Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BN201 is able to cross the blood-brain barrier by active transport and activate pathways (IGF-1 pathway) associated with the response to stress and neuron survival. BN201 promotes neuronal differentiation, the differentiation of precursor cells to mature oligodendrocytes (EC50 of 6.3 μM) in vitro. The myelination of new axons (EC50 of 16.6 μM). BN201 has potently neuroprotective effects[1].
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | BN201, a chemical compound, actively crosses the blood-brain barrier and activates the IGF-1 pathway, which is associated with stress response and neuron survival. It facilitates neuronal differentiation and the maturation of precursor cells into oligodendrocytes with an EC50 of 6.3 μM, in addition to promoting the myelination of new axons with an EC50 of 16.6 μM in vitro. BN201 exhibits potent neuroprotective effects[1]. |
体外活性 | BN201 promotes the survival of cultured neural cells when subjected to oxidative stress or when deprived of trophic factors[1]. BN201 (10 μM; 0.5-4 hours; Hela cells) treatment induces the phosphorylation of NDGR1 in Hela cells in a time-dependent manner[1]. |
体内活性 | BN201 (12.5-150 mg/kg; intraperitoneal injection; daily; for 30 days; female C57BL/6 mice) treatment shows less axonal loss and neuron loss in both the spinal cord and in the optic nerve than the animals that received placebo[1]. |
分子量 | 491.6 |
分子式 | C25H38FN5O4 |
CAS No. | 1361200-34-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
BN201 1361200-34-1 Others BN-201 BN 201 Inhibitor inhibitor inhibit