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77

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T21661L	BIM 23042 Acetate BIM 23042 Acetate (111857-96-6 Free base)	Others	Others
	BIM 23042 Acetate 是一种选择性的神经调节素 B 拮抗剂。
T21944L	BIM 23056 Acetate BIM 23056 Acetate (150155-61-6 Free base)	Others	Others
	BIM 23056 Acetate 是一种有效且可克服的人类重组 sst5 受体拮抗剂。
T39262L	BIM-23190 aceate	Somatostatin	GPCR/G Protein
	BIM-23190 aceate 是一种生长抑素类似物，一种 SSTR2 和 SSTR5 的选择性激动剂。 BIM-23190 可用于癌症和肢端肥大症研究。
T16519L	BIM-46187 4HCl PH-064 4HCl	Others	Others
	BIM-46187 4HCl (PH-064 4HCl) 是一种异源三聚体 G 蛋白复合物抑制剂。
T34281	Relamorelin BIM28131,RM 131,BIM-28131,BIM-28163,BIM 28163,BIM28163,BIM 28131	GHSR	GPCR/G Protein
	Relamorelin (RM-131)是一种具有选择性和有效性的生长素释放肽/生长激素促分泌素受体 (GHSR) 激动剂，是一种有效的生长素释放肽模拟物，对 GHS-1a 受体具有很高的亲和力。Relamorelin 是一种具有中枢渗透性的五肽，可增加生长激素水平，加速胃排空，具有研究恶病质的潜力。
T8359	Lanreotide acetate Lanreotide acetate (108736-35-2 free base),BIM 23014 (acetate),BIM 23014 acetate	Others	Others
	Lanreotide acetate (BIM 23014 acetate) 是生长抑素类似物，具有抗肿瘤活性，可用于类癌综合症。
T25154	Bim 21009 LHRH-Ncpapa,Bim-21009,Bim21009,LHRHNcpapa,LHRH Ncpapa
	Bim 21009 is an inhibitor of gonadorelin.
T26817	Bim-BLK-A Bim Blocker A,Compound A,Bim BLK A,BimBLKA
	Bim-BLK-A efficiently blocks Bim-induced apoptosis after Bax is activated on the mitochondria. The cellular target of Bim-BLK-A was identified to be the succinate dehydrogenase subunit B (SDHB) protein of complex II of the mitochondrial electron transfer
T69993	BIM-46068
	BIM-46068 is a potent and specific inhibitor of human farnesyltransferase. In regard to a panel of cell lines, using the Compare analysis to determine the Pearson coefficient correlation, the anti-proliferative spectrum of BIM-46068 has been shown to be distinct from the profile of typical chemotherapeutic agents.
T10550	Bisindolylmaleimide X hydrochloride BIM-X hydrochloride,Ro31-8425 hydrochloride	CDK; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling
	Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).
T39262	BIM-23190
	BIM-23190 is a somatostatin analog that acts as a selective agonist for SSTR2 and SSTR5 receptors. It displays potency with K i values of 0.34 nM and 11.1 nM for SSTR2 and SSTR5, respectively. BIM-23190 finds utility in cancer and acromegaly research.
TP2224	BIM, Biotinylated	Others	Others
	BIM, Biotinylated is a Bim peptide fragment (residues 81-106) with a biotin moiety attached.
T70039	BIM-46174
	BIM-46174 is a New Inhibitor of the Heterotrimeric Gα/Gβγ Protein Complex. BIM-46174 acts as a selective inhibitor of heterotrimeric G-protein complex. BIM-46174 prevents the heterotrimeric G-protein signaling linked to several GPCRs mediating (a) cyclic AMP generation (Gαs), (b) calcium release (Gαq), and (c) cancer cell invasion by Wnt-2 frizzled receptors and high-affinity neurotensin receptors (Gαo/i and Gαq). BIM-46174 inhibits the growth of a large panel of human cancer cell lines, includ...
T12882L	Setmelanotide Acetate(920014-72-8 free base) RM-493 Acetate,IRC-022493 Acetate,BIM-22493 Acetate	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	Setmelanotide Acetate(920014-72-8 free base) (RM-493 Acetate) 是黑皮质素 4 受体 (MC4R) 的选择性激动剂（人和大鼠 MC4R，EC50 分别为 0.27 nM 和 0.28 nM）。
TP1215	Abaloparatide TFA BA 058 TFA,Abaloparatide TFA (247062-33-5 free base),BIM 44058 TFA	Others	Others
	Abaloparatide TFA (BIM 44058 TFA) 是一种甲状旁腺激素相关蛋白 (PTHrP) 类似物药物，与相关药物特立帕肽一样用于治疗骨质疏松症。
T37109	BIM-23190 hydrochloride
	BIM-23190 hydrochloride, a selective agonist for somatostatin receptors SSTR2 and SSTR5 with Ki values of 0.34 nM and 11.1 nM respectively, is a somatostatin analog utilized in research on cancer and acromegaly[1][3].
TP1718	Bim BH3, Peptide IV TFA (721885-31-0 free base) Bim BH3, Peptide IV TFA
	Bim BH3, Peptide IV TFA is a 26-site residue of BH3 protein Bim, belonging to the pro-apoptotic group of bcl-2 protein family.
TP1611	Bim BH3, Peptide IV
	This Bim peptide belongs to the pro-apoptotic group of the Bcl-2 family of proteins.
T16519	PH-064 BIM-46187	Others	Others
	PH-064 (BIM-46187) 是一种异源三聚体 G-protein 复合物的抑制剂。
T21410	Triptorelin acetate(57773-63-4 free base) 醋酸曲普瑞林,Wy 42422,Triptorelin Acetate,CL 118532,AY 25650,CL 118,532,Wy 42462,BIM 21003	GNRH Receptor	GPCR/G Protein
	Triptorelin acetate(57773-63-4 free base) (CL 118,532) 用作 GnRH 激动剂。它通过引起垂体的持续刺激来减少垂体促性腺激素促黄体激素 (LH) 和促卵泡激素 (FSH) 的分泌。曲普瑞林可用于治疗激素反应性癌症，如乳腺癌或前列腺癌、性早熟、雌激素依赖性疾病和辅助生殖。
T82883	BIM-23027
	BIM-23027为高选择性sst2受体激动剂（EC50=0.32 nM），其功能效果类似生长抑素（SRIF，环状十四肽）。该化合物可促进多巴胺的释放，此过程通过Glu依赖的机制进行调控。
T75707	BIM-26226
	BIM-26226 是一种胃泌素释放肽，是一种强效选择性的bombesin receptor 拮抗剂。 BIM-26226 抑制 BN 或 GRP 刺激的淀粉酶释放，IC50值在纳摩尔范围内。BIM-26226 可用于癌症研究。
T40886	Onzigolide BIM-23A760,TBR-760,Onzigolide
	Onzigolide (BIM-23A760), a chimeric compound combining properties of both dopamine and somatostatin, exhibits strong agonistic activity towards the D2 subtype of dopamine receptors (D2R) as well as type 2 somatostatin receptors (SSTR2).
T69994	BIM-46050
	BIM-46050 is a potent and specific inhibitor of human farnesyltransferase. BIM-46050 is free acidic form of BIM-46068. The IC50 values for in vitro inhibition of human brain FTase indicate that BIM-46050 and the ester form BIM-46068 are potent inhibitors of farnesyltransferase. Their potencies are in the nanomolar range and compare favorably with the compounds B581, FTI-277 and L745,631. B581 is an analog of the tetrapeptide Cys-Val-Phe-Met obtained by replacement of the amino-terminal amide bon...
T80038	Bim BH3
	BimBH3，一种具有生物活性的肽，属于促凋亡Bcl-2蛋白家族。
T81949	Lanreotide diTFA BIM 23014 diTFA
	Lanreotide (BIM 23014) diTFA是一种生长抑素类似物，具抗肿瘤活性，适用于类癌综合症研究。
T70038	MJN68390	Caspase	Apoptosis; Proteases/Proteasome
	MJN68390 对 CASP8 的表观 IC50值为 15 μM，对 CASP10 不显示活性。
T12882	Setmelanotide BIM-22493,IRC-022493,RM-493	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	Setmelanotide (BIM-22493) 是黑皮质素 4 受体 (MC4R) 的选择性激动剂(人和大鼠 MC4R，EC50 分别为 0.27 nM 和 0.28 nM)。
T62157	Bim-IN-1
	Bim-IN-1 是一种 Bim 表达的有效抑制剂，毒性较低。Bim-IN-1 可以减少 Bim 的表达水平，且几乎不会抑制蛋白激酶 A。
T75844	BIM-23056 TFA
	BIM23056 TFA为线性八肽类化合物，作为sst3与sst5生长抑素受体的有效拮抗剂，其Ki值分别为10.8和5.7。
T39236	Relamorelin acetate Relamorelin acetate,RM-131 acetate,BIM-28131acetate
	Relamorelin (RM-131) acetate is a pentapeptide ghrelin analog that acts as a selective agonist for the ghrelin/growth hormone secretagogue receptor (GHSR). It exhibits a high affinity for the GHS-1a receptor, with a Ki value of 0.42 nM. Notably, Relamorelin acetate can cross the blood-brain barrier and target the central nervous system. This compound effectively increases growth hormone levels and promotes faster gastric emptying. Due to these properties, Relamorelin acetate holds promise for it...
T20534	Lanreotide BIM 23014,Somatulin,Lanreotide Autogel,Somatuline,Ipstyl
	Lanreotide, a somatostatin analogue, suppresses GH/IGF-I hypersecretion in acromegaly patients. It also used to manage neuroendocrine tumours.
T83114	Angiopep-Bim BH3 hydrochloride
	Angiopep-Bim BH3 hydrochloride，一种可穿透血脑屏障的多肽，用于探究中枢神经系统通透性的研究。
T76030	Bim BH3, Peptide IV TFA
	BimBH3, Peptide IV TFA 是一种来自 BH3-only proteinBim 的 26 个残基肽，属于Bcl-2蛋白家族的促凋亡家族。
TP1041	Setmelanotide TFA (1294000-61-5 free base) IRC-022493 TFA,BIM-22493 TFA,Setmelanotide TFA,RM-493 TFA
	Setmelanotide TFA (RM-493 TFA; BIM-22493 TFA; IRC-022493 TFA) is a selective melanocortin 4 receptor (MC4R) agonist.
T25087	Angiopeptin 血管抑肽,D-Nal-cys-tyr-trp-lys-val-cys-thr-NH2,Bim 23014 C
	Angiopeptin is a synthetic octapeptide analog of somatostatin; suppresses accelerated transplant atherosclerosis in rabbit heart arteries.
T5104	BTSA1	Apoptosis; BCL	Apoptosis
	BTSA1 是一种有口服活性的 BAX 激活剂，IC50为 250 nM，EC50为 144 nM。它以高亲和力和特异性与 N 末端激活位点结合，并诱导 BAX 发生构象变化，从而导致BAX 介导的细胞凋亡。
T69992	Glutathione sodium
	Glutathione sodium is a hydrophilic derivative of the protein tyrosine phosphatase inhibitor phenylarsine oxide (PAO). It inhibits angiogenesis and tumour growth.
T7790	Bisindolylmaleimide V 双吲哚马来酰亚胺 V,双吲哚马来酰亚胺	PKC; S6 Kinase	Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Bisindolylmaleimide V 是一种弱蛋白激酶 C (PKC) 抑制剂( IC50 >100 µM)。
T2099	ABT-737	Mitophagy; BCL; Autophagy	Apoptosis; Autophagy
	ABT737 是 BH3 模拟物，是Bcl-2、Bcl-xL 和Bcl-w 抑制剂，EC50分别为 30.3 nM、78.7 nM 和 197.8 nM。它诱导自噬，有研究急性髓系白血病的潜力。它还诱导 BCL-2/BAX 复合物的破坏和 BAK 依赖性。
T13091	Taspoglutide R1583,BIM51077,ITM077	Others	Others
	Taspoglutide is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist(EC50 value of 0.06 nM),and for treatment of type 2 diabetes
T2265	Bimiralisib 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine,PQR309,PI3K-IN-2	Others; PI3K; S6 Kinase; mTOR	MAPK; Others; PI3K/Akt/mTOR signaling
	Bimiralisib (PI3K-IN-2) 是一种有效的，可渗透脑的 mTOR/PI3K 抑制剂，是一种 mTORC1和 mTORC2抑制剂。它能够抑制 PI3Kα,PI3Kδ,PI3Kβ,PI3Kγ和 mTOR，IC50分别为 33 nM，451 nM，661 nM，708 nM 和 89 nM。
T3481	Bimolane	Topoisomerase	DNA Damage/DNA Repair
	Bimolane 是一种拓扑异构酶 II 抑制剂。
T0952	Carbimazole 卡比马唑,Athyromazole,卡比吗唑,Carbimazol,Neomercazole	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	Carbimazole (Athyromazole) 是咪唑类甲状腺拮抗试剂，在体内快速转化为 MMI 而发挥作用，在体外可转化为甲咪唑，可用于 Graves 病的研究。
T18929	Bromobimane Monobromobimane	Autophagy	Autophagy
	Bromobimane (Monobromobimane) 是一种非荧光物质，但与硫醇反应反应时生成荧光产物。Bromobimane 可被当作一种探针使用，常在临床医学上检验血液中硫化物的含量。
T3623	Cobimetinib 可美替尼,考比替尼,RG7420,XL518,GDC-0973	Apoptosis; MEK	Apoptosis; MAPK
	Cobimetinib (GDC-0973) 是一种可口服的 MEK1选择性抑制剂，抑制MEK1的IC50为4.2 nM。
T2538	Bimatoprost AGN 192024,比马前列素	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Bimatoprost (AGN 192024) 是一种氯前列醇衍生的酰胺，用作治疗开角型青光眼和高眼压症的抗高血压药。
T21946	BIMU 8	5-HT Receptor	GPCR/G Protein; Neuroscience
	BIMU 8 是 5-HT4 的选择性激动剂，对野生型 5HT4 受体、T3.36A 和 W6.48A 突变体 5-HT4 的 EC50 分别为 18 nM、77 nM 和 540 nM。
T19028	Monochlorobimane mBBr,Chlorobimane
	Monochlorobimane (mBBr) 是一种荧光染料 ,λex 值为380 nm，λem 值为470 nm。Monochlorobimane 可用于测定细胞中谷胱甘肽 (GSH)。
T3485	Probimane AT-2153,MM-159	Others	Others
	Probimane (AT-2153) 具有抗增殖作用、细胞周期 G2/M 期阻滞和用 MST-16 阻断人类肿瘤细胞系中的染色体分离。

化合物

BIM 23042 Acetate

Cat.No: T21661L

Synonym: BIM 23042 Acetate (111857-96-6 Free base)

Target: Others

BIM 23056 Acetate

Cat.No: T21944L

Synonym: BIM 23056 Acetate (150155-61-6 Free base)

Target: Others

BIM-23190 aceate

Cat.No: T39262L

Target: Somatostatin

BIM-46187 4HCl

Cat.No: T16519L

Synonym: PH-064 4HCl

Target: Others

Cat.No: T34281

Synonym: BIM28131,RM 131,BIM-28131,BIM-28163,BIM 28163,BIM28163,BIM 28131

Target: GHSR

Lanreotide acetate

Cat.No: T8359

Synonym: Lanreotide acetate (108736-35-2 free base),BIM 23014 (acetate),BIM 23014 acetate

Target: Others

Cat.No: T25154

Synonym: LHRH-Ncpapa,Bim-21009,Bim21009,LHRHNcpapa,LHRH Ncpapa

Cat.No: T26817

Synonym: Bim Blocker A,Compound A,Bim BLK A,BimBLKA

Cat.No: T69993

Bisindolylmaleimide X hydrochloride

Cat.No: T10550

Synonym: BIM-X hydrochloride,Ro31-8425 hydrochloride

Target: CDK, PKC

Cat.No: T39262

BIM, Biotinylated

Cat.No: TP2224

Target: Others

Cat.No: T70039

Setmelanotide Acetate(920014-72-8 free base)

Cat.No: T12882L

Synonym: RM-493 Acetate,IRC-022493 Acetate,BIM-22493 Acetate

Target: Melanocortin Receptor

Abaloparatide TFA

Cat.No: TP1215

Synonym: BA 058 TFA,Abaloparatide TFA (247062-33-5 free base),BIM 44058 TFA

Target: Others

BIM-23190 hydrochloride

Cat.No: T37109

Bim BH3, Peptide IV TFA (721885-31-0 free base)

Cat.No: TP1718

Synonym: Bim BH3, Peptide IV TFA

Bim BH3, Peptide IV

Cat.No: TP1611

Cat.No: T16519

Synonym: BIM-46187

Target: Others

Triptorelin acetate(57773-63-4 free base)

Cat.No: T21410

Synonym: 醋酸曲普瑞林,Wy 42422,Triptorelin Acetate,CL 118532,AY 25650,CL 118,532,Wy 42462,BIM 21003

Target: GNRH Receptor

Cat.No: T82883

Cat.No: T75707

Cat.No: T40886

Synonym: BIM-23A760,TBR-760,Onzigolide

Cat.No: T69994

Cat.No: T80038

Lanreotide diTFA

Cat.No: T81949

Synonym: BIM 23014 diTFA

Cat.No: T70038

Target: Caspase

Cat.No: T12882

Synonym: BIM-22493,IRC-022493,RM-493

Target: Melanocortin Receptor

Cat.No: T62157

BIM-23056 TFA

Cat.No: T75844

Relamorelin acetate

Cat.No: T39236

Synonym: Relamorelin acetate,RM-131 acetate,BIM-28131acetate

Cat.No: T20534

Synonym: BIM 23014,Somatulin,Lanreotide Autogel,Somatuline,Ipstyl

Angiopep-Bim BH3 hydrochloride

Cat.No: T83114

Bim BH3, Peptide IV TFA

Cat.No: T76030

Setmelanotide TFA (1294000-61-5 free base)

Cat.No: TP1041

Synonym: IRC-022493 TFA,BIM-22493 TFA,Setmelanotide TFA,RM-493 TFA

Cat.No: T25087

Synonym: 血管抑肽,D-Nal-cys-tyr-trp-lys-val-cys-thr-NH2,Bim 23014 C

Cat.No: T5104

Target: Apoptosis, BCL

Glutathione sodium

Cat.No: T69992

Bisindolylmaleimide V

Cat.No: T7790

Synonym: 双吲哚马来酰亚胺 V,双吲哚马来酰亚胺

Target: PKC, S6 Kinase

Cat.No: T2099

Target: Mitophagy, BCL, Autophagy

Cat.No: T13091

Synonym: R1583,BIM51077,ITM077

Target: Others

Cat.No: T2265

Synonym: 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine,PQR309,PI3K-IN-2

Target: Others, PI3K, S6 Kinase, mTOR

Cat.No: T3481

Target: Topoisomerase

Cat.No: T0952

Synonym: 卡比马唑,Athyromazole,卡比吗唑,Carbimazol,Neomercazole

Target: Thyroid hormone receptor(THR)

Cat.No: T18929

Synonym: Monobromobimane

Target: Autophagy

Cat.No: T3623

Synonym: 可美替尼,考比替尼,RG7420,XL518,GDC-0973

Target: Apoptosis, MEK

Cat.No: T2538

Synonym: AGN 192024,比马前列素

Target: Prostaglandin Receptor

Cat.No: T21946

Target: 5-HT Receptor

Monochlorobimane

Cat.No: T19028

Synonym: mBBr,Chlorobimane

Cat.No: T3485

Synonym: AT-2153,MM-159

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T20939	Bimatoprost acid 17-phenyl trinor PGF2α,17-phenyl trinor Prostaglandin F2α	GPR	Endocrinology/Hormones; GPCR/G Protein
	Bimatoprost acid (17-phenyl trinor PGF2α) 是一种代谢稳定的 PGF2α 类似物，对 FP 受体具有潜在的拮抗活性。与 PGF2α 相比，它与绵羊黄体细胞上的 FP 受体结合的相对效力为 756%。
TN2637	15-Dihydroepioxylubimin	Others	Others
	15-Dihydroepioxylubimin 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2637，CAS号为 129214-59-1。
T5668	Triacetylresveratrol 乙酰化白藜芦醇,三乙酰基白藜芦醇,Acetyl-trans-resveratrol	BCL; NF-κB; STAT	Apoptosis; JAK/STAT signaling; NF-κB; Stem Cells
	Triacetylresveratrol (Acetyl-trans-resveratrol) 是 Resveratrol 的乙酰化类似物，可降低 STAT3和 NF-κB 磷酸化，具有抗癌作用。

天然产物

Bimatoprost acid

Cat.No: T20939

Synonym: 17-phenyl trinor PGF2α,17-phenyl trinor Prostaglandin F2α

Target: GPR

15-Dihydroepioxylubimin

Cat.No: TN2637

Target: Others

Triacetylresveratrol

Cat.No: T5668

Synonym: 乙酰化白藜芦醇,三乙酰基白藜芦醇,Acetyl-trans-resveratrol

Target: BCL, NF-κB, STAT

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