 agonist 3

Cat.No: T13167

Target: TLR

MD2-TLR4-IN-1

Cat.No: T7672

Target: TLR

TLR7 agonist 2

Cat.No: T4258

Synonym: TLR7-agonist-1,TLR7-IN-1

Target: TLR

Cat.No: T38078

Synonym: TLR7/8-IN-1

Target: TLR

TLR7/8 agonist 1 dihydrochloride

Cat.No: T5561

Synonym: TLR7/8 agonist-5d,二盐酸TLR7/8 agonist 1

Target: TLR

TLR7 agonist 3

Cat.No: T38614

TLR8 agonist 2 hydrochloride

Cat.No: T40040

TLR8 agonist 2

Cat.No: T40039

Synonym: TLR8 agonist 2

Cat.No: T7317

Target: TLR

Cat.No: T10899

Target: TLR

Cat.No: T22698

Synonym: CU CPT 4a

Target: TLR

Cat.No: T15020

Target: TLR

TLR7/8 agonist 4 TFA

Cat.No: T39969

Cat.No: T15777

Synonym: RWJ 21757,7-Allyl-8-oxoguanosine,洛索立宾

Target: Influenza Virus, TLR

Cat.No: T9570

Target: TLR

Cat.No: T11598

Target: TLR

Cat.No: T39654

Synonym: BMS-986256

Target: TLR

Cat.No: T4231

Target: TLR

Cat.No: T16506

Synonym: 3M-852A

Target: TLR

Cat.No: T3502

Target: TLR

TLR4-IN-C34-C2-COOH

Cat.No: T38547

Synonym: TLR4-IN-C34-C2-COOH

Cat.No: T7347

Synonym: TLR8-specific antagonist

Target: TLR

Cat.No: T40423

Cat.No: T7860

Synonym: SM 324405

Target: TLR

Cat.No: T17032

Synonym: MEDI9197,3M-052

Target: TLR

Cat.No: T8727

Target: TLR, Antibacterial

Cat.No: T38423

Synonym: CL097

Target: Reactive Oxygen Species, TLR

Cat.No: T15371

Target: TLR, HIV Protease

Cat.No: T5521

Synonym: U-54461,溴匹立明

Target: TLR

Polyinosinic-polycytidylic acid

Cat.No: T23171

Synonym: Poly(I:C),聚胞苷酸

Target: TLR

Cat.No: T15017

Target: TLR

Cat.No: T6898

Synonym: VTX-378,VTX-2337

Target: TLR

Cat.No: T9765

Target: MyD88

Cat.No: T8316

Synonym: TLR7 agonist T7

Target: TLR

TLR7/8 agonist 4 hydroxy-PEG10-acid

Cat.No: T39968

Synonym: TLR7/8 agonist 4 hydroxy-PEG10-acid

Cat.No: T12933

Target: TLR, COX

Cat.No: T7302

Synonym: CU-CPT-9b,TLR8-specific antagonist 1

Target: TLR

Cat.No: T6964

Synonym: R848,雷西莫特,S28463

Target: HCV Protease, TLR

Cat.No: T6846

Synonym: GS-9620,维沙莫德

Target: Apoptosis, HCV Protease, HBV, TLR, HIV Protease

Hydroxychloroquine

Cat.No: T9287

Synonym: 2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol,羟氯喹

Target: SARS-CoV, TLR, Parasite, Autophagy

TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride

Cat.No: T39970

Synonym: TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride

Hydroxychloroquine sulfate

Cat.No: T0951

Synonym: Acidum iopanoicum,硫酸羟基氯喹,硫酸羟氯喹,HCQ sulfate

Target: DNA, SARS-CoV, TLR, Parasite, Autophagy

Cat.No: T19675

Synonym: CL-087,SM 360320,CL 087,1V136,SM-360320,CL087

Target: TLR

TLR7 agonist 1

Cat.No: T13168

Target: TLR

Polyinosinic-polycytidylic acid sodium

Cat.No: T12516

Synonym: 双链聚肌胞,Poly(I:C) sodium

Target: Apoptosis, Others, TLR

Cat.No: T70905

Cat.No: TQ0181

Synonym: CLI-095,TAK-242,瑞沙托维

Target: TNF, TLR, Autophagy, Interleukin

Cat. No.	Product Name	Target	Signaling Pathways
T2S0265	Robinin NSC 9222,刺槐素	TLR	Immunology/Inflammation
	Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of the human colon cancer cell line Colo 320 expreβing MDR1/LRP was explored by monitoring their uptake of Rhodamine 123, but was shown to have minimal effect. Robinin (NSC-9222) was detected in lysates of the human breast cancer cell line MCF-7 using liquid chromatography-tandem maβ spectrometry.
TN2008	Okanin	NF-κB; TLR	Immunology/Inflammation; NF-κB
	Okanin 是鬼针草中的一种有效成分，可通过抑制TLR4/NF-κB 信号通路减弱 LPS 诱导的小胶质细胞活化。
TQ0205	Procyanidin B1 原花青素B1,原花青素 B1	TLR	Immunology/Inflammation
	Procyanidin B1 是水果中常见的多酚类黄酮，能够与TLR4/MD-2复合体结合，具有抗炎活性。
T8689	Chloroquine CQ,氯喹	SARS-CoV; TLR; HIV Protease; Antibiotic; Parasite; Autophagy	Autophagy; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Chloroquine 是一种 Toll 样受体抑制剂，可以抑制自噬。Chloroquine 具有抗疟疾和抗炎活性，广泛用于治疗疟疾和类风湿性关节炎。Chloroquine 还具有抗 SARS-CoV-2 (COVID-19) 活性、抗 HIV-1 活性。
T5S0167	Atractylenolide I 白术内酯 I,白术内酯I；苍术内酯I	IL Receptor; TNF; TLR; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells
	Atractylenolide I 是从白术根中得到的一种倍半萜烯，具有神经保护、抗过敏、抗炎和抗癌等多种生物活性。它是一种TLR4拮抗剂，在 A375 细胞中，能够降低JAK2和STAT3的磷酸化水平。
T3826	Polygalasaponin F 异牡荆苷,瓜子金皂苷己	NF-κB; TLR; Akt; PI3K	Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling
	Polygalasaponin F 是从瓜子金中提取的齐墩果烷型三萜皂苷，可通过调节TLR4-PI3K/AKT-NF-kB 信号通路减少神经炎症细胞因子的分泌，能降低炎性细胞因子肿瘤坏死因子 α 的释放。
T3898	Schaftoside 夏佛塔苷,APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside	Dynamin; Antioxidant; TLR; MyD88; Mitochondrial Metabolism; Autophagy	Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; oxidation-reduction
	Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) 是在多种中草药中发现的一种黄酮类天然产物。它抑制 TLR4 和 Myd88 表达，还降低 Drp1 表达和磷酸化，并减少线粒体分裂，具有抗氧化和抗癌活性。
T5S0045	Isofraxidin 6,8-Dimethoxyumbelliferone,异秦皮啶,Phytodolor,异嗪皮啶	MMP; ERK; p38 MAPK; TLR; COX	Immunology/Inflammation; MAPK; Neuroscience; Proteases/Proteasome
	Isofraxidin (Phytodolor) 是来自刺五加的香豆素成分，抑制MMP-7表达和人肝癌细胞侵袭。它作用于肝癌细胞，抑制ERK1/2磷酸化。它减弱iNOS 和COX-2表达，还抑制TLR4/髓样分化蛋白 2 复合物的形成。
T0194	Chloroquine phosphate Chloroquine diphosphate,Aralen phosphate,磷酸氯喹,Chingamin phosphate	SARS-CoV; TLR; HIV Protease; Antibiotic; Parasite; Autophagy	Autophagy; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Chloroquine phosphate (Aralen phosphate) 是广泛用于疟疾和类风湿性关节炎的抗疟疾和抗炎剂。它是autophagy 和toll-like receptors 抑制剂，有效抑制SARS-CoV-2(COVID-19) 感染 (EC50=1.13 μM)。
T6S1487	Ginsenoside Rg5 人参皂苷Rg5,人参皂甙 Rg5	NF-κB; COX; IGF-1R	Immunology/Inflammation; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors
	Ginsenoside Rg5 是红参的主要成分，可阻断IGF-1与其受体的结合，IC50约为90 nM。它还通过抑制NF-κB p65的 DNA 结合活性来抑制COX-2的 mRNA 表达。它可促进血管生成和改善高血压，具有抗炎和治疗阿尔茨海默病的潜力。

天然产物

Cat.No: T2S0265

Synonym: NSC 9222,刺槐素

Target: TLR

Cat.No: TN2008

Target: NF-κB, TLR

Cat.No: TQ0205

Synonym: 原花青素B1,原花青素 B1

Target: TLR

Cat.No: T8689

Synonym: CQ,氯喹

Target: SARS-CoV, TLR, HIV Protease, Antibiotic, Parasite, Autophagy

Atractylenolide I

Cat.No: T5S0167

Synonym: 白术内酯 I,白术内酯I；苍术内酯I

Target: IL Receptor, TNF, TLR, JAK, STAT

Polygalasaponin F

Cat.No: T3826

Synonym: 异牡荆苷,瓜子金皂苷己

Target: NF-κB, TLR, Akt, PI3K

Cat.No: T3898

Synonym: 夏佛塔苷,APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside

Target: Dynamin, Antioxidant, TLR, MyD88, Mitochondrial Metabolism, Autophagy

Cat.No: T5S0045

Synonym: 6,8-Dimethoxyumbelliferone,异秦皮啶,Phytodolor,异嗪皮啶

Target: MMP, ERK, p38 MAPK, TLR, COX

Chloroquine phosphate

Cat.No: T0194

Synonym: Chloroquine diphosphate,Aralen phosphate,磷酸氯喹,Chingamin phosphate

Target: SARS-CoV, TLR, HIV Protease, Antibiotic, Parasite, Autophagy

Ginsenoside Rg5

Cat.No: T6S1487

Synonym: 人参皂苷Rg5,人参皂甙 Rg5

Target: NF-κB, COX, IGF-1R

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