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476

抑制剂 & 化合物

14

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T31008	Copper probe CF4 Copper probe CF-4,Copper probe CF 4,Copper fluor CF4,CF4 prob
	Copper probe CF4 (Copper fluor CF4) 是一种荧光铜探针，可用于研究结肠癌。
T8483	Cysteine thiol probe Methyl (4-bromobenzoyl)-L-cysteinate	Others	Others
	Cysteine thiol probe (Methyl (4-bromobenzoyl)-L-cysteinate) 是基于硫醇的探针，旨在标记亲电子的天然产物。它能够结合基于烯酮，β-内酰胺和 β-内酯的亲电子代谢物。它具有理想药效团探针的每个特征，并具有发色团。
T38855	Melanin probe-1
	Melanin probe-1, an 18F-picolinamide-based PET probe, is utilized for PET imaging of malignant melanoma. It demonstrates remarkable tumor targeting efficacy, superior tumor imaging contrasts, favorable biodistribution profiles, and robust in vivo stability.
T40235	Kbz probe 1
	Kbz probe 1, an adaptable probe utilized for examining histone benzoylation and interactions within living cells, showcases extensive versatility.
T18915	Alkyne-probe 1	Others	Others
	Alkyne-probe 1 is usually used as an Alkyne-labeled fluorescent or chemical probe.
T35575	Aldehyde Reactive Probe (trifluoroacetate salt)
	DNA is continually damaged by endogenous and environmental agents leading to the formation of abasic (apurinic/apyrimidinic, AP) sites that are disruptive to DNA synthesis. Aldehyde Reactive Probe (ARP) is a biotinylated reagent for the detection and quantification of AP sites in damaged DNA. ARP reacts with aldehyde groups formed when reactive oxygen species depurinate DNA, resulting in covalent linkage of biotin to these AP sites. The biotin-tagged DNA can then be detected using common avidin-...
T37720	Difluorinated H2S Fluorescent Probe 1
	Difluorinated H2S probe 1 is a fluorescent probe for hydrogen sulfide (H2S).1It selectively fluoresces in the presence of H2S over Zn2+, Fe3+, S2O32-, ClO-, SO32-, H2O2, NO2-, cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) when used at a concentration of 1 μM. Difluorinated H2S probe 1 displays excitation/emission maxima of 365/450 nm, respectively. 1.Zhang, J., Gao, Y., Kang, X., et al.o,o-Difluorination of aromatic azide yields a fast-response fluorescent probe for H2S detection and...
T36104	Citrulline-specific Probe-Rhodamine
	Protein arginine deiminases (PADs) catalyze the posttranslational modification of arginine residues on proteins to form citrulline, which plays a large role in regulating gene expression. Abnormally high PAD activity has been observed in a host of human diseases. Citrulline-specific probe-rhodamine is a highly sensitive, rhodamine phenylglyoxal-based fluorophore that specifically detects protein citrullination via a chemoselective reaction between glyoxal and citrulline. This chemical probe (com...
T19064	TAMRA-probe 1	Others	Others
	TAMRA-probe 1 is a fluorescent probe for labeling.
T18926	Biotin-probe 1	Others	Others
	Biotin-probe 1 is a non-radiolabeled probe and can be applied to in situ hybridization.
T12562	Protein kinase affinity probe 1	Others	Others
	Protein kinase affinity probe 1 is a protein kinase affinity probe for the functional identification of protein kinases (PKs).
T32104	Hras-1Y i-motif Probe-1
	Hras-1Y i-motif Probe-1 is a probe of the hras-1Y i-motif which selectively and directly interacts with it.
T38117	WSP-5 Washington State Probe-5,WSP-5
	Hydrogen sulfide (H2S) is an important gaseous mediator, like nitric oxide, that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals. WSP-5 is a reactive disulfide-containing, fluorescent probe designed for fast detection of H2S in biological samples and cells. Through a reaction-based fluorescent turn-on strategy, WSP-5 selectively and rapidly reacts with H2S, generating a fluorophore with excitation and emission maxima of 502 and 525 nm, ...
T30874	Chemodosimeter 1 Pi-Probe-1,Chemodosimeter-1
	Chemodosimeter 1 is designed as a highly selective phosphate ion (PI) sensor capable of demonstrating exogenous and endogenous ATP-catalysed PI production and is the first probe capable of tracking PI production and enrichment through half-channel closure
T15082	DDAO	Others	Others
	DDAO 是有潜在用途的近红外红色荧光探针，其激发波长 (600-650 nm) 和长发射波长 (λem = 656 nm)可以调节。它可用于不同酶活性的检测，如 β-半乳糖苷酶，羧酸酯酶 2，硫酸酯酶，蛋白质磷酸酶 2A，人白蛋白和酯酶。
T32416	KP-1 KP 1,KP1,Kyoto Probe 1
	KP-1 is a selective fluorescent probe for labeling human pluripotent stem cells.
T32124	HyP-1 HyP 1,HyP1,Hypoxia Probe 1
	HyP-1 is a probe for photoacoustic imaging of hypoxia.
T75346	PARP7-probe-1
	PARP7-probe-1为配备化学发光标记的PARP7探针，能特异性结合PARP7活性位点。其为生物素化探针，适用于PARP7功能的研究。
T83764	Sulfane Sulfur Probe 4 SSP4
	Sulfane sulfur probe 4 (SSP4) 是用于检测含硫化氢衍生的多硫化物、过硫化物和硫化物的荧光探针。在含硫磺物种存在下，SSP4 经核苷酸攻击反应生成荧光素，其激发/发射峰值分别为494/515 nm，以及两分子的1,2-苯并二硫杂环-3-酮。SSP4 已应用于确定H2S3在原代小鼠神经元中的定位，并检测L. japonicus 幼苗根部的多硫化物。
T74459	Y1R probe-1
	Y1R probe-1 (Compound 39) 是一种针对神经肽Y Y1受体的高亲和力荧光探针，具有潜在应用于癌症疾病研究。
T72328	Cyclopropenone probe 1
	Cyclopropenone probe 1 可以通过在催化活性位点共价结合，特异且有效地修饰三阴性乳腺癌驱动因子 GSTP1。
T64640	Melanin probe-2
	Melanoma is a lethal skin cancer. The early detection of melanoma using positron emission tomography (PET) probes is critical for improving the survival of melanoma patients. Melanin probe-2 is a non-radioactive bromo-picolinamide precursor that has been used for the synthesis of18F-picolinamides based PET probe (melanin probe-1). The tumor-targeting efficacy and imaging property of three melanin probes were evaluated in B16F10 tumor-bearing mice.18F-1 and18F-3 had much lower tumor uptake compar...
T74604	CB2R probe 1
	CB2R probe 1 是一种安全绿色的 CB2R (2 型大麻素受体)荧光探针，Ki 为 130 nM。CB2R probe 1 在癌细胞中显示出低细胞毒性。
T19036	Ninhydrin	Others	Others
	Ninhydrin 是一种显色分析探针，可用于氨基酸和蛋白质的定量分析。
T64306	CXCR4 probe 1
	CXCR4 probe 1 (compound 5) 是一种有效地、特异性的 CXCR4 靶向 PET 示踪剂，能够作用于 CXCR4 特异性拮抗剂 TN14003 (IC50: 6.9 nM)。CXCR4 probe 1 具有潜力作为 CXCR4 特异性成像探针，用于炎性疾病、CXCR4 阳性肿瘤和转移性肿瘤的诊断和预后监测。
T74212	BLT2 probe 1	Leukotriene Receptor	GPCR/G Protein
	BLT2 probe 1 (化合物 13) 是一款以 CAY10583 合成激动剂为基础的荧光探针，主要靶向糖尿病伤口愈合和胃肠道病变中潜在的 BLT2。该探针适用于多种检测系统中对 BLT2 受体配体进行药理学研究。
T80522	Keap1-Nrf2 probe
	Keap1-Nrf2probe是一款专为检测Keap1-Nrf2相互作用而设计的荧光探针。
T0778	Phenacetin 非那西丁,Acetophenetidin	COX	Immunology/Inflammation; Neuroscience
	Phenacetin (Acetophenetidin) 是一种非阿片类解热化合物，可用于缓解疼痛的研究。它是一种选择性的COX-3抑制剂，能作为人肝微粒体和大鼠体内 CYP1A2 的探针。
T2379	UNC1215	Apoptosis; Epigenetic Reader Domain; Histone Methyltransferase	Apoptosis; Chromatin/Epigenetic
	UNC1215 是一种选择性 L3MBTL3甲基赖氨酸结构域的拮抗剂，IC50为40 nM，Kd 为 120 nM。它可研究恶性脑瘤。
T74613	G-quadruplex DNA fluorescence probe 1
	G-quadruplexDNA fluorescence probe 1 (Compound E1) 是一种选择性的G-quadruplexDNA 靶向荧光探针。G-quadruplexDNA fluorescence probe 1 能通过膜进入活细胞，具有低细胞毒性。
T0734	Antipyrine 安替比林,Phenazone,Phenazon	COX	Immunology/Inflammation; Neuroscience
	Antipyrine (Phenazone) 是一种退烧剂和止痛剂。它可用作氧化药物代谢的探针药物，常用于评估人类的肝氧化能力。
T7900	BAY-474	c-Met/HGFR	Tyrosine Kinase/Adaptors
	BAY-474 是酪氨酸蛋白激酶 c-MET 抑制剂，能够用于表观遗传学探针。
T18968	Dansylcadaverine Monodansyl cadaverine,丹酰尸胺	Others; Autophagy	Autophagy; Others
	Dansylcadaverine (Monodansyl cadaverine) 是谷氨酰胺转胺酶的高亲和力底物，能阻断受体介导的多种配体的内吞作用。它是一种用于标记自噬空泡的荧光探针。
T3594	ML346	HSP	Cytoskeletal Signaling; Metabolism
	ML346是 Hsp70和 HSF-1活性的激活剂，针对 Hsp70 的 EC50为 4.6 μM。它诱导热休克反应 (HSR) 的基因和蛋白质效应子的特异性增加，如 Hsp70、Hsp40 和 Hsp27。
T8371	ML188	Virus Protease; SARS-CoV	Microbiology/Virology
	ML188是一种选择性非共价 SARS-CoV3CLpro 抑制剂，具有抗病毒活性，IC50为 1.5 μM。
T15784	LP99	Epigenetic Reader Domain	Chromatin/Epigenetic
	LP99 是一种表观遗传探针，可破坏 BRD7 和 BRD9 与细胞中染色质的结合。它是一种选择性的 BRD7 和 BRD9 溴结构域抑制剂，对 BRD9 的 Kd 为 99 nM。
T41302	Itaconate-alkyne ITalk	Others	Others
	Itaconate-alkyne (ITalk) 是一种生物正交探针，用于对炎症性巨噬细胞中的衣康酸进行定量和位点特异性化学蛋白质组学分析，并能够对其直接靶标进行生化评估和蛋白质组学分析。
T8551	Nitrobenzylthioinosine NBMPR,S-(4-硝基苄基)-6-硫代肌苷	AChR; Adenosine Receptor	GPCR/G Protein; Neuroscience
	Nitrobenzylthioinosine (NBMPR) 是一种 ENT1 转运蛋白抑制剂，可与 ENT1 转运蛋白以高亲和力结合。它是一种可穿过血脑屏障的光亲和探针，用于追踪大脑中腺苷的摄取位点。
T8954	ML179 ML-179	Others	Others
	ML179 是一种有效的选择性肝受体同源物 1 (LRH1, NR5A2) 反向激动剂，IC50 为 320 nM。
T14591	Biotin-PEG3-azide N-[2-[2-[2-(2-叠氮乙氧基)乙氧基]乙氧基]乙基]生物素胺	Others; PROTAC Linker	Others; PROTAC
	Biotin-PEG3-azide 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成
T6859	I-BRD9 GSK602	Epigenetic Reader Domain	Chromatin/Epigenetic
	I-BRD9 (GSK602) 是一种选择性的 BRD9 细胞抑制剂，pIC50 为 7.3。
T5045	GSK4112 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate,SR6452	Autophagy	Autophagy
	GSK4112 (SR6452) 是一种 Rev-erbα 激动剂，EC50 为 0.4 μM。它也是一种用于核血红素受体 Rev-erbα 的细胞生物学的小分子化学探针。
TD0103	Safranin 碱性红 2,Safranine T,Basic Red 2	Others	Others
	Safranin (Basic Red 2) 是一种经典的吩嗪染料，具有平面结构和阳离子电荷，能够轻易插入包括 DNA、蛋白质在内的生物大分子。它在学术领域被广泛用作光谱探针及指示剂，可作为金属离子浓度测定中的氧化还原指示剂。
T5053	Eprobemide LIS 630,依普贝胺	MAO; Monoamine Oxidase	Metabolism; Neuroscience
	Eprobemide (LIS 630) 是一种非竞争性的、可逆的单胺氧化酶 A 抑制剂。
T0457	Probenecid Benemid,丙磺舒	HIV Protease; Antibacterial; TRP/TRPV Channel	Membrane transporter/Ion channel; Microbiology/Virology; Proteases/Proteasome
	Probenecid (Benemid) 是一种苯甲酸衍生物，具有抗高尿酸特性。它也是一种选择性瞬时受体电位香草酸受体通道 2 激动剂，还可抑制pannexin 1通道。
T31736	Exiproben DCH 21
	Exiproben is a biochemical.
T25987	Probestin
	Probestin is an aminopeptidase M inhibitor, isolated from Streptomyces azureus MH663-2F6.
T31737	Exiproben sodium salt DCH 21,DCH-21,DCH21
	Exiproben sodium salt is a biochemical.
T25539	Iprobenfos Ricid P,Kitazin P,Kitazin L,异稻瘟净,Ricid II
	Iprobenfos (IBP) is used as an organophosphorus pesticide.
T33602	NBD-Pen NBDPen,LipiRADICAL Green,NBD Pen,FDV-0042,Funakoshi
	NBD-Pen (LipiRADICAL Green) 是一种可检测活细胞中的脂质自由基的荧光探针。

化合物

Copper probe CF4

Cat.No: T31008

Synonym: Copper probe CF-4,Copper probe CF 4,Copper fluor CF4,CF4 prob

Cysteine thiol probe

Cat.No: T8483

Synonym: Methyl (4-bromobenzoyl)-L-cysteinate

Target: Others

Melanin probe-1

Cat.No: T38855

Cat.No: T40235

Alkyne-probe 1

Cat.No: T18915

Target: Others

Aldehyde Reactive Probe (trifluoroacetate salt)

Cat.No: T35575

Difluorinated H2S Fluorescent Probe 1

Cat.No: T37720

Citrulline-specific Probe-Rhodamine

Cat.No: T36104

TAMRA-probe 1

Cat.No: T19064

Target: Others

Biotin-probe 1

Cat.No: T18926

Target: Others

Protein kinase affinity probe 1

Cat.No: T12562

Target: Others

Hras-1Y i-motif Probe-1

Cat.No: T32104

Cat.No: T38117

Synonym: Washington State Probe-5,WSP-5

Chemodosimeter 1

Cat.No: T30874

Synonym: Pi-Probe-1,Chemodosimeter-1

Cat.No: T15082

Target: Others

Cat.No: T32416

Synonym: KP 1,KP1,Kyoto Probe 1

Cat.No: T32124

Synonym: HyP 1,HyP1,Hypoxia Probe 1

PARP7-probe-1

Cat.No: T75346

Sulfane Sulfur Probe 4

Cat.No: T83764

Synonym: SSP4

Cat.No: T74459

Cyclopropenone probe 1

Cat.No: T72328

Melanin probe-2

Cat.No: T64640

Cat.No: T74604

Cat.No: T19036

Target: Others

CXCR4 probe 1

Cat.No: T64306

Cat.No: T74212

Target: Leukotriene Receptor

Keap1-Nrf2 probe

Cat.No: T80522

Cat.No: T0778

Synonym: 非那西丁,Acetophenetidin

Target: COX

Cat.No: T2379

Target: Apoptosis, Epigenetic Reader Domain, Histone Methyltransferase

G-quadruplex DNA fluorescence probe 1

Cat.No: T74613

Cat.No: T0734

Synonym: 安替比林,Phenazone,Phenazon

Target: COX

Cat.No: T7900

Target: c-Met/HGFR

Dansylcadaverine

Cat.No: T18968

Synonym: Monodansyl cadaverine,丹酰尸胺

Target: Others, Autophagy

Cat.No: T3594

Target: HSP

Cat.No: T8371

Target: Virus Protease, SARS-CoV

Cat.No: T15784

Target: Epigenetic Reader Domain

Itaconate-alkyne

Cat.No: T41302

Synonym: ITalk

Target: Others

Nitrobenzylthioinosine

Cat.No: T8551

Synonym: NBMPR,S-(4-硝基苄基)-6-硫代肌苷

Target: AChR, Adenosine Receptor

Cat.No: T8954

Synonym: ML-179

Target: Others

Biotin-PEG3-azide

Cat.No: T14591

Synonym: N-[2-[2-[2-(2-叠氮乙氧基)乙氧基]乙氧基]乙基]生物素胺

Target: Others, PROTAC Linker

Cat.No: T6859

Synonym: GSK602

Target: Epigenetic Reader Domain

Cat.No: T5045

Synonym: 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate,SR6452

Target: Autophagy

Cat.No: TD0103

Synonym: 碱性红 2,Safranine T,Basic Red 2

Target: Others

Cat.No: T5053

Synonym: LIS 630,依普贝胺

Target: MAO, Monoamine Oxidase

Cat.No: T0457

Synonym: Benemid,丙磺舒

Target: HIV Protease, Antibacterial, TRP/TRPV Channel

Cat.No: T31736

Synonym: DCH 21

Cat.No: T25987

Exiproben sodium salt

Cat.No: T31737

Synonym: DCH 21,DCH-21,DCH21

Cat.No: T25539

Synonym: Ricid P,Kitazin P,Kitazin L,异稻瘟净,Ricid II

Cat.No: T33602

Synonym: NBDPen,LipiRADICAL Green,NBD Pen,FDV-0042,Funakoshi

Cat. No.	Product Name	Target	Signaling Pathways
T4820	Maleimide 马来酰亚胺,2,5-Pyrroledione	Others	Others
	Maleimide (2,5-Pyrroledione) 可用于制备荧光探针，主要用于硫醇分析物的特异性检测。它也可用于制备用于癌症研究的抗体-药物偶联物 (ADC)。
T20585	3-Acetylindole 3-乙酰吲哚,Acetyl-3-indole,3-Acetyl-1H-indole,3-Acetylindole	Others	Others
	3-Acetylindole (3-Acetyl-1H-indole) 可用作取代基和 Sudlow 位点 II 的 L-色氨酸的探针。
T8712	1-Palmitoyl-sn-glycero-3-phosphocholine 1-十六酰-SN-丙三醇-磷酸胆碱,1-Hexadecanoyl-sn-glycero-3-phosphocholine	Others	Others
	1-Palmitoyl-sn-glycero-3-phosphocholine (1-Hexadecanoyl-sn-glycero-3-phosphocholine) 是一种用于荧光探针设计的磷酸胆碱。
T10023	1-Naphthol NSC 9586,Nako TRB,1-萘酚,Furro ER	Endogenous Metabolite	Metabolism
	1-Naphthol (Furro ER) 是激发态质子转移荧光分子探针。
T40607	2,4,6-Trimethylphenol Mesitol	Others	Others
	2,4,6-Trimethylphenol (Mesitol) 是一种与有机物 (3DOM*) 反应的探针化合物，可在水溶液中被单线态氧快速氧化。
T7937	2-Amino-4'-fluorobenzophenone	Others	Others
	2-Amino-4'-fluorobenzophenone 是一种苯甲酮的衍生物。它可用于合成对氟苯甲酰氯，还被用作生物化学研究的荧光探针，如 DNA 和 RNA 的检测。
T2910	Flavonol 3-羟基黄酮,3-Hydroxyflavone,3-HF,Flavon-3-ol,3-Hydroxy-2-phenylchromone	Others; Endogenous Metabolite	Metabolism; Others
	Flavonol (3-Hydroxyflavone) 是内源性代谢产物的一种。
T5S2361	Epiberberine	ERK; Beta-Secretase; MEK; BACE; AMPK; AChR; AChE	Chromatin/Epigenetic; MAPK; Neuroscience; PI3K/Akt/mTOR signaling
	Epiberberine 是一种从黄连中得到的生物碱，是AChE 和BChE 抑制剂，和非竞争性BACE1抑制剂。在 3T3-L1 细胞分化早期，它能够下调 Raf/MEK1/2/ERK1/2 和 AMPKα/Akt 信号通路。它具有抗氧化作用，能够清除 ONOO-，可用于阿尔滋海默症和糖尿病的研究。
TN6661	4-(Dimethylamino)cinnamic acid
	4-(Dimethylamino)cinnamic acid (DMACA) could be as charge transfer (ICT) probe.
T11683	Isoglycycoumarin	Others	Others
	Isoglycycoumarin, a flavonoid derived from the roots of Glycyrrhiza uralensis, serves as a highly selective probe for human cytochrome P450 2A6.
T10194	7-Methylguanine	Others	Others
	7-Methylguanine is a metabolite of DNA methylation. It can be generated by methylating agents and used as a probe of DNA–protein interactions and a key component of the DNA sequencing method.
T3S0804	Worenine 甲基黄连碱,Worenin	Others	Others
	Worenine (Worenin) 是一种从黄连中提取的物质。它在大鼠体内第一阶段代谢中显示出脱氢，氢化，羟基化和脱亚甲基反应。在大鼠体内 II 期代谢中显示为硫酸化和葡萄糖醛酸化反应。
TN4062	Flavidin	COX; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Flavidin shows very good antioxidant capacity. Flavidin can enhance fluorescent imaging, allowing more sensitive and specific cell labeling in tissues, it should have wide application in molecular detection, providing a general insight into how to optimiz
TN6663	trans-4-(Trifluoromethyl)cinnamic acid
	trans-4-(Trifluoromethyl)cinnamic acid 是一种光敏化合物。它被用作合成各种化合物的试剂，如杂环化合物和药物。它也被用作有机反应的催化剂，例如赫克反应和铃木-宫浦反应。它还被用作生物学研究中的荧光探针，以检测和监测各种生物分子。

天然产物

Cat.No: T4820

Synonym: 马来酰亚胺,2,5-Pyrroledione

Target: Others

Cat.No: T20585

Synonym: 3-乙酰吲哚,Acetyl-3-indole,3-Acetyl-1H-indole,3-Acetylindole

Target: Others

1-Palmitoyl-sn-glycero-3-phosphocholine

Cat.No: T8712

Synonym: 1-十六酰-SN-丙三醇-磷酸胆碱,1-Hexadecanoyl-sn-glycero-3-phosphocholine

Target: Others

Cat.No: T10023

Synonym: NSC 9586,Nako TRB,1-萘酚,Furro ER

Target: Endogenous Metabolite

2,4,6-Trimethylphenol

Cat.No: T40607

Synonym: Mesitol

Target: Others

2-Amino-4'-fluorobenzophenone

Cat.No: T7937

Target: Others

Cat.No: T2910

Synonym: 3-羟基黄酮,3-Hydroxyflavone,3-HF,Flavon-3-ol,3-Hydroxy-2-phenylchromone

Target: Others, Endogenous Metabolite

Cat.No: T5S2361

Target: ERK, Beta-Secretase, MEK, BACE, AMPK, AChR, AChE

4-(Dimethylamino)cinnamic acid

Cat.No: TN6661

Isoglycycoumarin

Cat.No: T11683

Target: Others

7-Methylguanine

Cat.No: T10194

Target: Others

Cat.No: T3S0804

Synonym: 甲基黄连碱,Worenin

Target: Others

Cat.No: TN4062

Target: COX, Prostaglandin Receptor

trans-4-(Trifluoromethyl)cinnamic acid

Cat.No: TN6663

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