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Search Results for " topoisomerase i "

107

抑制剂 & 化合物

25

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T31011	Coralyne chloride	Topoisomerase	DNA Damage/DNA Repair
	Coralyne chloride 是一种具有强抗癌活性的原小檗碱。它可用于制备 Coralyne 衍生物，是一种基于荧光 DNA 的分子整流剂，通过位点特异性插入构建成 DNA 双链体。它可作为一种拓扑异构酶 I 毒性分子，诱导拓扑异构酶 I 介导 DNA 裂解。
T80968	Topoisomerase I inhibitor 10	Topoisomerase	DNA Damage/DNA Repair
	TopoisomeraseI inhibitor 10 (compound 13)为一种抗利什曼原虫活性药物，特别针对L. donovani promastigotes的leishmanial topoisomerase IB表现出抑制作用，IC50值为27.91 μM。
T62094	Topoisomerase I inhibitor 6
	Topoisomerase I inhibitor 6 (Compound 3) 是一种 Topoisomerase I 的有效抑制剂，可以捕获 DNA-Top1 裂解复合物，在非癌细胞系中具有较小的细胞毒性。Topoisomerase I inhibitor 6 对癌症疾病表现出潜在的研究价值。
T60766	Topoisomerase I inhibitor 3
	Topoisomerase I inhibitor 3 (Compound ZML-14) 诱导 HepG2 细胞凋亡，并在 G2/M 期阻滞细胞周期。Topoisomerase I inhibitor 3 是与拓扑异构酶 I-DNA 复合物相互作用的拓扑异构酶 I 抑制剂。
T61717	Topoisomerase I inhibitor 4
	Topoisomerase I inhibitor 4 (compound 7a) is a potent inhibitor of topoisomerase I activity. It effectively inhibits the proliferation of various cancer cell lines including HepG2, A549, MCF-7, and HeLa, with IC50 values of 1.20 μM, 2.09 μM, 1.56 μM, and 1.92 μM, respectively. Thus, Topoisomerase I inhibitor 4 holds promise for cancer research applications [1].
T60617	Topoisomerase I inhibitor 2
	Topoisomerase I inhibitor 2 是一种高度选择性的DNA 拓扑异构酶 I(Top1) 抑制剂，可抑制Top1活性并导致 DNA 损伤。Topoisomerase I inhibitor 2 阻断 G2/M 期并诱导细胞凋亡，具有抗肿瘤作用。
T62002	Topoisomerase I inhibitor 7
	Topoisomerase I inhibitor 7 (Compound 8) 是有效的Topoisomerase I 抑制剂。Topoisomerase I inhibitor 7 显著抑制肿瘤生长（高达 79%）。在接受 P388 淋巴瘤移植的小鼠模型中，Topoisomerase I inhibitor 7延长了小鼠寿命（153%）。
T61501	Topoisomerase I inhibitor 5
	Topoisomerase I inhibitor 5 is an efficient inhibitor of topoisomerase I, with an IC50 value. It effectively disrupts DNA and inhibits the activity of topoisomerase I. Moreover, it can induce apoptosis in MCF-7 cells and arrest the cell cycle at the G1 phase. Topoisomerase I inhibitor 5 also exhibits potency in reversing P-gp-mediated resistance to Adriamycin [1].
T62225	Topoisomerase I inhibitor 8
	Topoisomerase I inhibitor 8 是一种喜树碱六环类似物，也是 topoisomerase I 的强效抑制剂，对肿瘤细胞有毒性。
T80967	Topoisomerase I inhibitor 9	Topoisomerase	DNA Damage/DNA Repair
	TopoisomeraseI inhibitor 9 (compound 3d) 是针对leishmanial topoisomerase IB的抑制剂，具有针对L. donovani promastigotes的抗利什曼原虫活性，其IC50值为34.81 μM。
T61045	Topoisomerase I/II inhibitor 2
	Topoisomerase I/II inhibitor 2 (compound 1a) 可显著抑制小鼠模型中的异种移植肿瘤的生长，可用于肝癌治疗。Topoisomerase I/II inhibitor 2 是一种DNA 拓扑异构酶 I/II 的双重抑制剂。Topoisomerase I/II inhibitor 2 是有效的拓扑异构酶抑制剂，对LM9 细胞和Huh7 细胞的 IC50值分别为 6.83 μM 和9.82 μM 。
T63526	Topoisomerase I/II inhibitor 4
	Topoisomerase I/II inhibitor 4 是有效的拓扑异构酶 I(Topo I) 和 II(Topo II) 双重抑制剂，对细胞增殖、侵袭和迁移，诱导细胞凋亡 (apoptosis) 具有抑制作用，能够用于研究肝癌。
T61990	Topoisomerase I/II inhibitor 3
	Topoisomerase I/II inhibitor 3 (化合物7) 是拓扑异构酶 I (Topo I)和 II (Topo II)的有效双抑制剂。通过抑制 PI3K/Akt/mTOR 信号通路，Topoisomerase I/II inhibitor 3抑制细胞增殖、侵袭和迁移，诱导细胞凋亡(apoptosis)。Topoisomerase I/II inhibitor 3 在肝癌中具有研究价值。
T17731	CL2A-SN-38	Others	Others
	CL2A-SN-38 是一种药物-接头偶联物，由一种有效的 DNA 拓扑异构酶 I 抑制剂 SN-38 和接头 CL2A 组成，用于制造抗体药物偶联物。它对一系列人类实体瘤类型提供显着和特异性的抗肿瘤作用。
T21319	Gimatecan LBQ707,STI481	Topoisomerase	DNA Damage/DNA Repair
	Gimatecan (STI481) 是一种有效的拓扑异构酶 I (topoisomerase I) 抑制剂。Gimatecan 是一种具有口服活性的喜树碱类似物。具有抗肿瘤活性。
T60123	Chimmitecan (S)-9-Allyl-10-hydroxycamptothecin,吉米替康	Topoisomerase	DNA Damage/DNA Repair
	Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) 是一种topoisomerase I 抑制剂，在体内、外表现有效的活性。
T60200	IndiMitecan LMP776	Topoisomerase	DNA Damage/DNA Repair
	IndiMitecan (LMP776) 是一种具有抗癌活性的拓扑异构酶 I（Top1）抑制剂。
T7187	Genz-644282 Genz644282	Topoisomerase	DNA Damage/DNA Repair
	Genz-644282 是一种用于癌症治疗的新型非喜树碱拓扑异构酶 I 抑制剂。
T21319L	Gimatecan HCl ST1481 HCL,Gimatecan HCl(292618-32-7 Free base)	Topoisomerase	DNA Damage/DNA Repair
	Gimatecan HCl (ST1481 HCL) 是一种有效的拓扑异构酶 I (topoisomerase I) 抑制剂。Gimatecan HCl 是一种具有口服活性的喜树碱类似物。具有抗肿瘤活性。
TQ0088	Exatecan Mesylate 依沙替康甲磺酸盐,依喜替康甲磺酸盐,DX8951f	Topoisomerase	DNA Damage/DNA Repair
	Exatecan Mesylate (DX8951f) 是一种 DNA 拓扑异构酶 I 抑制剂，IC50值为 2.2 μM，可研究癌症。
T60163	Lurtotecan GI147211,OSI-211	Topoisomerase	DNA Damage/DNA Repair
	Lurtotecan (GI147211) 是一种半合成的喜树碱类似物。Lurtotecan 是一种具有抗癌作用的拓扑异构酶I 抑制剂。
T15168	DRF-1042	Topoisomerase	DNA Damage/DNA Repair
	DRF-1042 是一种具有口服活性的喜树碱类似物，具有抗癌活性和杀虫活性，抑制 DNA 拓扑异构酶 I (DNA topoisomerase I) ，可用于研究前列腺癌和结肠癌等实体肿瘤。
T7309	TAS-103 dihydrochloride 6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐,TAS-103 (dihydrochloride),BMS-247615 dihydrochloride	Topoisomerase	DNA Damage/DNA Repair
	TAS-103 dihydrochloride (BMS-247615 dihydrochloride) 是可用于癌症研究的一种 DNA 拓扑异构酶 I/II 双重抑制剂。
T68896	Daniquidone NSC 320846,BAY-H 2049	Topoisomerase	DNA Damage/DNA Repair
	Daniquidone (Batracylin) 是一种有效的 DNA 拓扑异构酶 I 和 DNA 拓扑异构酶 II 双重抑制剂，具有细胞毒性和抗增殖活性，可诱导 DNA 断裂，可用于研究肿瘤、免疫系统疾病和淋巴系统疾病。
T26339L	XR-11576 HCl XR-11576 HCl(346689-77-8 Free base)	Topoisomerase	DNA Damage/DNA Repair
	XR-11576 HCl 是一种新型口服活性拓扑异构酶I 和II 双重抑制剂，具有抗肿瘤活性。
T7551	Belotecan hydrochloride CKD-602	Topoisomerase	DNA Damage/DNA Repair
	Belotecan hydrochloride (CKD-602) 是一种合成的水溶性喜树碱衍生物和拓扑异构酶 I 抑制剂，具有潜在的抗肿瘤活性。
T6336	Amonafide NSC308847,AS1413,氨萘非特,Nafidimide,AS1413,Quinamed	Topoisomerase	DNA Damage/DNA Repair
	Amonafide (NSC-308847,AS1413) 是一种拓扑异构酶 II 的抑制剂和 DNA 的嵌入剂，通过拓扑异构酶 II 介导的反应产生蛋白质相关的 DNA 链断裂
T11872L	LMP744 hydrochloride NSC706744 hydrochloride,MJ-III65 hydrochloride	Topoisomerase	DNA Damage/DNA Repair
	LMP744 hydrochloride (NSC-706744 hydrochloride) 是一种是拓扑异构酶 1 抑制剂，显示出抗肿瘤的活性。
T71137	Simmitecan hydrochloride	Topoisomerase	DNA Damage/DNA Repair
	Simmitecan hydrochloride 是一种喜树碱衍生物，是一种拓扑异构酶 I 抑制剂，具有抗癌活性，可用于研究是实体瘤。
T9088	Topovale ARC111,ARC 111,ARC-111,Topoval	Topoisomerase	DNA Damage/DNA Repair
	Topovale (ARC111) 是一种有效的拓扑异构酶 I 抑制剂。Topovale 抑制缺氧介导的缺氧诱导因子 1alpha 的积累。 Topovale 对一组癌细胞表现出低 nM 细胞毒性。与 P388 细胞相比，在 CPT 抗性拓扑异构酶 I (TOP1) 缺陷的 P388/CPT45 细胞中，Topovale 细胞毒性和 Topovale 诱导的细胞凋亡减少了 > 100 倍。
T11249L	Dxd Exatecan derivative for ADC,OQM5SD32BQ,UNII-OQM5SD32BQ	Topoisomerase	DNA Damage/DNA Repair
	Dxd (OQM5SD32BQ) 是一种有效的DNA 拓扑异构酶 I 抑制剂，IC50值为 0.31 μM，用作HER2靶向ADC 的偶联药物。
T11249	Exatecan 依喜替康,DX-8951,DX-8951f	Topoisomerase	DNA Damage/DNA Repair
	Exatecan (DX-8951f) 是一种 DNA 拓扑异构酶 I (TOP1) 抑制剂，IC50 值为 2.2 μM (0.975 μg/mL)。Exatecan 具有抗肿瘤活性，可用于癌症研究。
T24610	Pegamotecan Prothecan,PEG-camptothecin,PEG-beta-CPT	Topoisomerase	DNA Damage/DNA Repair
	Pegamotecan (PEG-camptothecin)是一种拓扑异构酶I(TOP1)抑制剂，具有抗癌活性，它可用于治疗食管癌、非小细胞肺癌和胰腺癌。
T77584	Tubulin inhibitor 35 Tubulin IN 35	Apoptosis; Microtubule Associated; Topoisomerase	Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair
	Tubulin inhibitor 35 (Tubulin IN 35) 是一种有效的拓扑异构酶 I 和微管蛋白聚合的双重抑制剂，具有抗肿瘤活性，对 MGC-803 和 RKO 细胞株的迁移和侵袭有抑制作用，中断细胞周期，诱导凋亡 (apoptosis)。
T17731L	CL2A-SN-38 DCA 1279680-68-0(free base)	Others	Others
	CL2A-SN-38 DCA 1279680-68-0(free base) 是一种药物-接头偶联物，由有效的 DNA 拓扑异构酶 I 抑制剂 SN-38 和接头 CL2A 组成，用于制造抗体药物偶联物 (ADC)。CL2A-SN-38 由有效的 DNA 拓扑异构酶组成I 抑制剂 SN-38 和接头 CL2A 以制造抗体药物偶联物 (ADC)。 CL2A-SN-38 对一系列人类实体瘤类型提供显着和特异性的抗肿瘤作用。 CL2A 是一种不可切割的复杂 PEG8 和含有三唑的 PABC-肽-mc 接头。 CL2A 可通过 pH 敏感性裂解，产生旁观者效应，并通过二硫键在半胱氨酸残基处结合抗体。
T15586	Intoplicine	Topoisomerase	DNA Damage/DNA Repair
	Intoplicine is an inhibitor of DNA topoisomerase I and II.
T11872	LMP744 NSC706744,MJ-III65	Others	Others
	LMP744 is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.
T27147	Deoxynybomycin
	Deoxynybomycin, a selective anti-tumor agent, inhibits topoisomerase I and induces apoptosis.
T24036	WJ35435 WJ 35435,WJ-35435
	WJ35435 is a histone deacetylase and topoisomerase I dual inhibitor.
T29168	XR-5000 NSC-601316,CRC8805,SN-22995,DACA,CRC-8805
	XR-5000 is a DNA topoisomerase I and II inhibitor.
T13183	Top1 inhibitor 1	Others	Others
	Top1 inhibitor 1 is a potent inhibitor of human topoisomerase I (Top1)(IC50: 29 nM).
T70445	Lurtotecan dihydrochloride
	Lurtotecan dihydrochloride is an antineoplastic (DNA Topoisomerase I Inhibitor)
T26339	XR-11576 MLN-576,MLN 576,MLN576,XR 11576
	XR-11576 is a DNA topoisomerase I and II inhibitor for the treatment of solid tumors.
T71185	Indotecan hydrochloride
	Indotecan hydrochloride is a novel selective and potent topoisomerase I inhibitor with potential anticancer activitity.
T39373	PNU-EDA-Gly5 PNU-EDA-Gly5
	PNU-EDA-Gly5 is a DNA topoisomerase I inhibitor-based oligo-glycine linker-payload used for the synthesis of antibody-drug conjugates (ADCs). It consists of the DNA topoisomerase I inhibitor PNU-159682 and the linker EDA-Gly5.
T12209	Netropsin dihydrochloride	Others	Others
	Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder), inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei.
T13191	TP3011 CH0793011	Others	Others
	TP3011 is a potent topoisomerase I inhibitor equipotent as SN38 and is an active metabolite of CH-0793076.
T40365	T-2513
	T-2513 is a potent and specific inhibitor of topoisomerase I. It acts by forming covalent bonds with the topoisomerase I-DNA complex, thereby enhancing its stability. This interaction disrupts the normal process of DNA replication and RNA synthesis, ultimately resulting in cellular apoptosis.
T14703	Karenitecin BNP 1350,Cositecan	Topoisomerase	DNA Damage/DNA Repair
	Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.
T70513	NB-506 Free Base
	NB-506 Free Base is an indolocarbazole antitumor agent; a DNA topoisomerase I inhibitor.

化合物

Coralyne chloride

Cat.No: T31011

Target: Topoisomerase

Topoisomerase I inhibitor 10

Cat.No: T80968

Target: Topoisomerase

Topoisomerase I inhibitor 6

Cat.No: T62094

Topoisomerase I inhibitor 3

Cat.No: T60766

Topoisomerase I inhibitor 4

Cat.No: T61717

Topoisomerase I inhibitor 2

Cat.No: T60617

Topoisomerase I inhibitor 7

Cat.No: T62002

Topoisomerase I inhibitor 5

Cat.No: T61501

Topoisomerase I inhibitor 8

Cat.No: T62225

Topoisomerase I inhibitor 9

Cat.No: T80967

Target: Topoisomerase

Topoisomerase I/II inhibitor 2

Cat.No: T61045

Topoisomerase I/II inhibitor 4

Cat.No: T63526

Topoisomerase I/II inhibitor 3

Cat.No: T61990

Cat.No: T17731

Target: Others

Cat.No: T21319

Synonym: LBQ707,STI481

Target: Topoisomerase

Cat.No: T60123

Synonym: (S)-9-Allyl-10-hydroxycamptothecin,吉米替康

Target: Topoisomerase

Cat.No: T60200

Synonym: LMP776

Target: Topoisomerase

Cat.No: T7187

Synonym: Genz644282

Target: Topoisomerase

Cat.No: T21319L

Synonym: ST1481 HCL,Gimatecan HCl(292618-32-7 Free base)

Target: Topoisomerase

Exatecan Mesylate

Cat.No: TQ0088

Synonym: 依沙替康甲磺酸盐,依喜替康甲磺酸盐,DX8951f

Target: Topoisomerase

Cat.No: T60163

Synonym: GI147211,OSI-211

Target: Topoisomerase

Cat.No: T15168

Target: Topoisomerase

TAS-103 dihydrochloride

Cat.No: T7309

Synonym: 6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐,TAS-103 (dihydrochloride),BMS-247615 dihydrochloride

Target: Topoisomerase

Cat.No: T68896

Synonym: NSC 320846,BAY-H 2049

Target: Topoisomerase

Cat.No: T26339L

Synonym: XR-11576 HCl(346689-77-8 Free base)

Target: Topoisomerase

Belotecan hydrochloride

Cat.No: T7551

Synonym: CKD-602

Target: Topoisomerase

Cat.No: T6336

Synonym: NSC308847,AS1413,氨萘非特,Nafidimide,AS1413,Quinamed

Target: Topoisomerase

LMP744 hydrochloride

Cat.No: T11872L

Synonym: NSC706744 hydrochloride,MJ-III65 hydrochloride

Target: Topoisomerase

Simmitecan hydrochloride

Cat.No: T71137

Target: Topoisomerase

Cat.No: T9088

Synonym: ARC111,ARC 111,ARC-111,Topoval

Target: Topoisomerase

Cat.No: T11249L

Synonym: Exatecan derivative for ADC,OQM5SD32BQ,UNII-OQM5SD32BQ

Target: Topoisomerase

Cat.No: T11249

Synonym: 依喜替康,DX-8951,DX-8951f

Target: Topoisomerase

Cat.No: T24610

Synonym: Prothecan,PEG-camptothecin,PEG-beta-CPT

Target: Topoisomerase

Tubulin inhibitor 35

Cat.No: T77584

Synonym: Tubulin IN 35

Target: Apoptosis, Microtubule Associated, Topoisomerase

CL2A-SN-38 DCA 1279680-68-0(free base)

Cat.No: T17731L

Target: Others

Cat.No: T15586

Target: Topoisomerase

Cat.No: T11872

Synonym: NSC706744,MJ-III65

Target: Others

Cat.No: T27147

Cat.No: T24036

Synonym: WJ 35435,WJ-35435

Cat.No: T29168

Synonym: NSC-601316,CRC8805,SN-22995,DACA,CRC-8805

Top1 inhibitor 1

Cat.No: T13183

Target: Others

Lurtotecan dihydrochloride

Cat.No: T70445

Cat.No: T26339

Synonym: MLN-576,MLN 576,MLN576,XR 11576

Indotecan hydrochloride

Cat.No: T71185

Cat.No: T39373

Synonym: PNU-EDA-Gly5

Netropsin dihydrochloride

Cat.No: T12209

Target: Others

Cat.No: T13191

Synonym: CH0793011

Target: Others

Cat.No: T40365

Cat.No: T14703

Synonym: BNP 1350,Cositecan

Target: Topoisomerase

NB-506 Free Base

Cat.No: T70513

Cat. No.	Product Name	Target	Signaling Pathways
T1123	Camptothecin NSC-100880,Campathecin,喜树碱,(S)-(+)-Camptothecin,CPT	Apoptosis; Influenza Virus; Topoisomerase; Antibiotic; Antifungal	Apoptosis; DNA Damage/DNA Repair; Microbiology/Virology
	Camptothecin (CPT) 属于生物碱类天然产物，是一种 DNA 拓扑异构酶 I (Topo I) 的抑制剂 (IC50=679 nM)，具有特异性。Camptothecin 具有抗肿瘤活性，可以诱导细胞凋亡。
TQ0134	Podocarpusflavone A	Topoisomerase	DNA Damage/DNA Repair
	Podocarpusflavone A is a DNA topoisomerase I inhibitor. It has moderated anti-proliferative activity induce cell apoptosis in MCF-7.
T6407	β-Lapachone 3,4-二氢-2,2-二甲基-2H-萘并[1,2-B]吡喃-5,6-二酮,Beta-Lapachone,NSC-26326,SL-11001,ARQ-501	IDO; Apoptosis; Topoisomerase; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism
	β-Lapachone (ARQ-501) 是一种萘醌类天然产物，是拓扑异构酶 I 抑制剂，通过抑制细胞周期进程来诱导细胞凋亡。
T3S1957	9-amino-CPT 9-氨基喜树碱,Aminocamptothecin,9-amino-2(S)-camptothecin,9-Aminocamptothecin	Topoisomerase	DNA Damage/DNA Repair
	9-amino-CPT (Aminocamptothecin) 是一种拓扑异构酶I 的抑制剂，具有抗肿瘤活性。
T5853	Rubitecan RFS 2000,鲁比特康,9-Nitrocamptothecin	Topoisomerase	DNA Damage/DNA Repair
	Rubitecan (9-Nitrocamptothecin) 是一种与喜树碱相关的半合成药物，具有有效的抗肿瘤和抗病毒特性。它是一种 DNA 拓扑异构酶 I 抑制剂，以浓度依赖性方式抑制 DNA 拓扑异构酶 I 并在无细胞试验中增加超螺旋 DNA 的比例。
T5784	Topotecan NSC 609669,拓扑替康,SKF 104864A	Topoisomerase; Autophagy	Autophagy; DNA Damage/DNA Repair
	Topotecan (NSC-609669) 是一种拓扑异构酶 I 抑制剂，通过抑制 DNA 拓扑异构酶起抗肿瘤作用，可用于治疗卵巢癌。
T2764	(S)-10-Hydroxycamptothecin 10-羟喜树碱,10-羟基喜树碱,10-Hydroxycamptothecin,10-HCPT	Apoptosis; Topoisomerase	Apoptosis; DNA Damage/DNA Repair
	(S)-10-Hydroxycamptothecin (10-HCPT) 是一种从喜树中分离的 DNA 拓扑异构酶 I 抑制剂。它显著诱导细胞凋亡，可研究肝癌、胃癌、结肠癌和白血病。
TN1917	Mauritianin	Topoisomerase	DNA Damage/DNA Repair
	Mauritianin 是一种从 Acalypha indica 的花和叶中分离出来的山柰酚苷，是一种拓扑异构酶 I 抑制剂。Mauritianin 具有细胞保护活性。
T1703	SN-38 7-乙基-10-羟基喜树碱,NK012,伊立替康杂质B,SN 38	DNA/RNA Synthesis; Topoisomerase; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	SN-38 (NK012) 是 DNA 拓扑异构酶 I (Topo I) 抑制剂 Irinotecan 的活性代谢产物，可以抑制 DNA 和 RNA 合成 (IC50=0.077/1.3 μM)。SN-38 具有抗肿瘤活性，可以诱导细胞自噬。
T6228	Irinotecan CPT-11,Topotecin,伊立替康,(+)-Irinotecan	Topoisomerase; Autophagy	Autophagy; DNA Damage/DNA Repair
	Irinotecan (CPT-11) 是喜树碱的衍生物，是一种 DNA 拓扑异构酶 I (Topo I) 的抑制剂。Irinotecan 通过与 Topo I 复合物结合来阻止 DNA 链的重新连接，并导致双链 DNA 断裂和细胞死亡，具有抗肿瘤活性。
T0486L	Irinotecan Hydrochloride 盐酸伊立替康,伊立替康盐酸盐,Camptothecin 11 hydrochloride,CPT-11 hydrochloride	Topoisomerase; Autophagy	Autophagy; DNA Damage/DNA Repair
	Irinotecan Hydrochloride (CPT-11 hydrochloride) 是喜树碱半合成衍生物的盐酸盐，是一种拓扑异构酶 I 抑制剂，可研究结肠癌和直肠癌。
T1020	Doxorubicin hydrochloride Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,盐酸多柔比星,盐酸阿霉素,NSC 123127	Apoptosis; Mitophagy; HBV; HIV Protease; Topoisomerase; Antibacterial; Antibiotic; AMPK; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Doxorubicin hydrochloride (Adriamycin) 属于蒽环类抗生素，是人类 DNA 拓扑异构酶 I/II 抑制剂 (IC50=0.8/2.67 μM)。Doxorubicin hydrochloride 具有细胞毒性和抗肿瘤活性。Doxorubicin hydrochloride 可降低 AMPK 及其下游靶蛋白乙酰辅酶 A 羧化酶的磷酸化，还可诱导凋亡和自噬。
TN1037	Groenlandicine	Topoisomerase	DNA Damage/DNA Repair
	Groenlandicine 是来自黄连的一种原小檗碱生物碱，能诱导拓扑异构酶 I 介导的 DNA 裂解。它对人类重组醛糖还原酶(HRAR)具有中度的抑制作用，IC50值为 154.2 μM。
T2830	Betulinic acid 白桦脂酸,桦木酸,ALS-357,Lupatic acid,Betulic acid	Apoptosis; Mitophagy; NF-κB; HIV Protease; Topoisomerase; Endogenous Metabolite; Aminopeptidase; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	Betulinic acid (ALS-357) 是从白桦树皮中分离出来的一种五环三萜类天然产物，是真核细胞拓扑异构酶 I 的抑制剂，IC50值为 5 μM，具有抗逆转录病毒、抗疟疾、抗癌和抗炎特性。
T3339	Sophoridine 5-Epidihydrosophocarpine,槐定碱,Dihydro-5-episophocarpine	Apoptosis; Topoisomerase	Apoptosis; DNA Damage/DNA Repair
	Sophoridine (Dihydro-5-episophocarpine) 是一种从豆科植物槐豆斜生植物的叶子中分离出来的喹喔啉生物碱。它是胰腺癌的候选药物，诱导细胞凋亡。
T16726	Rebeccamycin	Topoisomerase	DNA Damage/DNA Repair
	Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I. It also has a negligible effect on protein kinase C and topoisomerase II.
TN1734	Heveaflavone 橡胶树双黄酮	Antioxidant; Topoisomerase	DNA Damage/DNA Repair; oxidation-reduction
	Heveaflavone 抑制拓扑异构酶 I 并清除 DPPH 自由基，具有抗增殖和抗氧化作用。
T14196	Alternariol	Others	Others
	Alternariol (AOH), a mycotoxin synthesized by Alternaria species, displays numerous therapeutic and biological effects, including phytotoxic, cytotoxic, anti-HIV, anti-cancer, and anti-microbial properties. It functions by inhibiting the catalytic activity of topoisomerase I and II enzymes.
T10238	Aclacinomycin A hydrochloride 盐酸阿柔比星,Aclarubicin hydrochloride	Proteasome	Proteases/Proteasome; Ubiquitination
	Aclacinomycin A (Aclarubicin) hydrochloride is a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. Aclacinomycin A hydrochloride is also a dual inhibitor of topoisomerase I and II.
TN2105	Proscillaridin A	Topoisomerase	DNA Damage/DNA Repair
	Proscillaridin A 是从Drimia robusta 中提取的一种天然产物。是强力的拓扑异构酶 I 和 II 的抑制剂，IC50值分别为 30 nM 和 100 nM。
T75655	Hippeastrine
	Hippeastrine 是一种活性生物碱，对拓扑异构酶 ITop I 具有良好的剂量依赖性抑制作用，IC50为7.25 μg/mL。具有抗增殖和抗癌活性。
T72236	erythro-Austrobailignan-6
	erythro-Austrobailignan-6 是一种口服活性的抗癌化合物，能够抑制 DNA 拓扑异构酶 I 及 II 的活性，同时诱导细胞凋亡并增加 p38 和 JNK 的磷酸化。
T1521	(±)-10-Hydroxycamptothecin Hydroxy Camptothecine,10-羟基喜树碱,10-Hydroxycamptothecin	Topoisomerase	DNA Damage/DNA Repair
	(±)-10-Hydroxycamptothecin (Hydroxy Camptothecine) 是一种从喜树茎木中分离出来的生物碱，抑制拓扑异构酶 I 活性，具有广谱抗肿瘤活性。
TN4283	Isodiospyrin	Topoisomerase; Antifection	DNA Damage/DNA Repair; Microbiology/Virology
	Isodiospyrin is a novel human DNA topoisomerase I inhibitor, it exhibits cytotoxic activity to tumor cell lines. Isodiospyrin has antibacterial activity, the minimum inhibitory concentrations (MICs) against Gram-positive bacteria ranged from 0.78 to 50 mi
T1456	Doxorubicin Hydroxydaunorubicin,阿霉素,Adriamycin	Topoisomerase; AMPK	Chromatin/Epigenetic; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	Doxorubicin (Adriamycin) 是一种有细胞毒性的蒽环类抗生素，具有肿瘤化疗作用。它抑制DNA 拓扑异构酶 I 和拓扑异构酶 II，IC50分别为0.8 μM 和2.67 μM，从而抑制 DNA 复制。它下调AMPK 的基础磷酸化以及下游 acetyl-CoA 羧化酶。它诱导凋亡和自噬。

天然产物

Cat.No: T1123

Synonym: NSC-100880,Campathecin,喜树碱,(S)-(+)-Camptothecin,CPT

Target: Apoptosis, Influenza Virus, Topoisomerase, Antibiotic, Antifungal

Podocarpusflavone A

Cat.No: TQ0134

Target: Topoisomerase

Cat.No: T6407

Synonym: 3,4-二氢-2,2-二甲基-2H-萘并[1,2-B]吡喃-5,6-二酮,Beta-Lapachone,NSC-26326,SL-11001,ARQ-501

Target: IDO, Apoptosis, Topoisomerase, Autophagy

Cat.No: T3S1957

Synonym: 9-氨基喜树碱,Aminocamptothecin,9-amino-2(S)-camptothecin,9-Aminocamptothecin

Target: Topoisomerase

Cat.No: T5853

Synonym: RFS 2000,鲁比特康,9-Nitrocamptothecin

Target: Topoisomerase

Cat.No: T5784

Synonym: NSC 609669,拓扑替康,SKF 104864A

Target: Topoisomerase, Autophagy

(S)-10-Hydroxycamptothecin

Cat.No: T2764

Synonym: 10-羟喜树碱,10-羟基喜树碱,10-Hydroxycamptothecin,10-HCPT

Target: Apoptosis, Topoisomerase

Cat.No: TN1917

Target: Topoisomerase

Cat.No: T1703

Synonym: 7-乙基-10-羟基喜树碱,NK012,伊立替康杂质B,SN 38

Target: DNA/RNA Synthesis, Topoisomerase, Autophagy

Cat.No: T6228

Synonym: CPT-11,Topotecin,伊立替康,(+)-Irinotecan

Target: Topoisomerase, Autophagy

Irinotecan Hydrochloride

Cat.No: T0486L

Synonym: 盐酸伊立替康,伊立替康盐酸盐,Camptothecin 11 hydrochloride,CPT-11 hydrochloride

Target: Topoisomerase, Autophagy

Doxorubicin hydrochloride

Cat.No: T1020

Synonym: Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,盐酸多柔比星,盐酸阿霉素,NSC 123127

Target: Apoptosis, Mitophagy, HBV, HIV Protease, Topoisomerase, Antibacterial, Antibiotic, AMPK, Autophagy

Cat.No: TN1037

Target: Topoisomerase

Cat.No: T2830

Synonym: 白桦脂酸,桦木酸,ALS-357,Lupatic acid,Betulic acid

Target: Apoptosis, Mitophagy, NF-κB, HIV Protease, Topoisomerase, Endogenous Metabolite, Aminopeptidase, Autophagy

Cat.No: T3339

Synonym: 5-Epidihydrosophocarpine,槐定碱,Dihydro-5-episophocarpine

Target: Apoptosis, Topoisomerase

Cat.No: T16726

Target: Topoisomerase

Cat.No: TN1734

Synonym: 橡胶树双黄酮

Target: Antioxidant, Topoisomerase

Cat.No: T14196

Target: Others

Aclacinomycin A hydrochloride

Cat.No: T10238

Synonym: 盐酸阿柔比星,Aclarubicin hydrochloride

Target: Proteasome

Proscillaridin A

Cat.No: TN2105

Target: Topoisomerase

Cat.No: T75655

erythro-Austrobailignan-6

Cat.No: T72236

(±)-10-Hydroxycamptothecin

Cat.No: T1521

Synonym: Hydroxy Camptothecine,10-羟基喜树碱,10-Hydroxycamptothecin

Target: Topoisomerase

Cat.No: TN4283

Target: Topoisomerase, Antifection

Cat.No: T1456

Synonym: Hydroxydaunorubicin,阿霉素,Adriamycin

Target: Topoisomerase, AMPK

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