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56

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9099	Disperse Fast Yellow 4K 分散黄,Disperse Yellow	Others	Others
	Disperse Fast Yellow 4K (Disperse Yellow) 是一种用于染料的颜色添加剂。
T31749	Fast Green free acid J247.014D
	Fast Green free acid is a dye that resists acid once applied.
T7772	Fast Green FCF C.I. 42053,固绿 FCF,Food green 3,FD&C Green No. 3	Others	Others
	Fast Green FCF (FD&C Green No. 3) 是海绿色三芳基甲烷食用染料，最大吸收在625nm 处，将在电泳过程中的蛋白质染色，。
T30665	C.I. Direct Red 1, disodium salt Japanol Fast Red 1,COLUMBIA FAST RED F,Chrome Fast Red F,Neonyl Red 2B,Enianil Fast Red F
	C.I. Direct Red 1, disodium salt is a dye.
T31652	Epicocconone Deep purple,Lightning fast
	Epicocconone is a fluorescent compound comes from the fungus epicoccumnigrum.
T20037	C.I. Direct Black 17 Azine Fast Black D,CERN prima 17,Telon Fast Black PE,Diazol Black SD
	C.I. Direct Black 17 is a compound of dye.
T38612	Linaprazan glurate	Others	Others
	Linaprazan glurate 抑制外源性或内源性刺激的胃酸分泌。 Linaprazan glurate 可用于胃肠道炎症性疾病和消化性溃疡疾病的研究。
T78453	Fast Blue B Salt
	Fast Blue B Salt作为染色剂，能溶解黑麦提取物中的脂肪及苯酚化合物和重氮剂。该化合物能够用于黑麦中的烷基间苯二酚半定量分析，并在加入丙酮的情况下形成有色沉淀。
T30421	Benzyl orange Orange 45,Benzyl Orange 2R,BZR Acid,Acid Leather Orange,Benzyl Fast Orange 2RN
	Benzyl orange is bioactive chemical.
T3185	R112 (E)-Elafibranor	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	R112 ((E)-Elafibranor) 是ATP 竞争性的 Syk 激酶抑制剂，它能够抑制Syk 激酶活性，Ki=6 nM，IC50=226 nM。
T34146	Propanidid FBA 1420,Epontol,Sombrevin,Fabontal,Fabantol	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Propanidid (Sombrevin) 是一种 γ-氨基丁酸 A 型受体 (GABAA) 激动剂，也是一种可快速发挥作用的静脉注射麻醉剂,可以降低动脉血压。
T77752	HMBR 4-Thiazolidinone, 5-[(4-hydroxy-3-methylphenyl)methylene]-2-thioxo-, (5Z)-	Others	Others
	HMBR本身不具有荧光，但当与 Y-FAST 结合时，它们在蓝光激发时会发出黄光。
T4539	Nicainoprol 尼卡普醇,RU-42924	Sodium Channel	Membrane transporter/Ion channel
	Nicainoprol (RU-42924) 是一种快速钠通道阻断剂，是有效的抗心律失常剂。
T8581	Flecainide hydrochloride	Others	Others
	Flecainide hydrochloride 是一种用于预防和治疗异常快速心率的药物。这包括室性和室上性心动过速。
T18994	Fuchsine base monohydrochloride 碱性品红,Magenta base monohydrochloride,Rosaniline Base monohydrochloride,Basic Fuchsin monohydrochloride	Others	Others
	Fuchsine base monohydrochloride (Rosaniline Base monohydrochloride) 是品红染料，可用作石碳酸-品红的抗酸染色。
T3966	Tirasemtiv CK-2017357,泰拉生替	Others	Others
	Tirasemtiv (CK-2017357) 是一种快速骨骼肌型肌钙蛋白复合物激活剂。
T31716L	Etidocaine	Others	Others
	Etidocaine 是一种氨基酸酰胺，用作局部麻醉剂，具有快速起效和长效特性。
T7219	Flecainide acetate Flecainide (acetate),氟卡胺,R-818,醋酸洗必太	Sodium Channel	Membrane transporter/Ion channel
	Flecainide acetate (R-818) 是位于心脏的 Nav1.5钠离子通道的阻断剂，具有抗心律失常的作用。
T16728	Reldesemtiv CK-2127107	Others	Others
	Reldesemtiv (CK-2127107) 是一种快速骨骼肌肌钙蛋白的选择性激活剂，EC50 为 3.4 μM。 Reldesemtiv 提高了心力衰竭模型中的运动表现。
T16471	Perflubron Perfluorooctyl bromide,全氟溴辛烷,PFOB	Others	Others
	Perflubron (Perfluorooctyl bromide) 是一种用于磁共振成像和超声检查的造影剂，可以与卵磷脂(EYP)一起乳化，并表现出较迅速的排泄特性。
T12585	PXS-5153A	Others; Monoamine Oxidase	Neuroscience; Others
	PXS-5153A 是一种有效、特异性和速效的Lysyl Oxidase-like 2/3 (LOXL2/3) 抑制剂，其酶活性在 15 分钟内几乎完全阻断。 PXS-5153A 可以减少交联并改善纤维化。
T30251	AZD-1305 UNII-CZO834LXQM,AZD 1305	Others	Others
	AZD-1305是一种新型抗心律失常化合物，主要阻断哺乳动物细胞和心室心肌细胞中 IKr 的快速组分、l 型钙电流和病房内钠电流，可用于研究逆转心律失常。
T5434	ARV-825	Epigenetic Reader Domain	Chromatin/Epigenetic
	ARV-825 是一种双功能 PROTAC，蛋白水解靶向嵌合体，将 BRD4 募集到 E3 泛素连接酶大脑中，导致 BRD4 在所有测试的 BL 细胞系中快速、有效和延长降解。对 BRD4 的 BD1 和 BD2 结构域具有高亲和力，Kd 值分别为 90 和 28 nM。
T68173	ZD-2138 Ici-D2138	Lipoxygenase	Metabolism
	ZD-2138是一种有效且具有选择性的5-脂氧合酶（5-LOX）的特异性抑制剂，抑制了过敏原诱导的肺支气管收缩，可减少豚鼠孤立气道的神经诱发性快速激肽能收缩。ZD-2138可用来治疗哮喘疾病。
T64317	ZZL-7	Serotonin Transporter	Neuroscience
	ZZL-7是一种起效快的抗抑郁药。ZZL-7破坏中缝背核（DRN）神经元一氧化氮合酶（nNOS）和血清素转运蛋白（SERT）之间的相互作用。ZZL-7可以很容易地穿过血脑屏障。ZZL-7在重度抑郁症（MDD）中具有研究价值。
T22037	AS 1892802	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	AS 1892802是一种强效和选择性的ROCK 抑制剂。AS 1892802 用于人ROCK2、大鼠ROCK2和人ROCK1的 IC50值分别为52nM、57nM 和122nM。AS 1892802的镇痛作用起效速度与曲马多和双氯芬酸的起效速度一样快。
T0866	Propafenone Rythmol,普罗帕酮,Propafenonum	Potassium Channel; MRP; Sodium Channel	Immunology/Inflammation; Membrane transporter/Ion channel
	Propafenone (Propafenonum) 是钠通道阻滞剂，它对 β 受体具有高亲和力 (IC50=32 nM)。它能够阻断瞬时外向钾电流 (Ito) (IC50: 4.9 nM) 和持续延迟整流器K+电流 (Isus) (IC50: 8.6 nM) ，具有抗心律失常的作用。它能够诱导线粒体功能障碍及诱导细胞凋亡，从而抑制食管癌增殖。
T11722	JNJ-37822681 dihydrochloride	Dopamine Receptor	GPCR/G Protein; Neuroscience
	JNJ-37822681 dihydrochloride 是特异性的、有中枢活性的，可快速解离的多巴胺 D2受体拮抗剂，与多巴胺 D2L 受体结合的亲和力适中 (Ki=158 nM)。JNJ-37822681 dihydrochloride 在精神分裂症和躁郁症领域有研究价值。
T12977	Soraprazan BYK61359	Others	Others
	Soraprazan is a reversible, and fast-acting gastric H+/K+ ATPase inhibitor.
T33506	MRS2220 MRS 2220,MRS-2220
	MRS2220 is a selective enhancer of the ATP effects at fast desensitizing P2X (P2X1 and P2X3) receptors.
T38026	Cellobiosan
	Cellobiosan is an anhydro sugar formed during biofuel production from the fast pyrolysis of wood.
T71854	AA43279
	AA43279 is a novel selective Nav1.1 activator, increasing the firing activity of parvalbumin-expressing, fast-spiking GABAergic interneurons and increasing the spontaneous inhibitory post-synaptic currents (sIPSCs) recorded from pyramidal neurons.
T71406	SA 2572
	SA 2572 is a newly synthesized Ca2+ antagonist having a inhibitory effect on the fast Na+ inward channel.
T14682	BMS-962212	Others	Others
	BMS-962212, a direct, reversible, and selective factor XIa (FXIa) inhibitor, demonstrates fast pharmacodynamic (PD) response onset and rapid elimination with a well-tolerated profile. It dependently increases activated partial thromboplastin time and decreases FXI clotting activity exposure [1].
T20584	Octanophenone Heptyl phenyl ketone,Caprylophenone
	Octanophenone can be analyzed by reverse phase (RP) HPLC method with simple conditions. The phosphoric acid needs to be replaced with formic acid for Mass-Spec (MS) compatible applications. For fast UPLC applications, smaller 3 µm particles columns is av
T68361	Asocainol hydrochloride
	Asocainol hydrochloride ia an antiarrhythmic drug which inhibits slow Ca2+ influx. This is accompanied by alterations in normal Na+-carried action potentials. Therefore, Asocainol not only inhibits Ca2+ inflow but also interferes with the fast inward Na+ current.
T25757	Lorcainide hydrochloride Ro 13-1042,EINECS 261-504-6,Lorcainide HCl,Lopantrol,R 15889
	Lorcainide hydrochloride is an antiarrhythmic drug with local anesthetic activity. The antiarrhythmic actions of lorcainide are mediated by an impairment of fast sodium conductance. Lorcainide appears effective in suppressing reentry phenomena and ectopic
T37733	AMP-PNP tetralithium
	Non-hydrolyzable AMP analog. Kir6 (KATP) channel blocker. Inhibits fast axonal transport and stabilizes the interaction of membranous organelles with microtubules. Brady (1985) A novel brain ATPase with properties expected for the fast axonal transport motor. Nature 317 73 PMID:2412134 \|Yount et al (1971) Adenylyl imidodiphosphate, an adenosine triphosphate analog containing a P-N-P linkage. Biochemistry 10 2484 PMID:4326768 \|Hehl and Neumcke (1994) KATP channels of mouse skeletal muscle: mechan...
T39700	Ga(III) protoporphyrin IX
	Ga(III)protoporphyrin-IX, a model for interporphyrin interactions in malaria pigment, possesses potent antibacterial effects against gram-negative, gram-positive, and acid-fast bacteria. It exhibits high solubility in methanol (MeOH) and serves as a malarial pigment analogue for drug development, as well as a potential antibacterial agent.
T71000	RO-5328673
	RO-5328673 is a dual NK2/NK3 antagonist. O5328673. [(3)H]RO5328673 bound to a single saturable site on hNK2, hNK3 and gpNK3 with high-affinity. RO5328673 acted as an insurmountable antagonist at both human and guinea-pig NK3 receptors in the [(3)H]IP accumulation assay. In binding kinetic analyses, [(3)H]RO5328673 had fast association and dissociation rates at hNK2 while it had a fast association rate and a remarkably slow dissociation rate at gp and hNK3. In electrophysiological recordings of g...
T71800	Metoprolol HCl
	Metoprolol is a selective β1 receptor blocker medication. It is used to treat high blood pressure, chest pain due to poor blood flow to the heart, and a number of conditions involving an abnormally fast heart rate. It is also used to prevent further heart problems after myocardial infarction and to prevent headaches in those with migraines.
T39234	BODIPY-TS Thiol-green 2,BODIPY-TS
	BODIPY-TS (also known as Thiol-green 2) is a highly efficient thiol-specific turn-on probe with a fast response. It incorporates a thiosulfonate scaffold as its thiol recognition unit. BODIPY-TS displays excellent selectivity, low detection limit, and quantitative reactivity towards thiols. Moreover, it exhibits low toxicity. Notably, BODIPY-TS exhibits excitation at 490 nm and emission at 515 nm.
T30667	C.I. Food Yellow 10 NSC-11228,BRN 1842536,Oil Yellow AB,NSC 11228,NSC11228
	C.I. Food Yellow 10, also known as Fast Yellow AB or Acid Yellow, is an azo dye used primarily as a food dye that is now delisted in both Europe and USA and is forbidden if used in foods and drinks. Ungraded products supplied by Spectrum are indicative of
TP1972	OD1
	Potent rat Nav1.7, human Nav1.4 and rat Nav1.6 channel activator (EC50 values are 7, 10 and 47 nM, respectively). Exhibits minimal activation at mammalian Nav1.2, Nav1.3 and Nav1.5 (EC50 values >3 μM). Inhibits fast inactivation on all channels. Increases
T4497L	Amifampridine phosphate BRN0110232,3,6-DAP,SC10,BRN 0110232,BRN-0110232,NSC 521760
	Amifampridine is mainly used to treat many rare muscle diseases. In the United States, aminopyridine is being studied for the treatment of Lambert-Eaton myasmus syndrome (LEMS). Amifampridine is also used to treat many congenital myasthenia syndromes, par
T41209	DPNB-ABT 594
	DPNB-ABT 594 is a nitrobenzyl-caged ABT 594, a selective α4β2 nAChR agonist. One-photon uncaging evokes large inward currents and Ca2+transients on cell bodies and dendrites of medial habenular neurons in mouse brain slices. Two-photon uncaging induces fast nAChR-mediated currents. Photolyzed with high quantum yield of 0.20. Effective photolysis occurs using one- or two-photon excitation; one-photon uncaging requires illumination at 410 nm for 1.5-3 ms; two-photon uncaging requires illumination ...
T60407	L-Buthionine-(S,R)-sulfoximine hydrochloride
	L-Buthionine-(S,R)-sulfoximine hydrochloride 是一种有效的、可细胞渗透的，作用快的 G-谷氨酸半胱氨酸合成酶 (γ-glutamylcysteine synthetase, γ-GCS)的不可逆抑制剂并可耗尽细胞内的谷胱甘肽水平，在黑色素瘤、乳腺癌和卵巢癌标本上的 IC50值分别为1.9 μM、8.6 μM 和 29 μM。
T37217	N-Decanoyl p-Nitroaniline
	N-Decanoyl p-nitroaniline (DepNA) is one of several nitroaniline fatty acid amides which can be used to measure fatty acid amide hydrolase (FAAH) activity. FAAH is a relatively unselective enzyme in that it accepts a variety of amide head groups other than the ethanolamine of its endogenous substrate anandamide (AEA). It also will hydrolyze fatty acid amides with fewer carbons and fewer double bonds than arachidonate. Exposure of DepNA to FAAH activity results in the release of the yellow colori...
T38117	WSP-5 Washington State Probe-5,WSP-5
	Hydrogen sulfide (H2S) is an important gaseous mediator, like nitric oxide, that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals. WSP-5 is a reactive disulfide-containing, fluorescent probe designed for fast detection of H2S in biological samples and cells. Through a reaction-based fluorescent turn-on strategy, WSP-5 selectively and rapidly reacts with H2S, generating a fluorophore with excitation and emission maxima of 502 and 525 nm, ...
T12585L	PXS-5153A monohydrochloride PXS-5153A monohydrochloride (2125956-82-1 free base)	Others	Others
	PXS-5153A monohydrochloride 是一种有效的、选择性的、具有口服活性和快速起效的赖氨酰氧化酶 2/3(LOXL2/LOXL3)的双抑制剂，对几乎所有哺乳动物物种 LOXL2的 IC50均< 40 nM，对人类 LOXL3 的 IC50为63 nM。PXS-5153A monohydrochloride 可减少交联并改善纤维化。

化合物

Disperse Fast Yellow 4K

Cat.No: T9099

Synonym: 分散黄,Disperse Yellow

Target: Others

Fast Green free acid

Cat.No: T31749

Synonym: J247.014D

Fast Green FCF

Cat.No: T7772

Synonym: C.I. 42053,固绿 FCF,Food green 3,FD&C Green No. 3

Target: Others

C.I. Direct Red 1, disodium salt

Cat.No: T30665

Synonym: Japanol Fast Red 1,COLUMBIA FAST RED F,Chrome Fast Red F,Neonyl Red 2B,Enianil Fast Red F

Cat.No: T31652

Synonym: Deep purple,Lightning fast

C.I. Direct Black 17

Cat.No: T20037

Synonym: Azine Fast Black D,CERN prima 17,Telon Fast Black PE,Diazol Black SD

Linaprazan glurate

Cat.No: T38612

Target: Others

Fast Blue B Salt

Cat.No: T78453

Cat.No: T30421

Synonym: Orange 45,Benzyl Orange 2R,BZR Acid,Acid Leather Orange,Benzyl Fast Orange 2RN

Cat.No: T3185

Synonym: (E)-Elafibranor

Target: Syk

Cat.No: T34146

Synonym: FBA 1420,Epontol,Sombrevin,Fabontal,Fabantol

Target: GABA Receptor

Cat.No: T77752

Synonym: 4-Thiazolidinone, 5-[(4-hydroxy-3-methylphenyl)methylene]-2-thioxo-, (5Z)-

Target: Others

Cat.No: T4539

Synonym: 尼卡普醇,RU-42924

Target: Sodium Channel

Flecainide hydrochloride

Cat.No: T8581

Target: Others

Fuchsine base monohydrochloride

Cat.No: T18994

Synonym: 碱性品红,Magenta base monohydrochloride,Rosaniline Base monohydrochloride,Basic Fuchsin monohydrochloride

Target: Others

Cat.No: T3966

Synonym: CK-2017357,泰拉生替

Target: Others

Cat.No: T31716L

Target: Others

Flecainide acetate

Cat.No: T7219

Synonym: Flecainide (acetate),氟卡胺,R-818,醋酸洗必太

Target: Sodium Channel

Cat.No: T16728

Synonym: CK-2127107

Target: Others

Cat.No: T16471

Synonym: Perfluorooctyl bromide,全氟溴辛烷,PFOB

Target: Others

Cat.No: T12585

Target: Others, Monoamine Oxidase

Cat.No: T30251

Synonym: UNII-CZO834LXQM,AZD 1305

Target: Others

Cat.No: T5434

Target: Epigenetic Reader Domain

Cat.No: T68173

Synonym: Ici-D2138

Target: Lipoxygenase

Cat.No: T64317

Target: Serotonin Transporter

Cat.No: T22037

Target: ROCK

Cat.No: T0866

Synonym: Rythmol,普罗帕酮,Propafenonum

Target: Potassium Channel, MRP, Sodium Channel

JNJ-37822681 dihydrochloride

Cat.No: T11722

Target: Dopamine Receptor

Cat.No: T12977

Synonym: BYK61359

Target: Others

Cat.No: T33506

Synonym: MRS 2220,MRS-2220

Cat.No: T38026

Cat.No: T71854

Cat.No: T71406

Cat.No: T14682

Target: Others

Cat.No: T20584

Synonym: Heptyl phenyl ketone,Caprylophenone

Asocainol hydrochloride

Cat.No: T68361

Lorcainide hydrochloride

Cat.No: T25757

Synonym: Ro 13-1042,EINECS 261-504-6,Lorcainide HCl,Lopantrol,R 15889

AMP-PNP tetralithium

Cat.No: T37733

Ga(III) protoporphyrin IX

Cat.No: T39700

Cat.No: T71000

Cat.No: T71800

Cat.No: T39234

Synonym: Thiol-green 2,BODIPY-TS

C.I. Food Yellow 10

Cat.No: T30667

Synonym: NSC-11228,BRN 1842536,Oil Yellow AB,NSC 11228,NSC11228

Cat.No: TP1972

Amifampridine phosphate

Cat.No: T4497L

Synonym: BRN0110232,3,6-DAP,SC10,BRN 0110232,BRN-0110232,NSC 521760

Cat.No: T41209

L-Buthionine-(S,R)-sulfoximine hydrochloride

Cat.No: T60407

N-Decanoyl p-Nitroaniline

Cat.No: T37217

Cat.No: T38117

Synonym: Washington State Probe-5,WSP-5

PXS-5153A monohydrochloride

Cat.No: T12585L

Synonym: PXS-5153A monohydrochloride (2125956-82-1 free base)

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T29607	Acid Red 88 11391 Red,Eniacid Fast Red A,Peony,Red No. 506
	Acid red 88 is an anionic dye with potentially useful photocatalytic research applications. Acid red 88 has been used to determine the effect of Au deposition on ZnO photocatalytic activity under visible light. Additionally, the photocatalyst Au-TiO2 was
T3327	Artemotil SM-227,β-Arteether,Beta-Arteether,蒿乙醚,Arteether,(+)-Arteether	CXCR; CCR; Parasite	Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology
	Artemotil (SM-227) 是一种新型的速效抗疟药，可研究耐Plasmodium falciparum 的恶性疟原虫疟疾，IC50值为 1.61 nM。
TN6791	Palvanil Hexadecanamide	TRP/TRPV Channel	Membrane transporter/Ion channel
	Palvanil (Hexadecanamide) 是一种快速脱敏的 TRPV1 激动剂。它可能是治疗 IBS 的有前途的药物，因为它可以调节肠道蠕动并减轻内脏疼痛。
T2O2728	glycine 2-Aminoacetic acid,Glycolixir,Aminoacetic acid,Glycosthene,Glycocoll,甘氨酸	MT Receptor; Endogenous Metabolite; iGluR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	glycine (2-Aminoacetic acid) 是中枢神经系统的抑制性神经递质，也是谷氨酸的联合激动剂，有促进谷氨酸能NMDA 受体兴奋的潜力。它主要存在于明胶和丝素蛋白中，并在治疗上用作营养物质。
T5120	Rhamnose 6-Deoxyhexopyranose,L-鼠李糖,6-Deoxy-L-mannose,alpha-L-Rhamnose	Calcium Channel; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism
	alpha-L-Rhamnose (6-Deoxy-L-mannose) 是存在植物和细菌中的一种单糖。Rhamnose- 免疫原连接物能被用于免疫疗法。Rhamnose 能通过胞外途径穿过上皮细胞，能够作为肠吸收的标志。
T29599	Acetyldigitoxin Acylanide
	Acetyldigitoxin is a derivative of lanatoside A or of DIGITOXIN and can be used for fast digitalization in congestive heart failure.

天然产物

Cat.No: T29607

Synonym: 11391 Red,Eniacid Fast Red A,Peony,Red No. 506

Cat.No: T3327

Synonym: SM-227,β-Arteether,Beta-Arteether,蒿乙醚,Arteether,(+)-Arteether

Target: CXCR, CCR, Parasite

Cat.No: TN6791

Synonym: Hexadecanamide

Target: TRP/TRPV Channel

Cat.No: T2O2728

Synonym: 2-Aminoacetic acid,Glycolixir,Aminoacetic acid,Glycosthene,Glycocoll,甘氨酸

Target: MT Receptor, Endogenous Metabolite, iGluR

Cat.No: T5120

Synonym: 6-Deoxyhexopyranose,L-鼠李糖,6-Deoxy-L-mannose,alpha-L-Rhamnose

Target: Calcium Channel, Endogenous Metabolite

Acetyldigitoxin

Cat.No: T29599

Synonym: Acylanide

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