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53

抑制剂 & 化合物

10

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T15598	Isosulfan blue	Others	Others
	Isosulfan blue 是用于淋巴管造影中淋巴管识别的蓝色染料，可用于乳腺癌前哨淋巴结活检，但其在乳腺癌手术中有发生过敏反应的可能性。
T22459	Xanthinol Nicotinate Angioamin,烟酸占替诺,Complamin	Others	Others
	Xanthinol Nicotinate (Complamin) 是血管扩张剂，可直接作用于小动脉和毛细血管的平滑肌，能够扩大血管，改善血液流变学并降低外周血管阻力。
T0042	Xylometazoline hydrochloride 盐酸赛洛唑啉,Xylometazoline HCl	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Xylometazoline hydrochloride (Xylometazoline HCl) 是一种 α- 肾上腺素受体激动剂，是一种鼻血管收缩药。
T1275	Phentolamine mesylate Phentolamine methanesulfonate,甲磺酸酚妥拉明,Phentolamine mesilate	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Phentolamine mesylate (Phentolamine methanesulfonate) 是一种非选择性的、可逆的，具有口服活性的 α1 和 α2 肾上腺素能受体阻滞剂，能够扩张使血管，降低周围血管阻力。它可用于研究嗜铬细胞瘤相关的高血压，心力衰竭和勃起功能障碍。
T1615	Irbesartan 厄贝沙坦,SR-47436,BMS-186295	Apoptosis; RAAS	Apoptosis; Endocrinology/Hormones
	Irbesartan (SR-47436) 是一种 1 型血管紧张素 II 受体拮抗剂，IC50为1.3 nM。
T0504	Cyclandelate 安脉生,BS 572,环扁桃酯,3,5,5-Trimethylcyclohexyl mandelate	Acyltransferase	Metabolism
	Cyclandelate (BS 572) 是直接作用的平滑肌松弛剂，用于扩张血管。
T5161	Gadodiamide	Others	Others
	Gadodiamide 是一种含钆造影剂，可用于医学成像。
T21231	Almotriptan 阿莫曲坦,LAS 31416,阿莫曲普坦	5-HT Receptor	GPCR/G Protein; Neuroscience
	Almotriptan (LAS 31416) 是一种用于研究偏头痛的5-HT1B/1D 受体激动剂。
T4509	Inositol nicotinate Inositol niacinate,Hexanicotol,Myo-Inositol hexanicotinate,Mesotal,肌醇烟酸酯,Dilexpal,Inositol hexanicotinate	Others	Others
	Inositol nicotinate (Mesotal) 是一种血管扩张剂，可用于研究外周动脉疾病。
T6863	Isosorbide Mononitrate 单硝酸异山梨酯,Isosorbide-5-mononitrate,5-单硝酸异山梨酯,Imdur,Mononit,Corangin,Monoket,Elantan	Others; Autophagy	Autophagy; Others
	Isosorbide Mononitrate (Corangin) 是一种硝酸盐血管扩张剂，扩张血管从而降低血压，可用于心绞痛。
T12478L	Pinacidil 吡那地尔,S 1230,P 1134,S-1230,P-1134,P1134	Potassium Channel	Membrane transporter/Ion channel
	Pinacidil (P 1134) 是钾通道的有效激活剂。Pinacidil 通过打开 K+-通道使血管平滑肌超极化，显示出抗高血压活性。它显著改善再灌注功能和心脏顺应性。它具有直接的心脏保护作用。
T3996	Dapiprazole Hydrochloride 盐酸达哌唑,Glamidolo Hydrochloride,Reversil Hydrochloride	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Dapiprazole Hydrochloride (Glamidolo Hydrochloride) 是 α-adrenergic 阻断剂的药物。
T4287	Succinobucol Probucol monosuccinate,AGI-1067	Antioxidant; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Succinobucol (Probucol monosuccinate) 是酚类抗氧化剂，具有抗炎、抗血小板聚集活性。
T4506	Gadopentetate dimeglumine Meglumine gadopentetate,SH-L-451A,Gd-DTPA,Gadopentetic acid dimeglumine,钆喷酸葡胺,Gadopentetic acid dimeglumine salt	Others	Others
	Gadopentetate dimeglumine (Gd-DTPA) 可用于核磁共振成像 (MRI) 中，使血管、器官和其他非骨组织能够更清晰地被看到。
T15273	Fedovapagon VA483,A106483	Vasopressin Receptor	GPCR/G Protein
	Fedovapagon (VA106483) 是一种具有选择性和高效性的加压素 V2 受体 (V2R) 激动剂，可抑制斑马鱼节间血管的生长。Fedovapagon 可用于研究膀胱过度活动症、夜尿症和膀胱疼痛综合征。
T0397	Tetrahydrozoline 四氢唑林,四氢唑啉,Tetryzolin,Tetryzoline	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Tetrahydrozoline (Tetryzoline) 是一种咪唑啉的衍生物，是一种 α-肾上腺素能 (α-adrenergic) 激动剂，能引起血管收缩，广泛用于研究鼻充血、结膜充血。
T21447	Tolazoline Priscol,妥拉苏林,Priscoline,Pridazole,Divascol,Vasimid,Benzalolin	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Tolazoline (Benzalolin) 是一种竞争性的α-肾上腺素受体拮抗剂。
TP1277	Bradykinin 缓激肽	Endogenous Metabolite; Bradykinin Receptor	GPCR/G Protein; Metabolism
	Bradykinin 是由激肽释放酶-激肽系统产生的活性肽。它是炎症调节因子和神经调节因子，对几种血管和肾功能也有调节作用。
T37436	C12-Ceramide N-Laurylsphingosine,C12 Ceramide (d18:1/12:0),N-Lauroyl-D-erythro-sphingosine
	C12-Ceramide (C12 Ceramide (d18:1/12:0)) 是一种存在于先兆子痫妇女所生婴儿围绕脐带血管的保护膜的神经酰胺，是 C12 鞘磷脂被酸性鞘磷脂酶（ASM）水解后形成的，可用于评估 A 型或 B 型尼曼-皮克病患者血浆中的 ASM 活性水平。
T0075	Nicorandil SG-75,尼可地尔	Potassium Channel	Membrane transporter/Ion channel
	Nicorandil (SG-75) 是一种有效的钾通道激活剂，靶向血管核苷二磷酸依赖性 K+通道和心脏 ATP 敏感 K+通道 (KATP)。Nicorandil 是一种烟酰胺酯，具有血管舒张和心脏保护作用，并具有治疗心绞痛和缺血性心脏病的潜力。
T1092	Zolmitriptan 佐米曲普坦,311C90,BW-311C90	5-HT Receptor	GPCR/G Protein; Neuroscience
	Zolmitriptan (311C90) 是一种5-HT1B/1D 受体部分激动剂，可用于偏头痛的研究，对 5-HT1B、5-HT1D、5-HT1F 受体的Ki 分别为 5.01、0.63 和 63.09 nM。
T6602	Naratriptan hydrochloride Naratriptan HCl,Amerge,Naramig,盐酸那拉曲坦,GR-85548A hydrochloride	5-HT Receptor	GPCR/G Protein; Neuroscience
	Naratriptan hydrochloride (GR-85548A hydrochloride) 是一种5-HT1受体激动剂，有抗偏头疼特性。它还可以通过刺激三叉神经系统感觉神经末梢上的 5-HT1D/1B 受体来发挥其作用，从而减少促炎神经肽的释放。
T1083L	Theophylline monohydrate Quibron,茶碱一水合物	HDAC; PDE; Adenosine Receptor	Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience
	Theophylline monohydrate (Quibron) 似乎抑制磷酸二酯酶和前列腺素的产生，调节钙通量和细胞内钙分布，并拮抗腺苷。茶碱是黄嘌呤的天然生物碱衍生物，从植物山茶花和小粒咖啡中分离出来。在生理上，该药剂可放松支气管平滑肌，产生血管舒张（脑血管除外），刺激中枢神经系统，刺激心肌，利尿，增加胃酸分泌；它还可以抑制炎症并改善横膈膜的收缩性。
T19478	Nicotinoyl cyclandelate RV 12128,米西烟酯	Others	Others
	Nicotinoyl cyclandelate can effectively reduce blood pressure in the femoral artery and perfusion pressure in cerebral blood vessels.
T31857	Fosbretabulin [free base] Fosbretabulin,Combretastatin A-4,CA4DP
	Fosbretabulin is a natural cis-stilbene that interferes with cellular tubulin dynamics and selectively destroys tumor blood vessels.
T25173	Bradykinin potentiator-5 BPP-5a\,BPP 5a\,BPP5a\
	Bradykinin potentiator-5 is a peptide inflammatory mediator, causes blood vessels to dilate (enlarge), and therefore causes blood pressure to fall.
T25670	Lercanidipine. (R)- (-)-Lercanidipine,(R)-Lercanidipine
	Lercanidipine. (R)- is an enantiomer of antihypertensive drugs Lercanidipine. Lercanidipine acts by blocking L-type calcium channels, allowing relaxation and opening of blood vessels.
T70609	Bisnafide mesylate
	Bisnafide is a Naphthalimide Analogue that acts as DNA intercalator and topo II inhibitor. It is also an antiangiogenic agent. Antiangiogenic agents can normalize tumor vessels and promote the delivery of cytotoxic agents to tumor sites.
T25159	Bisnafide DMP 840
	Bisnafide is a Naphthalimide Analogue that acts as a DNA intercalator and topo II inhibitor. It is also an antiangiogenic agent that can normalize tumor vessels and promote the delivery of cytotoxic agents to tumor sites.
T69813	AZD-6126
	AZD6126, also known as ANG-453, a water-soluble phosphate prodrug of N-acetylcolchinol with potential antiangiogenesis and antineoplastic activities. AZD-6126 is an angiogenesis inhibitor and tubulin inhibitor potentially for the treatment of solid tumours. AZD6126 is converted in vivo into N-acetylcolchinol. N-acetylcolchinol binds to and destabilizes the tubulin cytoskeleton of endothelial cells in tumor blood vessels, which may result in tumor endothelial cel apoptosis, the selective occlusio...
TP1224	[Sar1, Ile8]-Angiotensin II TFA Angiotensin 2 TFA,AngiotensinII TFA
	[Sar1, Ile8]-Angiotensin II (TFA) is a peptide compound that exerts various effects on vascular smooth muscle. These effects include the contraction of normal arteries as well as the hypertrophy or hyperplasia of cultured cells or diseased vessels.
T68478	Arnolol
	Arnolol is a beta blocker. Beta blockers block the hormone epinephrine, also known as adrenaline. This causes the heart to beat more slowly and with less force, thereby reducing blood pressure. Beta blockers also help blood vessels open up to improve blood flow.
T38697	[Tyr(P)4] Angiotensin II
	[Tyr(P)4] Angiotensin II is a peptide that exerts a multitude of effects on vascular smooth muscle. These effects include the contraction of normal arteries, as well as the induction of hypertrophy or hyperplasia in cultured cells or diseased vessels.
T61729	Terazosin
	Terazosin, a quinazoline derivative, is an orally active and competitive antagonist of α1-adrenoceptors. Its mechanism of action involves relaxing blood vessels and promoting bladder opening. Terazosin exhibits therapeutic potential for treating benign prostatic hyperplasia (BPH) and high blood pressure [1][2][3].
T3443	Argiprestocin 精氨缩宫素,Arginine vasotocin	Others	Others
	Argiprestocin (Arginine vasotocin) 也称为抗利尿激素，在维持渗透压中起关键作用。它是在大多数哺乳动物中发现的一种神经垂体激素。用于引起血管收缩的药物。
T81306	REA
	REA为一种特定的肽，具有识别癌症早期阶段的淋巴管的能力，然而对于肿瘤淋巴管则无法识别。
T19377	Ioxilan	Others	Others
	Ioxilan is a low-osmolar, nonionic, and tri-iodinated diagnostic contrast agent used for excretory urography and contrast-enhanced computed tomographic (CECT) imaging of the head and body. Intravascularly injected causes opacification of vessels, allowing for radiographic visualization of internal structures until significant hemodilution occurs.
T71583	Amlodipine hydrochloride, (R)-
	Amlodipine hydrochloride, (R)-, is a medication used to lower blood pressure and prevent chest pain. It belongs to a group of medications known as dihydropyridine-type calcium channel blockers. By widening of blood vessels it lowers blood pressure. In angina, amlodipine increases blood flow to the heart muscle to relieve pain due to angina.
T68367	Amlodipine orotate
	Amlodipine orotate is a medication used to lower blood pressure and prevent chest pain. It belongs to a group of medications known as dihydropyridine-type calcium channel blockers. By widening of blood vessels it lowers blood pressure. In angina, amlodipine increases blood flow to the heart muscle to relieve pain due to angina.
T9922	Matuzumab	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Matuzumab 是一种用于癌症治疗的人源化单克隆抗体。它对 EGFR 具有高亲和力，通常与恶性肿瘤中血管的生长有关，从而促进肿瘤的生长和存活。
T60263	Povafonidine
	Povafonidine (PGE-6201204) 是一种有效的 α-2 肾上腺素受体激动剂。Povafonidine 可以收缩血管，减轻粘膜充血，可用于鼻塞研究。
T60795	Oxyfedrine
	Oxyfedrine 是具有口服活性的 β-肾上腺素受体的激动剂。Oxyfedrine 是一种血管扩张剂，可降低冠状动脉血管的张力，用于研究心血管疾病。
T69452	AG-13958 monohydrochloride
	AG-13958 monohydrochloride is the HCl salt of AG-13958 --- a VEGFA inhibitor potentially for the treatment of age-related macular degeneration. Neovascular AMD, a subtype characterized by the growth of new, pathologic blood vessels, results in most of the cases of severe and rapid vision loss associated with AMD. A critical activator of angiogenesis in neovascular AMD is VEGF.
T35850	19(S)-HETE
	19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. When formed by the CYP2E1 isoform, 19-HETE is composed of 70% and 30% of the (S) and (R) stereoisomers, respectively. Both 19(S)- and 19(R)-HETE are potent vasodilators of renal preglomerular vessels. 19(S)-HETE stimulates both renal sodium-potassium ATPase and volume absorption in the rabbit proximal straight tubule.
T31396	Dexbrompheniramine maleate D-Brompheniramine,Brompheniramine d-,Dexbrompheniraminum,Disophrol,Drixoral
	Dexbrompheniramine is an antihistamine with anticholinergic properties. It is used to treat allergic diseases such as hay fever or urticaria. It can compete with histamine for H1 receptor sites on effector cells of the gastrointestinal tract, blood vessel
T1120L2	Dacarbazine citrate DTIC citrate
	Dacarbazine citrate is an alkylating agent used to treat cancers of the lymphatic system and malignant melanoma (a type of skin cancer) in patients with certain conditions: islet cell carcinoma (part of the pancreas) Soft tissue sarcoma (cancer of muscles
T36216	19(R)-HETE
	19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. When formed by the CYP2E1 isoform, 19-HETE is composed of 70% and 30% of the (S) and (R) stereoisomers, respectively. Both 19(S)- and 19(R)-HETE are potent vasodilators of renal preglomerular vessels. However, 19(R)-HETE at 1 μM completely blocks 20-HETE-induced vasoconstriction of renal arterioles, whereas 19(S)-HETE remains inactive.
T76550	CooP
	CooP为一种针对线性胶质母细胞瘤的九肽，与胶质母细胞瘤细胞及其相关血管系统中的乳腺来源生长抑制剂/脂肪酸结合蛋白3 (FABP3) 发生结合。该化合物主要应用于化学疗法和多种纳米粒子的靶向递送。
T70906	EHT-6706
	EHT-6706 is a novel microtubule-disrupting agent that targets the colchicine-binding site to inhibit tubulin polymerization. At low nM concentrations, EHT 6706 exhibits highly potent antiproliferative activity on more than 60 human tumor cell lines, even those described as being drug resistant. EHT 6706 also shows strong efficacy as a vascular-disrupting agent, since it prevents endothelial cell tube formation and disrupts pre-established vessels, changes the permeability of endothelial cell mon...
TP2097	ELA-32(human) ELA-32 (human)
	Potent, high affinity apelin receptor agonist (IC50 = 0.27 nM; Kd = 0.51 nM). Exhibits no binding GPR15 and GPR25. Activates the PI3K/AKT pathway and promotes self-renewal of hESCs via cell-cycle progression and protein translation. Also potentiates the T

化合物

Cat.No: T15598

Target: Others

Xanthinol Nicotinate

Cat.No: T22459

Synonym: Angioamin,烟酸占替诺,Complamin

Target: Others

Xylometazoline hydrochloride

Cat.No: T0042

Synonym: 盐酸赛洛唑啉,Xylometazoline HCl

Target: Adrenergic Receptor

Phentolamine mesylate

Cat.No: T1275

Synonym: Phentolamine methanesulfonate,甲磺酸酚妥拉明,Phentolamine mesilate

Target: Adrenergic Receptor

Cat.No: T1615

Synonym: 厄贝沙坦,SR-47436,BMS-186295

Target: Apoptosis, RAAS

Cat.No: T0504

Synonym: 安脉生,BS 572,环扁桃酯,3,5,5-Trimethylcyclohexyl mandelate

Target: Acyltransferase

Cat.No: T5161

Target: Others

Cat.No: T21231

Synonym: 阿莫曲坦,LAS 31416,阿莫曲普坦

Target: 5-HT Receptor

Inositol nicotinate

Cat.No: T4509

Synonym: Inositol niacinate,Hexanicotol,Myo-Inositol hexanicotinate,Mesotal,肌醇烟酸酯,Dilexpal,Inositol hexanicotinate

Target: Others

Isosorbide Mononitrate

Cat.No: T6863

Synonym: 单硝酸异山梨酯,Isosorbide-5-mononitrate,5-单硝酸异山梨酯,Imdur,Mononit,Corangin,Monoket,Elantan

Target: Others, Autophagy

Cat.No: T12478L

Synonym: 吡那地尔,S 1230,P 1134,S-1230,P-1134,P1134

Target: Potassium Channel

Dapiprazole Hydrochloride

Cat.No: T3996

Synonym: 盐酸达哌唑,Glamidolo Hydrochloride,Reversil Hydrochloride

Target: Adrenergic Receptor

Cat.No: T4287

Synonym: Probucol monosuccinate,AGI-1067

Target: Antioxidant, Reactive Oxygen Species

Gadopentetate dimeglumine

Cat.No: T4506

Synonym: Meglumine gadopentetate,SH-L-451A,Gd-DTPA,Gadopentetic acid dimeglumine,钆喷酸葡胺,Gadopentetic acid dimeglumine salt

Target: Others

Cat.No: T15273

Synonym: VA483,A106483

Target: Vasopressin Receptor

Tetrahydrozoline

Cat.No: T0397

Synonym: 四氢唑林,四氢唑啉,Tetryzolin,Tetryzoline

Target: Adrenergic Receptor

Cat.No: T21447

Synonym: Priscol,妥拉苏林,Priscoline,Pridazole,Divascol,Vasimid,Benzalolin

Target: Adrenergic Receptor

Cat.No: TP1277

Synonym: 缓激肽

Target: Endogenous Metabolite, Bradykinin Receptor

Cat.No: T37436

Synonym: N-Laurylsphingosine,C12 Ceramide (d18:1/12:0),N-Lauroyl-D-erythro-sphingosine

Cat.No: T0075

Synonym: SG-75,尼可地尔

Target: Potassium Channel

Cat.No: T1092

Synonym: 佐米曲普坦,311C90,BW-311C90

Target: 5-HT Receptor

Naratriptan hydrochloride

Cat.No: T6602

Synonym: Naratriptan HCl,Amerge,Naramig,盐酸那拉曲坦,GR-85548A hydrochloride

Target: 5-HT Receptor

Theophylline monohydrate

Cat.No: T1083L

Synonym: Quibron,茶碱一水合物

Target: HDAC, PDE, Adenosine Receptor

Nicotinoyl cyclandelate

Cat.No: T19478

Synonym: RV 12128,米西烟酯

Target: Others

Fosbretabulin [free base]

Cat.No: T31857

Synonym: Fosbretabulin,Combretastatin A-4,CA4DP

Bradykinin potentiator-5

Cat.No: T25173

Synonym: BPP-5a\,BPP 5a\,BPP5a\

Lercanidipine. (R)-

Cat.No: T25670

Synonym: (-)-Lercanidipine,(R)-Lercanidipine

Bisnafide mesylate

Cat.No: T70609

Cat.No: T25159

Synonym: DMP 840

Cat.No: T69813

[Sar1, Ile8]-Angiotensin II TFA

Cat.No: TP1224

Synonym: Angiotensin 2 TFA,AngiotensinII TFA

Cat.No: T68478

[Tyr(P)4] Angiotensin II

Cat.No: T38697

Cat.No: T61729

Cat.No: T3443

Synonym: 精氨缩宫素,Arginine vasotocin

Target: Others

Cat.No: T81306

Cat.No: T19377

Target: Others

Amlodipine hydrochloride, (R)-

Cat.No: T71583

Amlodipine orotate

Cat.No: T68367

Cat.No: T9922

Target: EGFR

Cat.No: T60263

Cat.No: T60795

AG-13958 monohydrochloride

Cat.No: T69452

Cat.No: T35850

Dexbrompheniramine maleate

Cat.No: T31396

Synonym: D-Brompheniramine,Brompheniramine d-,Dexbrompheniraminum,Disophrol,Drixoral

Dacarbazine citrate

Cat.No: T1120L2

Synonym: DTIC citrate

Cat.No: T36216

Cat.No: T76550

Cat.No: T70906

Cat.No: TP2097

Synonym: ELA-32 (human)

Cat. No.	Product Name	Target	Signaling Pathways
T13509	4-Vinylphenol	Apoptosis; Endogenous Metabolite	Apoptosis; Metabolism
	4-Vinylphenol 是酒中乳酸菌对香豆酸和阿魏酸的代谢产物，在白花蛇舌草中发现。 4-Vinylphenol 在体内诱导细胞凋亡。
T2230	Paeoniflorin 芍药苷,Peoniflorin	HSP; COX	Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; Neuroscience
	Paeoniflorin (Peoniflorin) 是从芍药根中提取的一种蒎烷单萜糖苷，具有抗癌作用、抗氧化应激、抗血小板聚集、血管扩张、降低血液粘度和抗炎活性等多种生物活性。它是一种热休克蛋白诱导剂，通过自噬途径保护 PC12 细胞免受 MPP+和酸性损伤。
TMS2171	(±)-Naringenin (±)-柚皮素,Salipurpol,柚皮素,Naringenine,Naringenin	Potassium Channel	Membrane transporter/Ion channel
	(±)-Naringenin (Naringenine) 是一种天然的类黄酮。它通过激活肌细胞中 BKCa 通道发挥对内皮剥脱血管的舒张作用。
T6S0657	Isorhynchophylline IsoRhy,异钩藤碱,Isorhyncophylline,Isorhychophylline,7-Isorhyncophylline	Others	Others
	Isorhynchophylline (7-Isorhyncophylline) 是一种分离自钩藤中的生物碱类化合物，具有舒张血管、降血压、保护神经免于局部缺血造成损伤的作用。
T3752	4-Hydroxybenzyl alcohol 4-Methylolphenol,P-Methylolphenol,对羟基苯甲醇	Apoptosis; Endogenous Metabolite	Apoptosis; Metabolism
	4-Hydroxybenzyl alcohol (P-Methylolphenol) 是广泛分布于各种植物中的一种酚类天然产物，具有抗炎、抗氧化和抗伤害感受活性。它抑制肿瘤血管生成和生长，有神经保护作用。
T5074	Cholesteryl palmitate	Others; Endogenous Metabolite	Metabolism; Others
	Cholesteryl palmitate 是一种慢性间质性肺炎的有用预后生物标志物。
T4S1551	Cinnamaldehyde Cinnamic Aldehyde,肉桂醛	HIF	Angiogenesis; Chromatin/Epigenetic
	Cinnamaldehyde (Cinnamic Aldehyde) 具有解热作用。它是镇静剂。它抑制MDA-MB-435S 细胞的侵袭能力与下调miR-27a 的表达有关。它诱导活性氧的产生，发挥血管扩张和抗癌作用。它似乎是一种有希望的候选药物，可作为与 5-氟尿嘧啶 (5-FU) 和奥沙利铂 (OXA) 这两种用于 CRC 治疗的化疗药物联合治疗的辅助剂。其作用的可能机制可能涉及药物代谢基因的调节。它在抑制黑色素瘤的发生和发展方面具有一定的作用，其作用机制可能表现为抑制VEGF 和HIF-α的表达，从而使血管模拟和黑色素瘤细胞新生血管的形成，促进肿瘤的生长。
T80867	Villocarine A
	Villocarine A为一种天然源自的吲哚生物碱类化合物，具有血管松弛作用。
T6535	Histamine Phosphate 组胺磷酸盐,Histamine diphosphate,二磷酸组胺,Histamine acid phosphate	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Histamine Phosphate (Histamine acid phosphate) 是组胺受体的强激活剂和血管扩张神经剂，可激活一氧化氮合成酶。
T2S0118	Daurinoline	Calcium Channel; 5-HT Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a protective function on microcirculation of cerebral pia mater, which may be beneficial to relieve cerebral ischemic injury. Daurinoline could significantly reverse noradrenaline induced constriction of pial arterioles and venules, and increase the number of blood vessels which were decreased by noradrenaline.

天然产物

Cat.No: T13509

Target: Apoptosis, Endogenous Metabolite

Cat.No: T2230

Synonym: 芍药苷,Peoniflorin

Target: HSP, COX

(±)-Naringenin

Cat.No: TMS2171

Synonym: (±)-柚皮素,Salipurpol,柚皮素,Naringenine,Naringenin

Target: Potassium Channel

Isorhynchophylline

Cat.No: T6S0657

Synonym: IsoRhy,异钩藤碱,Isorhyncophylline,Isorhychophylline,7-Isorhyncophylline

Target: Others

4-Hydroxybenzyl alcohol

Cat.No: T3752

Synonym: 4-Methylolphenol,P-Methylolphenol,对羟基苯甲醇

Target: Apoptosis, Endogenous Metabolite

Cholesteryl palmitate

Cat.No: T5074

Target: Others, Endogenous Metabolite

Cat.No: T4S1551

Synonym: Cinnamic Aldehyde,肉桂醛

Target: HIF

Cat.No: T80867

Histamine Phosphate

Cat.No: T6535

Synonym: 组胺磷酸盐,Histamine diphosphate,二磷酸组胺,Histamine acid phosphate

Target: Histamine Receptor

Cat.No: T2S0118

Target: Calcium Channel, 5-HT Receptor, Histamine Receptor

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