112
8
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T79557 |
fac-[Re(CO)3(L6)(H2O)][NO3]
|
Apoptosis | Apoptosis |
fac-[Re(CO)3(L6)(H2O)][NO3](compound 6)是一种具有针对线粒体功能失调的抗癌活性的铼(I)三羰基水配合物。该化合物对前列腺癌细胞展现出显著的细胞毒性,具有50 nM的IC50值(PC-3细胞)。fac-[Re(CO)3(L6)(H2O)][NO3]能够主要集中在细胞核,抑制PC3细胞的ATP生成并诱导细胞凋亡,而不触发坏死、焦亡或自噬过程。 | |||
T79558 |
fac-[Re(CO)3(L3)(H2O)][NO3]
|
||
fac-[Re(CO)3(L3)(H2O)][NO3](简称compound 3),是一种与线粒体功能障碍相关的抗前列腺癌剂。这种铼(I)三羰基水配合物对前列腺癌细胞系(PC-3)表现出显著的细胞毒性,其IC50值为0.32 μM。研究表明,fac-[Re(CO)3(L3)(H2O)][NO3]主要在线粒体中积聚,能够降低PC-3细胞的ATP生成,进而触发细胞副凋亡(paraptosis)机制,而不通过引发坏死、凋亡或自噬途径作用。 | |||
T29687 |
Afacifenacin
Afacifenacin fumarate,SMP-986,NS 986,NS-986,SMP 986,NS986,SMP986 |
AChR | Neuroscience |
Afacifenacin (SMP-986) fumarate 是一种 M3 毒蕈碱受体选择性拮抗剂,可用于研究缺血性心脏病,尿失禁和膀胱炎和其他疾病。 | |||
TP1106L |
α-Factor Mating Pheromone, yeast acetate
Mating Factor α acetate,α-Factor Mating Pheromone, yeast acetate(59401-28-4 free base) |
Others | Others |
α-Factor Mating Pheromone, yeast acetate (Mating Factor α acetate)(59401-28-4 free base) 是由酿酒酵母α细胞分泌的13个氨基酸的肽。 | |||
T28531 |
Facinicline hydrochloride
RG3487 |
5-HT Receptor; AChR | GPCR/G Protein; Neuroscience |
Facinicline hydrochloride (RG3487) 是一种口服有效的烟碱α7 receptor 部分激动剂,对人 nAChR 的 Ki 值为 6 nM。它可改善啮齿类动物的认知和感觉运动门控。它与5-HT3受体结合的 Ki 为 1.2 nM。 | |||
T21723L |
Epidermal Growth Factor Receptor Peptide Acetate
Epidermal Growth Factor Receptor Peptide Acetate(96249-43-3 Free base) |
Others | Others |
Epidermal Growth Factor Receptor Peptide Acetate (Epidermal Growth Factor Receptor Peptide Acetate (96249-43-3 Free base)) 存在于细胞表面,通过与其特异性配体的结合而被激活。EGFR 属于受体酪氨酸激酶(RTK) 的 ErbB 家族。 | |||
TP1144L |
Corticotropin-releasing factor (human) acetate
Corticotropin-releasing factor (human) acetate (86784-80-7 Free base) |
CRFR | GPCR/G Protein |
Corticotropin-releasing factor (human) acetate 刺激垂体前叶合成和分泌促肾上腺皮质激素。 | |||
T22774L |
eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species](TFA)
|
Others | Others |
eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species](TFA) 是延伸因子 1 亚基。真核翻译延伸因子 1 alpha 1 (EEF1A1) 编码延伸因子 alpha 亚基的同种型- 1 复合物,负责将氨酰 tRNA 酶促递送至核糖体。这种亚型(α 1)在脑、胎盘、肺、肝、肾和胰腺中表达,另一种亚型(α 2)在脑、心脏和骨骼肌中表达。这种亚型在 66% 的 Felty 综合征患者中被鉴定为自身抗原。已发现该基因在许多染色体上具有多个拷贝,其中一些(如果不是全部)代表不同的假基因。 | |||
T12218 |
NFAT Transcription Factor Regulator-1
|
IL Receptor | Immunology/Inflammation |
NFAT Transcription Factor Regulator-1 是 IL-2 合成 的抑制剂,IC50 值为182 nM。 | |||
T40042 |
Evifacotrep
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
Evfacotrep 是一种有效的短期瞬态受体电位通道5 拮抗剂。Evfacotrep 可用于神经系统疾病的研究。 | |||
T2184 |
Sulfachloropyridazine
Sulfachlorpyridazine,磺胺二甲基嘧啶 |
Antibacterial; Antibiotic | Microbiology/Virology |
Sulfachloropyridazine (Sulfachlorpyridazine) 是一种广谱磺酰胺,抑制革兰氏阳性和革兰氏阴性好氧细菌的生长。 | |||
T7121 |
Sulfaclozine
磺胺氯吡嗪,Sulfachloropyrazine,Sulfachloropyrazine sodium,N-(5-氯-3-吡嗪基)-4-氨基苯磺酰胺 |
Antibacterial; Antibiotic; Parasite | Microbiology/Virology |
Sulfachloropyrazine sodium(Sulfachloropyrazine) 是一种磺酰胺衍生物,具有抗菌和抗球虫作用。Sulfachloropyrazine sodium(Sulfachloropyrazine) 用于各种家禽疾病。 | |||
T0241 |
Sulfacarbamide
Sulfanilylurea,磺胺脲 |
Others | Others |
Sulfacarbamide (Sulfanilylurea) 是降血糖药物, 也具有作用于植物神经系统的能力。 | |||
T30785 |
Cefacetrile
Cefacetrilum,Cefacetrilo,Celospor,Cephacetrile,Cefacetril |
Antibiotic | Microbiology/Virology |
Cefacetrile (Cephacetrile) 是一种广谱的头孢类抗生素,具有抗菌活性,可用于研究革兰氏菌感染,作用与头孢噻吩作用。 | |||
T13041 |
Surfactin
|
HSV | Microbiology/Virology |
Surfactin 是一种有效的环状脂肽生物表面活性剂,可介导单价和二价阳离子(如钙)穿过脂质双层膜的通量,具有抗菌、抗真菌、抗支原体和溶血作用。 | |||
T1495 |
Cefaclor monohydrate
Cefaclor,头孢克洛一水物,头孢克洛一水合物,Cefaclorum,Cefachlor |
Antibacterial; Antibiotic | Microbiology/Virology |
Cefaclor monohydrate (Cefaclorum) 是一种抗生素,可特异性地结合青霉素结合蛋白。 | |||
T6374 |
Alfacalcidol
Bondiol,Etalpha,阿法骨化醇,1-hydroxy Vitamin D3,1.alpha.-Hydroxyvitamin D3,1-hydroxycholecalciferol |
Others | Others |
Alfacalcidol (Etalpha) 是一种维生素 D3 衍生物,是非选择性的维生素 D 受体活化剂,有用于骨质疏松研究的潜力。 | |||
T8679 |
Epidermal Growth Factor
|
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Epidermal Growth Factor 与表皮生长因子受体 (EGFR) 结合并刺激细胞生长和增殖。它被批准用于治疗糖尿病足溃疡。 | |||
T6321 |
Tofacitinib
托法替尼,Tasocitinib,CP-690550 |
ROCK; Apoptosis; JAK; Src | Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Tofacitinib (Tasocitinib) 是口服小分子 Janus 激酶抑制剂,用于治疗中度至重度类风湿性关节炎。 | |||
T0409 |
Phthalylsulfacetamide
酞磺醋胺,Enterosulfon,Enterosulfamid,Tamid |
Antibacterial | Microbiology/Virology |
Phthalylsulfacetamide (Tamid) 是一种磺胺类抗生素,用于皮肤和结膜的局部应用。 | |||
T2150 |
Guanfacine hydrochloride
盐酸胍法辛,Tenex,Intuniv,Guanfacine |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Guanfacine hydrochloride (Intuniv) 是一种 α2A 肾上腺素受体激动剂,Kd=31 nM,具有抗高血压作用。 | |||
T2398 |
Tofacitinib Citrate
CP-690550 citrate,柠檬酸托法替尼,枸橼酸托法替尼,Tasocitinib citrate,Tofacitinib (CP-690550) Citrate |
Apoptosis; Influenza Virus; JAK; Antibacterial; Antifungal | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Microbiology/Virology; Stem Cells |
Tofacitinib Citrate (CP-690550 citrate) 是 JAK1/2/3抑制剂,IC50分别为112,20 和 1 nM。它具有抗菌,抗真菌和抗病毒活性。 | |||
T21434 |
Sulfacetamide
NSC 63871,磺胺醋酰,NSC-63871,Sebizon,Region,NSC63871,Sulphacetamide,Acetosulfamine |
Others; Antibacterial; Antibiotic | Microbiology/Virology; Others |
Sulfacetamide (NSC-63871) 是一种抗生素,通过限制细菌生存所需的叶酸的存在来治疗睑缘炎或结膜炎,有潜力用于眼部感染的研究。 | |||
T0087 |
Sulfacetamide sodium monohydrate
磺胺乙酰钠水合物,Sulfacetamide sodium salt hydrate,Sulfacetamide sodium |
Antibacterial; Antibiotic; Autophagy | Autophagy; Microbiology/Virology |
Sulfacetamide sodium monohydrate 是一种磺胺类药物,用于治疗酒渣鼻和花斑糠疹。 | |||
T20503 |
Elfacos EHP
2-ethylhexyl palmitate,棕榈酸辛酯 |
Others | Others |
Elfacos EHP (2-ethylhexyl palmitate) 是一种衍生自 2-乙基己醇和棕榈酸的脂肪酸酯,可用作化妆品配方。 | |||
T38332 |
Complement factor D-IN-2
|
Complement System | Immunology/Inflammation |
Complement factor D-IN-2 是 omplement factor D 的有效抑制剂,在替代补体途径的早期和关键时刻靶向 factor D 并抑制补体级联反应。Complement factor D-IN-2在自身免疫疾病的方面有研究的价值。 | |||
TP1155L |
Human growth hormone-releasing factor acetate
|
GHSR | GPCR/G Protein |
Human growth hormone-releasing factor acetate 是一种下丘脑多肽,通过与垂体前叶细胞上的 GHRH 受体 (GHRHR) 结合来刺激 GH 的产生和释放。 | |||
T1996 |
Defactinib
PF-04554878,VS-6063 |
FAK | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Defactinib (VS-6063) 是新型的 FAK 抑制剂,能够时间和剂量依赖性的抑制 FAK 在 Tyr397 位点磷酸化。 | |||
T0087L |
Sulfacetamide sodium
Sulamyd sodium,磺乙酰胺钠盐,磺胺醋酰钠 |
Antibacterial; Antibiotic; Autophagy | Autophagy; Microbiology/Virology |
Sulfacetamide sodium (Sulamyd sodium) 是磺胺类抗感染剂,可局部用于口服治疗尿路感染和皮肤感染。 | |||
T13426 | (3R,4S)-Tofacitinib | Others | Others |
(3R,4S)-Tofacitinib is an less active enantiomer of Tofacitinib. Tofacitinib is a JAK3 inhibitor(IC50 : 1 nM). | |||
T31741 |
Facinicline (free base)
MEM-3454,RO-5313534,RG-3487,RG3487,R-3487,Facinicline |
||
Facinicline (free base) is a partial agonist of the nicotinic alpha-7 (α7) receptor. It is used for the oral treatment of Alzheimer's. | |||
T23407 | surface antigen (208-215) [Hepatitis B Virus] | Others | Others |
The nucleocapsid of the hepatitis B virus is covered by an envelope of HBV surface antigen (HBsAg), which has the common, group-specific determinant a. The four major subtypes of HBsAg, adw, adr, ayw and ayr, are generated, and they have been proposed to | |||
T15092 |
Defactinib hydrochloride
VS-6063 hydrochloride,PF 04554878 hydrochloride |
FAK | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Defactinib hydrochloride (PF 04554878 hydrochloride) (VS-6063 hydrochloride; PF 04554878 hydrochloride) 是一种新型 FAK 抑制剂,抑制 FAK 在 Tyr397 位点磷酸化,这种作用具有时间和剂量依赖性。 | |||
TP2229 |
Epidermal growth factor receptor (994-1002) acetyl/amide
|
Others | Others |
The epidermal growth factor receptor is the cell-surface receptor for members of the epidermal growth factor family of extracellular protein ligands. | |||
T76361 |
[DPro5] Corticotropin Releasing Factor, human, rat
|
||
[DPro5] Corticotropin Releasing Factor, human, rat 是人类和大鼠促肾上腺皮质激素释放因子/激素 R2 的选择性激动剂。作为一种下丘脑激素,促肾上腺皮质激素释放因子 (CRF) 能够促进肾上腺皮质激素 (ACTH) 和 β-内啡肽的分泌。值得注意的是,[DPro5] Corticotropin Releasing Factor, human, rat 并不触发典型的焦虑反应,而是能调控大鼠的学习与记忆过程。 | |||
T76362 |
[Met(O)21] Corticotropin Releasing Factor, ovine
|
||
[Met(O)21] Corticotropin Releasing Factor, ovine 是一种从绵羊下丘脑提取物中分离出的促肾上腺皮质激素释放因子(CRF)。该因子为一类下丘脑激素,主要功能为促进肾上腺皮质激素(ACTH)的分泌。 | |||
TP2451 |
Arthrofactin
|
||
Arthrofactin is a lipopeptide biosurfactant. | |||
T37819 |
Brain-Derived Acidic Fibroblast Growth Factor (102-111) (bovine) (trifluoroacetate salt)
|
||
Brain-derived acidic fibroblast growth factor (102-111) is a peptide fragment of brain-derived acidic fibroblast growth factor (aFGF). aFGF is an angiogenic vascular endothelial cell mitogen produced in bovine brain that has sequence homology to interleukin-1. It also shares sequence homology with the known neuropeptides neuromedin C , bombesin , neuromedin K , substance K , substance P , physalaemin, and eledoisin. aFGF (102-111) corresponds to amino acid residues 102-111 of the fulllength pept... | |||
T30743 |
Carbon dioxide reduction factor
Methanofuran,Cdr factor |
||
Carbon dioxide reduction factor is a coenzyme of methanogenesis from carbon dioxide. | |||
T62688 |
Factor B-IN-4
|
||
Factor B-IN-4 是一种补体因子 B (complement factor B) 的有效抑制剂 (IC50: 1 μM)。Factor B-IN-4 能够用于研究炎症和免疫相关疾病。 | |||
T16898 |
Complement factor D-IN-1
|
Others | Others |
Complement factor D-IN-1 is an effective and selective small-molecule reversible factor d inhibitor (IC50s: 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively). | |||
T62292 |
Factor B-IN-2
|
||
Factor B-IN-2 是一种补体因子 B (complement factor B) 的有效抑制剂 (IC50: 1.5 μM)。Factor B-IN-2 能够用于研究炎症和免疫相关疾病。 | |||
T34740 |
Sulfacytine
Renoquid,CI636,CI-636,CI 636,磺胺西汀,Sulfacitinum |
||
Sulfacytine is a short-acting sulfonamides antibiotic that is taken orally to treat bacterial infections. Sulfonamides, a group of antibiotics, work by inhibiting bacterial production of folic acid. | |||
T11644 |
Impurity C of Alfacalcidol
|
Others | Others |
Impurity of Alfacalcidol is an impurity of Alfacalcidol. Alfacalcidol is a non-selective VDR activator medication. | |||
T22774 |
eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]
|
Others | Others |
eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed | |||
T72406 |
Tofacitinib Prodrug-1
|
||
Tofacitinib Prodrug-1 是减轻托法替尼 (Tofacitinib) 全身性不良反应的口服有效前药。Tofacitinib Prodrug-1 能在小鼠模型有效减轻恶唑酮诱导的结肠炎,具有低毒性,是治疗溃疡性结肠炎的潜在候选药物。 | |||
TP2466 |
Platelet factor 4 (59-70)
PF4 (59-70) |
||
Platelet factor 4 (59-70) elicits human neutrophil & monocyte chemotaxis. | |||
T81087 |
Stick Insect Hypertrehalosaemic Factor II
|
||
Stick Insect Hypertrehalosaemic Factor II为合成肽,展现出与天然样品一致的FAB光谱、反相高效液相色谱特性以及生物活性,适用于高海藻糖效应的研究。 | |||
TMIH-0531 |
Sulfachloropyrazine-d4
|
||
Sulfachloropyrazine-d4 是 Sulfachloropyrazine 的氘代化合物。Sulfachloropyrazine 的 CAS 号为 102-65-8。Sulfachloropyrazine sodium是一种磺酰胺衍生物,具有抗菌和抗球虫作用。Sulfaclozine 用于各种家禽疾病。 | |||
T35591 |
Guanfacine-13C,15N3
Guanfacine-13C,15N3 |
||
Guanfacine-13C,15N3is intended for us as an internal standard for the quantification of guanfacine by GC- or LC-MS. Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with Kivalues of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand binding assay.1It has EC50values of 52, 288, and 602 nM for α2A-, α2B-, and α2C-ARs, respectively, for stimulated [35S]GTPγS binding. It also binds to imidazoline receptor 1 (Ki= 19 nM in a radioligand binding assay).2Guanfacin... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T20819 |
Ammonium iron(III) citrate
柠檬酸铁铵,柠檬酸铁 (III) 铵,Ferric ammonium citrate |
Others; Ferroptosis | Apoptosis; Others |
Ammonium iron(III) citrate (Ferric ammonium citrate) 是一种非运铁蛋白结合的铁的生理形式,会引起的细胞内铁超负荷从而导致细胞铁死亡,能增强蛋白质产生。 | |||
TN1634 |
Euphorbia factor L7b
千金子素L7B |
Others | Others |
Euphorbia factor L7b 是从大戟属植物大戟中提取的天然产物。 | |||
T2S0410 |
Euphorbia factor L1
Euphorbiasteroid,大戟因子L1,大戟因子 L1 |
Apoptosis; P-gp | Apoptosis; Membrane transporter/Ion channel; Neuroscience |
Euphorbia factor L1 (Euphorbiasteroid) 可降低 Bcl-2,PI3K,AKT 和 mTOR 蛋白和 mRNA 水平,上调 caspase-9 and caspase-3 蛋白水平。它可诱导自噬,具有抗癌、抗脂肪生成、抗破骨细胞生成和多重耐药调节作用。 | |||
T125211 |
Deoxy euphorbia factor L1
|
Others | Others |
Deoxy euphorbia factor L1是一种天然产物,存在于植物续随子 Euphorbia lathyris L 的种子中。 | |||
T5798 |
Euphorbia Factor L2
千金子素L2,euphorbiafactor L2,大戟因子L2 |
Apoptosis; NF-κB | Apoptosis; NF-κB |
Euphorbia Factor L2 是从大戟种子中分离得到的一种赤藓烷二萜,显示强烈的细胞毒性并通过线粒体途径诱导细胞凋亡,具有抗癌活性。 | |||
TN1635 |
Euphorbia factor L8
|
Others | Others |
Euphorbia factor L8 是大戟种子中的二萜。 | |||
T78500 |
α-Factor Mating Pheromone, yeast TFA
Mating Factor α TFA |
||
α-Factor Mating Pheromone, yeast (TFA)为一来自S. cerevisiae的α细胞分泌的十三肽,通过Ste2p受体发挥作用。 | |||
TN1633 |
Euphorbia factor L7a
|
Others | Others |
Euphorbia factor L7a 是大戟种子中的二萜。 |