Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PKM2-IN-1 (compound 3k) 是丙酮酸激酶 M2 (PKM2) 抑制剂,其IC50=2.95 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 263 | 现货 | ||
2 mg | ¥ 382 | 现货 | ||
5 mg | ¥ 659 | 现货 | ||
10 mg | ¥ 987 | 现货 | ||
25 mg | ¥ 1,920 | 现货 | ||
50 mg | ¥ 2,930 | 现货 | ||
100 mg | ¥ 4,260 | 现货 | ||
200 mg | ¥ 5,920 | 现货 | ||
500 mg | ¥ 8,960 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 689 | 现货 |
产品描述 | PKM2-IN-1 (compound 3k) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2. |
靶点活性 | PKM2:2.95 μM |
体外活性 | Results show that most of the tested compounds exhibit some degree of PKM2 inhibition and some compounds, such as PKM2-IN-1 (compound 3k) and 6d, display more potent activity than the positive control shikonin. The representative compounds PKM2-IN-1, 6d display dose-dependent inhibition of PKM2 with less inhibition of PKM1 and PKL like shikonin. Among all tested compounds, the most potent compounds are 3a, PKM2-IN-1 and 3r, which exhibit IC50 values against HCT116 and Hela cells ranging from 0.39 to 0.41 μM, 0.18 to 0.29 μM and 0.18 to 0.38 μM, respectively. |
细胞实验 |
在 THP-1 细胞中,使用WB检测抑制或激活 PKM2 后 p-STAT3 的表达情况,用 PKM2-IN-1 (T4170, 10 μM) 和 PKM2 activator 2 (T62758, 100 nM) 处理 48 h。
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别名 | PKM2 inhibitor, compound 3k |
分子量 | 345.48 |
分子式 | C18H19NO2S2 |
CAS No. | 94164-88-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6 mg/mL (17.36 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.8945 mL | 14.4726 mL | 28.9452 mL | 72.3631 mL |
5 mM | 0.5789 mL | 2.8945 mL | 5.789 mL | 14.4726 mL | |
10 mM | 0.2895 mL | 1.4473 mL | 2.8945 mL | 7.2363 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
PKM2-IN-1 94164-88-2 Metabolism PKM Pyruvate Kinase inhibit PKM2 IN 1 Inhibitor PKM2 inhibitor PKM2IN1 PKM-2-IN-1 compound 3k inhibitor