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52

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T25049	Allethrin	BCL; Caspase	Apoptosis; Proteases/Proteasome
	Allethrin 是拟除虫菊酯杀虫剂，是主要的驱蚊剂。它在大鼠睾丸癌细胞 (LC540) 中诱导氧化应激、细胞凋亡和钙释放。它还诱导 BCL-2、caspase-3 激活和细胞内钙的释放。
TP1806L	BCMA72-80 acetate(2293841-58-2 free base)	Others	Others
	BCMA72-80 acetate(2293841-58-2 free base) 是一种 HLA-A2 特异性 B 细胞成熟抗原 (BCMA) 肽。它用于研究表达 B 细胞成熟抗原的多发性骨髓瘤和肿瘤。
T9773	Thioquinapiperifil dihydrochloride KF-31327	PDE	Metabolism
	Thioquinapiperifil dihydrochloride 是一种磷酸二酯酶(PDE-5)抑制剂（IC50： 0.074 nM），具有有效性、选择性和非竞争性，可用于研究性成熟。
T15436	GSK2838232	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	GSK2838232 是一种新型人类免疫病毒成熟抑制剂，抑制 HIV 逆转录酶活性。
T26854	BMS641 BMS-641,BMS-209641,BMS 641	Retinoid Receptor	Metabolism
	BMS641 (BMS-209641) 是一种具有选择性和有效性的 RARβ 激动剂。BMS641 对 RARβ 有很高的亲和力，可协同激活 RARβ 和 RARgamma 诱导细胞成熟为专门的神经元亚型。
T26955	Cavosonstat N91115,N 91115,N-91115	GSNOR; CFTR	Membrane transporter/Ion channel; Metabolism
	Cavosonstat (N91115) 是一种口服活性 S-亚硝基谷胱甘肽还原酶(GSNOR)抑制剂，可促进囊性纤维化跨膜传导调节器(CFTR)成熟和质膜稳定。
T67887	BDCRB
	BDCRB 抑制疱疹病毒 DNA 成熟。 BDCRB 导致 HCMV 终止酶跳过正常的切割位点并继续包装 DNA，直到在多联体上 30 kb 处遇到第二个切割位点。
T2595	Lumacaftor 鲁玛卡托,VX-809,VRT 826809	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	Lumacaftor (VRT 826809) 是一种 CFTR 调节剂，可纠正 CFTR 蛋白的折叠和运输。它增强了 FRT 细胞中 F508del-CFTR 蛋白的成熟，EC50为100 nM。
T21992	Vacuolin-1	PI3K; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	Vacuolin-1 是一种细胞渗透性抑制剂，可抑制 Ca2+ 依赖性溶酶体与细胞膜的融合。它通过抑制溶酶体内容物的释放起作用。它是一种有效的选择性 PIKfyve 抑制剂，通过损害溶酶体成熟来抑制晚期自噬。
T2162	Maribavir BW1263W94,GW257406X,Benzimidavir,马立巴韦,1263W94	Others; HCV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Maribavir (GW257406X) 是一种可口服的苯并咪唑核苷化合物，具有抗巨细胞病毒的活性。
T9975	GPR183 3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide	Others	Others
	GPR183 (3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide) 是一种趋化受体，在 B 细胞中具有成熟作用，其内源性配体是氧甾醇 7α,25-二羟基胆固醇 (7α,25-OHC)。 GPR183 可用于炎症性肠病 (IBD) 的研究。
TP1293	Jagged-1 (188-204) TFA(219127-21-6 free base) Jagged-1 (188-204) TFA	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Jagged-1 (188-204) TFA(219127-21-6 free base) 是 JAG-1 蛋白的一个片段。 JAG-1 是 Notch 配体，是一种在皮肤中表达最明显的肽。 JAG-1 诱导表皮成熟。将淹没的角质形成细胞单层暴露于钙浓度升高的 JAG-1 会产生具有 loricrin 表达和 NF-alphaB 激活的分层。
T3226	Paritaprevir free base ABT-450,Veruprevir,帕利瑞韦	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Paritaprevir free base (ABT-450) 是一种口服生物可利用的合成酰基磺酰胺抑制剂，可抑制丙型肝炎病毒 (HCV) 蛋白酶复合物，由非结构蛋白 3 和 4A (NS3/NS4A) 组成，对 HCV 基因型 1 具有潜在活性。给药后，paritaprevir 可逆地结合 HCV NS3/NS4A 蛋白酶的活性中心和结合位点，并阻止 NS3/NS4A 蛋白酶介导的多蛋白成熟。这会破坏病毒蛋白的加工和病毒复制复合物的形成，从而抑制病毒在 HCV 基因型 1 感染的宿主细胞中的复制。 NS3 是一种丝氨酸蛋白酶，对于 HCV 多蛋白内多个位点的蛋白水解切割至关重要，并且在 HCV 核糖核酸 (RNA) 复制过程中起关键作用。 NS4A 是 NS3 的激活因子。 HCV 是属于黄病毒科的一种小的、有包膜的单链 RNA 病毒，感染与肝细胞癌 (HCC) 的发展有关。
T69986	BMS-955176 HCl
	GSK-3532795 is a second generation inhibitor of hiv-1 maturation, exhibiting a broader spectrum of antiviral effect in vitro and in clinical studies than the prototypical maturation inhibitor bevirimat
T28386	PF-46396 PF 46396
	PF-46396 is a HIV maturation inhibitor and can be used against HIV-1 clade B and C.
T27737	KNI-272 NSC-651714,Kynostatin-272,Kynostatin272,KNI272,Kynostatin 272
	Kynostatin-272 is a HIV protease inhibitor. KNI-272 blocked the maturation of viral particles.
T26933	BzDANP Benzo DANP,Benzo-DANP,BenzoDANP
	BzDANP is a modulator of pre-miR-29a maturation by Dicer.
T72534	HIV-1 inhibitor-10
	HIV-1inhibitor-10 是一种纳摩尔的HIV-1成熟抑制剂。
TP1806	BCMA72-80
	BCMA72-80 is a HLA-A2-specific B-cell maturation antigen (BCMA) peptide, with a strong affinity to HLA-A2. It is used to used in the research of multiple myeloma or other B-cell maturation antigen expressing tumors.
T63251	Riodoxol
	Riodoxol 是抗病毒剂，能够有效影响病毒的繁殖和成熟。
T36912	17α,20β-Dihydroxy-4-pregnen-3-one 17α,20β-dihydroxy Progesterone,17α,20β-DHP,17α,20β-Dihydroxy-4-pregnen-3-one
	17α,20β-Dihydroxy-4-pregnen-3-one (17α,20β-DHP) is an endogenous, maturation-inducing steroid that stimulates oocyte maturation in females of several teleost species. For example, 1 μg/ml of 17α,20β-DHP applied to Persian sturgeon oocytes has been shown to effectively induce germinal vesicle breakdown, an essential step during oocyte maturation.1 Gonadotropin-releasing hormone and the gonadotropins, follicle-stimulating hormone and luteinizing hormone, have been shown to stimulate the production...
T68428	ZK-Thiazolidinone
	ZK-Thiazolidinone, also known as TAL, is an ATP-competitive inhibitor of PLK1. In vitro, ZK-Thiazolidinone counteracts the role of Plk1 in previously established functions, notably, sister chromatid separation, centrosome maturation, and bipolar spindle assembly. In vivo, ZK-Thiazolidinone selectively inhibits PLK1 and causes a prometaphase-like mitotic (G2–M) arrest. ZK-Thiazolidinone inhibits human PLK1 (IC50, 19± 12 nM) and various human and mouse tumor cell lines (IC50, 0.2–1.3 μM). ZK-Thiaz...
T27165	Diazaborine Diazaborine compound 2b18,Pkf 84.474,Pkf 84474,Pkf-84474,SA-84474
	Diazaborine inhibits maturation of rRNAs for the large ribosomal subunit. Diazaborine blocks ribosome biogenesis by inhibiting the AAA-ATPase Drg1. Diazaborine treatment causes, within minutes, a rapid redistribution of the protein from the nucleolus to t
T73680	Urofollitropin
	Urofollitropin是从更年期人类尿液中提取的蛋白质，具有促进卵泡发育和成熟的作用，但其含有的尿蛋白量极少。
T23807	BMS-955176 TFA BMS 955176,GSK-3532795,BMS955176,BMS-955176,GSK3532795
	GSK3532795 is an orally active inhibitor of HIV-1 maturation. GSK3532795 combines broad coverage of polymorphic viruses (EC50: 15 nM toward a panel of common polymorphisms representative of 96.5% HIV-1 subtype B virus) with a favorable pharmacokinetic pro
T81512	Peptide B, bovine
	Peptide B, bovine 是源自 αs1 酪蛋白 B-8P (f1-13) 的免疫调节肽，主要存在于牛乳中，并在其成熟过程中发挥降压作用。
T11494	GSK3532795 BMS-955176	Others	Others
	GSK3532795 is a potent, orally active, second-generation HIV-1 maturation inhibitor (EC50s: 10.2, 1.9, 2.7, and 13 nM for HIV-1 WT(human serum), HIV-1 WT, HIV-1 V370A, and HIV-1 ΔV370).
T82927	Azintuxizumab
	Azintuxizumab是针对B细胞成熟抗原(BCMA)的IgG4型双特异性单克隆抗体，显示出在治疗复发/难治性多发性骨髓瘤(RRMM)中的应用潜力。
T73576	EP39
	EP39 是一种有效的HIV-1成熟抑制剂。EP39 与 Gag 的 SP1 结构域相互作用。EP39 通过与 SP1 结构域的 QVT 基序结合来降低 CA-SP1 连接的动力学，并通过稳定瞬态 α 螺旋结构来扰乱 SP1 结构域两侧的自然螺旋平衡。EP39 通过阻止HIV-1的成熟而起作用，从而阻断其感染性。
T68888	Avatrombopag maleate
	Avatrombopag, also known as AKR-501, YM477, AS 1670542 or E5501, is a novel orally-active thrombopoietin (TPO) receptor agonist. AKR-501 specifically targeted the TPO receptor and stimulated megakaryocytopoiesis throughout the development and maturation of megakaryocytes just as rhTPO did. AKR-501 may be useful in the treatment of patients with thrombocytopenia. Avatrombopag was first approved in 2018.
T37490	11(R)-HETE
	11(R)-HETE is biosynthesized by 11(R)-LOs of the sea urchin, S. purpuratus, and the fresh water hydra, H. vulgaris. The biological activity of 11(R)-HETE relates to oocyte maturation and tentacle regeneration, respectively, in these two species. 11(R)-HETE is also produced when aspirin-treated recombinant COX-2 is incubated with arachidonic acid. Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results.
T77903	Belantamab mafodotin Belantamab mafodotin-blm,GSK2857916
	Belantamab mafodotin (GSK2857916) 为人源化的抗B细胞成熟抗原(BCMA)单克隆抗体与McMMAF共轭物，展现出对骨髓瘤的治疗活性。
T36116	Concanamycin B
	Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases, also known as V-ATPases (IC50 = 5 nM). In this way, it blocks the acidification of vacuolar organelles as well as early to late endosomal transport. Concanamycin B interferes with bone resorption and maturation of CD8 T lymphocytes. It also prevents processing of major histocompatibility complex (MHC) class II precursors in human B cells, inhibiting the expression of MHC class II molecules on the cell su...
T77076	Luspatercept
	Luspatercept (ACE-536) 是一种重组修饰的 ActRIIB 融合蛋白，与转化生长因子β超家族配体结合，通过与GDF11结合抑制Smad2/3信号通路，从而增加红细胞数量并促进红细胞前体成熟，用于贫血的研究。
TP1540	Jagged-1 （188-204） Jagged-1 188-204	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Jagged-1 （188-204）是 JAG-1 蛋白的一个片段。其中 JAG-1 能够诱导单核细胞衍生的人树突状细胞成熟，是一种在培养的和原发性多发性骨髓瘤细胞中高度表达的 Notch 配体。
T77127	Pacanalotamab
	Pacanalotamab (AMG 420；BI-836909) 是一种双特异性 T 细胞接合剂 (BiTE)，靶向 BCMA 和 CD3ɛ。BCMA 是指 B 细胞成熟抗原，而 Pacanalotamab 会将 T 细胞重定向到细胞表面的 BCMA 表达细胞。Pacanalotamab 可对人多发性骨髓瘤 (MM) 细胞系进行 T 细胞重定向裂解。
T68383	BIIB028
	BIIB028 is a small-molecule inhibitor of heat shock protein (Hsp) 90 with potential antineoplastic activity. Hsp90 inhibitor BIIB028 blocks the binding of oncogenic client proteins to Hsp90, which may result in the proteasomal degradation of these proteins and so the inhibition of tumor cell proliferation. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as Her2/Erbb2, Akt, Raf1, Bcr-Abl, and mutated p53, in addition to o...
T76023	Jagged-1 (188-204) (TFA)
	Jagged-1 (188-204) TFA 是 JAG-1 蛋白的一个片段，具有Notch 激动剂活性。JAG-1 是一种在培养的和原发性多发性骨髓瘤 (MM) 细胞中高度表达的Notch 配体。JAG-1 诱导单核细胞衍生的人树突状细胞成熟。
T37954	Sphingosine (d20:1) Sphingosine (d20:1)
	Sphingosines are long-chain base precursors of cellular sphingolipids used directly in the synthesis of ceramide, which in combination with sialic acid forms ganglioside. Sphingosine can exist in four stereoisomers, however only sphingosine occurs naturally. Compared to other sphingolipids throughout the body, which are predominantly composed of C-18 sphingosine, only central nervous system (CNS) gangliosides contain significant amounts of sphingosine. The concentration of sphingosine within mam...
T77139	Pavurutamab
	Pavurutamab (AMG-701) 是一种抗 CD3和抗 B 细胞成熟抗原 (BCMA) 的双特异性 T 细胞接合剂分子。Pavurutamab 在 Pacanalotamab 的基础上延长了半衰期。Pavurutamab 的 Fc 与分子偶联，可改善药代动力学参数。Pavurutamab 在免疫调节和多发性骨髓瘤 (MM) 中有潜在应用。
T14693	BN201	Others	Others
	BN201 is able to cross the blood-brain barrier by active transport and activate pathways (IGF-1 pathway) associated with the response to stress and neuron survival. BN201 promotes neuronal differentiation, the differentiation of precursor cells to mature
T77021	Gedivumab
	Gedivumab (MHAA4549A; RG7745)，一种高特异性人源单克隆抗体，靶向甲型流感病毒 (IAV)，通过与IAV血凝素蛋白的高度保守茎区结合，阻止其成熟并阻断核内体中的血凝素介导的膜融合，适用于IAV感染疾病研究。
T79608	DPP	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	DPP，一种含紫檀芪衍生轴向配体的铂(IV)络合物，能够抑制乳腺癌(BC)细胞的JAK2-STAT3通路并显示出抗增殖特性。它通过激活caspase-3和裂解聚ADP-核糖聚合酶诱导细胞凋亡(apoptosis)，同时促进树突状细胞成熟及抗原呈现功能，并已证明体内具有安全性。
T78809	NDNA3	HSP	Cytoskeletal Signaling; Metabolism
	NDNA3 (compound 14)，一种选择性Hsp90α抑制剂，IC50为0.51 μM。该永久带电类似物具低膜渗透性，并对Ovcar-8细胞（IC50为12.66 μM）和MCF-10A细胞（IC50为11.72 μM）展现较低细胞毒性。NDNA3能够防止hERG通道成熟受损，不引发热休克反应或导致对Hsp90α依赖的客户蛋白降解。
T79609	STAT3-IN-18	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	STAT3-IN-18 (compound SPP)，一种带紫檀芪衍生轴向配体的铂(IV)络合物，能抑制乳腺癌(BC)细胞的JAK2-STAT3通路，显示出抗增殖活性。它激活caspase-3和裂解聚ADP-核糖聚合酶，诱导apoptosis。此外，STAT3-IN-18可促进树突状细胞成熟与抗原呈递，体现了良好的体内安全性。
T37564	C4 Ceramide (d18:1/4:0) C4 Ceramide (d18:1/4:0),Cer(d18:1/4:0)
	C4 Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. [1] [2] [3] It inhibits IL-4 production by 16% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. [1] C4 Ceramide is cytotoxic to SK-BR-3 and MCF-7/Adr breast cancer cells (IC50s = 15.9 and 19.9 μM, respectively). [2] C4 Ceramide also increases maturation and stability of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing...
T78808	NDNA4	HSP	Cytoskeletal Signaling; Metabolism
	NDNA4（compound 17）作为Hsp90α选择性抑制剂，具有0.34 μM的IC50值。作为永久带电的类似物，该化合物显示出低膜渗透性，并在Ovcar-8和MCF-10A细胞中表现出较低的细胞毒性（IC50>100 μM）。NDNA4能够保护hERG通道免遭破坏，同时不触发热休克反应或引起对Hsp90α依赖的客户蛋白进行降解。
T80544	PTPσ Inhibitor, ISP	Phosphatase	Metabolism
	PTPσ Inhibitor, ISP 结合并抑制重组人PTPσ的信号传导，具有穿透细胞膜的能力，有助于缓解CSPG介导的脊髓损伤模型中轴突的生长抑制。该抑制剂能增强LPC引起的脊髓脱髓鞘损伤的髓鞘再生，并在MS动物模型中促进OPC的迁移、分化、髓鞘形成及功能恢复。
T38394L	PSMα3 acetate(1001405-52-2 Free base)
	PSMα3 acetate(1001405-52-2 Free base) 是一种肽化合物，可用于诱导树突状细胞 (DC) 对 DC 疫苗接种策略的耐受性。PSMα3 acetate 通过改变 TLR2 或 TLR4 诱导的成熟过程，有效渗透和调节人类单核细胞衍生的 DC。此外，PSMα3 acetate 可抑制促炎细胞因子和抗炎细胞因子的产生，并减少抗原摄取。 PSMα3 acetate 是大多数致病性耐甲氧西林金黄色葡萄球菌 (MRSA) 菌株释放的重要毒力因子。
T81360	PSMα3 TFA
	PSMα3 TFA 作为一种肽类化合物，主要用于诱导生成耐受性的树突细胞（DC），以应用于DC疫苗接种。该化合物能对TLR2和TLR4诱导的DC成熟过程进行调节，抑制促炎和消炎细胞因子的产生，降低抗原摄取，并影响人单核细胞来源DC的渗透和调节能力。此外，PSMα3 TFA 是耐甲氧西林金黄色葡萄球菌（MRSA）中最有毒株释放的关键毒素之一。

化合物

Cat.No: T25049

Target: BCL, Caspase

BCMA72-80 acetate(2293841-58-2 free base)

Cat.No: TP1806L

Target: Others

Thioquinapiperifil dihydrochloride

Cat.No: T9773

Synonym: KF-31327

Target: PDE

Cat.No: T15436

Target: HIV Protease

Cat.No: T26854

Synonym: BMS-641,BMS-209641,BMS 641

Target: Retinoid Receptor

Cat.No: T26955

Synonym: N91115,N 91115,N-91115

Target: GSNOR, CFTR

Cat.No: T67887

Cat.No: T2595

Synonym: 鲁玛卡托,VX-809,VRT 826809

Target: CFTR, Autophagy

Cat.No: T21992

Target: PI3K, Autophagy

Cat.No: T2162

Synonym: BW1263W94,GW257406X,Benzimidavir,马立巴韦,1263W94

Target: Others, HCV Protease

Cat.No: T9975

Synonym: 3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide

Target: Others

Jagged-1 (188-204) TFA(219127-21-6 free base)

Cat.No: TP1293

Synonym: Jagged-1 (188-204) TFA

Target: Gamma-secretase

Paritaprevir free base

Cat.No: T3226

Synonym: ABT-450,Veruprevir,帕利瑞韦

Target: HCV Protease

Cat.No: T69986

Cat.No: T28386

Synonym: PF 46396

Cat.No: T27737

Synonym: NSC-651714,Kynostatin-272,Kynostatin272,KNI272,Kynostatin 272

Cat.No: T26933

Synonym: Benzo DANP,Benzo-DANP,BenzoDANP

HIV-1 inhibitor-10

Cat.No: T72534

Cat.No: TP1806

Cat.No: T63251

17α,20β-Dihydroxy-4-pregnen-3-one

Cat.No: T36912

Synonym: 17α,20β-dihydroxy Progesterone,17α,20β-DHP,17α,20β-Dihydroxy-4-pregnen-3-one

ZK-Thiazolidinone

Cat.No: T68428

Cat.No: T27165

Synonym: Diazaborine compound 2b18,Pkf 84.474,Pkf 84474,Pkf-84474,SA-84474

Cat.No: T73680

Cat.No: T23807

Synonym: BMS 955176,GSK-3532795,BMS955176,BMS-955176,GSK3532795

Peptide B, bovine

Cat.No: T81512

Cat.No: T11494

Synonym: BMS-955176

Target: Others

Cat.No: T82927

Cat.No: T73576

Avatrombopag maleate

Cat.No: T68888

Cat.No: T37490

Belantamab mafodotin

Cat.No: T77903

Synonym: Belantamab mafodotin-blm,GSK2857916

Cat.No: T36116

Cat.No: T77076

Jagged-1 （188-204）

Cat.No: TP1540

Synonym: Jagged-1 188-204

Target: Gamma-secretase

Cat.No: T77127

Cat.No: T68383

Jagged-1 (188-204) (TFA)

Cat.No: T76023

Sphingosine (d20:1)

Cat.No: T37954

Synonym: Sphingosine (d20:1)

Cat.No: T77139

Cat.No: T14693

Target: Others

Cat.No: T77021

Cat.No: T79608

Target: JAK

Cat.No: T78809

Target: HSP

Cat.No: T79609

Target: JAK

C4 Ceramide (d18:1/4:0)

Cat.No: T37564

Synonym: C4 Ceramide (d18:1/4:0),Cer(d18:1/4:0)

Cat.No: T78808

Target: HSP

PTPσ Inhibitor, ISP

Cat.No: T80544

Target: Phosphatase

PSMα3 acetate(1001405-52-2 Free base)

Cat.No: T38394L

Cat.No: T81360

Cat. No.	Product Name	Target	Signaling Pathways
T7992	4-Hydroxyflavanone	NO Synthase	Immunology/Inflammation
	4-Hydroxyflavanone 是一种黄酮的合成类似物，是 SREBP 成熟和脂质合成的抑制剂。它具有研究肝脏脂肪变性及血脂异常的潜力。
T5782	Bevirimat YK FH312,MPC-4326,PA-457,贝韦立马	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Bevirimat (PA-457) 是一种 HIV-1 成熟抑制剂，可在病毒体成熟过程中阻断 Gag 衣壳 (CA) 前体 CA-SPI 裂解为成熟的 CA 蛋白。
T5S2357	Acetylcorynoline (+)-Corynoline Acetate,O-Acetylcorynoline,乙酰紫堇灵	Antifungal	Microbiology/Virology
	Acetylcorynoline (O-Acetylcorynoline) 是提取自 Corydalis bungeana 中的一种主要生物碱成分，具有抗炎活性。
T2563	Acetyl-L-carnitine hydrochloride Acetyl L-carnitine hydrochloride,O-Acetylcarnitine,乙酰-L-肉(毒)碱盐酸盐,O-acetyl-L-carnitine,O-Acetyl-L-carnitine hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	Acetyl-L-carnitine hydrochloride (Acetyl L-carnitine hydrochloride) 是一种由内源性左旋肉碱的乙酰化形式的盐酸盐组成的营养补充剂，具有潜在的神经保护、认知增强、抗抑郁和免疫调节活性。还可缓解化疗、糖尿病或其他疾病引起的周围神经病变。此外，乙酰左旋肉碱可能通过增加T淋巴细胞成熟来调节免疫反应，并可能下调促炎细胞因子对病毒(如SARS-CoV-2)的反应。它还可能破坏ACE2信号通路并抑制活性氧(ROS)的产生。
T16719	Radicicol 根赤壳菌素,Monorden	HSP	Cytoskeletal Signaling; Metabolism
	Radicicol is an antifungal antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB. Radicicol is an inhibitor of Hsp90 (IC50: 1 μM). Radicicol binds to the ATPase domain of Hsp90 and prevents maturation of Hsp90 clients,
T82406	FF-MAS
	FF-MAS是一种有效的meiotic maturation激动剂，能促进小鼠卵母细胞在体外成熟，促进其发展到MII阶段，并增强从2细胞阶段到囊胚阶段转变的潜力。
T19169	9-cis-Retinal	Others	Others
	9-cis-Retinal is a natural retinoid. Dietary 9-cis-β-carotene generates 9-cis-retinoids via cleavage into 9-cis-retinal. 9-cis Retinal binds to CRBP-I and CRBP-II (Kds: 8 nM and 5 nM). It expedites differentiation and maturation of rod photoreceptors in r
T38394	PSMα3
	PSMα3 is a peptide compound that can be utilized to induce tolerance in dendritic cells (DCs) for DC vaccination strategies. It effectively penetrates and modulates human monocyte-derived DCs by modifying the maturation process induced by TLR2 or TLR4. Additionally, PSMα3 inhibits the production of both pro- and anti-inflammatory cytokines and decreases antigen uptake. Notably, PSMα3 is a significant virulence factor released by the most pathogenic strains of methicillin-resistant Staphylococcus...

天然产物

4-Hydroxyflavanone

Cat.No: T7992

Target: NO Synthase

Cat.No: T5782

Synonym: YK FH312,MPC-4326,PA-457,贝韦立马

Target: HIV Protease

Acetylcorynoline

Cat.No: T5S2357

Synonym: (+)-Corynoline Acetate,O-Acetylcorynoline,乙酰紫堇灵

Target: Antifungal

Acetyl-L-carnitine hydrochloride

Cat.No: T2563

Synonym: Acetyl L-carnitine hydrochloride,O-Acetylcarnitine,乙酰-L-肉(毒)碱盐酸盐,O-acetyl-L-carnitine,O-Acetyl-L-carnitine hydrochloride

Target: Others, Endogenous Metabolite

Cat.No: T16719

Synonym: 根赤壳菌素,Monorden

Target: HSP

Cat.No: T82406

Cat.No: T19169

Target: Others

Cat.No: T38394

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