58
7
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12365 |
PARP/PI3K-IN-1
|
PARP; PI3K | Chromatin/Epigenetic; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
PARP/PI3K-IN-1 是一种 新型双重聚(ADP-核糖)聚合酶(PARP)和磷酸肌醇 3-激酶(PI3K)双重抑制剂,具有抗癌、抗肿瘤和抗癌细胞增殖活性,可用于研究乳腺癌、胰腺癌和肺癌。 | |||
T40310 |
PARP/EZH2-IN-1
PARP/EZH2-IN-1 |
||
PARP/EZH2-IN-1 is a novel compound that functions as a dual inhibitor for both PARP (IC50 6.87 nM) and EZH2 (IC50 36.51 nM), showing promising potential for the treatment of triple-negative breast cancer with wild-type BRCA. | |||
T12364 |
PARP-2-IN-1
|
Others | Others |
PARP-2-IN-1 is a potent and selective inhibitor of PARP-2(IC50 of 11.5 nM). | |||
T6329 |
3-Aminobenzamide
3-AB,INO1001,INO-1001,3-ABA,PARP-IN-1,INO 1001 |
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
3-Aminobenzamide (PARP-IN-1) 是一种有效的 PARP 抑制剂,在 CHO 细胞中,对 PARP 的 IC50值约为 50 nM。它是再灌注过程中氧化剂诱导的肌细胞功能障碍的介质。 | |||
T9610 |
PARP1-IN-5 dihydrochloride
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
PARP1-IN-5 dihydrochloride 是一种具有口服活性的有效选择性 PARP-1 抑制剂 (IC50 =14.7 nM)。它可用于癌症的研究。 | |||
T72862 |
PARP-2/1-IN-2
ABT-888对映体 |
||
PARP-2/1-IN-2 是 Veliparib 的对映异构体,是一种有效的PARP 抑制剂,对PARP-2和PARP-1的Ki 分别为 2 和 5 nM。在以PARP 活性为基础的细胞测定中,PARP-2/1-IN-2 的 EC50为 3 nM。 | |||
T78182 |
PARP-1-IN-4
|
Others; PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair; Others |
PARP-1-IN-4 是一种有效的 PARP-1抑制剂,具有潜在的看抗肿瘤活性,抑制 PARP-1 可用于癌症的发生。 | |||
T78157 |
PARP-1-IN-3
|
Apoptosis; PARP | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair |
PARP-1-IN-3 是一种高效的 PARP-1 抑制剂,对 PARP-1 和 PARP-2 具有抑制作用, IC50 值分别为 0.25 nM 和 2.34 nM。PARP-1-IN-3 具有潜在的抗炎活性,促使细胞凋亡并使细胞周期停滞在 G2/M 期。PARP-1-IN-3 可用于研究与癌症相关的疾病。 | |||
T62281 |
PARP-1-IN-2
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
PARP-1-IN-2 是一种有效且可透过血脑屏障的 PARP1 抑制剂(IC50: 149 nM)。PARP-1-IN-2 在细胞实验中对人肺腺癌上皮细胞系 A549 显示出显著的抗增殖活性。PARP-1-IN-2 可诱导 A549 细胞凋亡。 | |||
T9891 |
PARP1-IN-8
N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide |
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
PARP1-IN-8 (N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide) 是PARP1的有效抑制剂(IC50 = 97 nM)。 | |||
T79647 |
VEGFR/PARP-IN-1
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
VEGFR/PARP-IN-1 (Compound 14b) 是一款针对VEGFR和PARP两个靶点的双重抑制剂,其对VEGFR和PARP的IC50值分别为191 nM和60.9 nM。该化合物能够抑制DNA损伤修复机制,诱导apoptosis,并使细胞在G2/M期阻滞。此外,VEGFR/PARP-IN-1对BRCA野生型乳腺癌细胞表现出较强的抗增殖效果,尤其是在MDA-MB-231和MCF-7细胞系上,其IC50值分别为4.1 μM和3.5 μM,是潜在的抗肿瘤和抗转移药物。 | |||
T39139 |
PARP1-IN-6
PARP1-IN-6 |
||
PARP1-IN-6 is a dual tubulin/PARP-1 inhibitor with IC 50 values of 0.94 and 0.48 μM, respectively. | |||
T61798 | PARP-1-IN-1 | ||
PARP-1-IN-1 is a highly selective and orally active inhibitor of the enzyme PARP-1, with an IC50 value of 0.96 nM. It exhibits excellent tolerance and demonstrates significant activity in a single dose in the MDA-MB-436 xenotransplantation model [1]. | |||
T79330 |
PARP-1-IN-13
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
PARP-1-IN-13 (Compound 19c) 为一种高效PARP-1抑制剂,其IC50值为26 nM。该化合物能够抑制DNA单链断裂修复并增强DNA双链断裂效应。此外,PARP-1-IN-13通过激活线粒体凋亡(apoptosis)途径来促进癌细胞死亡。 | |||
T61962 | PARP-1/HDAC-IN-1 | ||
PARP-1/HDAC-IN-1 是有效的 PARP-1/HDAC6双重抑制剂,IC50分别为 68.90 nM 和 510 nM。PARP-1/HDAC-IN-1 具有抗癌、抗迁移和抗血管生成活性。 | |||
T62508 |
PARP-1/2-IN-1
|
||
PARP-1/2-IN-1是一种有效的 PARP-1 (IC50: 0.51 nM) 和 PARP-2 (IC50: 23.11 nM) 抑制剂。 | |||
T78787 |
PARP-1/2-IN-2
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
PARP-1/2-IN-2(Compound 12e)是一款抑制PARP1/2/CDK12的分子,IC50值分别为34、30和285 nM。该化合物阻碍DNA损伤修复过程,并能诱发细胞周期阻滞与细胞凋亡。此外,PARP-1/2-IN-2能够有效抑制三阴性乳腺癌(TNBC)细胞和异种移植瘤的增长。 | |||
T72437 |
PARP1/2/TNKS1/2-IN-1
|
Apoptosis; PARP; Wnt/beta-catenin | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Stem Cells |
PARP1/2/TNKS1/2-IN-1 是一种多靶点抑制剂,抑制 PARP-1、PARP-2、TNKS1 和 TNKS2 。PARP1/2/TNKS1/2-IN-1 具有潜在的抗肿瘤活性,可诱导细胞凋亡。 | |||
T4463 |
Rucaparib
AG-14447,PF-01367338,瑞卡帕布,AG014699 |
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Rucaparib (PF-01367338) 是一种口服有效的 PARP 蛋白抑制剂,对 PARP-1 的 Ki 为 1.4 nM。它是六磷酸己糖脱氢酶 (H6PD) 抑制剂,有用于去势抵抗性前列腺癌 (CRPC) 的研究潜力。 | |||
T6768 |
AZ6102
|
PARP; Wnt/beta-catenin | Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Stem Cells |
AZ6102 是TNKS1和TNKS2双重抑制剂,IC50值分别为 3 和 1 nM,选择性是对 PARP 家族其他蛋白的 100 多倍,对 PARP1、PARP2 和 PARP6 的IC50值分别为 2.0、0.5 和大于 3 μM。 | |||
T72553 |
ARTD10/PARP10-IN-1
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
ARTD10/PARP10-IN-1 是一种强效性的 PARP 抑制剂,抑制单 ADP 核糖转移酶 ARTD7/PARP15,ARTD8/PARP14,ARTD10/PARP10 和聚 ADP-核糖聚合酶-1 (ARTD1/PARP1),具有潜在的抗癌抗肿瘤活性,可用于研究前列腺癌和乳腺癌。 | |||
T6127 |
Rucaparib Phosphate
AG-014699 phosphate,PF-01367338,芦卡帕利,AG-014699,瑞卡帕布磷酸盐,PF-01367338 phosphate |
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Rucaparib Phosphate (PF-01367338 phosphate) 是一种口服有效的PARP 蛋白抑制剂,对 PARP-1 的Ki 为 1.4 nM。它是六磷酸己糖脱氢酶 (H6PD) 抑制剂,有用于去势抵抗性前列腺癌 (CRPC) 的研究潜力。 | |||
T22264 |
AZ9482
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
AZ9482 是一种选择性 PARP1/2/6的三重抑制剂,IC50值分别为 1 、1 和640 nM。 | |||
T10896L |
CSRM617 hydrochloride
CSRM617 hydrochloride(787504-88-5 Free base) |
Apoptosis; Others; Androgen Receptor | Apoptosis; Endocrinology/Hormones; Others |
CSRM617 hydrochloride 是转录因子ONECUT2(OC2,雄激素受体 AR 的主要调节剂) 的选择性小分子抑制剂,在 SPR 测定中Kd 为 7.43 uM,直接与 OC2-HOX 结构域结合。CSRM617 hydrochloride 通过裂解 Caspase-3 和 PARP 诱导细胞凋亡 (apoptosis)。CSRM617 hydrochloride 在小鼠的前列腺癌模型中具有良好的耐受性。 | |||
T60039 |
KSQ-4279
USP1-IN-1 |
PARP; DUB | Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Ubiquitination |
KSQ-4279 (USP1-IN-1)是 USP1 和 PARP 的抑制剂。KSQ-4279 具有抗癌活性,可用于研究非小细胞肺癌、骨肉瘤、卵巢癌、乳腺癌、胶质母细胞瘤、膀胱癌、子宫癌和胰腺癌。 | |||
T3157 |
COH29
RNR Inhibitor COH29 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
COH29 (RNR Inhibitor COH29) 是一种口服可用的芳香族取代噻唑,是人类核糖核苷酸还原酶 (RNR) 的抑制剂,具有潜在的抗肿瘤活性。它抑制核糖核苷酸还原酶的IC50为 16 μM。 | |||
T64289 | Rucaparib camsylate | ||
Rucaparib (AG014699) camsylate 是一种口服具有活力的 PARP 蛋白 (PARP-1、PARP-2 及 PARP-3) 抑制剂,对 PARP-1 的 Ki=1.4 nM。Rucaparib camsylate 是一种六磷酸己糖脱氢酶 (H6PD) 抑制剂。Rucaparib camsylate 具有潜力进行去势抵抗性前列腺癌 (CRPC) 的研究研究。 | |||
T71026 | MC2050 HCl | ||
MC2050 is a potent PARP-1 inhibitor. The IC50 for inhibition of PARP-1 activity is 119 nM, compared to 1.8 μM for PARP-2. MC2050 inhibits apoptosis and blocks poly ADP-ribosylation of histone H1 in hydrogen peroxide treated SH-SY5Y neuroblastoma cells. | |||
T74173 |
PROTAC PARP/EGFR ligand 1
|
||
PROTACPARP/EGFR ligand 1 是一种活性化合物,可通过蛋白水解靶向嵌合体(PROTAC)技术用于合成双 PARPEGFR 降解剂的合成。 | |||
T63065 |
Rucaparib tartrate
|
||
Rucaparib (AG014699) tartrate 是一种口服具有活力的 PARP 蛋白 (PARP-1, PARP-2 和 PARP-3) 抑制剂,作用于 PARP-1 (Ki: 1.4 nM)。Rucaparib tartrate 是一种六磷酸己糖脱氢酶 (H6PD) 抑制剂。Rucaparib tartrate 具有潜力用于去势抵抗性前列腺癌 (CRPC) 的研究。 | |||
T81543 | PARP1-IN-17 | PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
PARP1-IN-17为一种选择性PARP-1抑制剂,其针对PARP-1的IC50为19.24 nM ,对PARP-2的IC50为32.58 nM ,能够有效诱导(apoptosis)。此外,PARP1-IN-17显示出优秀的抗增殖作用。 | |||
T70732 | APX2014 | ||
APX2014 is a novel potent and specific Ref-1 inhibitor, blocking in vitro cell proliferation and activating apoptosis via PARP cleavage. | |||
T61335 |
Rucaparib hydrochloride
|
||
Rucaparib hydrochloride, also known as AG014699, is a powerful and orally active compound that inhibits PARP proteins including PARP-1, PARP-2, and PARP-3 with a Ki value of 1.4 nM for PARP1. Additionally, Rucaparib hydrochloride acts as a modest inhibitor of hexose-6-phosphate dehydrogenase (H6PD). This compound shows potential in research for castration-resistant prostate cancer (CRPC) [1] [2] [3] [4]. | |||
T61657 | Rucaparib acetate | ||
Rucaparib (AG014699) acetate is a highly effective oral inhibitor of PARP proteins, specifically targeting PARP-1, PARP-2, and PARP-3, with a Ki value of 1.4 nM for PARP1. Additionally, it exhibits inhibitory action on hexose-6-phosphate dehydrogenase (H6PD) to a moderate extent. Rucaparib acetate shows promise in the field of research for castration-resistant prostate cancer (CRPC). [1] [2] [3] [4] | |||
T36251 | DP-C-4 | ||
DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP[1]. DP-C-4 (1-50 μM; 24 hours) has degradation effects on EGFR and PARP simultaneously in a dose-dependent manner in SW1990 cells[1]. [1]. Mengzhu Zheng, et al. Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP. J Med Chem. 2021 May 26. | |||
T26229 |
ST7710AA1
ST-7710-AA1,ST 7710 AA1 |
||
ST7710AA1 is a PARP-1 inhibitor that acts by showing significant in vitro target inhibition and capability to substantially bypass the multidrug resistance mediated by Pgp. | |||
T60695 |
DPQ
|
||
DPQ 是PARP-1的有效抑制剂,可用于研究神经保护。DPQ 可降低 N-甲基-D-天冬氨酸(NMDA) 诱导的 PARP 激活,将 ATP 恢复至接近正常水平,并且显著减轻 NMDA 暴露模型中的神经元损伤。 | |||
T16334 |
NMS-P515
|
Others | Others |
NMS-P515 is an effective, orally active, and stereospecific PARP-1 inhibitor (Kd: 16 nM and an IC50: 27 nM (in Hela cells)). It has anti-tumor activity. | |||
T68663 |
GPI-15427
|
||
GPI-15427 is a potent PARP-1 inhibitor capable of crossing the blood-brain barrier, which can significantly increased the antitumor activity of the methylating agent TMZ against malignant melanoma, glioblastoma multiforme, or lymphoma growing at the CNS site. GPI-15427 acts as a potent inhibitor of the enzyme, being capable of inhibiting the activity of purified PARP-1 at nanomolar concentrations. GPI-15427 induced significant sensitization to radiotherapy, representing a promising new treatment... | |||
T60410 |
ART-IN-1
|
||
ART-IN-1 (compound 7) 是一种 PARP 的选择性抑制剂,对 PARP2, TNKS2, PARP10, PARP14, PARP15 的 IC50值分别为 19, 22, 2.4, >100, 1.1 μM。 | |||
T81541 |
PARP7-IN-16
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
PARP7-IN-16是一种高效、选择性且具有口服生物活性的PARP-1/2/7抑制剂,其IC50分别为0.94 nM , 0.87 nM 和0.21 nM 。PARP7-IN-16适合用于乳腺癌与前列腺癌的研究。 | |||
T62955 | PARP1-IN-5 | ||
PARP1-IN-5 是一种有效的、选择性的、口服具有活力的、低毒的 PARP-1 抑制剂,其 IC50 值为 14.7 nM。PARP1-IN-5 能够用于研究癌症。 | |||
T78401 |
pNP-ADPr disodium
ADP-ribose-pNP disodium |
||
pNP-ADPr 二钠是一种用于检测Poly(ADP-ribose) glycohydrolase (PARG)和ADP-ribosyl hydrolase 3 (ARH3)活性的比色底物。它也适用于poly(ADP-ribose)polymerase (PARP)酶相关研究。 | |||
T69955 |
JPI-547 HCl
|
||
JPI 547, also known as NOV 1402, is an oral inhibitor of PARP 1/2 and Tankyrase 1/2. JPI-547 demonstrated anti-tumor activity in BRCA-deficient xenograft models as a single-agent and in combination with chemotherapy and immune checkpoint inhibitors. | |||
T72017 |
6(5H)-Phenanthridinone
|
||
6(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2. It decreases radiation-induced PARP activity and proliferation of RDM4 murine lymphoma cells. 6(5H)-Phenanthridinone reduces NF-κB-induced transcription of the genes encoding TNF-α, IL-2, and IFN-γ in rat lymphocytes. In vivo, 6(5H)-phenanthridinone reduces spinal cord expression of inducible nitric oxide synthase (iNOS), IL-1β, TNF-α, IL-2, and IFN-γ and reduces disease score in a rat model of experimenta... | |||
T79791 |
Immunosuppressant-1
|
Apoptosis | Apoptosis |
Immunosuppressant-1(Compound 31)抑制抗-CD3/抗-CD28共刺激的T细胞增殖,具备免疫抑制活性。该化合物能激活活化的淋巴结细胞中的caspase-3和PARP,从而诱导细胞凋亡(apoptosis)。 | |||
T79482 |
Anticancer agent 137
|
PI3K | PI3K/Akt/mTOR signaling |
Anticanceragent 137 (8q) 是一种高效的 PI3k 抑制剂,展现出广谱的抗肿瘤活性。它能够诱导 G2/M 阶段的细胞周期阻滞与细胞凋亡(apoptosis),并促进 PARP、caspase 3 和 caspase 7 的裂解。该化合物主要用于癌症相关的生物医学研究。 | |||
T75074 | 6-Methoxypurine-9-β-D-5’(R)-C-methylriboside | ||
6-Methoxypurine-9-β-D-5’(R)-C-methylriboside 是一种嘌呤碱基,属于次黄嘌呤似物,主要在肌肉组织中发现。作为黄嘌呤在嘌呤氧化酶作用下的代谢产物,次黄嘌呤具备显著的抗炎性质,并可作为内源性 poly(ADP-ribose) polymerase (PARP) 的抑制剂。其通过抑制 PARP 活性,防止过氧亚硝酸盐引起的线粒体去极化及次级超氧化物的产生,展现出细胞保护作用。同时,次黄嘌呤也被用作缺氧的生物标志物。 | |||
T79667 |
YCH1899
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
YCH1899为一种口服活性PARP抑制剂,其对PARP1/2的IC50均低于0.001 nM。该化合物对Olaparib和Talazoparib耐药的Capan-1细胞株(Capan-1/OP及Capan-1/TP细胞)表现出显著抗增殖能力,IC50分别为0.89 nM和1.13 nM。在大鼠体内,YCH1899展现优良的药代动力学属性。 | |||
T74359 | PP-C8 | ||
PP-C8 是一种有效的选择性 PROTACCDK12-Cyclin K 降解剂。PP-C8 诱导 CDK12-Cyclin K 降解,对 CDK12 和 Cyclin K 的DC50分别为 416 和 412 nM。PP-C8 与PARP 抑制剂在三阴性乳腺癌 (TNBC) 中具有高效的协同抗增殖作用。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3S1471 |
Cucurbitacin IIA
葫芦素Iia,Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA |
Apoptosis; Survivin | Apoptosis |
Cucurbitacin IIA (Dihydrocucurbitacin Q1) 是从园果雪胆中分离得到的一种三萜烯,可诱导细胞凋亡和增强自噬,有助于葫芦素IIA 对炎症相关疾病的抗炎活性。它可降低癌细胞中生存素的表达,降低磷酸化组蛋白 H3 的水平,增加裂解的 PARP 的水平。 | |||
TN1880 |
Lucidenic acid B
Lucidenicacid B |
Apoptosis; Caspase | Apoptosis; Proteases/Proteasome |
Lucidenic acid B (Lucidenicacid B) 是从灵芝中提取得到的天然化合物,可诱导caspase-9 和 caspase-3 的活化和 PARP 的裂解,可通过线粒体介导诱导人白血病细胞凋亡 。 Lucidenic acid B通过灭活MAPK / ERK信号转导途径和降低NF-kappaB和AP-1的结合活性来抑制PMA诱导的人肝癌细胞侵袭。。Lucidenic acid B 对细胞周期和坏死细胞没有影响。 | |||
T5S2358 |
Dehydrocorydaline
Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine |
BCL; PARP; p38 MAPK; Caspase; Parasite; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Proteases/Proteasome |
Dehydrocorydaline (13-Methylpalmatine) 是一种生物碱。它调节Bax,Bcl-2蛋白表达,激活caspase-7,caspase-8,并使PARP 失活。它能增强p38 MAPK 活化,具有抗炎、抗癌等功效。它具有强大的抗疟疾作用,并具低细胞毒性。 | |||
T4973 |
Paraxanthine
1,7-二甲基黄嘌呤,1,7-DIMETHYLXANTHINE |
Endogenous Metabolite | Metabolism |
Paraxanthine (1,7-dimethylxanthine) 是一种 caffeine 的代谢物,能够刺激Ryanodine 受体通道来抑制多巴胺能细胞的死亡。 | |||
T6S2391 |
L-Chicoric Acid
(-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,L-菊苣酸,dicaffeoyltartaric acid,菊苣酸 |
Others; HIV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
L-Chicoric Acid (trans-Caffeoyltartaric acid) 是一种二咖啡酰酒石酸,是一种选择性可逆的 HIV-1 整合酶抑制剂,IC50约为 100 nM。它还可抑制 HIV-1 复制。 | |||
T2S2362 |
Dehydrocorydaline nitrate
去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱 |
BCL; Others; PARP; p38 MAPK; Caspase; Parasite; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Others; Proteases/Proteasome |
Dehydrocorydaline nitrate 是生物碱。Dehydrocorydaline 调节 Bax,Bcl-2蛋白表达,激活 caspase-7,caspase-8,并使 PARP 失活。它能增强 p38 MAPK 活化,具有抗炎、抗癌、抗疟疾等功效。 | |||
T5S1805 |
5,7-Dihydroxychromone
5,7-Dihydroxy-4H-Chromen-4-One,5,7-二羟基色酮,5,7-二羟基色原酮 |
Others; Virus Protease; PARP; Caspase; Nrf2 | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Others; Proteases/Proteasome |
5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) 是一种Cudrania tricuspidata 的提取物,通过激活 Nrf2/ARE 信号对 6-OHDA 诱导的氧化应激和细胞凋亡发挥神经保护作用。它抑制 6-OHDA 诱导的 SH-SY5Y 细胞中活化的caspase-3,caspase-9以及切割的PARP 表达。 |