首页工具

登录

搜索结果

Search Results for " t-4 "

180

抑制剂 & 化合物

25

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T16967	T-00127_HEV1	PI4K	PI3K/Akt/mTOR signaling
	T-00127_HEV1 是有效的phosphatidylinositol 4-kinase III beta 抑制剂，IC50为 60 nM。
T8656	CAY10404 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T	Apoptosis; Akt; COX	Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Neuroscience; PI3K/Akt/mTOR signaling
	CAY10404 (3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T) 是一种有效且高度选择性的 COX-2 和 COX-1 抑制剂。它还是 PKB/Akt 和 MAPK 信号通路的有效抑制剂，可诱导 NSC-LC 细胞凋亡，具有镇痛、抗炎和抗癌活性。
T35719	T2AA T2AA,4-[4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy]phenol,ZINC95605533	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	T2AA (4-[4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy]phenol) 是一种增殖细胞核抗原 (PCNA) 抑制剂，对 PCNA/PIP-box 肽相互作用的 IC50 为 1 μM。 T2AA 通过停止 DNA 复制叉和抑制 PCNA 与 DNA 聚合酶 δ 的相互作用来引起 DNA 复制压力并抑制癌细胞生长。
T3189	B7/CD28 interaction inhibitor 1 CTLA-4 inhibitor	Others	Others
	B7/CD28 interaction inhibitor 1 (CTLA-4 inhibitor) 是B7.1-CD28相互作用抑制剂(IC50:50 nM)。
T6690	T0901317 N-(2,2,2-三氟乙基)-N-[4-[2,2,2-三氟-1-羟基-1-(三氟甲基)乙基]苯基]苯磺酰胺	Apoptosis; FXR; Liver X Receptor; ROR	Apoptosis; Metabolism
	T0901317 是一种口服有效且高度选择性的LXR 激动剂，对 LXRα 的EC50为 20 nM。它激活FXR，EC50为 5 μM。它是RORα和RORγ双重反向激动剂，Ki 值分别为 132 nM 和 51 nM。它诱导细胞凋亡，并抑制低密度脂蛋白受体缺失小鼠动脉粥样硬化的发展。
T22355	L-Thyroxine sodium 左旋甲状腺素钠,LT4 sodium,Levothyroxine sodium,L-T4 sodium	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	L-Thyroxine sodium (LT4 sodium) 是一种合成的甲状腺激素，用于研究甲状腺功能减退症。DIO 酶能够将Levothyroxine 转化成具有生物活性的三碘甲状腺氨酸 (T3)。
T6603	Nelarabine GW 506U78,Nelzarabine,奈拉滨,506U78	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Nelarabine (GW 506U78) 是一种嘌呤核苷酸类似物，为DNA 合成抑制剂，对肿瘤细胞的IC50为0.067-2.15 μM，可作用于T 细胞急性淋巴细胞白血病。
T39619	FmocNH-PEG4-t-butyl ester FmocNH-PEG4-t-butyl ester
	FmocNH-PEG4-t-butyl ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T34272	RC 121 RC121,IM 4-28,RC-121,P-Cttlvc-T
	RC 121 is a highly potent somatostatin (SRIF) analog.
T69799	4-Me-PDTic
	4-Me-PDTic is a potent and selective kappa opioid receptor antagonist.
T3298	Ethyl 3-amino-1H-pyrazole-4-carboxylate 3-Amino-4-ethoxycarbonylpyrazole

T39532	Bis-PEG4-t-butyl ester Bis-PEG4-t-butyl ester
	Bis-PEG4-t-butyl ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T41024	FmocNH-PEG4-t-butyl acetate FmocNH-PEG4-t-butyl acetate
	FmocNH-PEG4-t-butyl acetate is a polyethylene glycol (PEG)-derived PROTAC linker employed for the synthesis of PROTACs, bifunctional molecules designed to degrade target proteins.
T18741	t-Boc-Aminooxy-PEG4-NHS ester	Others	Others
	t-Boc-Aminooxy-PEG4-NHS ester is a polyethylene glycol (PEG) derivative, functioning as a linker for PROTAC synthesis[1].
T1389	Dyclonine hydrochloride 盐酸达克罗宁,Dyclocaine hydrochloride,Dyclonine HCl	Sodium Channel; Antibacterial; Antifungal	Membrane transporter/Ion channel; Microbiology/Virology
	Dyclonine hydrochloride (Dyclonine HCl) 是润喉片的有效成分，具有显著的杀菌和杀真菌作用。
T17133	Tos-PEG4-t-butyl ester Tos-PEG4-Boc	Others	Others
	Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker characterized by its PEG composition. This compound plays a crucial role in the synthesis of a range of PROTACs, including BI-3663, a highly selective PTK2/FAK PROTAC. It employs cereblon ligands to target E3 ligases for the degradation of PTK2, exhibiting potent inhibitory activity with an IC50 of 18 nM[1].
T16238	N-Methyl-N-(t-Boc)-PEG4-acid	Others	Others
	N-Methyl-N-(t-Boc)-PEG4-acid is a polyethylene glycol (PEG) derivative utilized as a PROTAC linker in the synthesis of PROTACs, which refers to proteolysis-targeting chimeras[1].
T14441	Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane azido-peg4-amido-tri-t-butoxycarbonylethoxymethyl-methane	Others	Others
	Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane, a PEG-derived PROTAC linker, is employed for PROTAC synthesis[1].
T17581	Biotin-PEG4-amino-t-Bu-DADPS-C3-alykne	Others	Others
	Biotin-PEG4-amino-t-Bu-DADPS-C3-alykne functions as a PEG-based linker for PROTAC synthesis[1].
T17582	Biotin-PEG4-amino-t-Bu-DADPS-C6-azide	Others	Others
	Biotin-PEG4-amino-t-Bu-DADPS-C6-azide is a PEGylated PROTAC linker suitable for PROTAC synthesis[1].
T16053	Methylamino-PEG4-Boc Methylamino-PEG4-t-butyl ester	Others	Others
	Methylamino-PEG4-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17078	Thiol-PEG4-Boc Thiol-PEG4-t-butyl ester	Others	Others
	Thiol-PEG4-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18286	Mal-PEG4-Lys(t-Boc)-NH-m-PEG24	Others	Others
	Mal-PEG4-Lys(t-Boc)-NH-m-PEG24 is a polyethylene glycol (PEG)-based PROTAC linker, suitable for the synthesis of PROTACs[1].
T18413	N-Desthiobiotin-N-bis(PEG4-t-butyl ester)	Others	Others
	N-Desthiobiotin-N-bis(PEG4-t-butyl ester) is a PEG-based linker compound employed for the synthesis of PROTACs, which are bifunctional molecules designed for targeted protein degradation[1].
T16196	N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester)	Others	Others
	N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester) is a polyethylene glycol (PEG)-based linker employed in the synthesis of proteolysis-targeting chimeras (PROTACs).
T19572	T4-ATA (S-isomer)	Others	Others
	T4-ATA S-isomer, the active form of the thyroid hormone, represents the S-isomer of T4-ATA.
T26250	Boc-NH-PEG4-NHS ester t-Boc-N-amido-PEG4-NHS ester
	t-Boc-N-amido-PEG4-NHS ester is a PEG derivative containing an NHS ester and a Boc-protected amino group. The NHS ester can be utilized to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
TNU1322	3’-O-t-Bulyldimethylsilyl-4’-C-hydroxymethylthymidine
	Nucleoside Derivatives - 4’-Modified nucleosides
TNU0613	S-2-(4-aminobenzyl)-diethylenetriamine penta-t-butyl acetate
	Super-chelating agent& MRI contrast agent
TNU1323	3’,5’-Bis(O-t-butyldimethylsilyl)-4’-C-hydroxymethyl thymidine
	Nucleoside Derivatives - 4’-Modified nucleosides; Protected nucleosides w/NH2/OH open
T66307	(2S,3S)-N-t-Boc-3-amino-1,2-epoxy-4-phenylbutane
	(2S,3S)-N-t-Boc-3-amino-1,2-epoxy-4-phenylbutane 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66307，CAS号为 98737-29-2。
TNU1346	4’-alpha-C-Azido-2’,3’-bis(O-t-butyldimethylsilyl)uridine
	Nucleoside Derivatives - 4’-Modified nucleosides; Azido nucleosides; Protected nucleosides w/NH2/OH open
TNU0949	2’,3’,5’-Tri-O-(t-butyldimethylsilyl)-4’-C-hydroxymethyl uridine
	Nucleoside Derivative –4’-Modified nucleosides; Protected nucleosides with NH2/OH group
TNU1347	4’-alpha-C-Allyl-2’,3’-bis(O-t-butyldimethylsilyl)uridine
	Nucleoside Derivatives - 4’-Modified nucleosides; Protected nucleosides w/NH2/OH open
TNU1186	2’,3’-Bis(O-t-butyldimethylsilyl)-4’,5’-Didehydro-5’-deoxyuridine
	Nucleoside Derivatives - 5’-Modified nucleosides, Didehydro-nucleosides
TNU1575	1,4-Anhydro-2,3-O-isopropylidene-5-O-t-butyldiphenylsilyl-4-thio-D-ribitol
	Carbohydrate Derivatives
T66069	t-Butyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate
	t-Butyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66069，CAS号为 147489-06-3。
TNU1068	4-Chloro-7-[(5-O-t-butyldimethylsilyl)-2,3-O-isopropyli-dene-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine
	Nucleoside Derivatives - 7-Deaza-purine nucleoside; Halo-nucleoside; Scaffolds and Template
T27135	DDD85646 DDD 85646,DDD-85646	Parasite	Microbiology/Virology
	DDD85646 是 T. brucei N-myristoyltransferase 的抑制剂，Ki 为 1.44 nM，IC50 为 2 nM，EC50 为 2 nM。 hNMT 的 IC50 为 4 nM。
T34793	TC-T 6000 TCT6000,TC-T6000,TCT 6000
	TC-T 6000 is an effective inhibitor of balanced nucleoside transporter protein 4 (ENT4) (IC50 = 74.4 nM).
T13000	Src Inhibitor 3	Others; Src	Angiogenesis; Others; Tyrosine Kinase/Adaptors
	Src Inhibitor 3 是一种有效的 c-terminal Src 激酶抑制剂（CSK HTRF 中 IC50 <3 nM，Caliper 中 IC50 <4 nM）。 Src Inhibitor 3 增加由 T 细胞受体信号传导诱导的 T 细胞增殖。
T77466	Tremelimumab Ticilimumab,CP-675206	Others	Others
	Tremelimumab 是一种细胞毒性T淋巴细胞相关抗原-4（CTLA-4）阻断抗体.Tremelimumab 常与 Durvalumab 联合使用来治疗肝癌、肺癌等实体癌。
T78230	2,4′-Dichloroacetanilide 2-chloro-N-(4-chlorophenyl)acetamide	Others	Others
	2,4′-Dichloroacetanilide (2-chloro-N-(4-chlorophenyl)acetamide) 具有抗真菌活性，抑制 T. asteroides，其最小抑菌浓度为 6.25 μg/mL。
T76782	Mogamulizumab KW-0761	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	Mogamulizumab (KW-0761) 是一种针对 T 细胞 CC 趋化因子受体 4 的单克隆抗体。Mogamulizumab 具有抗癌活性，通过抗体依赖性细胞毒性 (ADCC) 消除肿瘤细胞，可用于研究癌症、成人T细胞白血病/淋巴瘤 (ATLL)、皮肤T细胞淋巴瘤(CTCL)。
T6006	Romidepsin FR 901228,FK 228,Depsipeptide,罗米地辛,NSC 630176	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Romidepsin (FR 901228) 是一种 HDAC 抑制剂，抑制 HDAC1/2/4/6 (IC50=36/47/510/1400 nM)。Romidepsin 具有抗肿瘤活性，可以用于治疗外周 T 细胞淋巴瘤和皮肤 T 细胞淋巴瘤。
T35569	CTA 056	Apoptosis	Apoptosis
	CTA 056 是白细胞介素-2 诱导的 T 细胞激酶（ITK）抑制剂，抑制小鼠 MOLT-4 异种移植肿瘤的生长，诱导 Jurkat 细胞凋亡，可用于研究自身免疫性疾病和T细胞恶性肿瘤。
T76705	Utomilumab PF 05082566,PF-2566	TNF	Apoptosis
	Utomilumab (PF 05082566) 是一种人源化靶向T 细胞共刺激受体4-1BB/CD137的 IgG2 抗体，也是一种 4-1BB/CD137 激动剂。Utomilumab 具有抗肿瘤活性，可用于研究晚期恶性肿瘤患者。
T76773	Rolinsatamab	IL Receptor	Immunology/Inflammation
	Rolinsatamab 是一种完全人源化的选择性单克隆抗体，是一种有效的 IL-4 和 IL-13 双重抑制剂。Rolinsatamab 嵌合抗原受体序列 T 细胞。Rolinsatamab 可用于预防和治疗免疫疾病。
TQ0174	Mavorixafor AMD-070	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	Mavorixafor (AMD-070) 是一种有效的特异性 CXCR4 拮抗剂，对 CXCR4 125I-SDF 结合的 IC50 值为 13 nM。 Mavorixafor 在 MT-4 细胞 (IC50 = 1 nM) 和 PBMC (IC50 = 9 nM) 中抑制 T-tropic HIV-1 (NL4.3 株) 的复制。
T7204	PNU-74654	Apoptosis; Wnt/beta-catenin	Apoptosis; Cytoskeletal Signaling; Stem Cells
	PNU 74654是一种Wnt/β-catenin 通路抑制剂，在NCI-H295 细胞中的IC50值为129.8 μM。

化合物

Cat.No: T16967

Target: PI4K

Cat.No: T8656

Synonym: 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T

Target: Apoptosis, Akt, COX

Cat.No: T35719

Synonym: T2AA,4-[4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy]phenol,ZINC95605533

Target: DNA/RNA Synthesis

B7/CD28 interaction inhibitor 1

Cat.No: T3189

Synonym: CTLA-4 inhibitor

Target: Others

Cat.No: T6690

Synonym: N-(2,2,2-三氟乙基)-N-[4-[2,2,2-三氟-1-羟基-1-(三氟甲基)乙基]苯基]苯磺酰胺

Target: Apoptosis, FXR, Liver X Receptor, ROR

L-Thyroxine sodium

Cat.No: T22355

Synonym: 左旋甲状腺素钠,LT4 sodium,Levothyroxine sodium,L-T4 sodium

Target: Thyroid hormone receptor(THR)

Cat.No: T6603

Synonym: GW 506U78,Nelzarabine,奈拉滨,506U78

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

FmocNH-PEG4-t-butyl ester

Cat.No: T39619

Synonym: FmocNH-PEG4-t-butyl ester

Cat.No: T34272

Synonym: RC121,IM 4-28,RC-121,P-Cttlvc-T

Cat.No: T69799

Ethyl 3-amino-1H-pyrazole-4-carboxylate

Cat.No: T3298

Synonym: 3-Amino-4-ethoxycarbonylpyrazole

Bis-PEG4-t-butyl ester

Cat.No: T39532

Synonym: Bis-PEG4-t-butyl ester

FmocNH-PEG4-t-butyl acetate

Cat.No: T41024

Synonym: FmocNH-PEG4-t-butyl acetate

t-Boc-Aminooxy-PEG4-NHS ester

Cat.No: T18741

Target: Others

Dyclonine hydrochloride

Cat.No: T1389

Synonym: 盐酸达克罗宁,Dyclocaine hydrochloride,Dyclonine HCl

Target: Sodium Channel, Antibacterial, Antifungal

Tos-PEG4-t-butyl ester

Cat.No: T17133

Synonym: Tos-PEG4-Boc

Target: Others

N-Methyl-N-(t-Boc)-PEG4-acid

Cat.No: T16238

Target: Others

Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane

Cat.No: T14441

Synonym: azido-peg4-amido-tri-t-butoxycarbonylethoxymethyl-methane

Target: Others

Biotin-PEG4-amino-t-Bu-DADPS-C3-alykne

Cat.No: T17581

Target: Others

Biotin-PEG4-amino-t-Bu-DADPS-C6-azide

Cat.No: T17582

Target: Others

Methylamino-PEG4-Boc

Cat.No: T16053

Synonym: Methylamino-PEG4-t-butyl ester

Target: Others

Cat.No: T17078

Synonym: Thiol-PEG4-t-butyl ester

Target: Others

Mal-PEG4-Lys(t-Boc)-NH-m-PEG24

Cat.No: T18286

Target: Others

N-Desthiobiotin-N-bis(PEG4-t-butyl ester)

Cat.No: T18413

Target: Others

N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester)

Cat.No: T16196

Target: Others

T4-ATA (S-isomer)

Cat.No: T19572

Target: Others

Boc-NH-PEG4-NHS ester

Cat.No: T26250

Synonym: t-Boc-N-amido-PEG4-NHS ester

3’-O-t-Bulyldimethylsilyl-4’-C-hydroxymethylthymidine

Cat.No: TNU1322

S-2-(4-aminobenzyl)-diethylenetriamine penta-t-butyl acetate

Cat.No: TNU0613

3’,5’-Bis(O-t-butyldimethylsilyl)-4’-C-hydroxymethyl thymidine

Cat.No: TNU1323

(2S,3S)-N-t-Boc-3-amino-1,2-epoxy-4-phenylbutane

Cat.No: T66307

4’-alpha-C-Azido-2’,3’-bis(O-t-butyldimethylsilyl)uridine

Cat.No: TNU1346

2’,3’,5’-Tri-O-(t-butyldimethylsilyl)-4’-C-hydroxymethyl uridine

Cat.No: TNU0949

4’-alpha-C-Allyl-2’,3’-bis(O-t-butyldimethylsilyl)uridine

Cat.No: TNU1347

2’,3’-Bis(O-t-butyldimethylsilyl)-4’,5’-Didehydro-5’-deoxyuridine

Cat.No: TNU1186

1,4-Anhydro-2,3-O-isopropylidene-5-O-t-butyldiphenylsilyl-4-thio-D-ribitol

Cat.No: TNU1575

t-Butyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate

Cat.No: T66069

4-Chloro-7-[(5-O-t-butyldimethylsilyl)-2,3-O-isopropyli-dene-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine

Cat.No: TNU1068

Cat.No: T27135

Synonym: DDD 85646,DDD-85646

Target: Parasite

Cat.No: T34793

Synonym: TCT6000,TC-T6000,TCT 6000

Src Inhibitor 3

Cat.No: T13000

Target: Others, Src

Cat.No: T77466

Synonym: Ticilimumab,CP-675206

Target: Others

2,4′-Dichloroacetanilide

Cat.No: T78230

Synonym: 2-chloro-N-(4-chlorophenyl)acetamide

Target: Others

Cat.No: T76782

Synonym: KW-0761

Target: CXCR

Cat.No: T6006

Synonym: FR 901228,FK 228,Depsipeptide,罗米地辛,NSC 630176

Target: Apoptosis, HDAC

Cat.No: T35569

Target: Apoptosis

Cat.No: T76705

Synonym: PF 05082566,PF-2566

Target: TNF

Cat.No: T76773

Target: IL Receptor

Cat.No: TQ0174

Synonym: AMD-070

Target: CXCR

Cat.No: T7204

Target: Apoptosis, Wnt/beta-catenin

Cat. No.	Product Name	Target	Signaling Pathways
T0864	L-Thyroxine Levothyroxine,NSC 36397,L-甲状腺素,T4	Thyroid hormone receptor(THR); Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	L-Thyroxine (NSC 36397) 是一种合成的甲状腺激素，用于甲状腺功能减退症的研究。在 DIO 酶作用下，L-Thyroxine (NSC 36397) 转化成具有生物特性的三碘甲状腺氨酸(T3)。
T1653	Liothyronine Tresitope,O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine,碘噻罗宁,Triiodothyronine,三碘甲状腺原氨酸,L-3,3',5-Triiodothyronine,3,3',5-Triiodo-L-thyronine,Lyothyronine	Thyroid hormone receptor(THR); Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Liothyronine (Tresitope) 是一种有效的甲状腺激素，能够激活 β1 甲状腺激素受体 (TRβ1)。
T20557	Thyroxine sulfate T4 Sulfate
	Thyroxine sulfate is a sulfoconjugated derivative of Thyroxine and is also a metabolite of Thyroxine.
T10024	1-Octanol Octanol,正辛醇	Calcium Channel; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism
	1-Octanol (Octanol) 是一种饱和脂肪醇，是一种 T 型钙通道抑制剂，对天然 T 电流的IC50为 4 μM。它是一种具有类似柴油特性的极具吸引力的生物燃料。
TN3209	3′,4′,7-Trihydroxyflavone	ATPase; Others; p38 MAPK; NF-κB	MAPK; Membrane transporter/Ion channel; NF-κB; Others
	3',4',7-Trihydroxyflavone 是分离自蚕豆荚的黄酮苷元化合物。
T2S1792	Lycobetaine 石蒜内胺,Ungeremine,石蒜醋胺,石蒜碱内铵盐	Antibacterial	Microbiology/Virology
	Lycobetaine (Ungeremine) 是一种潜在的抗罗克福尔青霉和黑曲霉的生物杀菌剂。它对柱状黄杆菌有很强的抗菌活性。它有效地靶向哺乳动物以及细菌I 型和II 型拓扑异构酶。它显示出强烈的乙酰胆碱酯酶抑制活性（IC(50) 值为 0.35 microM）。它具有抗原生动物活性，在体外试验中对Trypanosoma brucei rhodesiense、T. cruzi 表现出良好的活性。
T37280	PE(18:1(9Z)/0:0)	Endogenous Metabolite	Metabolism
	PE(18:1(9Z)/0:0) 是一种天然存在的溶血磷脂，是缩醛磷脂溶血磷脂酰乙醇胺的类似物。 PE(18:1(9Z)/0:0) 以浓度依赖性方式诱导 PC12 大鼠神经元细胞中细胞内钙的瞬时增加。 PE(18:1(9Z)/0:0) 增加 IL-4 和 IL-2 的产生，但不增加 IFN-γ 的产生。在小鼠血清中，PE(18:1(9Z)/0:0)（1 μg/动物）诱导 T 辅助细胞 2 反应。在寒冷暴露三天后，小鼠肩胛间棕色脂肪组织中的 PE(18:1(9Z)/0:0) 水平增加。
T2S0843	Negletein 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether	IL Receptor; TNF; NOS; Interleukin	Apoptosis; Immunology/Inflammation
	Negletein (7-O-Methylbaicalein) 一种神经保护剂，可增强神经生长因子的作用并诱导 PC12 细胞中的神经突生长。它通过抑制TNF-α和IL-1β表现出抗炎活性，其 IC50值分别为 16.4 和 10.8 μM。它还具有抗菌、抗缺氧和抗阿尔茨海默病活性。
T3794	Pentagalloylglucose Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖	Influenza Virus	Microbiology/Virology
	1,2,3,4,6-O-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) 存在于多种植物中，具有重要的药理作用。Pentagalloylglucose 表现出显著的抗狂犬病病毒 (RABV) 活性。
T2S2215	Crebanine	Apoptosis; Others; Akt	Apoptosis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling
	Crebanine 是来自于韦诺萨千金藤的一种生物碱，通过抑制 MAPKs 和 Akt 信号通路表现出抗炎活性，还具有抗心律失常的作用。它可诱导人类癌细胞的 G1阻滞和凋亡。
T36738	4′-Hydroxy-2′-methylacetophenone
	4′-Hydroxy-2′-methylacetophenone, an aroma compound of red wines, is isolated from cv. Bobal grape variety. 4′-Hydroxy-2′-methylacetophenone has ciliate toxicity. 4′-Hydroxy-2′-methylacetophenone inhibits the growth of T. pyriformis, with an IC50 of 0.65 mM[1][2]. [1]. GómezGarcía-Carpintero E, et, al. Aroma characterization of red wines from cv. Bobal grape variety grown in La Mancha region. Food Research International. 2011 Jan; 44(1): 61-70. [2]. Schüürmann G, et, al. Stepwise discrimination ...
TN4650	Nervogenic acid	Antifection	Microbiology/Virology
	Nervogenic acid has antioxidative, pro-coagulant, and antibacterial activities, it exhibits higher activity than that of t-butyl-4- hydroxyanisole (BHA) using the ferric thiocyanate method.
T83567	(25R)-Spirost-4-ene-3,6,12-trione
	(25R)-Spirost-4-ene-3,6,12-trione，一种可从T. terrestrisL中提取的天然产物。
T35908	Paraherquamide E
	Paraherquamide E is a fungal metabolite originally isolated from P. charlesii with anthelmintic and insecticidal activities. It is lethal to C. elegans (LD50 = 6 μg/ml). Paraherquamide E is also lethal to O. fasciatus (LD50 = 0.089 μg/nymph). Oral administration of paraherquamide E (0.5-4 mg/kg) reduces T. colubriformis fecal egg count in gerbils.
T36845	Isogarcinol
	Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 μM) and suppressing the proliferation of T cells. Oral administration of isogarcinol in mice decreases delayed type hypersensitivity, prolongs graft survival in allogeneic skin transplants, suppresses inflammation in collagen-induced arthritis, and reduces clinical symptoms in experimental auto...
T37272	9(S),12(S),13(S)-TriHOME
	9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME...
T36348	Cerebroside C
	Cerebroside C is a fungal metabolite and glycosphingolipid that has been found in the rice pathogenic fungusM. grisea.1It induces production of the phytoalexin momilactone A when applied to wounded rice leaves, indicating that cerebroside C is an elicitor of the hypersensitive response in rice. Cerebroside C increases germination rate and reduces germination time in wheat seeds in a concentration-dependent manner at 4°C.2It also increases root length, fresh weight, and dry weight of wheat seedli...
T37609	(rel)-Asperparaline A
	Aspergillimide is a fungal metabolite originally isolated from A. japonicus.1 It reduces nicotinic acetylcholine receptor (nAChR) peak and slowly-desensitizing amplitudes induced by acetylcholine in silkworm (B. mori) larval neurons (IC50s = 20.2 and 39.6 nM, respectively) but has no effect on chicken α3β4-, α4β2-, and α7-containing nAChRs.2 Dietary administration of aspergillimide A (10 μg/g of diet) induces paralysis in silkworm fourth instar larvae.1 Aspergillimide A (10 and 20 mg/kg) reduces...
T35577	Phosphatidylserines (bovine)
	Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on the inner leaflet of the cell membrane. It is biosynthesized from phosphatidylcholine or phosphatidylethanolamine by phosphatidyl synthase 1 (PSS1) or PSS2, respectively, in the endoplasmic reticulum and can be reversibly converted back by the same enzymes. It can also be irreversi...
T36438	Sporogen-AO 1
	Sporogen-AO 1 is a fungal metabolite originally isolated fromA. oryzaethat has diverse biological activities.1,2,3,4,5It inhibits HIV-1 Tat transactivation in a cell-based assay with an IC50value of 15.8 μM.4Sporogen-AO 1 is cytotoxic to HeLa, KB, and NCI H187 cancer cells (IC50s = 8.3, 9, and 5.1 μM, respectively).2,5It is active againstC. albicans(MIC = 4 mM).3 1.Tanaka, S., Wada, K., Marumo, S., et al.Structure of sporogen-ao 1, a sporogenic substance of Aspergillus oryzaeTetrahedron Lett.25(...
T36329	Terpendole I
	Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 μg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 μg/ml for all) or the fungus C. albicans (MIC = 200 μg/ml).1,2 It is cytotoxic to HeLa cells with an IC50 value of 52.6 μM.3 \|1. Tomoda, H., Tabata, N., Yang, D.-J., et al. Ter...
T37452	Stephacidin B
	Stephacidin B is a fungal metabolite that has been found inA. ochraceus.1Dimeric stephacidin B is rapidly converted to a monomer, avrainvillamide ,in vitro.2Stephacidin B is cytotoxic to a variety of cancer cells, including testosterone-independent PC3 and -sensitive LNCaP prostate cancer cells (IC50s = 0.37 and 0.06 μM, respectively) and estradiol-independent SK-BR-3 and -sensitive MCF-7 breast cancer cells (IC50s = 0.32 and 0.27 μM, respectively).1It induces apoptosis in HepG2 and Huh7 hepatoc...
T35415	α-D-Glucose-1,6-bisphosphate (potassium salt hydrate)
	α-D-Glucose-1,6-bisphosphate is abis-phosphorylated derivative of α-D-glucose that has roles in carbohydrate metabolism.1It is the product of the reaction of glucose-1- or 6-phosphate with glucose-1,6-bisphosphate synthase (PGM2LI) in the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate.2It is also a cofactor for the bacterial enzyme phosphopentomutase.3,4α-D-Glucose-1,6-bisphosphate has been used in the study of carbohydrate metabolism. 1.Beitner, R.Regulation of carbohydrate metabol...
T35752	Xanthoquinodin A1 Xanthoquinodin A1
	Xanthoquinodin A1 is a fungal metabolite that has been found inHumicolaand has diverse biological activities.1,2It inhibitsE. tenellaschizont formation in BHK-21 cells with a minimum effective concentration (MEC) value of 0.02 μg/ml.1Xanthoquinodin A1 is active againstB. subtilis,M. luteus,S. aureus,A. laidlawii, andB. fragilisin a disc assay when used at a concentration of 1 mg/ml. It is also active againstB. cereus(MIC = 0.44 μM).2Xanthoquinodin A1 is cytotoxic to KB, MCF-7, and NCI H187 cance...
T35779	Oosporein
	Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ...

天然产物

Cat.No: T0864

Synonym: Levothyroxine,NSC 36397,L-甲状腺素,T4

Target: Thyroid hormone receptor(THR), Endogenous Metabolite

Cat.No: T1653

Synonym: Tresitope,O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine,碘噻罗宁,Triiodothyronine,三碘甲状腺原氨酸,L-3,3',5-Triiodothyronine,3,3',5-Triiodo-L-thyronine,Lyothyronine

Target: Thyroid hormone receptor(THR), Endogenous Metabolite

Thyroxine sulfate

Cat.No: T20557

Synonym: T4 Sulfate

Cat.No: T10024

Synonym: Octanol,正辛醇

Target: Calcium Channel, Endogenous Metabolite

3′,4′,7-Trihydroxyflavone

Cat.No: TN3209

Target: ATPase, Others, p38 MAPK, NF-κB

Cat.No: T2S1792

Synonym: 石蒜内胺,Ungeremine,石蒜醋胺,石蒜碱内铵盐

Target: Antibacterial

PE(18:1(9Z)/0:0)

Cat.No: T37280

Target: Endogenous Metabolite

Cat.No: T2S0843

Synonym: 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether

Target: IL Receptor, TNF, NOS, Interleukin

Pentagalloylglucose

Cat.No: T3794

Synonym: Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖

Target: Influenza Virus

Cat.No: T2S2215

Target: Apoptosis, Others, Akt

4′-Hydroxy-2′-methylacetophenone

Cat.No: T36738

Nervogenic acid

Cat.No: TN4650

Target: Antifection

(25R)-Spirost-4-ene-3,6,12-trione

Cat.No: T83567

Paraherquamide E

Cat.No: T35908

Cat.No: T36845

9(S),12(S),13(S)-TriHOME

Cat.No: T37272

Cat.No: T36348

(rel)-Asperparaline A

Cat.No: T37609

Phosphatidylserines (bovine)

Cat.No: T35577

Cat.No: T36438

Cat.No: T36329

Cat.No: T37452

α-D-Glucose-1,6-bisphosphate (potassium salt hydrate)

Cat.No: T35415

Xanthoquinodin A1

Cat.No: T35752

Synonym: Xanthoquinodin A1

Cat.No: T35779

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼