首页工具

登录

搜索结果

Search Results for " pyruvate kinase "

40

抑制剂 & 化合物

8

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T76115	Pyruvate kinase
	Pyruvate kinase 是一种糖酵解酶，催化磷酸烯醇式丙酮酸和 ADP 转化为丙酮酸和 ATP。
T12499	PKR-IN-2	PKM	Metabolism
	PKR-IN-2 是丙酮酸激酶PKR 亚型的激活剂，可用于 PKR 功能相关疾病的研究，包括癌症、糖尿病、肥胖、自身免疫性疾病、良性前列腺增生等。
T6816	DASA-58	PKM	Metabolism
	DASA58 是一种有效的丙酮酸激酶M2 (PKM2) 活化剂，其中AC90=680 nM，AC50=38 nM。
T4223	Mitapivat PKR-IN-1	PKM	Metabolism
	Mitapivat (PKR-IN-1) 是口服具有活性的变构丙酮酸激酶 (pyruvate kinase) 激活剂，其AC50=20 nM。它在广泛的 PKLR 基因型中增加酶活性、蛋白质稳定性和 ATP 水平。它有潜在的恢复 PK 缺乏的糖酵解途径活性的作用。
T11765	KPLH1130	Dehydrogenase; PDK	Metabolism; PI3K/Akt/mTOR signaling
	KPLH1130，一种选择性丙酮酸脱氢酶激酶(PDK)抑制剂，在高脂饮食(HFD)喂养的小鼠中提高了糖耐量。KPLH1130 抑制巨噬细胞极化并减轻了炎症反应。
T2447	AZD7545	Dehydrogenase	Metabolism
	AZD7545 是竞争性和选择性的PDHK2抑制剂，能够抑制PDHK1和PDHK2的活性，其IC50值分别为 36.8 nM 和 6.4 nM。
T17224	VER-246608	Dehydrogenase; PDK	Metabolism; PI3K/Akt/mTOR signaling
	VER-246608 是ATP 竞争性的丙酮酸脱氢酶激酶抑制剂，对PDK-1，PDK-3，PDK-2，和PDK-4的IC50分别为 35 nM，40 nM，84 nM 和 91 nM。
T22350	JX06	Apoptosis; Dehydrogenase; PDK	Apoptosis; Metabolism; PI3K/Akt/mTOR signaling
	JX06 是一种选择性共价PDK 抑制剂，抑制PDK1,PDK2和PDK3，IC50值分别为 49 nM，101 nM 和 313 nM。它以不可逆的方式与半胱氨酸残基共价结合来抑制PDK1活性，具有抗肿瘤活性。
T7214	TEPP-46 ML265	PKM	Metabolism
	TEPP-46 (ML265) 是选择性的丙酮酸激酶 M2 (pyruvate kinase M2; PKM2) 激活剂，AC50=92 nM，对 PKM1，PKL 和 PKR 作用较小或没有作用。
T4170	PKM2-IN-1 PKM2 inhibitor,compound 3k	PKM	Metabolism
	PKM2-IN-1 (compound 3k) 是丙酮酸激酶 M2 (PKM2) 抑制剂，其IC50=2.95 μM。
T12412L	PDK4-IN-1 hydrochloride	Apoptosis; PDK	Apoptosis; PI3K/Akt/mTOR signaling
	PDK4-IN-1 hydrochloride 是一种蒽醌衍生物，对丙酮酸脱氢酶激酶 4有抑制作用，IC50为 84 nM，具有口服活性。它抑制细胞转化和细胞增殖并诱导细胞凋亡。它具有抗过敏，抗糖尿病和抗癌作用。
T19783	Dehydroabiethylamine NSC-2955,NSC 2955,Dehydroabietylamine,NSC2955,Leelamine free base,Leelamine,脱氢松香胺	P450; PDK	Metabolism; PI3K/Akt/mTOR signaling
	Dehydroabiethylamine (NSC-2955) 是肝脏 CYP2B 活性的诱导剂。 Dehydroabiethylamine 抑制丙酮酸脱氢酶激酶 (PDK) 和细胞内胆固醇转运，具有抗肿瘤活性。
T0745	Disodium monofluorophosphate Sodium Monofluorophosphate,单氟磷酸钠,NSC248	Phosphatase; PKM; Phosphorylase	Metabolism
	Disodium monofluorophosphate (NSC248) 是丙酮酸激酶和碱性磷酸酶的竞争性抑制剂，它也不可逆地抑制磷酸化酶磷酸酶。
T67900	PKM2 inhibitor G	PKM	Metabolism
	PKM2 inhibitor G是丙酮酸激酶抑制剂。
T60102L	Dimethylaminomicheliolide HCl	PKM	Metabolism
	Dimethylaminomicheliolide HCl 具有潜在的抗炎和抗肿瘤活性，通过靶向丙酮酸激酶 2 （PKM2）和重新连接有氧细胞群来抑制胶质母细胞瘤细胞的增殖。
T15944	M77976	PDK	PI3K/Akt/mTOR signaling
	M77976 是一种选择性 ATP 竞争丙酮酸脱氢酶激酶 PDK4 抑制剂，对 PDK4 有抑制作用，IC50 值为 648 μM。M77976 有用于研究肥胖症和糖尿病。
T62758	PKM2 activator 2	PKM	Metabolism
	PKM2 activator 2是一种丙酮酸激酶 M2（PKM2）激活剂，AC 50 值为 66 nM。PKM2 activator 2具有抗肿瘤增殖和缓解沃伯格效应的作用，通过激活 PKM2 使细胞的糖酵解代谢恢复正常。
T15362	FX-11 LDHA Inhibitor FX11	Dehydrogenase	Metabolism
	FX-11 (LDHA Inhibitor FX11) 是一种有效的、选择性的和竞争性的乳酸脱氢酶 A (LDHA) 的特异性抑制剂，对LDHA 的Ki 为 8 μM。FX-11 对PKM2 (丙酮酸激酶 M2)具有激活作用。FX-11 可降低 ATP 水平，诱导氧化应激和ROS 生成，可引起细胞死亡。FX-11 在淋巴瘤和胰腺癌异种移植过程中表现出抗肿瘤活性。
T69865	Mitapivat sulfate
	Mitapivat sulfate, also known as AG-348 sulfate hydrate, is an allosteric activator of Pyruvate Kinase (PK) that may be useful in the treatment of Pyruvate Kinase Deficiency.
T69677	Mitapivat sulfate anhydrous
	Mitapivat sulfate anhydrous is an allosteric activator of Pyruvate Kinase (PK) that may be useful in the treatment of Pyruvate Kinase Deficiency.
T70665	PF-06284674
	PF-06284674 is a cell permeable, potent and selective M2 isoform of pyruvate kinase (PKM2) activator.
T70418	TLN-232
	TLN-232, also known as CAP-232, is a synthetic cyclic heptapeptide with potential antineoplastic activity. Pyruvate kinase (PK) inhibitor TLN-232 targets pyruvate kinase M2 (M2PK), which may disrupt tumor cell anaerobic glycolysis. M2PK is a dimeric isoform of PK and the predominant PK isoform found in tumor cells.
T12498	PKR activator 2	Others	Others
	PKR activator 2 is a potent activator of pyruvate kinase-R (PKR).
T12497	PKR activator 1	Others	Others
	PKR activator 1 is a potent activator of pyruvate kinase-R (PKR).
T71867	PKM2 inhibitor 2825-0090
	PKM2 inhibitor 2825-0090 is a Novel pyruvate kinase M2 (PKM2) inhibitor, reducing tumor growth of NSCLC xenografts in vivo.
T75132	PKR activator 4
	PKR activator 4 (example 7A) 是一种高效的丙酮酸激酶 R (pyruvate kinase R (PKR)) 激活剂，展现出研究血液疾病的潜力。
T74024	2,5-Anhydro-D-glucitol-1,6-diphosphate
	2,5-Anhydro-D-glucitol-1,6-diphosphate 为酵母丙酮酸激酶(Pyruvate Kinase)的有限刺激剂，并可作为 a 型2,5-anhydro-D-mannitol 1,6-bisphosphate的同系物。后者为丙酮酸激酶的有效变构激活剂。
T12412	PDK4-IN-1	Others	Others
	PDK4-IN-1 is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4)(IC50 value of 84 nM).
T68986	ZINC08383544
	ZINC08383544 is a specific pyruvate kinase M2 activator which promotes the formation of PKM2 tetramer. ZINC08383544 effectively blocks PKM2 nuclear translocation, and inhibits the growth of tumor.
T39753	Etavopivat FT-4202
	Etavopivat is a powerful, specific, orally bioavailable activator of pyruvate kinase (PKR) in red blood cells (RBCs). It exhibits potent properties against sickling.
T60527	PDHK-IN-3
	PDHK-IN-3 (compound 7) 是有效的丙酮酸脱氢酶激酶(PDHK)抑制剂，对PDHK2的IC50值为0.21μM，对PDHK4的IC50值为1.54 μM。
T63012	TM-1
	TM-1 是一种强效的丙酮酸脱氢酶激酶 (PDHK) 抑制剂，能够抑制 PDHK1 (IC50: 2.97 μM) 和 PDHK2 (IC50: 5.2 μM)的活性。TM-1 可以阻断丙酮酸脱氢酶复合物 (PDHC) 磷酸化，并抑制癌细胞增殖。
T74128	NCGC00188636
	NCGC00188636为一新型共价PYK抑制剂，可通过阻断核苷酸与PYK活性位点的结合，应用于不同生物及细胞类型的代谢研究中。
T72663	(Rac)-Etavopivat (Rac)-FT-4202
	(Rac)-Etavopivat((Rac)-FT-4202) 是Etavopivat 异构体。Etavopivat 是一种具有口服活性的的红细胞丙酮酸激酶-R (PKR) 激活剂，可以用于镰状细胞病和其他血红蛋白疾病研究。
T73525	ML202
	ML202作为一种变构激活剂，针对人丙酮酸激酶M2 (hPK-M2)展现出高度特异性，能够影响磷酸烯醇丙酮酸(PEP)结合的协同性，而对二磷酸腺苷(ADP)的结合几乎无影响。
T74830	PDK-IN-1
	PDK-IN-1（compound 7o）是一种针对丙酮酸脱氢酶激酶（PDK）的抑制剂，其对PDK1和HSP90的IC50值分别为0.03和0.1μM。通过靶向PDH/PDK轴，PDK-IN-1能有效降低肿瘤质量。
T81788	Mito-SilylDCA
	Mito-SilylDCA 是一种针对线粒体网络中的 PDK1 的丙酮酸氢酶激酶抑制剂。这种化合物结合了具有靶向 TPP 部分的 DCA 分子，以及聚乙烯长链与硅基，以实现其对 PDK1 的抑制作用。
T79637	CIAC001
	CIAC001是一种丙酮酸激酶PKM2的抑制剂，它展现出了抗神经炎症活性。这种化合物能够抑制LPS诱导的一氧化氮(NO)产生(IC50=2.5 μM)，并保护BV-2免疫活性细胞。在小鼠模型中，CIAC001减轻了慢性吗啡引起的成瘾和神经炎症症状。
T37355	CAY10703
	Dichloroacetate (DCA) is an inhibitor of all pyruvate dehydrogenase kinase (PDHK) isoforms, which are enzymes that phosphorylate and inhibit PDH in mitochondria. Inhibition of PDHK shifts cell metabolism from glycolysis to mitochondrial glucose oxidation, an effect that has relevance to cancer, type 2 diabetes, and other diseases. CAY10703 is a DCA trimer that is at least 10-fold more cytotoxic against leukemia cell lines than DCA. It is approximately 3-fold less cytotoxic than DCA against perip...
T38357	1,3,6,8-Pyrenetetrasulfonic Acid (sodium salt hydrate)
	1,3,6,8-Pyrenetetrasulfonic acid is an intermediate in the synthesis of the color additive pyranine.1It has been used to stabilize intermolecular interactions for the crystallization ofL. mexicanapyruvate kinase.2 1.Jitian, S., White, S.R., Yang, H.-H.W., et al.Conventional high-performance liquid chromatography versus derivative spectrophotometry for the determination of 1,3,6-pyrenetrisulfonic acid trisodium salt and 1,3,6,8-pyrenetetrasulfonic acid tetrasodium salt in the color additive D&C G...

化合物

Pyruvate kinase

Cat.No: T76115

Cat.No: T12499

Target: PKM

Cat.No: T6816

Target: PKM

Cat.No: T4223

Synonym: PKR-IN-1

Target: PKM

Cat.No: T11765

Target: Dehydrogenase, PDK

Cat.No: T2447

Target: Dehydrogenase

Cat.No: T17224

Target: Dehydrogenase, PDK

Cat.No: T22350

Target: Apoptosis, Dehydrogenase, PDK

Cat.No: T7214

Synonym: ML265

Target: PKM

Cat.No: T4170

Synonym: PKM2 inhibitor,compound 3k

Target: PKM

PDK4-IN-1 hydrochloride

Cat.No: T12412L

Target: Apoptosis, PDK

Dehydroabiethylamine

Cat.No: T19783

Synonym: NSC-2955,NSC 2955,Dehydroabietylamine,NSC2955,Leelamine free base,Leelamine,脱氢松香胺

Target: P450, PDK

Disodium monofluorophosphate

Cat.No: T0745

Synonym: Sodium Monofluorophosphate,单氟磷酸钠,NSC248

Target: Phosphatase, PKM, Phosphorylase

PKM2 inhibitor G

Cat.No: T67900

Target: PKM

Dimethylaminomicheliolide HCl

Cat.No: T60102L

Target: PKM

Cat.No: T15944

Target: PDK

PKM2 activator 2

Cat.No: T62758

Target: PKM

Cat.No: T15362

Synonym: LDHA Inhibitor FX11

Target: Dehydrogenase

Mitapivat sulfate

Cat.No: T69865

Mitapivat sulfate anhydrous

Cat.No: T69677

Cat.No: T70665

Cat.No: T70418

PKR activator 2

Cat.No: T12498

Target: Others

PKR activator 1

Cat.No: T12497

Target: Others

PKM2 inhibitor 2825-0090

Cat.No: T71867

PKR activator 4

Cat.No: T75132

2,5-Anhydro-D-glucitol-1,6-diphosphate

Cat.No: T74024

Cat.No: T12412

Target: Others

Cat.No: T68986

Cat.No: T39753

Synonym: FT-4202

Cat.No: T60527

Cat.No: T63012

Cat.No: T74128

(Rac)-Etavopivat

Cat.No: T72663

Synonym: (Rac)-FT-4202

Cat.No: T73525

Cat.No: T74830

Cat.No: T81788

Cat.No: T79637

Cat.No: T37355

1,3,6,8-Pyrenetetrasulfonic Acid (sodium salt hydrate)

Cat.No: T38357

Cat. No.	Product Name	Target	Signaling Pathways
T0809	Dicoumarol Dicumarol,双羟香豆素,双香豆素	Dehydrogenase; NADPH; PDK	Metabolism; PI3K/Akt/mTOR signaling
	Dicoumarol (Dicumarol) 是一种 NAD(P)H: 醌氧化还原酶 1 和PDK1的抑制剂，它们的IC50值分别为 0.37 和 19.42 μM。
T3604	Sodium dichloroacetate Sodium Dichloroacetate,DCA,BCA,bichloroacetic acid,二氯乙酸钠,Sodium dichloroacetate (DCA),二氯醋酸酯	Apoptosis; Dehydrogenase; Reactive Oxygen Species; PDK	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; PI3K/Akt/mTOR signaling
	Sodium dichloroacetate (BCA) 是癌细胞线粒体中的一种代谢调节剂，具有抗癌活性。它抑制丙酮酸脱氢酶激酶，从而导致肿瘤微环境中的乳酸减少。它增加活性氧的产生并促进癌细胞凋亡，还可作为NKCC 抑制剂。
T1125	Shikonin NSC 252844,Isoarnebin 4,(+)-Shikonin,紫草素,Alkanna Red,C.I. 75535,Anchusa acid	TNF; NF-κB; Chloride channel; HIV Protease; PKM	Apoptosis; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	Shikonin (Anchusa acid) 属于天然产物，是一种 TMEM16A 氯离子通道抑制剂 (IC50=6.5 μM) 和选择性 PKM2 抑制剂。Shikonin 具有抗肿瘤、抗炎和伤口愈合活性。
T5213	Acetyl phosphate(lithium potassium) 乙酰磷酸锂钾盐,Lithium potassium acetyl phosphate,Acetylphosphoric acid	Others; Endogenous Metabolite	Metabolism; Others
	Acetyl phosphate lithium potassium (Lithium potassium acetyl phosphate) 是内源性代谢产物的一种。
T4898	Potassium 1-carboxyvinyl hydrogenphosphate PEP-K,磷酸烯醇丙酮酸单钾盐,Phospho(enol)pyruvic acid monopotassium	Others; Endogenous Metabolite	Metabolism; Others
	Potassium 1-carboxyvinyl hydrogenphosphate (PEP-K) 是内源性代谢产物的一种。
T8363	DL-Serine	PKM	Metabolism
	DL-Serine 是 D-丝氨酸和 L-丝氨酸的混合物，是一种基础代谢物。它具有抗病毒作用，能抑制烟草花叶病毒的增殖。
T60581	Alkannin
	Alkannin 是一种有效且特异性的肿瘤型丙酮酸激酶-M2 (PKM2) 抑制剂，不抑制 PKM1 和丙酮酸激酶-L (PKL)。Alkannin 是一种潜在的抗癌剂。
T16837	SAICAR	Others	Others
	SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner (EC50: 0.3 mM).

天然产物

Cat.No: T0809

Synonym: Dicumarol,双羟香豆素,双香豆素

Target: Dehydrogenase, NADPH, PDK

Sodium dichloroacetate

Cat.No: T3604

Synonym: Sodium Dichloroacetate,DCA,BCA,bichloroacetic acid,二氯乙酸钠,Sodium dichloroacetate (DCA),二氯醋酸酯

Target: Apoptosis, Dehydrogenase, Reactive Oxygen Species, PDK

Cat.No: T1125

Synonym: NSC 252844,Isoarnebin 4,(+)-Shikonin,紫草素,Alkanna Red,C.I. 75535,Anchusa acid

Target: TNF, NF-κB, Chloride channel, HIV Protease, PKM

Acetyl phosphate(lithium potassium)

Cat.No: T5213

Synonym: 乙酰磷酸锂钾盐,Lithium potassium acetyl phosphate,Acetylphosphoric acid

Target: Others, Endogenous Metabolite

Potassium 1-carboxyvinyl hydrogenphosphate

Cat.No: T4898

Synonym: PEP-K,磷酸烯醇丙酮酸单钾盐,Phospho(enol)pyruvic acid monopotassium

Target: Others, Endogenous Metabolite

Cat.No: T8363

Target: PKM

Cat.No: T60581

Cat.No: T16837

Target: Others

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼