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4
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3189 |
B7/CD28 interaction inhibitor 1
CTLA-4 inhibitor |
Others | Others |
B7/CD28 interaction inhibitor 1 (CTLA-4 inhibitor) 是B7.1-CD28相互作用抑制剂(IC50:50 nM)。 | |||
T1454 |
Acyclovir
Aciclovir,Acycloguanosine,阿昔洛韦 |
Apoptosis; DNA/RNA Synthesis; Antibacterial; Antibiotic; HSV | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Acyclovir (Aciclovir) 是鸟嘌呤类似物和具有口服活性的抗病毒剂。它对HSV-1(IC50为 0.85 μM),HSV-2(IC50为 0.86 μM) 和水痘带状疱疹病毒有活性。 | |||
T8875 |
CD73-IN-3
EX-A4254,LY-3475070 |
CD73 | Immunology/Inflammation |
CD73-IN-3 (LY-3475070) 是一种有效的选择性 CD73 抑制剂,IC50 为 28 nM,具有癌症的研究潜力。 | |||
T27695 |
JTE-607
JTE-607 dihydrochloride,JTE-607 HCl,甲氧番荔枝碱 |
Cysteine Protease | Proteases/Proteasome |
JTE-607 HCl 是高选择性的炎性细胞因子合成抑制剂,可保护小鼠免受内毒素休克。它作用于 LPS 刺激的人 PBMC,抑制TNF-α(IC50:11 nM)、IL-1β(IC50:5.9 nM)、IL-6(IC50:8.8 nM)、IL-8(IC50:7.3 nM)和IL-10(IC50:9.1 nM)。 | |||
T7776 |
ADH-503
GB1275 |
Complement System | Immunology/Inflammation |
ADH-503 (GB1275) 是一种可口服的变构CD11b 激动剂,可以导致与肿瘤相关的巨噬细胞重新极化,可减轻骨髓细胞的免疫抑制,并增强树突状细胞的反应。 | |||
T22430 |
SRX3207
|
Others; PI3K; Syk | Angiogenesis; Others; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
SRX3207 是 Syk 和 PI3K 的抑制剂,可缓解肿瘤免疫抑制。 | |||
T10824 |
cis-Urocanic acid
cis-UCA,(Z)-Imidazole-4-acrylic acid,(Z)-Urocanic acid,(E)-Urocanic acid,(Z)-3-(1H-Imidazol-5-yl)acrylic acid,顺式-尿刊酸 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
cis-Urocanic acid ((E)-Urocanic acid) 是一种 5-HT2A 受体激动剂,cis-Urocanic acid 与 5-HT 受体结合的Kd 为 4.6 nM。cis-Urocanic acid 是一种免疫调节剂,通过与 5-HT2A 受体结合而诱导免疫抑制。 | |||
T6543 |
Indoximod
NLG-8189,Indoximod (NLG-8189),1-Methyl-D-tryptophan,吲哚莫德 |
Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
Indoximod (Indoximod (NLG-8189)) 是一种具有口服具有活力的吲哚胺2,3-双加氧酶(IDO) 途径抑制剂。它在调节 mTOR 中充当 Trp 模拟物。它是一种可用于癌症研究的免疫代谢佐剂。 | |||
T80726 |
Ziralimumab
ABX-RB2 |
||
Ziralimumab (ABX-RB2)为针对人类CD147/BSG的单克隆抗体,其应用于免疫抑制。 | |||
T71938 |
MNF
|
||
MNF, also known as 3,4-MNF, is an antagonist of the aryl hydrocarbon receptor (AhR). MNF reduces UVR-mediated immunosuppression and induces Tregs in murine contact hypersensitivity (CHS). | |||
T69648 | Inupadenant HCl | ||
Inupadenant, also known as EOS-850, is a highly selective small molecule antagonist of the adenosine A2a receptor, in the adenosine triphosphate adenosine pathway, a key driver of immunosuppression in the tumor microenvironment across a broad range of tumors. | |||
T40211 |
eIF4E-IN-1
eIF4E-IN-1 |
||
eIF4E-IN-1 (WO2021003194A1, compound Y), is a highly effective inhibitor of eIF4E, a key protein involved in immunosuppression. By targeting immune checkpoint proteins such as PD-1, PD-L1, LAG3, TIM3, and IDO, eIF4E-IN-1 functions to disrupt immune suppression and promote immune release in specific diseases such as cancer and infectious diseases. | |||
T30508 |
BMS-243117
UNII-MBE6KWV0QI,CHEMBL67237,MBE6KWV0QI |
||
BMS-243117 is an effective selective LCK inhibitor with good cell activity (IC(50)=1.1 microM) and inhibition of T cell proliferation, which has great potential for therapeutic immunosuppression and the treatment of diseases such as rheumatoid arthritis a | |||
T63956 | OP-5244 sodium | ||
OP-5244 sodium 是有效的、口服具有活力的 CD73 抑制剂 (IC50: 0.25 nM)。OP-5244 sodium 能够阻断腺苷的产生,进而逆转免疫抑制作用,对癌症表现出研究潜力。 | |||
T61053 |
CD73-IN-11
|
||
CD73-IN-11 可用于肿瘤相关疾病的药物制备。CD73-IN-11 是 CD73的有效抑制剂。CD73 可以催化细胞外5'-磷酸腺苷 (5'-AMP) 产生腺苷,从而诱导免疫抑制并促进肿瘤增殖和/或转移。 | |||
T64239 | Belatacept | ||
Belatacept (BMS 224818) 是一种选择性的 T 细胞共刺激 (T-cell costimulation) 阻滞剂。Belatacept 能够结合 CD 80/86 配体,从而对 CD-28 介导的 T 细胞共刺激表现出抑制作用。Belatacept 能够用于研究器官移植免疫抑制。 | |||
T12240 |
nor-NOHA acetate
Nω-Hydroxy-nor-L-arginine acetate |
Apoptosis; Arginase | Apoptosis; Immunology/Inflammation |
nor-NOHA acetate (Nω-Hydroxy-nor-L-arginine acetate) 是一种可逆的精氨酸酶抑制剂,具有抗白血病的作用,对内皮功能障碍、免疫抑制和代谢有效。在缺氧条件下,它可诱导 ARG2 表达细胞的凋亡。 | |||
T79653 | VISTA-IN-2 | Autophagy | Autophagy |
VISTA-IN-2(Compound 1)是一种抑制V结构域Ig抑制因子(VISTA)的化合物,能够诱导通过自噬(Autophagy)机制的VISTA降解。该化合物在克制VISTA介导的免疫抑制方面有效,提升免疫细胞对抗肿瘤的活性,并在CT26小鼠肿瘤模型中激发抗肿瘤免疫响应,进而抑止肿瘤生长。 | |||
T61000 |
CD73-IN-10
|
||
CD73-IN-10 可用于肿瘤相关疾病药物的制备。CD73-IN-10 是 CD73的有效抑制剂, 能够催化细胞外5'-磷酸腺苷 (5'-AMP) 产生腺苷。腺苷具有诱导免疫抑制的作用,能够促进肿瘤增殖和/或转移。 | |||
T79319 |
OATD-02
|
Arginase | Immunology/Inflammation |
OATD-02是一种口服可逆性的Arginase1和2双重抑制剂,表现出竞争性且非共价的抑制特性。作为缓释型抑制剂,OATD-02能够有效抑制细胞内的精氨酸酶活性,具有以下IC50s值:20 nM (hARG1)、39 nM (hARG2)、39 nM (mARG1)、28 nM (rARG1)。它还能够消除由两种精氨酸酶引起的肿瘤免疫抑制效应,适用于黑色素瘤研究。 | |||
T82609 |
Dargistotug
M-6223 |
||
Dargistotug (M-6223) 是一种靶向 TIGIT 的全人 IgG1 类型单克隆抗体。TIGIT 是一种带有 Ig 结构域和 ITIM 的 T 细胞免疫受体,充当抑制性免疫检查点。Dargistotug 通过与 CD155 等分子结合抑制 NK 细胞活性,减少细胞因子分泌,并能直接或间接地抑制效应 T 细胞活性和上调 Tregs,从而发挥免疫抑制作用。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2210 |
Genipin
京尼平,(+)-Genipin |
Others; Autophagy | Autophagy; Others |
Genipin ((+)-Genipin) 是衍生自黄栀果实的天然交联剂,可抑制细胞中的 UCP2 (解偶联蛋白 2)。它有蛋白质调节、抗肿瘤、抗炎症、免疫抑制、抗血栓形成和对海马神经元保护的多种生物活性,可研究 2 型糖尿病。 | |||
T0948L |
Corticosterone
皮质酮,17-Deoxycortisol,11β,21-Dihydroxyprogesterone,Kendall's compound B,肾上腺酮,Corticosterone (From plants) |
Glucocorticoid Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Corticosterone (Kendall's compound B) 是一种肾上腺皮质类固醇,有盐皮质激素和糖皮质激素的活性,具有口服活性。Corticosterone 参与体内能量、免疫反应和应激反应的调节。 | |||
T2729 |
Scoparone
滨蒿内酯,Escoparone,Scoparon,Aesculetin dimethyl ether,6,7-dimethoxycoumarin,6,7-Dimethylesculetin |
Others | Others |
Scoparone (Aesculetin dimethyl ether) 是分离自毛蒿中,具有抗凝血,抗血管舒张作用和抗炎活性。 | |||
TJS1779 |
Protosappanin A
原苏木素A,PTA |
NADPH-oxidase; IL Receptor; IκB/IKK; TNF; NF-κB; TLR; ROS; COX; HIV Protease; JAK; NO Synthase; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome; Stem Cells |
Protosappanin A (PTA) 是从苏木中分离得到的免疫抑制成分和主要联苯化合物,通过下调 JAK2和 STAT3的磷酸化,抑制 JAK2/STAT3依赖的炎症通路。 |