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117

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9832	(Rac)-EC5026 Urea, N-[3-fluoro-4-(trifluoromethoxy)phenyl]-N'-[1-(2-methyl-1-oxobutyl)-4-piperidinyl]-	Epoxide Hydrolase	Metabolism
	(Rac)-EC5026 ((Rac)-BPN-19186) 是一种有效的可溶性环氧水解酶 (sEH) 哌啶抑制剂，Ki 值为 0.06 nM。(Rac)-EC5026 可用于帕金森氏病和路易体痴呆 (DLB) 的研究。
T21468	CVT-2738 UNII-NYS3I6283H,CVT 2738,EC 610-916-8,CVT2738,RS-94287,N-(2,6-二甲基苯基)-1-哌嗪乙酰胺	Others	Others
	CVT-2738 (RS-94287) 是雷诺嗪的代谢物。 Ranolazine 是一种部分脂肪酸氧化 (pFOX) 抑制剂和抗心绞痛药物。
T21312	Afatinib 阿法替尼,Afatinib free base,BIBW 2992	EGFR; Autophagy	Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Afatinib (BIBW 2992) 是一种不可逆的 EGFR 家族抑制剂，抑制 EGFRwt、EGFRL858R、EGFRL858R/T790M 和 HER2的 IC50分别为0.5 nM、0.4 nM、10 nM 和 14 nM。
T20049	Brilliant Blue EC 272-939-6,Blue 1 lake,Brilliant Blue FCF Lake
	FD&C Blue No. 1 aluminum lake is an agent of dye.
T1773	Afatinib Dimaleate 马来酸阿法替尼,双马来酸盐阿法替尼,BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate	EGFR; HER; Autophagy	Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Afatinib Dimaleate (BIBW 2992MA2) 是一种可口服的苯胺基-喹唑啉衍生物和受体酪氨酸激酶表皮生长因子受体家族的抑制剂，具有抗肿瘤活性。它抑制 EGFRwt、EGFRL858R、EGFRL858R/T790M 和 HER2的 IC50分别为0.5 nM、0.4 nM、10 nM 和 14 nM。
T9147	FEN1-IN-3
	FEN1-IN-3 是一种人类皮瓣内切核酸酶-1 (hFEN1) 抑制剂，可使 hFEN1 稳定化，EC50为 6.8 μM。
T60218	YAP/TAZ inhibitor-2	YAP	Stem Cells
	YAP/TAZ inhibitor-2 是一种有效的具有口服活性的TEAD-YAP/TAZ 抑制剂，EC50值为 3 nM。YAP/TAZ inhibitor-2 具有抗增殖和抗肿瘤活性。
T9000	Pyrimorph	Antifungal	Microbiology/Virology
	Pyrimorph 是一种杀真菌剂，对 oomycetes 具有良好抑菌活性。
T60325	Viloxazine Emovit,Viloxazin	5-HT Receptor; Norepinephrine	GPCR/G Protein; Neuroscience
	Viloxazine (Viloxazin) (Viloxazin) is a dual-action compound that functions as a norepinephrine reuptake inhibitor and exhibits potent agonistic activity towards 5-HT 2C receptors while acting as an antagonist for 5-HT 2B receptors, with respective potency values of EC 50 = 32 μM and IC 50 = 27 μM. Its primary mechanism of action involves the modulation of serotonergic and noradrenergic pathways. Viloxazine is commonly employed in depression research [1] [2].
T6729	Lomibuvir VX-222,VCH-222	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Lomibuvir (VCH-222) (VX-222) 是丙型肝炎病毒 NS5B 聚合酶的一种非核苷变构抑制剂，Kd 值为 17 nM，已证明具有临床疗效。Lomibuvir 抑制 1b/Con1 型 HCV 亚基因组复制子，EC50为 5.2 nM。Lomibuvir 优先抑制延长的 RNA 合成，而非从头合成的 RNA。
T40319	PIM-IN-1
	PIM-IN-1 is a pan-PIM kinase inhibitor (KG-1, EC 50 = 61 nM; pS6, EC 50 = 71 nM).
T76670	hMC1R agonist 1
	hMC1R agonist 1 是一种有效的选择性hMC1R 激动剂(EC50=3 nM)，hMC1R agonist 1 对hMC1R 的选择性是hMC3R(b>EC50=902 nM)，hMC4R(b>EC50=915 nM)，和hMC5R(b>EC50=>1000 nM) 的 300 倍。hMC1R agonist 1 有研究和预防黑皮质素家族疾病的潜能。
T78342	Glutathione reductase EC 1.6.4.2
	Glutathione reductase (EC 1.6.4.2) 是维持还原型谷胱甘肽供应的还原酶。
T83163	Adrenomedullin (rat)
	Adrenomedullin(rat) 为一种由内皮细胞（EC）与血管平滑肌细胞（VSMC）分泌的有效血管舒张肽。
T61775	mGlu4 receptor agonist 1
	mGlu4 receptor agonist 1 (compound 62) is a highly effective positive allosteric modulator of mGlu4 receptors, displaying an EC 50 of 308 nM. Additionally, it exhibits noteworthy anxiolytic and antipsychotic properties [1].
T79415	Antiparasitic agent-18	Parasite	Microbiology/Virology
	Antiparasitic agent-18 (compound 3a) 对T. brucei (EC50=0.4 μM)、T. cruzi (EC50=0.21 μM) 和 L. donovani (EC50=0.26 μM) 表现出高度的活性和选择性，证明其为一种有效的抗原虫化合物。
T76046	BigLEN(rat) TFA
	BigLEN(rat)是一种有效的GPR171激动剂，其EC50为1.6 nM。
T38727	Azvudine hydrochloride RO-0622 hydrochloride,Azvudine hydrochloride,FNChydrochloride
	Azvudine hydrochloride (RO-0622) is a potent nucleoside reverse transcriptase inhibitor (NRTI) that exhibits strong antiviral effects against HIV, HBV, and HCV. It demonstrates highly potent inhibition of HIV-1 (EC 50 ranging from 0.03 to 6.92 nM) and HIV-2 (EC 50 ranging from 0.018 to 0.025 nM). Additionally, Azvudine hydrochloride effectively inhibits NRTI-resistant viral strains.
T61277	mGluR2 modulator 4
	mGluR2 modulator 4 (compound 47) is a highly potent positive allosteric modulator of mGluR2, exhibiting an EC 50 value of 0.8 μM. It holds the potential for investigating antipsychotic properties [1].
T75416	alpha-1,3-N-Acetylgalactosaminyltransferase (Pm1138)
	alpha-1,3-N-Acetylgalactosaminyltransferase (Pm1138) (EC 2.4.1.40(Pm1138))，是一种ABO系统转移酶，具备糖基转移酶活性。
T61645	Utrophin modulator 1
	Utrophin Modulator 1 (UM1) is a highly effective agent that upregulates utrophin protein levels, displaying an EC 50 of 0.11 μM. Its application in the investigation of Duchenne Muscular Dystrophy (DMD) has been well-established [1].
T60985	KCa2 channel modulator 1
	KCa2 channel modulator 1 (compound 2o) 是有效的亚型选择性的K/Ca 通道的正调节剂，其增强大鼠 KCa2.2 通道亚型的EC50值为 0.99 μM 和人KCa2.3 通道亚型的EC50值为 0.19 μM。
T29343	2-Decenoic acid Dec-2-enoic acid
	trans-Dec-2-enoic acid is an intermediate in fatty acid biosynthesis. Specifically, trans-Dec-2-enoic is converted from (R)-3-Hydroxydecanoic acid via enzyme, fatty-acid Synthase (EC:2. 3. 1. 85).
T61255	SDH-IN-1
	SDH-IN-1 (compound 4i) is a potent succinate dehydrogenase (SDH) inhibitor, exhibiting an IC 50 value of 4.53 μM. This compound displays strong antifungal properties, particularly against S. sclerotiorum, with an EC 50 value of 0.14 mg/L [1].
T61655	AM-1488
	AM1488 是一种有效的、具有口服活性的甘氨酸受体 (GlyR) 增效剂 (hGlyRα3EC50=0.45 μM)。
T41237	W146 TFA
	W146 TFA 是选择性 1-磷酸-鞘氨醇受体亚型 1 (S1PR1) 的拮抗剂，EC50值为 398 nM。
T61086	HN37
	HN37 是有效且稳定的抗癫痫活性的化合物，其对KCNQ2的EC50值为 37 nM。
T61079	RXFP3 agonist 1
	RXFP3 agonist 1 是一种非肽的RXFP3激动剂 (EC50=6937 nM)。
T73370	RSV-IN-7
	RSV-IN-7 (example 253) 是一种 RSV 抑制剂 (EC50: < 0.4 μΜ)。
T60810	Influenza virus-IN-2
	Influenza virus-IN-2 (compound 19) 具有抗甲型流感病毒活性，是有效的流感病毒抑制剂，CC50值为 150.85 μM，EC50值为 2.58 μM,。Influenza virus-IN-2 浓度依赖性的抑制 PAN 核酸内切酶，EC50为 489.39 nM。
T73313	DENV-IN-9
	DENV-IN-9 是一种DENV2抑制剂，EC50为 0.88 μM。
T61560	Antileishmanial agent-5
	Antileishmanial agent-4 is a ribonucleoside analogue with potent activity against L.infantum and T.cruzi, having EC 50 values of 0.68 μM and 0.83 μM, respectively [1].
T61417	PPARγ agonist 7
	PPARγ agonist 7 (Compound 3a) is a highly potent and selective agonist of the peroxisome proliferator-activated receptor gamma (PPARγ). It specifically stimulates adiponectin production in human bone marrow mesenchymal stem cells (hBM-MSCs), making it an innovative full agonist of PPARγ with an EC 50 value of 4.34 μM [1].
T62007	CXCR4 modulator-1
	CXCR4 modulator-1 (compound ZINC72372983) 是有效的CXCR4调节剂（EC50= 100 nM）。CXCR4 modulator-1 在抗炎、抗癌及抗 HIV 感染方面有研究价值。
T27786	L-796568 dihydrochloride L 796568,L-796568,L796568
	L-796568, is a β3 adrenergic receptor agonist. L-796568 is a potent full beta(3) agonist (EC(50) = 3.6 nM, 94% activation) with >600-fold selectivity over the human beta(1) and beta(2) receptors, which also displays good oral bioavailability in several
T61848	Rosiglitazone potassium
	Rosiglitazone (BRL 49653) potassium is a potent and selective PPARγ agonist (EC 50: 60 nM, Kd: 40 nM), administered orally. It also serves as an activator of TRPC5 (EC 50: 30 μM) and an inhibitor of TRPM3. This compound, widely used in research, has shown promise in investigating obesity, diabetes, senescence, and ovarian cancer [1] [2] [4] [7].
T6310L	GW3965
	GW3965 是选择性的肝 X 受体 (LXR) 激动剂，对 hLXRα 和 hLXRβ 的 EC50分别为 190 nM 和 30 nM。
T74984	ACBI2
	ACBI2 是一种高效且具有口服活性的VHLPROTAC(EC50: 7 nM)，可降解SMARCA2(RKO 细胞中DC50: 1 nM)。ACBI2 可用于肺癌的研究。
T61055	GPR40 agonist 6
	GPR40 agonist 6 (Compound 7a) 是游离脂肪酸受体 1的选择性激动剂（FFAR1或GPR40），其对于GPR40的EC50值为 0.058 μM。
T60977	TL8-506
	TL8-506 可用于研究自身免疫性疾病和结核病，它是 TLR8的特异性激动剂 (EC50 = 30 nM)。
T38793	THI0019 THI0019
	THI0019 is a highly potent agonist of the integrin α4β1 (VLA-4) receptor, with an EC 50 range of 1-2 μM. It effectively promotes the adhesion of stem/progenitor cells. Furthermore, THI0019 successfully modulates adhesion processes mediated by α4β7, α5β1, and αLβ2 integrins.
T60374	L-Fd4A
	L-Fd4A (compound 36) 是腺嘌呤衍生物，具有抗人类免疫缺陷病毒 (HIV) (EC50=1.5 μM) 和抗乙型肝炎病毒 (HBV) (EC50=1.7 μM) 活性。L-Fd4A 具有低细胞毒性。
T60743	Vin-C01
	Vin-C01 可用于研究Ⅱ型糖尿病，是胰腺 β 细胞的有效保护剂 (EC 50 = 0.22 μM)。Vin-C01 保护 β 细胞免受 STZ 诱导的细胞凋亡，并有效促进 β 细胞存活。
T26667	ASN04421891 ASN 04421891,ASN-04421891
	ASN04421891 是一种 GPR17受体调节剂，在 [35S]GTPγS 结合实验中 EC50为 3.67 nM，具有神经退行性疾病的研究潜力。
T61507	5-HT2A receptor agonist-2
	5-HT2A receptor agonist-2 is a potent compound that acts as an agonist on the serotonin 5-HT2 receptor. It specifically stimulates the 5-HT 2A, 5-HT 2B, and 5-HT 2C receptors, with EC 50 values of 1.7 nM, 0.58 nM, and 0.50 nM, respectively [1].
T61256	ARN1468
	ARN1468 (compound 5) is a highly effective orally active inhibitor of serpins. Inhibition of serpins activity by ARN1468 enables release of proteases, thereby reducing prion accumulation. ARN1468 demonstrates pronounced anti-prion effects in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC 50 values of 8.64, 19.3, 11.2, and 6.27 μM [1].
T61762	Zika virus-IN-3
	Zika virus-IN-3 (Compd 7) 是Zika 病毒的抑制剂，其EC50值为 3.4 μM。
T60697	Influenza virus-IN-1
	Influenza virus-IN-1 (compound 14) 具有抗甲型流感病毒活性，它是甲型流感病毒的有效抑制剂，其CC50值 >200 μM，EC50值为 2.46 μM。Influenza virus-IN-1 对 PAN 核酸内切酶显示出浓度依赖性的抑制活性 (EC50 = 312.36 nM)。
T38773	LeuRS-IN-1 hydrochloride
	LeuRS-IN-1 hydrochloride is a potent and orally active inhibitor of M. tuberculosis leucyl-tRNA synthetase (M.tb LeuRS). It has IC 50 and Kd values of 0.06 μM and 0.075 μM, respectively, for M.tb LeuRS. Additionally, LeuRS-IN-1 hydrochloride inhibits human cytoplasmic LeuRS with an IC 50 of 38.8 μM and HepG2 protein synthesis with an EC 50 of 19.6 μM.
T75921	[Ala11,D-Leu15]-Orexin B(human) TFA
	[Ala11,D-Leu15]-Orexin B(human) TFA为高效的orexin-2 receptor (OX2)选择性激动剂。其对OX2展现出比OX1 (52 nM) 高达400倍的较高选择性(EC50=0.13 nM)。

化合物

Cat.No: T9832

Synonym: Urea, N-[3-fluoro-4-(trifluoromethoxy)phenyl]-N'-[1-(2-methyl-1-oxobutyl)-4-piperidinyl]-

Target: Epoxide Hydrolase

Cat.No: T21468

Synonym: UNII-NYS3I6283H,CVT 2738,EC 610-916-8,CVT2738,RS-94287,N-(2,6-二甲基苯基)-1-哌嗪乙酰胺

Target: Others

Cat.No: T21312

Synonym: 阿法替尼,Afatinib free base,BIBW 2992

Target: EGFR, Autophagy

Cat.No: T20049

Synonym: EC 272-939-6,Blue 1 lake,Brilliant Blue FCF Lake

Afatinib Dimaleate

Cat.No: T1773

Synonym: 马来酸阿法替尼,双马来酸盐阿法替尼,BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate

Target: EGFR, HER, Autophagy

Cat.No: T9147

YAP/TAZ inhibitor-2

Cat.No: T60218

Target: YAP

Cat.No: T9000

Target: Antifungal

Cat.No: T60325

Synonym: Emovit,Viloxazin

Target: 5-HT Receptor, Norepinephrine

Cat.No: T6729

Synonym: VX-222,VCH-222

Target: HCV Protease

Cat.No: T40319

hMC1R agonist 1

Cat.No: T76670

Glutathione reductase

Cat.No: T78342

Synonym: EC 1.6.4.2

Adrenomedullin (rat)

Cat.No: T83163

mGlu4 receptor agonist 1

Cat.No: T61775

Antiparasitic agent-18

Cat.No: T79415

Target: Parasite

BigLEN(rat) TFA

Cat.No: T76046

Azvudine hydrochloride

Cat.No: T38727

Synonym: RO-0622 hydrochloride,Azvudine hydrochloride,FNChydrochloride

mGluR2 modulator 4

Cat.No: T61277

alpha-1,3-N-Acetylgalactosaminyltransferase (Pm1138)

Cat.No: T75416

Utrophin modulator 1

Cat.No: T61645

KCa2 channel modulator 1

Cat.No: T60985

2-Decenoic acid

Cat.No: T29343

Synonym: Dec-2-enoic acid

Cat.No: T61255

Cat.No: T61655

Cat.No: T41237

Cat.No: T61086

RXFP3 agonist 1

Cat.No: T61079

Cat.No: T73370

Influenza virus-IN-2

Cat.No: T60810

Cat.No: T73313

Antileishmanial agent-5

Cat.No: T61560

PPARγ agonist 7

Cat.No: T61417

CXCR4 modulator-1

Cat.No: T62007

L-796568 dihydrochloride

Cat.No: T27786

Synonym: L 796568,L-796568,L796568

Rosiglitazone potassium

Cat.No: T61848

Cat.No: T6310L

Cat.No: T74984

GPR40 agonist 6

Cat.No: T61055

Cat.No: T60977

Cat.No: T38793

Synonym: THI0019

Cat.No: T60374

Cat.No: T60743

Cat.No: T26667

Synonym: ASN 04421891,ASN-04421891

5-HT2A receptor agonist-2

Cat.No: T61507

Cat.No: T61256

Zika virus-IN-3

Cat.No: T61762

Influenza virus-IN-1

Cat.No: T60697

LeuRS-IN-1 hydrochloride

Cat.No: T38773

[Ala11,D-Leu15]-Orexin B(human) TFA

Cat.No: T75921

Cat. No.	Product Name	Target	Signaling Pathways
T21184	Decanenitrile AI3-11101,Caprinitrile,1-Cyanononane,EC 217-830-6,Decanonitrile
	Decanenitrile is a biochemical.
T3S1892	Crassicauline A 粗茎乌头碱甲,Crassicauline I	Others	Others
	Crassicauline A (Crassicauline I) 是一种乌头根中具有生物活性的生物碱。它对赤拟谷盗成虫具有拒食剂作用，其 EC50=1134.5 ppm。
T4S0999	(2S)-Isoxanthohumol Isoxanthohumol,(2S)-异黄腐酚,异黄腐醇	Virus Protease; HSV	Microbiology/Virology
	(2S)-Isoxanthohumol 是一种由啤酒花原异戊烯基二氢黄酮 Isoxanthohumol 的微生物转化代谢物。
TN3219	7,8-Didehydrocimigenol	ERK; IκB/IKK; TNF; NF-κB; Akt; PPAR	Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Metabolism; NF-κB; PI3K/Akt/mTOR signaling
	7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of TNF-α-activated EC which leads to selective inhibition of VCAM-1 expression.
T60245	Norepinephrine hydrochloride
	Norepinephrine hydrochloride (Levarterenol hydrochloride) 是一种β1选择性的肾上腺素受体激动剂，EC50值为 5.37 μM。
TN2533	1-Hydroxy-2,3,4,7-tetramethoxyxanthone	5-HT Receptor	GPCR/G Protein; Neuroscience
	1-Hydroxy-2,3,4,7-tetramethoxy-xanthone has vasodilatory action, it can cause vasodilation in the coronary artery pre-contracted with 1uM 5-hydroxytryptamine (5-HT), with the EC 50 value of 6.6±1.4 uM. 1-Hydroxy-2,3,4,7-tetramethoxyxanthone can effectivel
T75499	Maceneolignan H
	Maceneolignan H (Compound 8)是一种新的木脂素化合物，从肉豆蔻假种皮中分离而来。它表现为选择性CCR3拮抗剂(EC50=1.4 μM)，具有研究过敏性疾病潜力。
T83446	15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide
	15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide (compound 2), 一种从冬凌草提取的ent-kaurene diterpenoid，显示了对多个细胞系的细胞毒性作用。具体而言，其对EC-1、U87、A549、MCF-7 和 Hela 细胞系的IC50值分别为37.69 μM、79.362 μM、80.07 μM、197.35 μM、462.13 μM 和180.09 μM。
TN4585	Moronic acid	HIV Protease; Antifection; HSV	Microbiology/Virology; Proteases/Proteasome
	Moronic acid shows oral therapeutic efficacy in HSV-infected mice and possessed novel anti-HSV activity. It also shows significant anti-HIV activity (EC(50) 186) and was modified to develop more potent anti-AIDS agents. Moronic acid is a new structural lead for anti-EBV drug development, can substantially reduce the numbers of EBV particles produced by the cells after lytic induction. Morolic and moronic acids have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an...

天然产物

Cat.No: T21184

Synonym: AI3-11101,Caprinitrile,1-Cyanononane,EC 217-830-6,Decanonitrile

Crassicauline A

Cat.No: T3S1892

Synonym: 粗茎乌头碱甲,Crassicauline I

Target: Others

(2S)-Isoxanthohumol

Cat.No: T4S0999

Synonym: Isoxanthohumol,(2S)-异黄腐酚,异黄腐醇

Target: Virus Protease, HSV

7,8-Didehydrocimigenol

Cat.No: TN3219

Target: ERK, IκB/IKK, TNF, NF-κB, Akt, PPAR

Norepinephrine hydrochloride

Cat.No: T60245

1-Hydroxy-2,3,4,7-tetramethoxyxanthone

Cat.No: TN2533

Target: 5-HT Receptor

Maceneolignan H

Cat.No: T75499

15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide

Cat.No: T83446

Cat.No: TN4585

Target: HIV Protease, Antifection, HSV

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