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43

抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1575	Nizatidine Axid,Acinon,尼扎替丁,Zanizal	AChE; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Nizatidine (Acinon) 是一种竞争性和可逆的组胺 H2 受体拮抗剂，具有抗酸活性，可用于胃溃疡的研究。
T0081	Lafutidine 拉呋替丁,FRG-8813	5-HT Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Lafutidine (FRG-8813) 是一种组胺受体 H2RA 拮抗剂，可抑制胃酸分泌，具有胃粘膜保护作用，可用于研究胃食管反流疾病。
T1069	Metoclopramide hydrochloride 盐酸甲氧氯普胺,Maxolon,Metoclopramide HCl	Dopamine Receptor; 5-HT Receptor; AChR	GPCR/G Protein; Neuroscience
	Metoclopramide hydrochloride (Metoclopramide HCl) 是可口服的5-HT3和多巴胺D2受体拮抗剂，IC50值分别为 308 和 483 nM，用于恶心呕吐、胃食管反流和胃轻瘫的研究。
T4616	Metoclopramide 甲氧氯普胺,胃复安,5-Chloro-2-methoxyprocainamide	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Metoclopramide (5-Chloro-2-methoxyprocainamide) 是5-HT3和多巴胺D2受体拮抗剂，IC50值分别为 308 和 483 nM，可用于恶心呕吐、胃食管反流和胃轻瘫的研究。
T8385	Metoclopramide hydrochloride hydrate 盐酸甲氧氯普胺,甲氧氯普胺盐酸水合物,Metoclopramide monohydrochloride monohydrate	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Metoclopramide hydrochloride hydrate (Metoclopramide monohydrochloride monohydrate) 是5-HT3和多巴胺D2受体拮抗剂，IC50值分别为 308 和 483 nM，可用于恶心呕吐、胃食管反流和胃轻瘫的研究。
T8388	Vonoprazan TAK-438 (free base),沃诺拉赞	Proton pump	Membrane transporter/Ion channel
	Vonoprazan (TAK-438 (free base)) 是一种质子泵抑制剂，是口服活性钾竞争性酸阻断剂，有抗分泌作用。在 pH 为 6.5 时，它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性，IC50值为 19 nM。它可用于研究胃酸相关疾病。
T0424	Bismuth Subsalicylate Bismuth subsalicylat,Bismuth(III) salicylate basic,Bismuth oxysalicylate,碱式水杨酸铋,次水杨酸铋	COX; PGE Synthase	Immunology/Inflammation; Neuroscience
	Bismuth Subsalicylate (Bismuth subsalicylat) 是口服抗酸和止泻试剂。它能够抑制体内前列腺素合成，抑制胃和肠道黏膜炎症反应。它广泛用于研究腹泻疾病，如恶心、消化不良、腹泻等。
T21254	Vonoprazan Fumarate TAK-438,TAK 438,Vonoprazan Fumurate,TAK438,富马酸沃诺拉赞	Proton pump	Membrane transporter/Ion channel
	Vonoprazan Fumarate (TAK438) 是质子泵的有效抑制剂，是口服有效的高效钾竞争性酸阻断剂，具有抗分泌活性。在 pH 为 6.5 时，它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性，IC50为 19 nM。它被开发用于研究酸相关疾病，如消化性溃疡和胃食管反流病。
T1651	Rabeprazole sodium Dexrabeprazole Sodium,LY307640 sodium,Habeprazole Sodium,雷贝拉唑钠,Rebeprazole sodium,Aciphex Sodium	Apoptosis; Proton pump	Apoptosis; Membrane transporter/Ion channel
	Rabeprazole sodium (Habeprazole Sodium) 是一种质子泵抑制剂，不可逆地抑制胃 H+/K+-ATPase，可研究胃溃疡和胃食管反流。它诱导细胞凋亡，也抑制尿苷核苷核糖水解酶，IC50为 0.3 μM。
T14389	AZD 9272	GluR	Neuroscience
	AZD 9272 是一种脑渗透性的mGluR5 拮抗剂，可用于研究胃食管反流。
T1756L	Ilaprazole IY81149,艾普拉唑,IY 81149,IY-81149	Proton pump; TOPK	MAPK; Membrane transporter/Ion channel
	Ilaprazole (IY-81149) 是一种具有口服活性质子泵抑制剂，以剂量依赖性方式不可逆地抑制H+/K+-ATPase，在兔壁细胞制剂中的IC50为 6 μM。它也是一种有效的T 细胞起源蛋白激酶(TOPK)抑制剂，用于胃溃疡的研究。
T2093	PF 03716556 PF-3716556	ATPase	Membrane transporter/Ion channel
	PF 03716556 (PF-3716556) 是一种有效且特异性的 P-CAB（钾竞争性酸阻滞剂），用于治疗胃食管反流病。
T6928	Pantoprazole SKF96022,泮托拉唑,BY1023	Apoptosis; Proton pump; Autophagy	Apoptosis; Autophagy; Membrane transporter/Ion channel
	Pantoprazole (BY1023) 是一种质子泵抑制剂，用于短期治疗由胃食管反流病引起的食管糜烂和溃疡。它联合阿霉素可显著增加肿瘤生长延迟。它是一种取代的苯并咪唑，是H+/K+-ATPase 抑制剂，可改善 pH 值稳定性，具有抗分泌和抗溃疡的作用。
T1291	Cisapride 西沙必利,西沙比利,Prepulsid,R 51619,Pridesia,Kaudalit,(±)-Cisaprid,Kinestase	Potassium Channel; 5-HT Receptor; HER	Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Membrane transporter/Ion channel; Neuroscience; Tyrosine Kinase/Adaptors
	Cisapride (R 51619) 是一种5-HT4受体激动剂，还是 hERG 抑制剂。它可作用于肠道中的血清素受体，促进肠道蠕动，增加胃排空并减少食管反流。
T0161	Pantoprazole Sodium Hydrate SKF96022 sodium hydrate,泮托拉唑钠水合物,BY1023 (sodium hydrate),SKF96022 (sodium hydrate)	Apoptosis; Potassium Channel; Proton pump; Autophagy	Apoptosis; Autophagy; Membrane transporter/Ion channel
	Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) 是一种具有口服活性的质子泵抑制剂。它是取代的苯并咪唑，是H+/K+-ATPase 抑制剂。它可改善 pH 值稳定性，具有抗分泌和抗溃疡的作用。它联合阿霉素可显著增加肿瘤生长延迟。
T69984	Ticalopride	5-HT Receptor	GPCR/G Protein; Neuroscience
	Ticalopride是一种5-HT3 receptor激动剂，可用于治疗消化系统疾病、口颌疾病、耳鼻咽喉疾病，可用于研究神经性贪食症、胃食管反流和肠易激综合征。
T10221	Abeprazan hydrochloride DWP14012 hydrochloride,Fexuprazan hydrochloride	Proton pump	Membrane transporter/Ion channel
	Abeprazan hydrochloride (Fexuprazan hydrochloride) 是一种有效的、可逆的、具有口服活性的potassium-competitive acid 阻滞剂，通过竞争性的与钾离子结合抑制 H+，K+- ATPase，而无需酸激活。Abeprazan hydrochloride 是一种质子泵抑制剂(PPI)，通过减少胃酸的产生而起作用，可用于治疗胃酸相关疾病，如胃食管反流病(GERD)和消化性溃疡。
T21385	Cinitapride 西尼必利,Paxapride,Cidine,cinitapride tartrate,Blaston,Cintapro,Cinmove	5-HT Receptor	GPCR/G Protein; Neuroscience
	Cinitapride (Blaston) 是一种促胃药。它减缓肌肉的活动，以减轻诸如胃酸反流、胃排空延迟和溃疡性消化不良等病症的症状。 Cinitapride 作为 5-HT2 受体的拮抗剂和 5-HT1 和 5-HT4 受体的激动剂。
T8386	Esomeprazole Magnesium trihydrate 埃索美拉唑镁三水合物,埃索美拉唑镁(三水),(S)-Omeprazole magnesium trihydrate	Proton pump	Membrane transporter/Ion channel
	Esomeprazole Magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) 是一种口服有效的H+, K+-ATPase 抑制剂，在上消化道疾病和胃食管反流疾病的研究中具有价值。它是一种外泌体抑制剂，通过抑制 V-H+-ATPases 来阻断外泌体的释放。
T68662	AZD-3355
	AZD-3355, also known as Lesogaberan, is a GABA(B)-receptor agonist reflux inhibitor.
T70127	Famotine
	Famotine is a histamine H2 receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease.
T71049	Famotidine disulfide
	Famotidine disulfide is a histamine H2-receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease.
T33402	Mitemcinal fumarate GM 611,Kita-ku Tokyo,GM-611,Kita-ku Toyko,GM611
	Mitemcinal fumarate is a erythromycin derivative that is used to treat gastroesophageal reflux disease.
T30118	Arbaclofen placarbil XP 19986,XP19986,XP-19986
	Arbaclofen placarbil( XP19986) is a GABA(B) receptor agonist.Arbaclofen Placarbil is a novel R-baclofen prodrug with improved absorption, distribution, metabolism, and elimination properties compared to R-baclofen. And it can reduce postprandial reflux in
T26727	Azeloprazole E-3710,Z215,E3710,Z 215,E 3710,Z-215
	Azeloprazole, a proton pump inhibitor, is used potentially for the treatment of gastroesophageal reflux disease (GERD).
T70090	Nizatidine amide
	Nizatidine amide is a histamine H2 receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease.
T16737	Revexepride	Others	Others
	Revexepride is a highly selective agonist of the 5-HT4 receptor and a potential inducer of CYP3A4 enzyme. Revexepride is used for the treatment of gastroesophageal reflux disease.
T16683	Pumosetrag Hydrochloride MKC-733,DDP-733	5-HT Receptor	GPCR/G Protein; Neuroscience
	Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.
T1552L	Itopride free base HSR803,HSR-803,Itopride hydrochloride,HSR 803
	Itopride HCl is an AChE inhibitor and dopamine D2 receptor antagonist. It inhibits lower esophageal sphincter relaxation. It also used to treat functional dyspepsia and gastroesophageal reflux disease
T68725	Famotidine propanamide
	Famotidine propanamide is a histamine H2-receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease.
T71509	Famotidine sulfamoyl propanamide
	Famotidine sulfamoyl propanamide is a histamine H2-receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease.
T71485	Famotidine propionic acid
	Famotidine propionic acid is a histamine H2-receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease.
T27640	Itriglumide CR-2945,CR2945,CR 2945
	Itriglumide, a CCK2 receptor antagonist, is used potentially for the treatment of peptic ulcers, dyspepsia, and gastroesophageal reflux disease (GERD).
T61740	Esomeprazole hemistrontium
	Esomeprazole hemistrontium, also known as (S)-Omeprazole, is a potent and orally active proton pump inhibitor that effectively reduces acid secretion by inhibiting the H+, K+-ATPase in gastric parietal cells. This compound exhibits promising potential for research in symptomatic gastroesophageal reflux disease [1] [2] [3].
T68250	Omeprazole magnesium
	Omeprazole magnesium 是口服活性的质子泵（proton pump）抑制剂（PPI），用于抑制胃酸，常用于研究胃酸反流和烧心症相关症状。
T31743	Famotine hydrochloride Famotine HCl,UK-2054
	Famotine Hydrochloride is a histamine H2 receptor antagonist that suppresses acid production in the stomach and commonly treats peptic ulcer disease and gastroesophageal reflux disease.
T61467	Esomeprazole magnesium salt
	Esomeprazole magnesium salt is a potent and orally active proton pump inhibitor that effectively reduces acid secretion in gastric parietal cells by inhibiting the H+, K+-ATPase. This compound has shown promise for the research and treatment of symptomatic gastroesophageal reflux disease [1][2][3].
T19929	Ranitidine-S-oxide
	Ranitidine-S-oxide is a metabolite of Ranitidine. It is commonly used in the treatment of peptic ulcer disease, Zollinger–Ellison syndrome，and gastroesophageal reflux disease.
T71980	Omeprazole acid
	Omeprazole acid is a medication used in the treatment of gastroesophageal reflux disease, peptic ulcer disease, and Zollinger–Ellison syndrome. It is also used to prevent upper gastrointestinal bleeding in people who are at high risk. Omeprazole is a proton pump inhibitor and as such blocks the release of stomach acid.
T31404	Dextranomer Dextranomere,Dextranomero,Debrisan,Dextranomerum
	Dextranomer, for treatment of burns; consists of three-dimensional network of dextran polymers cross-linked by epichlorohydrin; dextranomer based implants usedas a bulking agent for endoscopic treatment of pediatric structural incontinence; ingredient of
T61667	Esomeprazole potassium salt
	Esomeprazole potassium salt ((S)-Omeprazole potassium salt) is an effective and orally active proton pump inhibitor that works by inhibiting the H+, K+-ATPase enzyme in the gastric parietal cells, leading to a reduction in acid secretion. It is a promising compound for investigating symptomatic gastroesophageal reflux disease [1] [2] [3].
T61643	Vonoprazan hydrochloride
	Vonoprazan hydrochloride 是一种高效且具口服活性的质子泵抑制剂 (PPI) 和钾竞争性酸阻断剂 (potassium-competitive acid blocker, P-CAB)，展示出优秀的抗分泌活性。在 pH 为 6.5 的条件下，该化合物可抑制猪胃微粒体内 H+,K+-ATPase 的酶活性，呈现出 19 nM 的 IC50 值。Vonoprazan hydrochloride 主要应用于胃酸相关疾病的研究，包括胃食管反流病和消化性溃疡，并可用于根除幽门螺杆菌。
T70070	Cisapride tartrate
	Cisapride tartrate is chemically related to metoclopramide, but unlike metoclopramide, it does not cross the blood-brain barrier or have antidopaminergic effects. Cisapride is a serotonin-4 (5-HT4) receptor agonist. Cisapride was indicated for the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease. The Food and Drug Administration (FDA) in America stopped the marketing of cisapride as of 14th July 2000. They had received at least 341 reports o...

化合物

Cat.No: T1575

Synonym: Axid,Acinon,尼扎替丁,Zanizal

Target: AChE, Histamine Receptor

Cat.No: T0081

Synonym: 拉呋替丁,FRG-8813

Target: 5-HT Receptor, Histamine Receptor

Metoclopramide hydrochloride

Cat.No: T1069

Synonym: 盐酸甲氧氯普胺,Maxolon,Metoclopramide HCl

Target: Dopamine Receptor, 5-HT Receptor, AChR

Cat.No: T4616

Synonym: 甲氧氯普胺,胃复安,5-Chloro-2-methoxyprocainamide

Target: Dopamine Receptor, 5-HT Receptor

Metoclopramide hydrochloride hydrate

Cat.No: T8385

Synonym: 盐酸甲氧氯普胺,甲氧氯普胺盐酸水合物,Metoclopramide monohydrochloride monohydrate

Target: Dopamine Receptor, 5-HT Receptor

Cat.No: T8388

Synonym: TAK-438 (free base),沃诺拉赞

Target: Proton pump

Bismuth Subsalicylate

Cat.No: T0424

Synonym: Bismuth subsalicylat,Bismuth(III) salicylate basic,Bismuth oxysalicylate,碱式水杨酸铋,次水杨酸铋

Target: COX, PGE Synthase

Vonoprazan Fumarate

Cat.No: T21254

Synonym: TAK-438,TAK 438,Vonoprazan Fumurate,TAK438,富马酸沃诺拉赞

Target: Proton pump

Rabeprazole sodium

Cat.No: T1651

Synonym: Dexrabeprazole Sodium,LY307640 sodium,Habeprazole Sodium,雷贝拉唑钠,Rebeprazole sodium,Aciphex Sodium

Target: Apoptosis, Proton pump

Cat.No: T14389

Target: GluR

Cat.No: T1756L

Synonym: IY81149,艾普拉唑,IY 81149,IY-81149

Target: Proton pump, TOPK

Cat.No: T2093

Synonym: PF-3716556

Target: ATPase

Cat.No: T6928

Synonym: SKF96022,泮托拉唑,BY1023

Target: Apoptosis, Proton pump, Autophagy

Cat.No: T1291

Synonym: 西沙必利,西沙比利,Prepulsid,R 51619,Pridesia,Kaudalit,(±)-Cisaprid,Kinestase

Target: Potassium Channel, 5-HT Receptor, HER

Pantoprazole Sodium Hydrate

Cat.No: T0161

Synonym: SKF96022 sodium hydrate,泮托拉唑钠水合物,BY1023 (sodium hydrate),SKF96022 (sodium hydrate)

Target: Apoptosis, Potassium Channel, Proton pump, Autophagy

Cat.No: T69984

Target: 5-HT Receptor

Abeprazan hydrochloride

Cat.No: T10221

Synonym: DWP14012 hydrochloride,Fexuprazan hydrochloride

Target: Proton pump

Cat.No: T21385

Synonym: 西尼必利,Paxapride,Cidine,cinitapride tartrate,Blaston,Cintapro,Cinmove

Target: 5-HT Receptor

Esomeprazole Magnesium trihydrate

Cat.No: T8386

Synonym: 埃索美拉唑镁三水合物,埃索美拉唑镁(三水),(S)-Omeprazole magnesium trihydrate

Target: Proton pump

Cat.No: T68662

Cat.No: T70127

Famotidine disulfide

Cat.No: T71049

Mitemcinal fumarate

Cat.No: T33402

Synonym: GM 611,Kita-ku Tokyo,GM-611,Kita-ku Toyko,GM611

Arbaclofen placarbil

Cat.No: T30118

Synonym: XP 19986,XP19986,XP-19986

Cat.No: T26727

Synonym: E-3710,Z215,E3710,Z 215,E 3710,Z-215

Nizatidine amide

Cat.No: T70090

Cat.No: T16737

Target: Others

Pumosetrag Hydrochloride

Cat.No: T16683

Synonym: MKC-733,DDP-733

Target: 5-HT Receptor

Itopride free base

Cat.No: T1552L

Synonym: HSR803,HSR-803,Itopride hydrochloride,HSR 803

Famotidine propanamide

Cat.No: T68725

Famotidine sulfamoyl propanamide

Cat.No: T71509

Famotidine propionic acid

Cat.No: T71485

Cat.No: T27640

Synonym: CR-2945,CR2945,CR 2945

Esomeprazole hemistrontium

Cat.No: T61740

Omeprazole magnesium

Cat.No: T68250

Famotine hydrochloride

Cat.No: T31743

Synonym: Famotine HCl,UK-2054

Esomeprazole magnesium salt

Cat.No: T61467

Ranitidine-S-oxide

Cat.No: T19929

Omeprazole acid

Cat.No: T71980

Cat.No: T31404

Synonym: Dextranomere,Dextranomero,Debrisan,Dextranomerum

Esomeprazole potassium salt

Cat.No: T61667

Vonoprazan hydrochloride

Cat.No: T61643

Cisapride tartrate

Cat.No: T70070

Cat. No.	Product Name	Target	Signaling Pathways
T21651	Lansoprazole sodium 兰索拉唑钠,Lansoprazole (sodium), AG-1749 sodium	Proton pump; Phospholipase; Antibacterial	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Lansoprazole sodium (Lansoprazole (sodium)) 是一种质子泵抑制剂，是中性鞘磷脂酶的外泌体抑制剂，能抑制胃酸生成。
T3605	Gastrodenol Bismuth tripotassium dicitrate,枸橼酸铋钾,Bismuth subcitrate	Others	Others
	Gastrodenol (Bismuth tripotassium dicitrate) 是一种对溃疡和胃不适具有潜在的应用价值的药物。

天然产物

Lansoprazole sodium

Cat.No: T21651

Synonym: 兰索拉唑钠,Lansoprazole (sodium), AG-1749 sodium

Target: Proton pump, Phospholipase, Antibacterial

Cat.No: T3605

Synonym: Bismuth tripotassium dicitrate,枸橼酸铋钾,Bismuth subcitrate

Target: Others

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