Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PARP1-IN-5 dihydrochloride 是一种具有口服活性的有效选择性 PARP-1 抑制剂 (IC50 =14.7 nM)。它可用于癌症的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 860 | 现货 | ||
5 mg | ¥ 1,950 | 现货 | ||
10 mg | ¥ 3,160 | 现货 | ||
25 mg | ¥ 6,230 | 现货 | ||
50 mg | ¥ 8,730 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,580 | 现货 |
产品描述 | PARP1-IN-5 dihydrochloride is an orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer. |
靶点活性 | PARP1:14.7 nM, PARP2:0.9 μM |
体外活性 | PARP1-IN-5 dihydrochloride (0.1~10 μM) can significantly increase the cytotoxicity of CBP on A549 cells in a dose-dependent manner. PARP1-IN-5 dihydrochloride (0.1~10 μM) decreases the expressions of MCM2-7 on SK-OV-3 cells. PARP1-IN-5 dihydrochloride (0.1~320 μM) has little cytotoxic effects on A549 cells. PARP1-IN-5 dihydrochloride can significantly decrease the PAR level on SK-OV-3 cells[1]. PARP1-IN-5 dihydrochloride exerts antitumor effects through PARP-1. PARP1-IN-5 dihydrochloride could increase the γ-H2AX expression[1]. |
体内活性 | PARP1-IN-5 dihydrochloride (1000 mg/kg; p.o.) shows that there is no significant difference in the body weight and blood routine[1]. PARP1-IN-5 dihydrochloride (25 and 50 mg/kg; p.o.; 12 days) significantly enhances the inhibitory effect of carboplatin on A549 cells at 50 mg/kg[1]. PARP1-IN-5 dihydrochloride (50 mg/kg; p.o.) positively correlates with the expression of PARP-1[1]. PARP1-IN-5 dihydrochloride can decrease the expression of PAR and upregulate the expression of γ-H2AX [1]. |
分子量 | 537.46 |
分子式 | C25H26Cl2N2O5S |
CAS No. | 2823308-89-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (232.58 mM), Sonication is recommended.
H2O: 1 mg/mL (1.86 mM), Sonication and heating to 60℃ are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O | 1 mM | 1.8606 mL | 9.303 mL | 18.606 mL | 46.5151 mL |
DMSO | 5 mM | 0.3721 mL | 1.8606 mL | 3.7212 mL | 9.303 mL |
10 mM | 0.1861 mL | 0.9303 mL | 1.8606 mL | 4.6515 mL | |
20 mM | 0.093 mL | 0.4652 mL | 0.9303 mL | 2.3258 mL | |
50 mM | 0.0372 mL | 0.1861 mL | 0.3721 mL | 0.9303 mL | |
100 mM | 0.0186 mL | 0.093 mL | 0.1861 mL | 0.4652 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
PARP1-IN-5 dihydrochloride 2823308-89-8 Chromatin/Epigenetic DNA Damage/DNA Repair PARP PARP1 IN 5 dihydrochloride PARP1-IN-5 Dihydrochloride PARP-1-IN-5 (dihydrochloride) PARP1IN5 dihydrochloride PARP1-IN-5 Inhibitor inhibitor inhibit