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Search Results for " protein kinase d "

27

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9779	Protein kinase inhibitor 6
	Protein kinase inhibitor 6 是一种蛋白激酶抑制剂。
T2458	CID755673	Serine/threonin kinase	Cell Cycle/Checkpoint; Metabolism
	CID755673是一种高效选择性 PKD1抑制剂，IC50为182 nM。
T1863	CID 2011756 CID2011756,CID-2011756	Serine/threonin kinase	Cell Cycle/Checkpoint; Metabolism
	CID 2011756 是一种具有抗肿瘤活性的ATP 竞争性广谱PKD 抑制剂，对 PKD1 的IC50值为 3.2 µM，在细胞中对 PKD2 和 PKD3 的IC50值分别为 0.6 和 0.7 µM。
T2062	kb NB 142-70	Serine/threonin kinase	Cell Cycle/Checkpoint; Metabolism
	kb NB 142-70 是一种PKD 有效抑制剂，具有抗肿瘤活性，对 PKD1、PKD2 和 PKD3 的IC50值分别为 28.3 nM、58.7 nM 和 53.2 nM。
T5508	PF-AKT400 (S)-N-[[3-氨基-1-(5-乙基-7H-吡咯并[2,3-D]嘧啶-4-基)吡咯烷-3-基]甲基]-2,4-二氟苯甲酰胺,AKT protein kinase inhibitor	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	PF-AKT400 (AKT protein kinase inhibitor) 是 ATP 竞争性的、选择性的 Akt 抑制剂，对 PKBα(IC50=0.5 nM) 的选择性比 PKA(IC50=450 nM) 高 900 倍。
T6440	CGP 57380 N3-(4-氟苯基)-1H-吡唑并[3,4-D]嘧啶-3,4-二胺,MNK1 Inhibitor	Apoptosis; MNK	Apoptosis; MAPK
	CGP 57380 (MNK1 Inhibitor) 是细胞渗透的吡唑-嘧啶类化合物，是一种具有选择性的Mnk1抑制剂，IC50值为 2.2 μM。
T61163	Protein kinase D inhibitor 1
	Protein kinase D inhibitor 1 (compound 17m) is a potent pan-PKD inhibitor. It exhibits inhibitory activity in the low nanomolar range, with IC50 values ranging between 17 and 35 nM. By inhibiting protein kinase D, this compound effectively suppresses cortactin phosphorylation, which is known to be PKD-dependent [1].
T2492	Perifosine NSC 639966,D21266,KRX-0401,哌立福新	Apoptosis; Akt; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Perifosine (KRX-0401) 是一种具有口服活性的烷基磷酸胆碱 Akt 抑制剂，具有抗肿瘤活性。
TQ0104	CRT0066101 dihydrochloride CRT0066101二盐酸盐	Serine/threonin kinase	Cell Cycle/Checkpoint; Metabolism
	CRT0066101 dihydrochloride 是一种选择性PKD 有效抑制剂，对PKD1、2和3的IC50值分别为1、2.5和2 nM。
T13017	STL127705 Compound L,7-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-fluorophenyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione	DNA-PK; Others	DNA Damage/DNA Repair; Others; PI3K/Akt/mTOR signaling
	STL127705 (Compound L) 是一种有效的 Ku 70/80 异二聚体蛋白抑制剂，抑制 Ku70/80-DNA 相互作用，IC50 为 3.5 μM。它抑制 Ku 依赖性 DNA-PKCS 激酶的激活，IC50 为 2.5 μM。
T9256	N-Cyclohexyl-4-[1-(1-piperazinyl)-2,6-naphthyridin-3-yl]-2-pyridinamine	Serine/threonin kinase; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism
	N-Cyclohexyl-4-[1-(1-piperazinyl)-2,6-naphthyridin-3-yl]-2-pyridinamine 是一种新型 2,6-naphthyridine，通过高通量筛选 (HTS) 鉴定为双蛋白激酶C/D (PKC/PKD) 抑制剂。
T4511	ST271 ST 271	Phospholipase; Tyrosine Kinases	Metabolism; Tyrosine Kinase/Adaptors
	ST271 是蛋白质酪氨酸激酶 (PTK) 抑制剂，抑制 fMet-Leu-Phe 和 PAF 引起的 phospholipase D 活化的IC50值分别为 6.7 和 9 μM。
T6904	Necrosulfonamide (E)-Necrosulfonamide	MLK	MAPK
	Necrosulfonamide ((E)-Necrosulfonamide) 是一种坏死性凋亡抑制剂，通过选择性靶向(MLKL)，可阻止 MLKL-RIP1-RIP3 坏死小体复合体与其下游效应子相互作用。MLKL 是诱导坏死过程中 RIP3 的重要底物。
T77504	JAK1/2/3 Inhibitor 1	PKA	Tyrosine Kinase/Adaptors
	JAK1/2/3 Inhibitor 1 是一种有效的蛋白激酶抑制剂。2,4-dichlorothieno[3,2-d]pyrimidine 具有抗肿瘤活性可抑制多种癌细胞株的生长。它通过与癌细胞的骨架结合，抑制新蛋白质的生成，从而抑制癌细胞的生长。
T25172	BPKDi
	BPKDi is a potent and selective inhibitor of PKD (protein kinase D).
T68654	Sapintoxin D
	Sapintoxin D is a fluorescent phorbol ester and selective activator of protein kinase C.
T71132	Calphostin D
	Calphostin D is isolated from the fungus Cladosporium cladosporioides and is an inhibitor of protein kinase C (PKC).
T36322	C8 D-threo Ceramide (d18:1/8:0) C8 D-threo Ceramide (d18:1/8:0)
	C8 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 17 μM) and induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 ceramide . C8 D-threo Ceramide is a substrate for E. coli diacylglycerol kinase. It activates ceramide-activated protein kinase (CAPK) in U937 cells. C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein r...
T75501	Morin 3-O-β-D-glucopyranoside
	Morin 3-O-β-D-glucopyranoside 是一种天然类黄酮，具有抗真菌、抗癌和抗氧化活性。Morin 3-O-β-D-glucopyranoside 抑制逆转录酶、蛋白酪氨酸激酶和黄嘌呤氧化酶，还具有抗 HIV、抗动脉硬化和超氧化物清除活性。
T38946	C8 Dihydroceramide C8 Dihydroceramide
	C8 Dihydroceramide acts as a negative control for C8 Ceramide, a cell-permeable analog of natural ceramides. C8 Ceramide, also known as N-Octanoyl-D-erythro-sphingosine, exhibits potent chemotherapeutic properties and anti-proliferation effects. Additionally, it stimulates dendritic cells to enhance T cell responses during viral infections. In vitro studies have also shown that C8 Ceramide induces a slight activation of protein kinase (PKC) [4].
T60718	3-IN-PP1
	3-IN-PP1是一种针对蛋白激酶D（PKD）家族成员PKD1、PKD2和PKD3具有高效抑制作用的抑制剂，IC50值分别为108、94和108 nM。此外，3-IN-PP1作为一种广谱抗癌剂，能抑制多种肿瘤细胞的生长，适用于癌症研究领域。
T35781	Sphinganine (d20:0) Sphinganine (d20:0)
	Sphinganine (d20:0) is a natural isomer of dihydro-D-erythro-sphinganine (sphinganine (d18:0); that is a precursor of ceramide and sphingosine as well as a substrate for sphingosine kinases, which generate sphingosine-1-phosphate (d18:1) . In S. cerevisiae, the amount of sphinganine (d20:0) increases 10.8-fold in response to heat stress, indicating it is involved in heat stress adaptation. Sphinganine levels increase significantly in response to certain mycotoxins, including fumonisins as well ...
T81451	PKCd (8-17)
	PKCd (8-17) 是源自蛋白激酶 C (PKC)d V1 结构域的生物活性肽。它能抑制由佛波醇 12-肉豆蔻酸酯 13-乙酸酯 (PMA) 诱导的 PKCd 易位和激活。此外，PKCd (8-17) 在降低心脏和脑细胞缺血损伤、促进成纤维细胞增殖、以及抑制小鼠移植冠状动脉疾病方面具有潜在应用。
T73359	NYX-2925
	NYX-2925 是一种口服有效的NMDAR 调节剂。NYX-2925 恢复 mPFC 中 GluN2A 和 GluN2B 上活化的Src 和Src 磷酸化位点的水平。NYX-2925 对 CAMKII 没有影响，也没有任何成瘾或镇静/共济失调的副作用。NYX-2925 可用于多种 NMDA 受体介导的中枢神经系统疾病的研究。
T36907	1-Oleoyl Lysophosphatidic Acid Oleoyl-sn-3-Glycerophosphate,1-Oleoyl LPA,1-Oleoyl Lysophosphatidic Acid
	1-Oleoyl lysophosphatidic acid is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of phospholipase D (PLD) or through a two step process involving liberation of diacylglycerol (DAG) by phospholipase C (PLC) followed by phosphorylation of DAG by diglycerol kinase.[1] Hydrolysis of the fatty acid at the sn-2 position by phospholipase A2 (PLA2) yields bioactive LPA. LPA binds to one of five differe...
T36779	NG 25 (hydrochloride hydrate)
	NG 25 is a type II kinase inhibitor that inhibits MAP4K2 and TAK1 (IC50s = 21.7 and 149 nM, respectively).1It also inhibits the Src family kinases Src and LYN (IC50s = 113 and 12.9 nM, respectively) and Abl family kinases (IC50s = 75.2 nM), as well as CSK, FER, and p38α (IC50s = 56.4, 82.3, and 102 nM, respectively). NG 25 (100 nM) prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells. It inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097, respectiv...
T36722	Deltorphin II (trifluoroacetate salt)
	Deltorphin II is a peptide agonist of δ2-opioid receptors.1,2It is selective for δ-opioid receptors over μ- and κ-opioid receptors in radioligand bindings assays (Kis = 0.0033, >1, and >1 μM, respectively) and induces [35S]GTPγS binding in mouse brain membrane preparations (EC50= 0.034 μM). Deltorphin II (0.12 mg/kg) decreases the infarction zone:risk zone ratio in a rat model of myocardial ischemia-reperfusion injury induced by coronary occlusion, an effect that can be reversed by the δ2-opioid...

化合物

Protein kinase inhibitor 6

Cat.No: T9779

Cat.No: T2458

Target: Serine/threonin kinase

Cat.No: T1863

Synonym: CID2011756,CID-2011756

Target: Serine/threonin kinase

Cat.No: T2062

Target: Serine/threonin kinase

Cat.No: T5508

Synonym: (S)-N-[[3-氨基-1-(5-乙基-7H-吡咯并[2,3-D]嘧啶-4-基)吡咯烷-3-基]甲基]-2,4-二氟苯甲酰胺,AKT protein kinase inhibitor

Target: Akt

Cat.No: T6440

Synonym: N3-(4-氟苯基)-1H-吡唑并[3,4-D]嘧啶-3,4-二胺,MNK1 Inhibitor

Target: Apoptosis, MNK

Protein kinase D inhibitor 1

Cat.No: T61163

Cat.No: T2492

Synonym: NSC 639966,D21266,KRX-0401,哌立福新

Target: Apoptosis, Akt, Autophagy

CRT0066101 dihydrochloride

Cat.No: TQ0104

Synonym: CRT0066101二盐酸盐

Target: Serine/threonin kinase

Cat.No: T13017

Synonym: Compound L,7-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-fluorophenyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

Target: DNA-PK, Others

N-Cyclohexyl-4-[1-(1-piperazinyl)-2,6-naphthyridin-3-yl]-2-pyridinamine

Cat.No: T9256

Target: Serine/threonin kinase, PKC

Cat.No: T4511

Synonym: ST 271

Target: Phospholipase, Tyrosine Kinases

Necrosulfonamide

Cat.No: T6904

Synonym: (E)-Necrosulfonamide

Target: MLK

JAK1/2/3 Inhibitor 1

Cat.No: T77504

Target: PKA

Cat.No: T25172

Cat.No: T68654

Cat.No: T71132

C8 D-threo Ceramide (d18:1/8:0)

Cat.No: T36322

Synonym: C8 D-threo Ceramide (d18:1/8:0)

Morin 3-O-β-D-glucopyranoside

Cat.No: T75501

C8 Dihydroceramide

Cat.No: T38946

Synonym: C8 Dihydroceramide

Cat.No: T60718

Sphinganine (d20:0)

Cat.No: T35781

Synonym: Sphinganine (d20:0)

Cat.No: T81451

Cat.No: T73359

1-Oleoyl Lysophosphatidic Acid

Cat.No: T36907

Synonym: Oleoyl-sn-3-Glycerophosphate,1-Oleoyl LPA,1-Oleoyl Lysophosphatidic Acid

NG 25 (hydrochloride hydrate)

Cat.No: T36779

Deltorphin II (trifluoroacetate salt)

Cat.No: T36722

Cat. No.	Product Name	Target	Signaling Pathways
T3889	Platycodin D	Prostaglandin Receptor; AMPK	Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; PI3K/Akt/mTOR signaling
	Platycodin D 是从桔梗中分离得到的一种皂苷类天然产物，是AMPKα的激活剂，具有抗肥胖活性。它可刺激 TNF-α 合成或抑制 TNF-α mRNA 的降解。
TN1405	Arnicolide D 山金车内酯 D,山金车内酯D	Akt; Caspase; PI3K; STAT; mTOR	Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Arnicolide D 是从石胡荽中分离出的一种倍半萜内酯，以浓度和时间依赖性方式抑制鼻咽癌细胞活力。它调节细胞周期，激活 caspase 信号通路并抑制 PI3K/AKT/mTOR 和 STAT3 信号通路。
T2974	Cyclovirobuxine D 黄杨碱,CVB-D,Bebuxine,Cyclovirobuxin D,环维黄杨星D	Apoptosis; Others; Akt; mTOR; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling
	Cyclovirobuxine D (Bebuxine) 是中药黄杨的主要活性成分，可诱导自噬并减弱Akt 和mTOR 的磷酸化。它通过抑制细胞周期进程和诱导线粒体介导的细胞凋亡抑制癌细胞的增殖，有用于心肌梗死引起的心力衰竭的研究潜力。
T5891	D-ERYTHRO-SPHINGOSINE trans-4-Sphingenine,erythro-C18-Sphingosine,Erythrosphingosine,鞘氨醇,D-鞘氨醇	Phosphatase; Endogenous Metabolite; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism
	D-erythro-Sphingosine (trans-4-Sphingenine) 是一种非常有效的p32激酶活化剂，EC50为 8 μM。它也是一种PP2A 激活剂，抑制蛋白激酶 C (PKC)。
TN1499	Cimiracemoside C 千层纸素A-7-0-Β-D-葡萄糖醛酸苷,Cimicifugoside M	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Cimiracemoside C (Cimicifugoside M) 是在升麻中发现的一种天然产物，可激活 AMPK 并具有抗糖尿病的潜在活性。
T19500	Palmitelaidic Acid trans-Palmitoleic acid,9-trans-Hexadecenoic acid,软脂酸	Glucokinase; AMPK; PPAR	Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling
	trans-Palmitelaidic Acid (trans-Palmitoleic acid) 是palmitoleic acid 的反式异构体。Palmitoleic acid 是血清和组织中最丰富的脂肪酸之一。

天然产物

Cat.No: T3889

Target: Prostaglandin Receptor, AMPK

Cat.No: TN1405

Synonym: 山金车内酯 D,山金车内酯D

Target: Akt, Caspase, PI3K, STAT, mTOR

Cyclovirobuxine D

Cat.No: T2974

Synonym: 黄杨碱,CVB-D,Bebuxine,Cyclovirobuxin D,环维黄杨星D

Target: Apoptosis, Others, Akt, mTOR, Autophagy

D-ERYTHRO-SPHINGOSINE

Cat.No: T5891

Synonym: trans-4-Sphingenine,erythro-C18-Sphingosine,Erythrosphingosine,鞘氨醇,D-鞘氨醇

Target: Phosphatase, Endogenous Metabolite, PKC

Cimiracemoside C

Cat.No: TN1499

Synonym: 千层纸素A-7-0-Β-D-葡萄糖醛酸苷,Cimicifugoside M

Target: AMPK

Palmitelaidic Acid

Cat.No: T19500

Synonym: trans-Palmitoleic acid,9-trans-Hexadecenoic acid,软脂酸

Target: Glucokinase, AMPK, PPAR

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