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Search Results for " stat1 "

Targets Recommended: Apoptosis Nucleoside Antimetabolite/Analog DNA/RNA Synthesis STAT

17

抑制剂 & 化合物

6

天然产物

1

化合物库

26

重组蛋白

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Cat. No.	Product Name
L3700	JAK-STAT 化合物库		252 compounds
	252 个 JAK/STAT 靶点相关的小分子化合物的独特集合，用于高通量、高内涵筛选；

化合物库

JAK-STAT 化合物库

Cat.No: L3700

Compounds: 252

Cat. No.	Product Name	Target	Signaling Pathways
T1038	Fludarabine NSC 118218,Fludarabinum,氟达拉宾,氟达拉滨,F-ara-A	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; STAT	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; JAK/STAT signaling; Stem Cells
	Fludarabine (Fludarabinum) 是一种氟化嘌呤类似物，一种核酸合成抑制剂和 STAT1 激活抑制剂。Fludarabine 具有抗肿瘤活性，可以用于治疗白血病和淋巴瘤。
T2168	2-(1,8-naphthyridin-2-yl)phenol	STAT	JAK/STAT signaling; Stem Cells
	2-NP 是选择性的STAT1转录增强剂。它能够增强 IFN-γ 的功能，提高对人乳腺癌和纤维肉瘤细胞增殖的抑制能力。
T2505	S3I-201 S3I 201,S3I201	STAT	JAK/STAT signaling; Stem Cells
	S3I-201 (S3I-201) 是一种选择性Stat3抑制剂，IC50为 86 μM。
T1563	Nifuroxazide Diarlidan,硝呋齐特,Nifuroxazid,Dicoferin,硝呋酚酰肼	Antibacterial; Antibiotic; STAT	JAK/STAT signaling; Microbiology/Virology; Stem Cells
	Nifuroxazide (Diarlidan) 是STAT3抑制剂，具有抗转移和抗癌活性。
T35544	ML115	STAT	JAK/STAT signaling; Stem Cells
	ML115 是一种有效且选择性的转录 3 (STAT3) 激活剂，abn EC50 为 2.0 nM，对相关的 STAT1 和 NFκB 抗靶点无活性。
T72029	CDK8-IN-13	Apoptosis; CDK	Apoptosis; Cell Cycle/Checkpoint
	CDK8-IN-13是一种 CDK8抑制剂（IC50：51.9 nM），具有强效性、选择性和口服活性。CDK8-IN-13能诱导细胞凋亡，降低了 p-STAT1 S727和p-STAT5 S726的表达。CDK8-IN-13表现出抗肿瘤活性。
TQ0037	Abrocitinib PF-04965842	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Abrocitinib (PF-04965842) 是可口服、选择性的JAK1抑制剂，可用于自身免疫症的研究，对 JAK1 和 JAK2 的IC50值分别为 29 和 803 nM。它可抑制 TYK2 的活性，IC50为1.253 μM，也可抑制刺激后 STAT1、STAT3 和 STAT5 的磷酸化水平。
T26895	BRD0476 BRD-0476,ML 187,ML187,ML-187,BRD 0476
	BRD0476 is a suppressor of pancreatic β-cell apoptosis. BRD0476 inhibits interferon-gamma (IFN-γ)-induced Janus kinase 2 (JAK2) and signal transducer and activation of transcription 1 (STAT1) signaling to promote β-cell survival. BRD0476 inhibits JAK-STAT
T21501	5,15-DPP
	5,15-Diphenylporphyrin (5,15-DPP) 是一种选择性STAT3-SH2拮抗剂，其对于STAT3 和 STAT1 的IC50值分别为 0.28 μM 和 10 μM。
T73472	Erasin
	Erasin 是一种有效的 Erlotinib 抗性STAT3抑制剂，对STAT3和STAT1的IC50分别为 9.7 和 24 μM。Erasin 诱导癌细胞凋亡(apoptosis)。
T61779	STAT3-IN-9
	STAT3-IN-9, a potent inhibitor of STAT3 activation at Tyr705, exhibits no impact on the phosphorylation of STAT1 at Tyr 701. Additionally, this compound efficiently induces apoptosis and cell cycle arrest specifically at the G2/M phase [1].
T71156	Poloxipan
	Poloxipan is a potent and pan-specific PLK1 inhibitor. In vitro, Poloxipan has IC50 3.2 uM (Plk1); 1.7 uM (Plk2); and 3 uM (Plk3). Poloxipan showed minor inhibition over FHA dommain of Chk2, S2 domian of STAT1, STAT5b, Lck, etc.
T26936	C188 Cpd188,STAT3-IN-C188,Cpd-188,C 188,C-188
	C188 is a cell-permeable naphthol compound and a STAT3 inhibitor. C188 inhibits IL-6-stimulated STAT3 Tyr705 phosphorylation and nuclear translocation in HepG2 cells by targeting STAT3 SH2 domain peptide-binding pocket, while exhibiting little effect agai
T77038	Interferon alfa
	Interferon alfa 是 I 型干扰素，可激活新基因，对靶细胞产生有效抗病毒和抗增殖活性。Interferon alfa 的信号传导需要 Stat1和 Stat2 的受体依赖性激活，形成异源二聚化 STAT。STAT 复合物与 DNA 结合蛋白 IRF-9 (p48) 结合并形成 ISGF-3 (IFN 刺激基因因子 3)。随后由 ISGF-3 进一步激活驱动基因，实现抗病毒功能。
T74784	LL-K8-22
	LL-K8-22 是一款高效且具有选择性和持久性的 CDK8-cyclin C 双重降解剂，其DC50值分别为2.52 μM和2.64 μM。该化合物还能抑制STAT1Ser 727的磷酸化，并能抑制由E2F 和 MYC 驱动的致癌转录程序，适用于三阴性乳腺癌 (TNBC) 的研究。
T36645	CAY10763 CAY10763
	CAY10763 is a dual inhibitor of indolamine 2,3-dioxygenase 1 (IDO1; IC50= 46 nM) and STAT3 activation.1It binds to STAT3 (Kd= 530 nM) and selectively reduces the levels of STAT3 phosphorylated at the tyrosine in position 705 (STAT3Y705) over phosphorylated STAT3S727, STAT1, and STAT5 in SKOV3 cells when used at a concentration of 500 nM. It also inhibits STAT3 nuclear translocation in SKOV3 cells. CAY10763 is cytotoxic to HCT116, SKOV3, A549, and HepG2 cancer cells (IC50s = 37, 28, 33, and 12 nM...
T68182	3-Hydroxykynurenamine
	3-Hydroxykynurenamine, also known as 3-Hydroxy-L-kynurenamine or 3-HKA, is a biogenic amine produced via an alternative pathway of tryptophan metabolism. In vitro, 3-HKA has an anti-inflammatory profile by inhibiting the IFN-γ mediated STAT1/NF-κΒ pathway in both mouse and human dendritic cells (DCs) with a consequent decrease in the release of pro-inflammatory chemokines and cytokines, most notably TNF, IL-6, and IL12p70. 3-HKA has protective effects in an experimental mouse model of psoriasis ...

化合物

Cat.No: T1038

Synonym: NSC 118218,Fludarabinum,氟达拉宾,氟达拉滨,F-ara-A

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, STAT

2-(1,8-naphthyridin-2-yl)phenol

Cat.No: T2168

Target: STAT

Cat.No: T2505

Synonym: S3I 201,S3I201

Target: STAT

Cat.No: T1563

Synonym: Diarlidan,硝呋齐特,Nifuroxazid,Dicoferin,硝呋酚酰肼

Target: Antibacterial, Antibiotic, STAT

Cat.No: T35544

Target: STAT

Cat.No: T72029

Target: Apoptosis, CDK

Cat.No: TQ0037

Synonym: PF-04965842

Target: JAK

Cat.No: T26895

Synonym: BRD-0476,ML 187,ML187,ML-187,BRD 0476

Cat.No: T21501

Cat.No: T73472

Cat.No: T61779

Cat.No: T71156

Cat.No: T26936

Synonym: Cpd188,STAT3-IN-C188,Cpd-188,C 188,C-188

Interferon alfa

Cat.No: T77038

Cat.No: T74784

Cat.No: T36645

Synonym: CAY10763

3-Hydroxykynurenamine

Cat.No: T68182

Cat. No.	Product Name	Target	Signaling Pathways
T14854	Caerulomycin A 浅蓝霉素,Cerulomycin,Caerulomycin	Antifungal	Microbiology/Virology
	Caerulomycin A (Caerulomycin) 是抗真菌和抗细菌化合物，能够诱导 T 细胞的产生。它能够抑制 IFN-γ 诱导的 STAT1 通路，从而增强 TGF-β-Smad3 信号通路。它可用于自身免疫病的研究。
T2814	Cryptotanshinone 隐丹参酮,Cryptotanshinon,Tanshinone c,隐丹参醌	STAT; Autophagy	Autophagy; JAK/STAT signaling; Stem Cells
	Cryptotanshinone (Cryptotanshinon) 是从丹参的根中提取的一种天然产物，抑制STAT3的IC50为4.6 μM，具有抗肿瘤活性。
T5681	ETHYL CAFFEATE 咖啡酸乙酯,ETHYL 3,4-DIHYDROXYCINNAMATE	NF-κB; COX; PGE Synthase; NO Synthase	Immunology/Inflammation; Neuroscience; NF-κB
	Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) 是从鬼针草分离的一种酚类天然产物，在体外或在小鼠皮肤中抑制NF-κB 活化及其下游炎症介质的诱导型一氧化氮合酶、环氧合酶 2 和前列腺素 E2。
T3824	Jaceosidin	Apoptosis; BCL; COX; UGT	Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience
	Jaceosidin 是从毛莲蒿中得到的一种黄酮类天然产物，可激活Bax，下调 Mcl-1 和 c-FLIP 的表达，诱导癌细胞凋亡。它能够降低炎性因子水平，激活 NF-κB，抑制COX-2的表达，具有抗癌和抗炎作用。
T6677	Sophocarpine	ERK; p38 MAPK; NF-κB; TLR; COX; HER; JNK; STAT	Angiogenesis; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors
	Sophocarpine 是一种从传统草药苦参中提取的重要生物碱。苦参具有抗病毒、抗肿瘤和抗炎等多种药理作用。它通过多种机制显著抑制癌细胞的生长，具有抗肿瘤活性。
TN6366	Lupinalbin A 鲁冰花
	Lupinalbin A as the most potent estrogen receptor α- and aryl hydrocarbon receptor agonist in Eriosema laurentii de Wild. (Leguminosae). It exerts anti-inflammatory effects via the inhibition of pro-inflammatory cytokines and blocking of IFN-β/STAT1 pathw

天然产物

Cat.No: T14854

Synonym: 浅蓝霉素,Cerulomycin,Caerulomycin

Target: Antifungal

Cryptotanshinone

Cat.No: T2814

Synonym: 隐丹参酮,Cryptotanshinon,Tanshinone c,隐丹参醌

Target: STAT, Autophagy

Cat.No: T5681

Synonym: 咖啡酸乙酯,ETHYL 3,4-DIHYDROXYCINNAMATE

Target: NF-κB, COX, PGE Synthase, NO Synthase

Cat.No: T3824

Target: Apoptosis, BCL, COX, UGT

Cat.No: T6677

Target: ERK, p38 MAPK, NF-κB, TLR, COX, HER, JNK, STAT

Cat.No: TN6366

Synonym: 鲁冰花

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00961	STAT1 Protein, Human, Recombinant Transcription Factor ISGF-3 Components p91/p84,...	Human	E. coli
	Signal Transducer and Activator of Transcription 1-Alpha/Beta (STAT1) contains one SH2 domain and belongs to the transcription factor STAT family. When tyrosine- and serine-phosphorylated, STAT1 can form a homodimer termed IFN-gamma-activated factor (GAF), migrate into the nucleus and bind to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. STAT1 functions as signal transducer and transcription activator that mediates cellul...
TMPY-02240	STAT1 Protein, Human, Recombinant (His & GST) IMD31A,IMD31B,IMD31C,STAT	Human	Baculovirus Insect Cells
	STAT1 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT1 can be activated by various ligands, including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. It is a signal transducer and transcription activator that mediates cellular responses to interferons (IFNs),...
TMPJ-00166	SCF Protein, Mouse, Recombinant SCF,Hematopoietic growth factor KL,MGF,Steel factor,Mast cel...	Mouse	E. coli
	Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the ...
TMPH-01322	FANCC Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. FANCC Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 79.4 kDa and the accession number is Q00597.
TMPH-03111	Erythropoietin Protein, Pig, Recombinant (B2M & His)	Sus scrofa (Pig)	E. coli
	Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Erythropoietin Protein, Pig, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 32.6 kDa and the accession number is P49157.
TMPH-03110	Erythropoietin Protein, Pig, Recombinant (His)	Sus scrofa (Pig)	P. pastoris (Yeast)
	Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Erythropoietin Protein, Pig, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 20.6 kDa and the accession number is P49157.
TMPH-02732	IFNAR2 Protein, Mouse, Recombinant (His)	Mouse	P. pastoris (Yeast)
	Associates with IFNAR1 to form the plasma membrane receptor in the type I interferon signaling pathway. Directly involved in signal transduction through its association with the TYR kinase JAK1. Involved in interferon-mediated STAT1, STAT2 and STAT3 activation.; May be potent inhibitors of type I IFN receptor activity.; May be potent inhibitors of type I IFN receptor activity. IFNAR2 Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 26.8 ...
TMPH-02426	Erythropoietin Protein, Cynomolgus, Recombinant (His & Myc)	Cynomolgus	HEK293 Cells
	Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Erythropoietin Protein, Cynomolgus, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-6xHis-Myc tag. The predicted molecular weight is 22.2 kDa and the accession number is P07865...
TMPH-02427	Erythropoietin Protein, Cynomolgus, Recombinant (His & SUMO)	Cynomolgus	E. coli
	Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Erythropoietin Protein, Cynomolgus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 34.2 kDa and the accession number is P...
TMPH-03287	EPOR Protein, Rat, Recombinant (His & SUMO)	Rat	E. coli
	Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate LYN tyrosine kinase. EPOR Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO and C-6xHis tag. The predicted molecular weight is 39.1 kDa and the accession number is Q07303.
TMPH-00828	Erythropoietin Protein, Horse, Recombinant (His & SUMO)	Horse	E. coli
	Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Erythropoietin Protein, Horse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 34.3 kDa and the accession number is Q867B1...
TMPH-00827	Erythropoietin Protein, Horse, Recombinant (hFc)	Horse	HEK293 Cells
	Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Erythropoietin Protein, Horse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFC tag. The predicted molecular weight is 47.3 kDa and the accession number is Q867B1.
TMPH-01560	IL-26 Protein, Human, Recombinant (His & Trx)	Human	E. coli
	May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. IL-26 Protein, Human, Recombinant (His & Trx) is expressed in E. coli expression system with N-6xHis-T...
TMPH-01559	IL-26 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. IL-26 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecula...
TMPK-00025	IL-9 Protein, Human, Recombinant (hFc) HP40,Cytokine P40,白细胞介素,Interleukin-9,白介素,P40,T-cell growth ...	Human	HEK293 Cells
	IL-9 is a pleiotropic cytokine that influences various distinct functions of different target cells such as T cells, B cells, mast cells and airway epithelial cells by activating STAT1, STAT3 and STAT5. Because of its pleiotropic functions, IL-9 has been demonstrated to be involved in several diseases, such as cancer, autoimmunity and other pathogen-mediated immune-regulated diseases. In this review, we focus on the role of Th9 and IL-9-producing cells in allergic asthma. IL-9 Protein, Human, Re...
TMPK-00026	IL-9 Protein, Mouse, Recombinant (hFc) P40,IL-9,Interleukin-9,Cytokine P40,T-cell growth factor P40...	Mouse	HEK293 Cells
	IL-9 is a pleiotropic cytokine that influences various distinct functions of different target cells such as T cells, B cells, mast cells and airway epithelial cells by activating STAT1, STAT3 and STAT5. Because of its pleiotropic functions, IL-9 has been demonstrated to be involved in several diseases, such as cancer, autoimmunity and other pathogen-mediated immune-regulated diseases. In this review, we focus on the role of Th9 and IL-9-producing cells in allergic asthma. IL-9 Protein, Mouse, Re...
TMPK-00568	IL-9 Protein, Cynomolgus, Recombinant (His) P40,HP40,IL-9,T-cell growth factor P40,Interleukin-9,Cytokin...	Cynomolgus	HEK293 Cells
	IL-9 is a pleiotropic cytokine that influences various distinct functions of different target cells such as T cells, B cells, mast cells and airway epithelial cells by activating STAT1, STAT3 and STAT5. Because of its pleiotropic functions, IL-9 has been demonstrated to be involved in several diseases, such as cancer, autoimmunity and other pathogen-mediated immune-regulated diseases. In this review, we focus on the role of Th9 and IL-9-producing cells in allergic asthma. IL-9 Protein, Cynomolgu...
TMPH-02740	IL-31R alpha Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro. IL-31R alpha Protein, Mouse, Recombinant (His) is expressed in E. coli expression...
TMPJ-00894	SCF Protein, Rat, Recombinant (His) Hematopoietic growth factor KL,Steel factor,Stem cell factor...	Rat	E. coli
	Stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase...
TMPJ-00331	IFNAR1 Protein, Rhesus macaque, Recombinant (His) IFN-al,CRF2-1,IFN-alpha/beta receptor 1,hu...	Rhesus	HEK293 Cells
	Interferon‑alpha/beta receptor 1 (IFN‑ alpha / beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphory...
TMPJ-00432	GITR Ligand/TNFSF18 Protein, Cynomolgus, Recombinant (His) GITRL,TNFSF18,Activation-inducible TNF-related liga...	Cynomolgus	HEK293 Cells
	TNFSF18 is a single-pass type II membrane protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 cytokine binds to TNFRSF18/AITR/GITR. It regulates T-cell responses, and functions as costimulator and lower the threshold for T-cell activation and T-cell proliferation. It is Important for interactions between activated T-lymphocytes and endothelial cells and Promotes leukocyte adhesion to endothelial cells. TNFSF18 mediates activation ...
TMPU-00003	STAT2 Protein, Human, Recombinant (His)	Human	E. coli
	Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of...
TMPH-00775	IFN gamma Protein, Goat, Recombinant (His & Myc)	Goat	E. coli
	Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activati...
TMPJ-01143	MERTK/Mer Protein, Human, Recombinant (aa 1-323, His) MER,Receptor tyrosine kinase MerTK,Tyrosine-protein kinase M...	Human	HEK293 Cells
	Tyrosine-protein kinase Mer (MERTK) is a single-pass type I membrane protein which belongs to the MER/AXL/TYRO3 receptor kinase family. MERTK include two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain. It can’t be expressed in normal B- and T-lymphocytes, but it is usually expressed in numerous neoplastic B- and T-cell lines. MERTK could regulate many physiological processes, such as cell survival, migration, differentiation. It was demonstrated that t...
TMPJ-00047	IL-31 Protein, Human, Recombinant IL-31,Interleukin-31,白介素,白细胞介素,IL31	Human	E. coli
	Human Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes a 164 amino acid precursor that contains a 23 amino acid signal peptide and a 141 amino acid mature protein. Human and mouse IL-31 share 24% sequence identity in the mature region. IL-31 is mainly associated with activated T cells and is preferentially expressed by type 2 helper...
TMPY-02122	IFNGR2 Protein, Mouse, Recombinant (His) interferon γ receptor 2 (interferon γ transducer 1)...	Mouse	HEK293 Cells
	Interferon-gamma receptor beta chain (IFNgammaR2), also known as IFNGR2, belongs to the type II cytokine receptor family, whose deficiency is a cause of autosomal recessive mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2. IFNGR2 is a component of the IFNgamma receptor complex al...

重组蛋白

STAT1 Protein, Human, Recombinant

Cat.No: TMPJ-00961

Species: Human

Expression System: E. coli

STAT1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02240

Species: Human

Expression System: Baculovirus Insect Cells

SCF Protein, Mouse, Recombinant

Cat.No: TMPJ-00166

Species: Mouse

Expression System: E. coli

FANCC Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01322

Species: Human

Expression System: E. coli

Erythropoietin Protein, Pig, Recombinant (B2M & His)

Cat.No: TMPH-03111

Species: Sus scrofa (Pig)

Expression System: E. coli

Erythropoietin Protein, Pig, Recombinant (His)

Cat.No: TMPH-03110

Species: Sus scrofa (Pig)

Expression System: P. pastoris (Yeast)

IFNAR2 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02732

Species: Mouse

Expression System: P. pastoris (Yeast)

Erythropoietin Protein, Cynomolgus, Recombinant (His & Myc)

Cat.No: TMPH-02426

Species: Cynomolgus

Expression System: HEK293 Cells

Erythropoietin Protein, Cynomolgus, Recombinant (His & SUMO)

Cat.No: TMPH-02427

Species: Cynomolgus

Expression System: E. coli

EPOR Protein, Rat, Recombinant (His & SUMO)

Cat.No: TMPH-03287

Species: Rat

Expression System: E. coli

Erythropoietin Protein, Horse, Recombinant (His & SUMO)

Cat.No: TMPH-00828

Species: Horse

Expression System: E. coli

Erythropoietin Protein, Horse, Recombinant (hFc)

Cat.No: TMPH-00827

Species: Horse

Expression System: HEK293 Cells

IL-26 Protein, Human, Recombinant (His & Trx)

Cat.No: TMPH-01560

Species: Human

Expression System: E. coli

IL-26 Protein, Human, Recombinant (His)

Cat.No: TMPH-01559

Species: Human

Expression System: P. pastoris (Yeast)

IL-9 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00025

Species: Human

Expression System: HEK293 Cells

IL-9 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00026

Species: Mouse

Expression System: HEK293 Cells

IL-9 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00568

Species: Cynomolgus

Expression System: HEK293 Cells

IL-31R alpha Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02740

Species: Mouse

Expression System: E. coli

SCF Protein, Rat, Recombinant (His)

Cat.No: TMPJ-00894

Species: Rat

Expression System: E. coli

IFNAR1 Protein, Rhesus macaque, Recombinant (His)

Cat.No: TMPJ-00331

Species: Rhesus

Expression System: HEK293 Cells

GITR Ligand/TNFSF18 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPJ-00432

Species: Cynomolgus

Expression System: HEK293 Cells

STAT2 Protein, Human, Recombinant (His)

Cat.No: TMPU-00003

Species: Human

Expression System: E. coli

IFN gamma Protein, Goat, Recombinant (His & Myc)

Cat.No: TMPH-00775

Species: Goat

Expression System: E. coli

MERTK/Mer Protein, Human, Recombinant (aa 1-323, His)

Cat.No: TMPJ-01143

Species: Human

Expression System: HEK293 Cells

IL-31 Protein, Human, Recombinant

Cat.No: TMPJ-00047

Species: Human

Expression System: E. coli

IFNGR2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02122

Species: Mouse

Expression System: HEK293 Cells

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