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43

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T19257	Cys modifier 1	Others	Others
	Cys modifier 1 是一种半胱氨酸选择性蛋白修饰剂。Cys modifier 1 是一种含硝基苯并呋喃嘧啶的荧光羰基丙烯酸衍生物 (λex=465nm，λem539 nm)。
T32102	HPG Protein Modifier
	HPG protein modifiers or p-hydroxyphenyl glyoxal react with arginine residues, producing an absorbance increase at about 340 nm, and are therefore a good choice for amino acid side chain modification.
TNU1282	N-(4-Isopropyloxy phenyl)-N-(1H-pyrrol-2-ylmethyl)urea; flavoring agent, flavor modifier
	N-(4-Isopropyloxy phenyl)-N-(1H-pyrrol-2-ylmethyl)urea; flavoring agent, flavor modifier 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 TNU1282。
T13748	L-2-Hydroxyglutaric acid disodium S-2-羟基戊二酸,(S)-2-Hydroxyglutaric acid disodium	Histone Demethylase; Mitochondrial Metabolism	Chromatin/Epigenetic; Metabolism
	L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium) 是一种表观遗传修饰因子，是肾癌中的表观遗传修饰剂和推定的癌代谢物，可用于肾癌的相关研究。它抑制线粒体肌酸激酶活性，Km 和 Ki 分别为 2.52 mM 和11.13 mM。它可抑制组蛋白去甲基化酶，从而促进组蛋白甲基化。
T12718L	RG7800 RO6885247	Others; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	RG7800 (RO6885247) 是一种 SMN2 拼接修饰剂，有用于治疗脊髓性肌萎缩的研究潜力。
T25534	Indazole-Cl Indazole Cl	Estrogen/progestogen Receptor	Endocrinology/Hormones
	Indazole-Cl 是一种选择性雌激素受体激动剂和选择性雌激素受体调节剂（SERM）。
T19335	Danegaptide Hydrochloride GAP-134 (Hydrochloride),ZP 1609 Hydrochloride,(4R)-甘氨酰基-4-(苯甲酰基氨基)-L-脯氨酸盐酸盐	Gap Junction Protein	Cytoskeletal Signaling
	Danegaptide Hydrochloride (GAP-134 (Hydrochloride)) 是一种具有口服活性的间隙连接蛋白选择性修饰剂，具有抗心律不齐的作用。
T64221	Linvencorvir RG7907	HBV; Antibiotic	Microbiology/Virology
	Linvencorvir 是一种乙型肝炎病毒（HBV）核心蛋白变构调节剂，用于治疗慢性HBV 感染。
T5199	COH000	E1/E2/E3 Enzyme	Ubiquitination
	COH000 是不可逆的泛素样激活酶1 共价变构抑制剂，体外测得对 SUMO 化修饰的IC50=0.2 μM。
T9493	DL-2-AMINOOCTANOIC ACID	Others	Others
	DL-2-AMINOOCTANOIC ACID 也称为α-氨基辛酸或α-氨基辛酸，可作为改性剂修饰钠蒙脱石(Na-MMT)粘土。
T27404	GAT107 GAT 107,GAT-107	AChR	Neuroscience
	GAT107 是一种新型有效的 α7 烟碱胆碱能受体变构激动剂和调节剂，具有抗炎活性，可逆转小鼠神经疼痛模型中的伤害感受。
T6482	Efaproxiral Sodium 乙丙昔罗钠,RSR13 sodium	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Efaproxiral Sodium (RSR13 sodium) 是血红蛋白 (Hb) 合成变构调节剂，能够减少血红蛋白氧 (O2) 的结合亲和力。
T0134	Imiquimod 咪喹莫特,R 837,S-26308	SARS-CoV; TLR; Autophagy; HSV	Autophagy; Immunology/Inflammation; Microbiology/Virology
	Imiquimod (R 837) 是一种免疫反应修饰剂，可作为 toll 样受体7 激动剂。它有抗病毒和抗肿瘤作用，可研究外生殖器、肛周疣、癌症和 COVID-19。
T16757	Risdiplam RO7034067,RG7916	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Risdiplam (RO7034067) 是一种中枢和外周分布的 SMN2 前 mRNA 剪接修饰剂，可增加运动神经元存活 (SMN) 蛋白水平。
T34093	pNNP p NNP,p-Nitrophenyl phosphate,p-NNP,Nitrophenylphosphate	Carbonic Anhydrase	Metabolism
	pNNP (Nitrophenylphosphate) 可用作 PP2C 试验的底物。pNNP 对β-碳酸酐酶和α-碳酸酯脱水酶有抑制作用，对幽门螺杆菌幽门螺杆菌也具有抑制作用。pNNP 是一种活性较弱的组织非特异性碱性磷酸酶调节剂。
T14348	Auristatin E	Microtubule Associated	Cytoskeletal Signaling
	Auristatin E 通过阻断微管蛋白的聚合来抑制细胞分裂。它是一种细胞毒性微管蛋白修饰剂，具有强效和选择性抗肿瘤活性。它是一种 MMAE 类似物，是抗体-药物偶联物中的细胞毒素。
T5521	Bropirimine U-54461,溴匹立明	TLR	Immunology/Inflammation
	Bropirimine (U-54461) 是 toll 样受体 7(TLR7)的合成激动剂，可通过 TLR7 介导 IFN-β 的产生抑制破骨细胞前体细胞向破骨细胞分化。它是一种生物反应调节剂，通过诱导淋巴因子起作用，在膀胱和上尿路的原位移行细胞癌中具有抗癌活性。
T3465	Vesnarinone 维司力农,OPC-8212,Arkin,Piteranometozine	HIV Protease; PDE	Metabolism; Microbiology/Virology; Proteases/Proteasome
	Vesnarinone (Arkin) 是一种喹啉酮衍生物，可抑制磷酸二酯酶III 活性，增加钙通量和减小钾通量。
TNU0355	N6-Methyl-2'-O-methyladenosine N6,2′-O-Dimethyladenosine	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	N6-Methyl-2'-O-methyladenosine (N6,2′-O-Dimethyladenosine) 是脂肪量和肥胖相关基因 (FTO) 的底物，是一种广泛存在于各种 RNA 分子上的可逆修饰化合物。N6,2′-O-Dimethyladenosine 可用于研究肥胖及其相关疾病。
T39704	KSC-34	Others	Others
	KSC-34 是蛋白二硫异构酶 A1（PDIA1）的共价修饰剂，是一种针对 PDIA1 的 a 位点的选择性抑制剂，以时间依赖的方式抑制PDIA1 还原酶活性，可用于研究淀粉样蛋白异常引起的疾病。
T67883	EZH2-IN-15 SHR2554	Histone Methyltransferase	Chromatin/Epigenetic
	EZH2-IN-15 是zeste 2组蛋白修饰增强子(EZH2)的特异性抑制剂。EZH2在许多人类癌症中异常过表达，通过调节Treg 活性来控制适应性反应。肿瘤内EZH2的表达也被证明可以控制先天免疫
T16102	ML-792	E1/E2/E3 Enzyme	Ubiquitination
	ML-792 是特异性的小泛素样修饰物活化酶抑制剂。ML-792选择性抑制SAE/SUMO1和SAE/SUMO2，IC50分别为 3 和 11 nM，对 NAE/NEDD8 和 UAE/ubiquitin 抑制作用微弱，IC50分别为 32 μM 和 >100 μM。
T32313	JP7 JP-7,JP 7
	JP7 is a hemoglobin allosteric modifier.
T19468	Nafocare B1 Methylfurylbutyrolactone	Others	Others
	Nafocare B1 is a modifier of synthetic immune biological response.
T29260	(R)-ß-lysine R ß lysine,MG1655,R-ß-lysine,(R) ß lysine,MG-1655
	(R) - ß - lysine is a functional modifier of elongation factor P (EF-P).
TP2348	Pimelautide RP 44102,RP44102,RP-44102
	Pimelautide is a biological response modifier medicine.
T31609	Eisenin Pglu-gln-ala,Pyroglutamyl-glutaminyl-alanine
	Eisenin shows the activity as a biological response modifier isolated from brown marine algae, Eisenia bicyclis Setchell.
T19159	Mal-β-CD 6-O-alpha-D-Maltosyl-beta-cyclodextrin	Others	Others
	Mal-β-CD is a cellular cholesterol modifier. It can form a soluble inclusion complex with cholesterol.
T22862	Imiquimod maleate	Others	Others
	Imiquimod maleate is an immune response modifier. It acts as a toll-like receptor 7 agonists and is commonly used topically to treat warts on the skin of the genital and anal areas.
T26122	Ropizine SC13504,Ropizina,SC-13504,SC 13504
	Ropizine is a benzhydryl piperazine that acts as an allosteric modifier to decreases the dissociation rate of [3H]DM so that can be used as an anticonvulsant.
TP1531	Guangxitoxin 1E
	Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials.
T3645	Endoxifen E-isomer hydrochloride E-Endoxifen hydrochloride	Estrogen Receptor/ERR; Estrogen/progestogen Receptor	Endocrinology/Hormones
	Endoxifen E-isomer hydrochloride (E-Endoxifen hydrochloride) 是 Endoxifen 的 E-异构体，是 Endoxifen Z-isomer 原料中主要的杂质，具有抗雌激素作用。
T39810	CEM114
	CEM114 is a potent chemical compound known as a chemical epigenetic modifier (CEM). It functions by employing CRISPR-Cas9 systems to harness endogenous chromatin machinery, thereby exerting its epigenetic modifying effects.
T18319	MC-Val-Cit-PAB-Auristatin E	Others	Others
	MC-Val-Cit-PAB-Auristatin E is an antibody-drug conjugate (ADC) linker compound featuring Auristatin E, a potent cytotoxic tubulin modifier, connected through the MC-Val-Cit-PAB linker, exhibiting significant antitumor activity.
T19941	MBS Crosslinker MBS protein crosslinker
	MBS crosslinker is a non-cleavable, water-insoluble, heterobifunctional protein crosslinking reagent. The MBS protein crosslinker extended spacer arm analog is SMPB crosslinker SATA Protein Modifier can be used to add sulfhydryl groups to proteins or pept
T19336	Danegaptide ZP 1609,GAP-134	Others	Others
	Danegaptide (GAP-134), has been identified as a potent and selective second generation gap junction modifier with oral bioavailability.a small modified dipeptide.
T37646	HB007
	HB007 is a potent degrader of small ubiquitin-related modifier 1 (SUMO1). It mediates the ubiquitination and subsequent degradation of SUMO1, leading to a decrease in tumor growth in vivo. HB007 is a valuable tool for investigating brain, breast, colon, and lung cancers[1][2].
T74483	Aminobenzenesulfonic auristatin E
	AminobenzenesulfonicauristatinE 是抗体偶联活性分子的一部分。AminobenzenesulfonicauristatinE 由细胞毒性微管蛋白修饰剂 AuristatinE 和 ADC linkerAminobenzenesulfonic 连接而成，具有抗肿瘤活性。
T80437	μ-TRTX-Hd1a	Sodium Channel	Membrane transporter/Ion channel
	μ-TRTX-Hd1a为特异性NaV 1.7抑制剂，源自蜘蛛毒液。该化合物作为门控修饰剂，通过与人NaV 1.7通道域II中S3b-S4桨基序互作，实现抑制功能。
T74484	Aminobenzenesulfonic auristatin E TFA
	AminobenzenesulfonicauristatinE TFA，作为一种抗体偶联药物(Antibody-Drug Conjugate, ADC)的活性成分，该化合物通过Aminobenzenesulfonic和细胞毒性微管蛋白修饰剂AuristatinE的连接构建而成，展现出对肿瘤的抗性活性。
T22091	Imiquimod hydrochloride
	Imiquimod hydrochloride (R 837 hydrochloride)是一种免疫反应调节剂，是一种选择性的 toll 样受体 7 (TLR7) 激动剂。Imiquimod hydrochloride 在体内表现出抗病毒和抗肿瘤作用。Imiquimod hydrochloride 可用于外生殖器、肛周疣、癌症和 COVID-19 的研究。
T5499	gardiquimod TFA salt
	Gardiquimod diTFA，咪唑啉类似物TLR7/8激动剂，可特异性抑制巨噬细胞和活化外周血单个核细胞(PBMCs)的HIV-1感染。在浓度低于10 μM时，该化合物特异性激活TLR7。
T75855	Phrixotoxin 3 TFA
	Phrixotoxin 3 TFA 是一种高效的电压门控钠通道阻滞剂，对NaV1.2、NaV1.3、NaV1.4、NaV1.1及NaV1.5的IC50值分别为0.6、42、72、288和610 nM。该化合物通过改变门控动力学的去极化并阻断钠电流的内向流，调控电压门控钠通道，表现出类似典型门控修饰毒素的作用机制。

化合物

Cys modifier 1

Cat.No: T19257

Target: Others

HPG Protein Modifier

Cat.No: T32102

N-(4-Isopropyloxy phenyl)-N-(1H-pyrrol-2-ylmethyl)urea; flavoring agent, flavor modifier

Cat.No: TNU1282

L-2-Hydroxyglutaric acid disodium

Cat.No: T13748

Synonym: S-2-羟基戊二酸,(S)-2-Hydroxyglutaric acid disodium

Target: Histone Demethylase, Mitochondrial Metabolism

Cat.No: T12718L

Synonym: RO6885247

Target: Others, DNA/RNA Synthesis

Cat.No: T25534

Synonym: Indazole Cl

Target: Estrogen/progestogen Receptor

Danegaptide Hydrochloride

Cat.No: T19335

Synonym: GAP-134 (Hydrochloride),ZP 1609 Hydrochloride,(4R)-甘氨酰基-4-(苯甲酰基氨基)-L-脯氨酸盐酸盐

Target: Gap Junction Protein

Cat.No: T64221

Synonym: RG7907

Target: HBV, Antibiotic

Cat.No: T5199

Target: E1/E2/E3 Enzyme

DL-2-AMINOOCTANOIC ACID

Cat.No: T9493

Target: Others

Cat.No: T27404

Synonym: GAT 107,GAT-107

Target: AChR

Efaproxiral Sodium

Cat.No: T6482

Synonym: 乙丙昔罗钠,RSR13 sodium

Target: Reactive Oxygen Species

Cat.No: T0134

Synonym: 咪喹莫特,R 837,S-26308

Target: SARS-CoV, TLR, Autophagy, HSV

Cat.No: T16757

Synonym: RO7034067,RG7916

Target: DNA/RNA Synthesis

Cat.No: T34093

Synonym: p NNP,p-Nitrophenyl phosphate,p-NNP,Nitrophenylphosphate

Target: Carbonic Anhydrase

Cat.No: T14348

Target: Microtubule Associated

Cat.No: T5521

Synonym: U-54461,溴匹立明

Target: TLR

Cat.No: T3465

Synonym: 维司力农,OPC-8212,Arkin,Piteranometozine

Target: HIV Protease, PDE

N6-Methyl-2'-O-methyladenosine

Cat.No: TNU0355

Synonym: N6,2′-O-Dimethyladenosine

Target: Nucleoside Antimetabolite/Analog

Cat.No: T39704

Target: Others

Cat.No: T67883

Synonym: SHR2554

Target: Histone Methyltransferase

Cat.No: T16102

Target: E1/E2/E3 Enzyme

Cat.No: T32313

Synonym: JP-7,JP 7

Cat.No: T19468

Synonym: Methylfurylbutyrolactone

Target: Others

Cat.No: T29260

Synonym: R ß lysine,MG1655,R-ß-lysine,(R) ß lysine,MG-1655

Cat.No: TP2348

Synonym: RP 44102,RP44102,RP-44102

Cat.No: T31609

Synonym: Pglu-gln-ala,Pyroglutamyl-glutaminyl-alanine

Cat.No: T19159

Synonym: 6-O-alpha-D-Maltosyl-beta-cyclodextrin

Target: Others

Imiquimod maleate

Cat.No: T22862

Target: Others

Cat.No: T26122

Synonym: SC13504,Ropizina,SC-13504,SC 13504

Guangxitoxin 1E

Cat.No: TP1531

Endoxifen E-isomer hydrochloride

Cat.No: T3645

Synonym: E-Endoxifen hydrochloride

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Cat.No: T39810

MC-Val-Cit-PAB-Auristatin E

Cat.No: T18319

Target: Others

MBS Crosslinker

Cat.No: T19941

Synonym: MBS protein crosslinker

Cat.No: T19336

Synonym: ZP 1609,GAP-134

Target: Others

Cat.No: T37646

Aminobenzenesulfonic auristatin E

Cat.No: T74483

Cat.No: T80437

Target: Sodium Channel

Aminobenzenesulfonic auristatin E TFA

Cat.No: T74484

Imiquimod hydrochloride

Cat.No: T22091

gardiquimod TFA salt

Cat.No: T5499

Phrixotoxin 3 TFA

Cat.No: T75855

Cat. No.	Product Name	Target	Signaling Pathways
T5043	Lentinan	Others	Others
	Lentinan 是一种 β-葡聚糖，从香菇中提取获得。它在日本已被批准用作胃癌的生物反应调节剂。
T20868	Isophthalic acid Acide isophtalique
	Isophthalic acid is an intermediate for a modifier of polyethylene terephthalate for bottles, gel coats, high solids paints, resins for coatings, and high-performance unsaturated polyesters.
T39614	Mogroside VI A
	Mogroside VI A is a saccharide compound, an isomer of Mogroside VI, that has been extracted from the Luo Han Guo plant. It possesses inherent sweetness properties. Mogroside VI A holds potential for application in sweetener and taste modifier studies.
T13749	L-2-Hydroxyglutaric acid (S)-2-Hydroxyglutaric acid	Others	Others
	L-2-Hydroxyglutaric acid, an epigenetic modifier and potential oncometabolite in renal cancer, impedes mitochondrial creatine kinase (Mi-CK) activity, exhibiting Km and Ki values of 2.52 mM and 11.13 mM, respectively. Additionally, it obstructs histone demethylases, thereby encouraging histone methylation.

天然产物

Cat.No: T5043

Target: Others

Isophthalic acid

Cat.No: T20868

Synonym: Acide isophtalique

Cat.No: T39614

L-2-Hydroxyglutaric acid

Cat.No: T13749

Synonym: (S)-2-Hydroxyglutaric acid

Target: Others

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