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Cat. No.	Product Name	Target	Signaling Pathways
T0251	Gemcitabine 吉西他滨,NSC 613327,LY188011	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Gemcitabine (LY188011) 是一种人工合成的胞嘧啶核苷衍生物，一种 DNA 合成抑制剂。Gemcitabine 具有抗肿瘤活性和抗代谢活性。Gemcitabine 可以引起细胞自噬和凋亡。
T15378L	Gemcitabine elaidate hydrochloride CO-101 hydrochloride,Gemcitabine elaidate hydrochloride(210829-30-4(free base)),Gemcitabine 5'-elaidate hydrochloride,CP-4126 hydrochloride	Others	Others
	Gemcitabine elaidate (CP-4126) hydrochloride 是 Gemcitabine 的亲脂性前药。Gemcitabine elaidate hydrochloride 通过酯酶转化为 Gemcitabine 以被磷酸化。Gemcitabine elaidate hydrochloride 可以口服给药，具有抗肿瘤活性。
T6069	Gemcitabine hydrochloride Gemcitabine HCl,吉西他滨盐酸盐,Gemzar,LY188011,盐酸吉西他滨,LY 188011 hydrochloride	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Gemcitabine hydrochloride (LY 188011 hydrochloride) 是一种人工合成的胞嘧啶核苷衍生物，一种 DNA 合成抑制剂。Gemcitabine 具有抗肿瘤活性和抗代谢活性。Gemcitabine 可以引起细胞自噬和凋亡。
T15378	Gemcitabine elaidate Gemcitabine 5'-elaidate,反油酸吉西他滨,吉西他滨反油酸酯,Gemcitabine (elaidate),CO-101,CP-4126	Apoptosis; Nucleoside Antimetabolite/Analog; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Gemcitabine elaidate (CP-4126) 是 Gemcitabine 的亲脂性前药。它通过酯酶转化为 Gemcitabine 以被磷酸化。它具有抗肿瘤活性。
T21329	Gemcitabine monophosphate disodium salt Gemcitabine monophosphate disodium salt monohydrate,Gemcitabine monophosphate disodium,GemMP
	R306465 is a novel HDAC inhibitor with broad-spectrum antitumor activity against solid (IC50: 30 to 300 nM) and hematological malignancies. R306465 was found to be a potent inhibitor of HDAC1 and -8 (class I) in vitro.
T4187	Gemcitabine monophosphate sodium salt hydrate	Others; DNA; DNA/RNA Synthesis; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	Gemcitabine monophosphate sodium salt hydrate 是Gemcitabine 的单磷酸盐衍生物。
T75252	Gemcitabine triphosphate
	Gemcitabine triphosphate (dFdCTP) 是 Gemcitabine 在细胞内的两种核苷代谢产物的一种。另一种是活性二磷酸 (dFdDTP)。Gemcitabine triphosphate 能够作为放射性标记探针成像研究的标准物，用于识别对 Gemcitabine 的肿瘤，并评估 Gemcitabine 被细胞摄取和保留性质。
T17985	Gemcitabine-O-Si(di-iso)-O-Mc	Others	Others
	Gemcitabine-O-Si(di-iso)-O-Mc, a drug-linker conjugate for Antibody-Drug Conjugates (ADC), exhibits potent antitumor activity. It incorporates Gemcitabine, a pyrimidine nucleoside analog antimetabolite and antineoplastic agent, connected through the ADC linker[1].
T4061	LY2334737	Nucleoside Antimetabolite/Analog; Others; Virus Protease	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	LY2334737 是一种具有口服活性的 Gemcitabine 的前药，也是核苷类似物。它抑制肠道病毒 A71 感染，有抗病毒和抗癌活性。
T6028	PF 477736 PF 00477736,PF-477736,PF-736,PF-00477736,PF477736	c-Fms; VEGFR; FGFR; FLT; c-RET; Chk; CDK; Src; Aurora Kinase	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
	PF 477736 (PF-736,PF-00477736) 是一种特异性、有效且具有 ATP 竞争性的 Chk1 抑制剂，Ki 值为0.49 nM。它也是Chk2抑制剂，Ki 值为 47 nM。它还抑制VEGFR2、Fms、Yes、Aurora-A、FGFR3、Flt3和Ret。
T4060	Acelarin N-(2'-脱氧-2',2'-二氟-P-苯基-5'-胞苷酰)-L-丙氨酸苄酯,NUC-1031	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Acelarin (NUC-1031) 是核苷类似物吉西他滨的 ProTide 改造和增强产品。
T67291	2′,2′-Difluorodeoxyuridine dFdU,2',2'-Difluoro-2'-deoxyuridine	Drug Metabolite	Metabolism
	2′,2′-Difluorodeoxyuridine (dFdU) 是 Gemcitabine 的主要代谢产物。2′,2′-Difluorodeoxyuridine 具有抗癌和抗肿瘤活性，在低氧条件下的显示出放射增敏作用，可用于研究胰腺癌。
T41345	AFMK Formyl-N-acetyl-5-methoxykynurenamine,Acetyl-N-formyl-5-methoxykynurenamine	Apoptosis; Free radical scavengers; Antioxidant; Endogenous Metabolite	Apoptosis; Metabolism; oxidation-reduction
	AFMK (Formyl-N-acetyl-5-methoxykynurenamine) 是褪黑激素的活性代谢物，具有抗氧化和自由基清除活性。 AFMK 是一种凋亡调节剂，可提高吉西他滨在 PANC-1 细胞中的抗肿瘤作用。
T16813	RX-3117 fluorocyclopentenylcytosine,TV-1360	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	RX-3117 (fluorocyclopentenylcytosine) 是一种新型的胞苷类似物，在几种癌细胞系中显示出抗癌活性，包括对吉西他滨耐药的变体。
T4126	CBL0137 Curaxin 137,CBLC137	NF-κB; p53	Apoptosis; NF-κB
	CBL0137 (Curaxin 137) 是一种代谢稳定的 curaxin，可激活 p53 (EC50: 0.37 μM) 并抑制 NF-κB (EC50: 0.47 μM)。它在功能上使促进染色质转录复合物 (FACT) 失活，从而驱动对 p53 和 NF-κB 的影响并促进癌细胞死亡。口服 CBL0137 在小鼠体内具有广泛的抗癌活性，可根除耐药性癌症干细胞，并增强吉西他滨在胰腺癌临床前模型中的疗效。
T71259	GNE-900 GNE900,GNE 900	Apoptosis; Chk	Apoptosis; Cell Cycle/Checkpoint
	GNE-900 是一种 ATP 竞争性、选择性和口服活性 ChK1抑制剂，对 ChKl,ChK2的 IC50值分别为为 0.0011，1.5 µM。GNE-900 废除 G2-M 检查点，增强 DNA 损伤，并诱导胞凋亡 (Apoptosis)。gemcitabine 和 GNE-900 给药显示抗肿瘤活性[1]< /sup>。
T19779	SL-01 Z L Phe chloromethyl ketone,NSC-251810,ZLPhe chloromethyl ketone,Z-Phe-chloromethylketone
	SL-01 is an oral derivative of gemcitabine. SL-01 inhibited human breast cancer growth through the induction of apoptosis. SL-01 inhibited human cancer growth more potently than gemcitabine.
T79198	S-Gem	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	S-Gem为TrxR依赖性前药，是Gemcitabine的衍生物，能够被TrxR选择性激活。与Gemcitabine相比，S-Gem展现出较低的细胞毒性。
T68981	PD-321852
	PD-321852 is a small-molecule Chk1 inhibitor, which potentiates gemcitabine-induced clonogenic death in a panel of pancreatic cancer cell lines and evaluated the relationship between endpoints associated with Chk1 inhibition and chemosensitization. Gemcitabine chemosensitization by minimally toxic concentrations of PD-321852 ranged from minimal (<3-fold change in survival) in Panc1 cells to >30-fold in MiaPaCa2 cells. PD-321852 inhibited Chk1 in all cell lines as evidenced by stabilization of Cd...
T82327	GEM–IB
	GEM–IB是一种由吉西他滨（GEM）-5'-磷酸与伊班膦酸盐（IB）组成的复合物。在小鼠骨肉瘤（OS）模型中，GEM–IB能够作为独立活性分子减轻肿瘤负担，并在与多西紫杉醇（DTX）联合使用时，能进一步保护骨结构并提高生存率。
T39290	FF-10502
	FF-10502 is a pyrimidine nucleoside antimetabolite and a structural analog of Gemcitabine. This compound effectively inhibits DNA polymerase α and β, demonstrating potent anticancer activity by targeting dormant cells.
T17175	Troxacitabine BCH-4556,SGX-145,SGX145,SPD-758,BCH4556,beta-L-OddC	Others	Others
	Troxacitabine, a DNA polymerase inhibitor, is potentially used for the treatment of acute myeloid leukemia (AML). In comparison with gemcitabine, troxacitabine was equally active against MiaPaCa and was more efficacious against Panc-01.
T74400	TC113
	TC113是一种与c(RGDyK)偶联的Gemcitabine。它通过整合素αvβ3可被A549细胞内化。此外，TC113对WM266.4和A549细胞表现出显著的抗增殖效果。
T18313	Mc-O-Si(di-iso)-Cl	Others	Others
	Mc-O-Si(di-iso)-Cl is a cleavable ADC linker, commonly employed in the synthesis of antibody-drug conjugates (ADCs) like Gemcitabine-O-Si(di-iso)-O-Mc [1].
T74765	Viral polymerase-IN-1 hydrochloride
	Viral polymerase-IN-1 hydrochloride 是一种 Gemcitabine 衍生物，有效抑制甲型和乙型流感病毒 (influenza) 感染，IC90值为 11.4-15.9 μM。Viral polymerase-IN-1 hydrochloride 对 SARS-CoV-2感染具有活性。Viral polymerase-IN-1 hydrochloride 通过影响细胞中的病毒 RNA 复制/转录来抑制流感病毒感染。
T63074	Ivaltinostat formic
	Ivaltinostat (CG-200745) formic 是一种口服具有活力的泛 HDAC 抑制剂，具有异羟肟酸部分，能够在催化袋底部结合锌。Ivaltinostat formic 对组蛋白 H3 和微管蛋白的脱乙酰作用具有抑制效果。Ivaltinostat formic 能够促使 p53 的积累，诱导 p53 依赖性反式激活，并提高 MDM2 和 p21 (Waf1/Cip1) 蛋白的表达。Ivaltinostat formic 增加 Gemcitabine 耐药细胞对 Gemcitabine 和 5-Fluorouracil (5-FU) 的敏感性。Ivaltinostat formic 诱导凋亡，并具有抗肿瘤效果。
T18369	N-(5-Hydroxypentyl)maleimide	Others	Others
	N-(5-Hydroxypentyl)maleimide is a non-cleavable ADC linker, commonly employed in the synthesis of antibody-drug conjugates (ADCs). It serves as a crucial component in the production of Gemcitabine-O-Si(di-iso)-O-Mc, an ADC compound [1].
T74530	GEM-5
	GEM-5为基于吉西他滨且含HIF-1α抑制剂(YC-1)的偶联物，IC50值为30 nM。此化合物能有效降低HIF-1α表达，并提高肿瘤抑制因子p53的表达量。GEM-5可诱导A2780细胞的凋亡(apoptosis)，进而抑制肿瘤生长。
T36103	TW9 TW9
	TW9 is a dual inhibitor of bromodomain 2 (BD2) in bromodomain-containing protein 4 (BRD4) and histone deacetylase 1 (HDAC1; IC50s = 0.074 and 0.29 μM, respectively).1It is selective for BD2 over BD1 in BRD4 (IC50= 0.72 μM) and for HDAC1 over HDAC2 (IC50= 2.5 μM). TW9 (50 nM) induces apoptosis in, and inhibits proliferation of, MIA PaCa-2 pancreatic cancer cells. It induces cell cycle arrest at the G1phase in HPAC pancreatic cancer cells when used at a concentration of 2 μM. TW9 acts synergistica...
T17059	Tetrahydrouridine NSC 112907,NSC112907,四氢尿苷,NSC-112907	DNA Methyltransferase	Chromatin/Epigenetic
	Tetrahydrouridine (NSC-112907; THU) 是一种多药耐药调节剂。它可用于癌症治疗，使肿瘤细胞对放射治疗更加敏感。它是一种竞争性胞苷脱氨酶 (CDA) 抑制剂，可抑制 ara-C 和吉西他滨等细胞毒性脱氧胞苷类似物分解代谢中的脱氨作用。
T79689	SIRT6-IN-3	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	SIRT6-IN-3 (compound 8a) 作为SIRT6的选择性抑制剂，其IC50值为7.49 μM。该化合物能有效抑制胰腺导管腺癌 (PDAC) 细胞的增殖，并诱导细胞凋亡。SIRT6-IN-3 通过抑制 DNA 损伤的修复作用，增强了吉西他滨对癌细胞的敏感性，常用于胰腺癌相关研究。
T70928	CB-1158-analog
	CB-1158-analog, also known as Numidargistat-analog and INCB01158-analog, is a potent and orally active arginase inhibitor with IC50=89 nM) . CB-1158 blocked myeloid cell-mediated suppression of T cell proliferation in vitro and reduced tumor growth in multiple mouse models of cancer, as a single agent and in combination with checkpoint blockade, adoptive T cell therapy, adoptive NK cell therapy, and the chemotherapy agent gemcitabine. CB-1158 increased tumor-infiltrating CD8+ T cells and NK cell...
T36424	DSPE-PEG(2000)-amine (sodium salt)
	DSPE-PEG(2000)-amine is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE . It has been used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents.1,2,3DSPE-PEG(2000)-amine has also been used in the synthesis of fluorescein isothiocyanate-loaded mesoporous silica nanoparticles for imaging applications.4It can be conjugated to a variety of functional molecules for improved cellular targeting and uptake of DSPE-PEG(2000)-amine-cont...

化合物

Cat.No: T0251

Synonym: 吉西他滨,NSC 613327,LY188011

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, Autophagy

Gemcitabine elaidate hydrochloride

Cat.No: T15378L

Synonym: CO-101 hydrochloride,Gemcitabine elaidate hydrochloride(210829-30-4(free base)),Gemcitabine 5'-elaidate hydrochloride,CP-4126 hydrochloride

Target: Others

Gemcitabine hydrochloride

Cat.No: T6069

Synonym: Gemcitabine HCl,吉西他滨盐酸盐,Gemzar,LY188011,盐酸吉西他滨,LY 188011 hydrochloride

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, Autophagy

Gemcitabine elaidate

Cat.No: T15378

Synonym: Gemcitabine 5'-elaidate,反油酸吉西他滨,吉西他滨反油酸酯,Gemcitabine (elaidate),CO-101,CP-4126

Target: Apoptosis, Nucleoside Antimetabolite/Analog, Autophagy

Gemcitabine monophosphate disodium salt

Cat.No: T21329

Synonym: Gemcitabine monophosphate disodium salt monohydrate,Gemcitabine monophosphate disodium,GemMP

Gemcitabine monophosphate sodium salt hydrate

Cat.No: T4187

Target: Others, DNA, DNA/RNA Synthesis, Autophagy

Gemcitabine triphosphate

Cat.No: T75252

Gemcitabine-O-Si(di-iso)-O-Mc

Cat.No: T17985

Target: Others

Cat.No: T4061

Target: Nucleoside Antimetabolite/Analog, Others, Virus Protease

Cat.No: T6028

Synonym: PF 00477736,PF-477736,PF-736,PF-00477736,PF477736

Target: c-Fms, VEGFR, FGFR, FLT, c-RET, Chk, CDK, Src, Aurora Kinase

Cat.No: T4060

Synonym: N-(2'-脱氧-2',2'-二氟-P-苯基-5'-胞苷酰)-L-丙氨酸苄酯,NUC-1031

Target: DNA/RNA Synthesis

2′,2′-Difluorodeoxyuridine

Cat.No: T67291

Synonym: dFdU,2',2'-Difluoro-2'-deoxyuridine

Target: Drug Metabolite

Cat.No: T41345

Synonym: Formyl-N-acetyl-5-methoxykynurenamine,Acetyl-N-formyl-5-methoxykynurenamine

Target: Apoptosis, Free radical scavengers, Antioxidant, Endogenous Metabolite

Cat.No: T16813

Synonym: fluorocyclopentenylcytosine,TV-1360

Target: Nucleoside Antimetabolite/Analog

Cat.No: T4126

Synonym: Curaxin 137,CBLC137

Target: NF-κB, p53

Cat.No: T71259

Synonym: GNE900,GNE 900

Target: Apoptosis, Chk

Cat.No: T19779

Synonym: Z L Phe chloromethyl ketone,NSC-251810,ZLPhe chloromethyl ketone,Z-Phe-chloromethylketone

Cat.No: T79198

Target: Nucleoside Antimetabolite/Analog

Cat.No: T68981

Cat.No: T82327

Cat.No: T39290

Cat.No: T17175

Synonym: BCH-4556,SGX-145,SGX145,SPD-758,BCH4556,beta-L-OddC

Target: Others

Cat.No: T74400

Mc-O-Si(di-iso)-Cl

Cat.No: T18313

Target: Others

Viral polymerase-IN-1 hydrochloride

Cat.No: T74765

Ivaltinostat formic

Cat.No: T63074

N-(5-Hydroxypentyl)maleimide

Cat.No: T18369

Target: Others

Cat.No: T74530

Cat.No: T36103

Synonym: TW9

Tetrahydrouridine

Cat.No: T17059

Synonym: NSC 112907,NSC112907,四氢尿苷,NSC-112907

Target: DNA Methyltransferase

Cat.No: T79689

Target: Sirtuin

Cat.No: T70928

DSPE-PEG(2000)-amine (sodium salt)

Cat.No: T36424

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