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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T7775	A2764 dihydrochloride	Potassium Channel	Membrane transporter/Ion channel
	A2764 dihydrochloride 是高选择性的TRESK (K2P18.1)抑制剂，对 TREK-1 和 TALK-1 有抑制作用。它相比基底 mTRESK 电流，对激活渠道更敏感 (IC50= 6.8 μM)。它可导致细胞去极化，增加细胞的兴奋性，在探索 TRESK 通道在偏头痛和痛觉中的作用中具有研究的价值。
T1092	Zolmitriptan 佐米曲普坦,311C90,BW-311C90	5-HT Receptor	GPCR/G Protein; Neuroscience
	Zolmitriptan (311C90) 是一种5-HT1B/1D 受体部分激动剂，可用于偏头痛的研究，对 5-HT1B、5-HT1D、5-HT1F 受体的Ki 分别为 5.01、0.63 和 63.09 nM。
T8682	Vazegepant hydrochloride Vazegepant HCl	CGRP Receptor	GPCR/G Protein; Neuroscience
	Vazegepant hydrochloride (Vazegepant HCl) 是一种用于偏头痛的鼻用 gepant，是一种高度亲和性CGRP 受体拮抗剂 (hCGRPKi=0.023 nM)。它可能有助于有效管理 COVID-19 相关肺部炎症。
T0203	Sumatriptan succinate 舒马普坦琥珀酸盐,GR 43175,琥珀酸舒马曲坦	5-HT Receptor	GPCR/G Protein; Neuroscience
	Sumatriptan succinate (GR 43175) 是一种5-HT1受体激动剂，可作用于偏头疼的急性治疗。
T1602	Valproic acid sodium salt 丙戊酸钠,Sodium Valproate	Mitophagy; Gamma-secretase; HIV Protease; GABA Receptor; HDAC; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome; Stem Cells
	Valproic acid sodium salt (Sodium Valproate) 是一种HDAC 抑制剂，可抑制HDAC1的活性，诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、偏头痛和双相情感障碍等。
T11326	Frovatriptan succinate hydrate Frovelan,夫罗曲坦琥珀酸盐水合物 ,Frova	5-HT Receptor	GPCR/G Protein; Neuroscience
	Frovatriptan succinate hydrate (Frova) 是一种有效、高亲和力、选择性和口服活性的 5-HT1B、HT1D 受体激动剂和中等有效的 5-HT7 受体激动剂，pKi 值分别为 8.6、8.4 和 6.7。它可有效治疗各种偏头痛，包括恶心、呕吐、畏光和畏声等相关症状。
T6474	Divalproex Sodium Valproate semisodium,Epival,双丙戊酸钠	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Divalproex Sodium (Valproate semisodium) 结合并抑制 γ-氨基丁酸 (GABA) 转氨酶，其抗惊厥活性可通过增加 GABA 脑浓度和抑制分解 GABA 或阻止 GABA 再摄取到神经胶质和神经末梢的酶来发挥。它也是一种 HDAC 抑制剂。由丙戊酸钠和丙戊酸组成，具有抗惊厥和抗癫痫活性。 Divalproex 还可以通过抑制电压敏感的钠通道来抑制重复的神经元放电。
T5479	AMG 333 AMG-333	TRP/TRPV Channel	Membrane transporter/Ion channel
	AMG 333 是有效的TRPM8高选择性拮抗剂，IC50为13 nM。
T8666	Naratriptan	5-HT Receptor	GPCR/G Protein; Neuroscience
	Naratriptan 是一种5-HT1受体选择性激动剂，可作用于偏头疼。
T69096	Femoxetine hydrochloride	5-HT Receptor	GPCR/G Protein; Neuroscience
	Femoxetine hydrochloride 是一种选择性5-羟色胺再摄取抑制剂，可用于研究偏头痛，抑郁和饮食失调。
T27932	LY-2300559 LY2300559	GluR	Neuroscience
	LY-2300559 是代谢型谷氨酸受体 2 (mGluR2) 的激动剂，可用于偏头痛治疗的研究。
T68145	Stacofylline
	Stacofylline 是一种黄嘌呤衍生物，可用于治疗偏头疼。
T31208	Dasolampanel NGX-426,NGX 426,NGX426	GluR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Dasolampanel (NGX-426) 是一种可口服的离子型谷氨酸受体 AMPA 和 Kainate 受体拮抗剂，可用于研究慢性疼痛疾病，包括神经性疼痛和偏头痛。
T68067L	Etilefrine pivalate HCl Etilefrine pivalate HCl（100696-30-8 Free base)
	Etilefrine pivalate HCl 是一种具有口服活性的化合物，可用于治疗偏头痛。
T8993L	BGC-20-1531 hydrochloride(1186532-61-5 free base) BGC-20-1531 hydrochloride,GTPL3380 hydrochloride,AP-1531 hydrochloride	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	BGC-20-1531 hydrochloride(1186532-61-5 free base) (GTPL3380 hydrochloride) 是一种 EP4 拮抗剂，用于治疗急性偏头痛。
T17194	Ubrogepant MK-1602	CGRP Receptor	GPCR/G Protein; Neuroscience
	Ubrogepant (MK-1602) 是新型的、口服有效的降钙素基因相关肽受体拮抗剂。Ubrogepant 有潜力用于急性偏头痛的相关研究。
T6571	Lomerizine dihydrochloride Terranas,盐酸洛美利嗪,Lomerizine 2HCl,Lomerizine hydrochloride,KB-2796	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Lomerizine dihydrochloride (KB-2796) 是双重 L 和 T 型电压门控钙通道拮抗剂。
T76874	Erenumab AMG-334	CGRP Receptor	GPCR/G Protein; Neuroscience
	Erenumab是一种全人单克隆抗体，作用于抑制降钙素基因相关肽(CGRP)受体，用于预防发作性偏头痛。
T77513	2-Chlorophenylboronic acid	FAAH	Metabolism; Neuroscience
	2-Chlorophenylboronic acid 是一种单卤代苯硼酸，是一种重要的医药中间体，在新药合成中应用广泛。2-Chlorophenylboronic acid 对脂肪酸酰胺酶有抑制作用，Ki 值为0.01-1 µM，可用于研究抑郁症、青光眼、神经性疼痛、焦虑、偏头痛、I 型糖尿病和胃炎等疾病。
T2317	Almotriptan Malate LAS 31416,PNU180638,马来酸阿莫曲坦	5-HT Receptor	GPCR/G Protein; Neuroscience
	Almotriptan Malate (PNU180638) 是一种选择性 5-HT1B/1D 受体激动剂，用于治疗成人偏头痛发作。
T17285	Zatosetron maleate LY 277359 maleate	5-HT Receptor	GPCR/G Protein; Neuroscience
	Zatosetron maleate（LY 277359 maleate）是一种具有有效性和选择性的血清素 5HT3 受体拮抗剂，可用于研究急性偏头痛。
T25615	Lanepitant LY303870,LY-303870,LY 303870	Others	Others
	Lanepitant (LY303870) 是一种非肽类神经激肽-1（NK-1）拮抗剂,具有镇痛活性，可抑制神经源性硬脑膜炎症,可用于预防偏头痛。
T1512	Rizatriptan benzoate 苯甲酸利扎曲坦,MK-462 Benzoate	5-HT Receptor	GPCR/G Protein; Neuroscience
	Rizatriptan benzoate (MK-462 Benzoate) 是 5-HT1激动剂，通过选择性结合并激活血清素 (5-HT) 1B 受体和 5-HT 1D 受体，从而缓解偏头痛。
T14384	AZD8797 KAN-0440567,KAND567	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	AZD8797 (KAND567) 是一种可口服且具有选择性和有效性的人 CX3CR1 变构拮抗剂，对 CX3CR1 和 CXCR2 具有抑制作用，对SARS-CoV-2诱导的神经元损伤有潜在的保护作用，可防止癫痫发作后偏头痛模型大鼠痛觉过敏和小胶质细胞活化的恶化。
T34609	Selurampanel BGG-492,BGG 492,BGG492	iGluR	Membrane transporter/Ion channel; Neuroscience
	Selurampanel (BGG492) 是一种具有口服活性和选择性的竞争性 AMPA 谷氨酸受体拮抗剂，是一种喹唑啉二酮磺酰胺。Selurampanel 可用于研究癫痫、偏头痛和耳鸣。
T6602	Naratriptan hydrochloride Naratriptan HCl,Amerge,Naramig,盐酸那拉曲坦,GR-85548A hydrochloride	5-HT Receptor	GPCR/G Protein; Neuroscience
	Naratriptan hydrochloride (GR-85548A hydrochloride) 是一种5-HT1受体激动剂，有抗偏头疼特性。它还可以通过刺激三叉神经系统感觉神经末梢上的 5-HT1D/1B 受体来发挥其作用，从而减少促炎神经肽的释放。
T4008	Metergoline 甲麦角林,Methergoline,Liserdol	Dopamine Receptor; 5-HT Receptor; Sodium Channel	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Metergoline (Methergoline) 是多巴胺激动剂和血清素拮抗剂。它是 h5-HT7受体的高亲和力配体，Ki 为 16 nM。它还是可逆神经 Na+通道抑制剂，用于研究季节性情绪障碍、催乳激素调节。
T21231	Almotriptan 阿莫曲坦,LAS 31416,阿莫曲普坦	5-HT Receptor	GPCR/G Protein; Neuroscience
	Almotriptan (LAS 31416) 是一种用于研究偏头痛的5-HT1B/1D 受体激动剂。
T0806	Flunarizine dihydrochloride Flunarizine 2HCl,KW-3149,R14950,盐酸氟桂利嗪	Calcium Channel; Dopamine Receptor; Sodium Channel	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Flunarizine dihydrochloride (R14950) 是 Na+/Ca2+(T 型) 通道双重阻滞剂。它也是 D2多巴胺受体拮抗剂。它具有用于扩张外周血管和预防偏头痛的潜力。
T0784	Tolfenamic Acid 托芬那酸,GEA 6414,托灭酸,Tolfedine	COX	Immunology/Inflammation; Neuroscience
	Tolfenamic Acid (GEA 6414) 是一种非甾体抗炎剂和抗癌剂，可用于治疗偏头痛的症状。它能选择性地抑制COX-2的活性，在 LPS 诱导的犬 DH82 单核细胞/巨噬细胞中，对COX-2的IC50值为 13.49 μM(3.53 μg/mL)。
T1442	Pizotifen Pizotyline,BC-105,苯噻啶	5-HT Receptor	GPCR/G Protein; Neuroscience
	Pizotifen (Pizotyline) 是5-HT2受体的有效拮抗剂，并对5-HT1C 有高亲和力。它是一种强血清素和色胺拮抗剂，具有较弱的抗胆碱能、抗组胺和抗激肽作用，还具有镇静和刺激食欲的特性。
T69734	Org GC 94
	Org GC 94 is a serotonin antagonist; anti-migraine.
T27628	IS-159 IS 159,IS159
	IS-159, a 5-HT1D agonist, is used potentially for the treatment of migraine.
T39522	HTL22562
	HTL22562 is a calcitonin gene-related peptide (CGRP) receptor antagonist for acute treatment of migraine.
T26079	RI 61 RI-61,Pro-his-pro-phe-his-leu-phe-val-phe,RI61
	RI 61 (sumatriptan succinate) is utilized in the therapy of migraine, cluster headaches, new daily persistent headache, and cyclic vomiting syndrome.
T27915	LY 302148 LY-302148,LY302148
	LY 302148 , a 5-HT1F receptor agonist, inhibits neurogenic dural inflammation in guinea pigs. It has potential for migraine therapeutics.
T70997	Fonazine mesylate
	Fonazine mesylate is a phenothiazine drug used for the treatment of migraine. It is a serotonin antagonist and histamine antagonist.
T38734	Vazegepant Zavegepant,BHV-3500
	Vazegepant is an intranasal CGRP receptor antagonist utilized for conducting acute migraine research.
T21407	Frovatriptan Succinate Frovatriptan succinate hydrate,NCGC00183880-01,Frovatriptan Succinate monohydrate,KB-295988
	Frovatriptan Succinate is a synthetic triptan with 5-HT1B/1D receptors agonist activity. It is indicated for the acute treatment of migraine.
T8993	BGC201531 AP-1531,GTPL3380,BGC-20-1531	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	BGC201531 (AP-1531) 是一种 EP4 拮抗剂，用于治疗急性偏头痛。
T26598	Alniditan dihydrochloride
	Alniditan dihydrochloride is a potent 5-HT1D agonist and migraine-abortive agent.
T26781	BF-1 BF1
	BF-1 is a 5-Hydroxytryptamine receptor 2B antagonist. BF-1 was tested as potential migraine prophylactic drug by blocking BW723C86 (5-((thiophen-2-yl)methoxy)-α-methyltryptamine) or meta-chlorophenylpiperazine (mCPP) induced neurogenic dural plasma protei
T30229	Avitriptan Fumarate BMS 180048,BMS180048,BMS-180048,UNII-2G25KE3954
	Amitriptan fumarate is serotonin 5HT-1B/1D receptor agonist with anti-migraine activity.
T34832	Tezampanel hydrate LY293558,NGX 424,NGX424,LY-293558,NGX-424,LY 293558
	Tezampanel is used for the treatment of migraine, neuropathic pain.
T25617	Lanepitant HCl trihydrate Lanepitant dihydrochloride trihydrate
	Lanepitant HCl trihydrate is an effective non-peptide neurokinin-1 receptor antagonist, suppresses neurogenic dural inflammation, and may have a role in migraine therapy.
T32105	Cipepofol HSK3486,HSK 3486,HSK-3486
	HSK3486 is similar to propofol and is a general anesthetic, which may have therapeutic potential in insomnia, migraine, anxiety, analgesia, and other aspects.
T31844	Fonazine Dimethodin,Banistyl,Dimetiotazine,Dimetotiazine,Dimethothiazine
	Forazine (dimethiazide) is a phenothiazine drug used in the treatment of migraine and is a serotonin antagonist and a histamine antagonist.
T69407	Fonazine hydrochloride
	Fonazine hydrochloride is a phenothiazine drug used for the treatment of migraine. It is a serotonin antagonist and histamine antagonist.
T21392	Flunarizine Flunarizinum,Flunarizin,Sibelium,Flunarizina,R-14950
	Flunarizine is a non-selective calcium entry blocker and a histamine H1 receptor blocker. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of
T70410	Cam 2445
	Cam 2445 is a nonpeptide, alpha-methyltryptophan derivative; an NK1 neurokinin receptor antagonist that is a potentially useful treatment for arthritis, asthma, migraine, anxiety, psychosis, and emesis.

化合物

A2764 dihydrochloride

Cat.No: T7775

Target: Potassium Channel

Cat.No: T1092

Synonym: 佐米曲普坦,311C90,BW-311C90

Target: 5-HT Receptor

Vazegepant hydrochloride

Cat.No: T8682

Synonym: Vazegepant HCl

Target: CGRP Receptor

Sumatriptan succinate

Cat.No: T0203

Synonym: 舒马普坦琥珀酸盐,GR 43175,琥珀酸舒马曲坦

Target: 5-HT Receptor

Valproic acid sodium salt

Cat.No: T1602

Synonym: 丙戊酸钠,Sodium Valproate

Target: Mitophagy, Gamma-secretase, HIV Protease, GABA Receptor, HDAC, Autophagy

Frovatriptan succinate hydrate

Cat.No: T11326

Synonym: Frovelan,夫罗曲坦琥珀酸盐水合物 ,Frova

Target: 5-HT Receptor

Divalproex Sodium

Cat.No: T6474

Synonym: Valproate semisodium,Epival,双丙戊酸钠

Target: HDAC

Cat.No: T5479

Synonym: AMG-333

Target: TRP/TRPV Channel

Cat.No: T8666

Target: 5-HT Receptor

Femoxetine hydrochloride

Cat.No: T69096

Target: 5-HT Receptor

Cat.No: T27932

Synonym: LY2300559

Target: GluR

Cat.No: T68145

Cat.No: T31208

Synonym: NGX-426,NGX 426,NGX426

Target: GluR, iGluR

Etilefrine pivalate HCl

Cat.No: T68067L

Synonym: Etilefrine pivalate HCl（100696-30-8 Free base)

BGC-20-1531 hydrochloride(1186532-61-5 free base)

Cat.No: T8993L

Synonym: BGC-20-1531 hydrochloride,GTPL3380 hydrochloride,AP-1531 hydrochloride

Target: Prostaglandin Receptor

Cat.No: T17194

Synonym: MK-1602

Target: CGRP Receptor

Lomerizine dihydrochloride

Cat.No: T6571

Synonym: Terranas,盐酸洛美利嗪,Lomerizine 2HCl,Lomerizine hydrochloride,KB-2796

Target: Calcium Channel

Cat.No: T76874

Synonym: AMG-334

Target: CGRP Receptor

2-Chlorophenylboronic acid

Cat.No: T77513

Target: FAAH

Almotriptan Malate

Cat.No: T2317

Synonym: LAS 31416,PNU180638,马来酸阿莫曲坦

Target: 5-HT Receptor

Zatosetron maleate

Cat.No: T17285

Synonym: LY 277359 maleate

Target: 5-HT Receptor

Cat.No: T25615

Synonym: LY303870,LY-303870,LY 303870

Target: Others

Rizatriptan benzoate

Cat.No: T1512

Synonym: 苯甲酸利扎曲坦,MK-462 Benzoate

Target: 5-HT Receptor

Cat.No: T14384

Synonym: KAN-0440567,KAND567

Target: CXCR

Cat.No: T34609

Synonym: BGG-492,BGG 492,BGG492

Target: iGluR

Naratriptan hydrochloride

Cat.No: T6602

Synonym: Naratriptan HCl,Amerge,Naramig,盐酸那拉曲坦,GR-85548A hydrochloride

Target: 5-HT Receptor

Cat.No: T4008

Synonym: 甲麦角林,Methergoline,Liserdol

Target: Dopamine Receptor, 5-HT Receptor, Sodium Channel

Cat.No: T21231

Synonym: 阿莫曲坦,LAS 31416,阿莫曲普坦

Target: 5-HT Receptor

Flunarizine dihydrochloride

Cat.No: T0806

Synonym: Flunarizine 2HCl,KW-3149,R14950,盐酸氟桂利嗪

Target: Calcium Channel, Dopamine Receptor, Sodium Channel

Tolfenamic Acid

Cat.No: T0784

Synonym: 托芬那酸,GEA 6414,托灭酸,Tolfedine

Target: COX

Cat.No: T1442

Synonym: Pizotyline,BC-105,苯噻啶

Target: 5-HT Receptor

Cat.No: T69734

Cat.No: T27628

Synonym: IS 159,IS159

Cat.No: T39522

Cat.No: T26079

Synonym: RI-61,Pro-his-pro-phe-his-leu-phe-val-phe,RI61

Cat.No: T27915

Synonym: LY-302148,LY302148

Fonazine mesylate

Cat.No: T70997

Cat.No: T38734

Synonym: Zavegepant,BHV-3500

Frovatriptan Succinate

Cat.No: T21407

Synonym: Frovatriptan succinate hydrate,NCGC00183880-01,Frovatriptan Succinate monohydrate,KB-295988

Cat.No: T8993

Synonym: AP-1531,GTPL3380,BGC-20-1531

Target: Prostaglandin Receptor

Alniditan dihydrochloride

Cat.No: T26598

Cat.No: T26781

Synonym: BF1

Avitriptan Fumarate

Cat.No: T30229

Synonym: BMS 180048,BMS180048,BMS-180048,UNII-2G25KE3954

Tezampanel hydrate

Cat.No: T34832

Synonym: LY293558,NGX 424,NGX424,LY-293558,NGX-424,LY 293558

Lanepitant HCl trihydrate

Cat.No: T25617

Synonym: Lanepitant dihydrochloride trihydrate

Cat.No: T32105

Synonym: HSK3486,HSK 3486,HSK-3486

Cat.No: T31844

Synonym: Dimethodin,Banistyl,Dimetiotazine,Dimetotiazine,Dimethothiazine

Fonazine hydrochloride

Cat.No: T69407

Cat.No: T21392

Synonym: Flunarizinum,Flunarizin,Sibelium,Flunarizina,R-14950

Cat.No: T70410

Cat. No.	Product Name	Target	Signaling Pathways
T7064	Valproic Acid Sodium valproate,2-Propylpentanoic Acid,丙戊酸,VPA,Depakine,2-Propylvaleric Acid	Mitophagy; Gamma-secretase; HIV Protease; GABA Receptor; Sodium Channel; HDAC; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome; Stem Cells
	Valproic Acid (2-Propylpentanoic Acid) 是一种 HDAC 抑制剂，可抑制 HDAC1 活性，诱导 HDAC2 降解，具有口服活性。Valproic Acid 可以用于癫痫和躁郁症的研究。

天然产物

Cat.No: T7064

Synonym: Sodium valproate,2-Propylpentanoic Acid,丙戊酸,VPA,Depakine,2-Propylvaleric Acid

Target: Mitophagy, Gamma-secretase, HIV Protease, GABA Receptor, Sodium Channel, HDAC, Autophagy

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