Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 594 | 5日内发货 | ||
25 mg | ¥ 4,920 | 6-8周 | ||
50 mg | ¥ 6,390 | 6-8周 | ||
100 mg | ¥ 10,800 | 6-8周 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,170 | 5日内发货 |
产品描述 | Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease. |
体内活性 | Pumosetrag delays liquid gastric emptying in association with the relaxation of the proximal stomach stimulates fasting antroduodenal migrating motor complex activity and accelerates small intestinal transit. Pumosetrag displays little to no response in the regions of the mouse intestine. Pumosetrag shows both regional and species specificities. Pumosetrag has lower efficacy than 5-HT in the rat jejunum, ileum, and distal colon. However, it has a similar efficacy and potency to 5-HT in the rat proximal colon. The activity profile of Pumosetrag is different in the guinea pig intestine where it exhibits greater potency and efficacy than 5-HT in all regions. Responses to Pumosetrag in the rat and guinea pig tissues are inhibited by ondansetron, confirming its action on 5-HT(3) receptors[1] [2]. |
别名 | MKC-733, DDP-733 |
分子量 | 339.84 |
分子式 | C15H18ClN3O2S |
CAS No. | 194093-42-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (88.28 mM), Sonication and heating are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.9426 mL | 14.7128 mL | 29.4256 mL | 73.564 mL |
5 mM | 0.5885 mL | 2.9426 mL | 5.8851 mL | 14.7128 mL | |
10 mM | 0.2943 mL | 1.4713 mL | 2.9426 mL | 7.3564 mL | |
20 mM | 0.1471 mL | 0.7356 mL | 1.4713 mL | 3.6782 mL | |
50 mM | 0.0589 mL | 0.2943 mL | 0.5885 mL | 1.4713 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Pumosetrag Hydrochloride 194093-42-0 GPCR/G Protein Neuroscience 5-HT Receptor DDP733 DDP 733 MKC 733 MKC-733 DDP-733 MKC733 Inhibitor inhibitor inhibit