37
15
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37858 |
Dehydroergosterol
9,11-dehydro Ergosterol,DHE |
||
Dehydroergosterol is a naturally occurring, fluorescent analog of cholesterol (ex/em = 324/375 nm) that mimics the properties of cholesterol in cell membranes.[1] It is readily bound by cholesterol-binding proteins and has been used for real-time probing of the sterol environment and to elucidate intracellular sterol trafficking in living organisms.[1] | |||
T8490 |
Butoconazole
1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole,布康唑 |
Antifungal | Microbiology/Virology |
Butoconazole (1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole) 是一种咪唑类抗真菌药物,可治疗白色念珠菌引起的阴道感染。它可通过抑制类固醇起抗菌作用。 | |||
T2305 |
Isavuconazole
艾沙康唑,BAL-4815,RO-0094815 |
P450; Antibiotic; Antifungal | Metabolism; Microbiology/Virology |
Isavuconazole (RO-0094815) 是一种三唑类前药,对酵母、霉菌和二型真菌具有抗真菌活性。它抑制麦角固醇生物合成,导致真菌膜结构和功能的破坏。它是 CYP3A4抑制剂。 | |||
T20625 |
Prochloraz
咪鲜胺,Sporgon,Prelude |
Estrogen Receptor/ERR; AhR; Androgen Receptor; Antifungal | Endocrinology/Hormones; Immunology/Inflammation; Metabolism; Microbiology/Virology |
Prochloraz (Prelude) 是咪唑类抗真菌剂。Prochloraz 抑制羊毛甾醇的细胞色素 P450 依赖性 14α-脱甲基作用,由此抑制麦角固醇的生物合成,从而导致真菌细胞膜破裂和细胞死亡。它也是雌激素受体和 雄激素受体的拮抗剂,IC50分别为25 μM 和4 μM, 并激活芳烃受体,EC50为1μM。 | |||
T19721 |
Epoxiconazole
BAS-480F,BAS 480F,EC 406 850 2,氟环唑,BAS480F,EC-406-850-2 |
Antifungal | Microbiology/Virology |
Epoxiconazole (BAS-480F) 是一种 14-α 去甲基化酶抑制剂,抑制麦角甾醇的合成和真菌细胞壁的形成。它是一种杀菌剂,对耐多菌灵和耐苯甲酰胺的菌株均表现出强大的抑制作用,可用于控制多种农作物病害。 | |||
T124072 |
9,11-Dehydroergosterol peroxide
|
||
9,11-Dehydroergosterol peroxide 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T124072,CAS号为 86363-50-0。 | |||
T2199 |
Myclobutanil
Systhane,腈菌唑 |
Antifungal | Microbiology/Virology |
Myclobutanil (Systhane) 是康唑类抗真菌剂,可用作农药。 | |||
T0187 |
Amorolfine hydrochloride
Amorolfin,盐酸阿莫洛芬,Amorolfine HCl,盐酸阿莫罗芬,Ro 14-4767/002 |
Antibiotic; Antifungal | Microbiology/Virology |
Amorolfine hydrochloride (Amorolfine HCl) 是一种抗真菌剂。 | |||
T6686 |
Sulconazole mononitrate
Exelderm,Sulconazole Nitrate,RS 44872,硝酸硫康唑 |
Antibacterial; Antibiotic; Antifungal | Microbiology/Virology |
Sulconazole mononitrate (Exelderm) 是一种咪唑类广谱杀菌剂。它可研究皮肤真菌病,花斑糠疹病,皮肤念珠菌病。 | |||
T1187 |
Bifonazole
联苯苄唑,Bay H-4502 |
P450; Antibiotic; Antifungal | Metabolism; Microbiology/Virology |
Bifonazole (Bay H-4502) 是咪唑类抗真菌剂。 | |||
T1497 |
Liranaftate
Piritetrate,利拉萘酯,M-732 |
Antifungal | Microbiology/Virology |
Liranaftate (Piritetrate) 是一种具有抗真菌活性的硫代氨基甲酸酯和角鲨烯环氧酶抑制剂,可研究皮肤癣菌。 | |||
T35353 |
Elubiol
dichlorophenyl imidazoldioxolan,新康唑 |
Antibacterial | Microbiology/Virology |
Elubiol (dichlorophenyl imidazoldioxolan) 是咪唑类的新型广谱抗真菌产品,可抑制真菌麦角甾醇的生物合成,改变细胞膜中其他脂质化合物的组成。 Elubiol 用于油性皮肤或头皮屑患者的皮肤和头发护理。 | |||
T5966 |
Hexaconazole
己唑醇,(-)-Hexaconazol |
Reactive Oxygen Species; Antifungal | Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Hexaconazole ((-)-Hexaconazol) 是一种广谱三唑类杀菌剂,通过抑制羊毛甾醇的细胞色素 P450 依赖性 14α-去甲基化来抑制麦角甾醇的生物合成,从而导致真菌细胞膜的破坏和细胞死亡。 | |||
T2213 |
Terconazole
Gyno-Terazol,Terazol 3,Terazol 7,Triaconazole,特康唑,曲康唑,R42470 |
Antifection; Antifungal | Microbiology/Virology |
Terconazole (Terazol 7) 是一种广谱抗真菌药物,用于研究阴道酵母菌感染。 | |||
T7866 |
Difenoconazole
|
Others; Antifungal | Microbiology/Virology; Others |
Difenoconazole 是一种广谱三唑类杀菌剂,通过抑制羊毛甾醇的细胞色素 P450 依赖性 14α-去甲基化来抑制麦角甾醇的生物合成,从而导致真菌细胞膜的破坏和细胞死亡。 | |||
T3934 |
Isavuconazonium sulfate
|
Antifungal | Microbiology/Virology |
Isavuconazonium sulfate 是一种口服活性抗真菌药,是活性三唑类抗真菌药物 Isavuconazole 的前药,可用于侵袭性曲霉菌病和毛霉菌病。 | |||
T1438 |
Butoconazole nitrate
RS 35887,硝酸布康唑 |
Estrogen/progestogen Receptor; Antifungal | Endocrinology/Hormones; Microbiology/Virology |
Butoconazole nitrate (RS 35887) 是一种咪唑类抗真菌药物,可治疗由白色念珠菌引起的阴道感染。它可通过抑制类固醇合成起到抗菌作用。 | |||
T1290 |
Oxiconazole nitrate
硝酸奥昔康唑,Ro 13-8996 |
Others; Antibiotic; Antifection; Antifungal | Microbiology/Virology; Others |
Oxiconazole nitrate (Ro 13-8996) 是广谱抗真菌药物,抑制T. tonsurans 和T.rubrum 的生长,MIC90值分别为 0.25 和 0.5 μg/mL。 | |||
T1543 |
Naftifine hydrochloride
Naftifungin,盐酸萘替芬,Naftifine HCl,Naftin,Exoderil |
Hedgehog/Smoothened; Antibiotic; Antifungal | GPCR/G Protein; Microbiology/Virology; Stem Cells |
Naftifine hydrochloride (Naftifine HCl) 是一种抗生素。它具有抗真菌活性,对皮肤真菌、曲霉、Sporothrix schenckii、假丝酵母属的酵母有抑制作用。 | |||
T28914 |
Tak 187
Tak-187,Tak187 |
||
Tak 187 is a long-lasting inhibitor of ergosterol biosynthesis. | |||
T34924 |
Triadimenol
Spinnaker,UK199,Baytan,UK 199,UK-199 |
||
Triadimenol is a systemic fungicide with a broad spectrum. It inhibits the ergosterol - and gibberellin - biosynthesis, and thus the rate of cell division. | |||
T26424 |
A 60586
A60586,A-60586 |
||
A 60586, a non-azole inhibitor of ergosterol biosynthesis, inhibits lanosterol 14alpha-demethylase and displays in-vitro antifungal activity. | |||
T6702L |
Terbinafine lactate
DRG-0286,Terbinafine hydrochloride,Lamisil Krem,SF 86-327 hydrochloride,Lamisil,Lamisil AT |
||
Terbinafine, a synthetic allylamine antifungal, inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is part of the fungal cell membrane synthesis pathway. | |||
T15708 |
Lanoconazole
|
Antifungal | Microbiology/Virology |
Lanoconazole is an orally active imidazole antifungal agent that displays a broad spectrum of activity against fungi in vitro and in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. | |||
T8812 |
Amorolfine HCL
|
Antibiotic | Microbiology/Virology |
Amorolfine HCL 是一种抗真菌试剂。它通过选择性地中断麦角甾醇合成途径中的两个步骤并随后破坏真菌细胞膜的功能和结构来发挥抗真菌活性。阿莫罗芬是一种吗啉类抗真菌药物,可抑制 D14 还原酶和 D7-D8 异构酶。这些酶可以消耗麦角甾醇并导致木甾醇在真菌细胞质细胞膜中积累。 | |||
T40798 |
Triflumizole
|
||
Triflumizole, an imidazole fungicide, acts as an inhibitor of ergosterol biosynthesis. This widely utilized compound effectively controls powdery mildew and scabs on a range of fruits and crops. | |||
T71341 |
Myclobutanil hydroxide
|
||
Myclobutanil hydroxide is a 14-α demethylase inhibitor that inhibits ergosterol synthesis and fungal cell wall formation. It also weakly inhibits testosterone production. | |||
T68998 |
Parconazole Free Base
|
||
Parconazole Free Base is used in veterinary as an oral fungicide with a broad-spectrum activity against dermatophytes, yeasts, and others fungi. This compound does not have any antibacterial effect. The mechanism of action involves inhibition of the fungal cytochrome P450 dependent 14alpha-dimethylation of lanosterol to ergosterol. | |||
T60853 | (Z)-Lanoconazole | ||
(Z)-Lanoconazole 是 Lanoconazole 的 Z 构型,用于研究皮肤癣菌病和甲癣。Lanoconazole 抑制甾醇 14-α脱甲基酶并阻断真菌膜上的麦角甾醇生物合成,从而干扰麦角甾醇的生物合成。Lanoconazole 是具有口服活性的咪唑类抗真菌剂,在体外和体内均具有广谱的抗真菌活性。 | |||
T21365 |
Butenafine
KP363,KP 363,Mentax,KP-363,Butop |
||
Butenafine hydrochloride is a hydrochloride of butenafine, which inhibits squalene epoxidase to inhibit the synthesis of ergosterol, leading to the increased permeability of the cell membranes, allowing their contents to leak out. | |||
T74273 |
Antifungal agent 52
|
||
Antifungal agent 52 (compound 6c) 是四唑衍生物。Antifungal agent 52 抑制麦角固醇 的合成。Antifungal agent 52 对白色念珠菌表现出显着的抗真菌活性 Antifungal agent 52 影响白色念珠菌基底细胞膜通透性。 | |||
T79551 | Antifungal agent 69 | ||
Antifungalagent 69 (compound 13),作为一种丁子香酚-咪唑类化合物,对白色念珠菌表现出有效的抗真菌活性,其MIC值为4.6 μM,并未展现显著的细胞毒性。此外,该化合物能够干预真菌的麦角甾醇生物合成路径。 | |||
T64105 |
Voriconazole camphorsulfonate
|
||
Voriconazole (UK-109496) camphorsulfonate 是一种二代广谱的三唑类抗真菌 (antifungal) 化合物,对真菌麦角甾醇的生物合成表现出抑制作用。Voriconazole camphorsulfonate 能够抑制由真菌细胞色素 P450 酶介导的 14-α-羊毛甾醇去甲基化作用,表现出抗真菌效果。 | |||
T79550 | Antifungal agent 68 | ||
Antifungalagent 68(compound 10)是抗真菌剂,针对念珠菌和格特隐球菌。它通过抑制麦角甾醇的生物合成发挥作用,靶向羊毛甾醇 14α-去甲基酶(CYP51)。Antifungalagent 68的咪唑环能与CYP51的血红素基团发生相互作用。 | |||
T83069 | Antifungal agent 75 | ||
Antifungalagent 75 (compound 6r) 是针对白色念珠菌有效的抗真菌剂。该化合物通过显著抑制生物膜形成、增加细胞膜通透性、降低麦角甾醇水平并破坏膜结构,从而破坏细胞结构完整性,发挥其抗真菌活性。 | |||
T79467 |
Antifungal agent 60
|
||
Antifungalagent 60(compound 16)是一种抑制麦角甾醇生物合成的广谱抗真菌剂。它能够有效抑制包括7种人类致病真菌、2种耐氟康唑的白色念珠菌分离株以及2种多重耐药的耳念珠菌分离株。 | |||
T78899 |
Laccase-IN-1
|
||
Laccase-IN-1 (compound 4b) 是一种口服laccase抑制剂,其IC50为11.3 μM。该化合物能够对苹果中的B. dothidea起到保护及治疗效果。它通过增强B. dothidea细胞膜的通透性、破坏其菌丝的表面形态以及细胞的超微结构,并且减少麦角甾醇和胞外多糖的含量,来发挥作用。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2912 |
Ergosterol
麦角固醇,Provitamin D,Ergosterin,Provitamin D2 |
Others; Endogenous Metabolite | Metabolism; Others |
Ergosterol (Provitamin D2) 是真菌中的主要固醇类,具有抗炎,抗氧化和抗增殖的作用。 | |||
TN7071 |
Ergosterol Acetate
Ergosta-5,7,22-trien-3-beta-yl acetate |
Others | Others |
Ergosterol Acetate (Ergosta-5,7,22-trien-3-beta-yl acetate) 是来自红曲霉的 Ergosterol 的乙酸酯衍生物之一。 | |||
TN5288 |
Ergosterol peroxide glucoside
过氧化麦角甾醇葡萄糖苷,Ergosterol peroxide 3-O-β-D-glucopyranoside |
||
Ergosterol peroxide exhibits anti-cancer, amoebicidal, anticomplementary, antibacterial, antiviral, anti-oxdiant, and anti-melanogenic activities. Ergosterol peroxide could as an anti-atherosclerosis agent, it exhibits hACAT-1 and Lp-PLA2 inhibitory effec | |||
TMA1743 |
Ergosterol peroxide
|
ERK; VEGFR; p38 MAPK; Wnt/beta-catenin; Akt; JAK; CDK; JNK; STAT; Antifection | Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pro-apoptotic protein Puma and Bax to | |||
TN3984 |
Ergosterol glucoside
|
Others | Others |
Ergosterol glucoside is a natural product from Rehmannia glutinosa. | |||
T1011 |
Itraconazole
伊曲康唑,R51211 |
P450; Hedgehog/Smoothened; Antibiotic; Autophagy; Antifungal | Autophagy; GPCR/G Protein; Metabolism; Microbiology/Virology; Stem Cells |
Itraconazole (R51211) 是三唑类抗真菌药,也是口服活性的Hedgehog 信号通路拮抗剂,IC50约为 800 nM。它也是 oxysterol-binding protein 抑制剂。它抑制羊毛甾醇 14α-脱甲基酶,从而抑制羊毛甾醇向麦角固醇的氧化转化。它有抗癌和抗血管作用。 | |||
TN7127 |
5,6-Epoxyergosterol
|
Others | Others |
5,6-Epoxyergosterol 来源于内生真菌 Phyllosticta capitalensis。 | |||
T1086 |
Vitamin D2
Calciferol,Ergocalciferol,Ercalciol,维生素D2 |
DNA/RNA Synthesis; Endogenous Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Vitamin D2 (Calciferol) 来源于植物或膳食补充剂,能够用作维生素 D 的补充剂。 | |||
T0344L |
Miconazole nitrate
NSC 169434 Nitrate,硝酸咪康唑,R18134 nitrate |
Antibacterial; Antibiotic; Antifungal | Microbiology/Virology |
Miconazole nitrate (R18134 nitrate) 是咪唑类可抗菌的抗真菌剂。 | |||
T0146 |
Tioconazole
UK-20349,Vagistat,噻康唑 |
Antibiotic; Antifection; Antifungal | Microbiology/Virology |
Tioconazole (Vagistat) 是一种广谱性的抗真菌咪唑衍生物。它抑制几种皮肤真菌和几种酵母菌的 MIC50分别小于 3.12 mg/L 和 9 mg/L。 | |||
T6702 |
Terbinafine
Terbinex,特比萘芬,SF 86-327,Lamisil,TDT 067 |
Antibacterial; Antibiotic; Antifungal | Microbiology/Virology |
Terbinafine (TDT 067) 是念珠菌属的角鲨烯环氧化酶有效的非竞争性抑制剂,Ki 值为 30 nM。它具有抗真菌感染活性。 | |||
T1067 |
Amphotericin B
NSC 527017,两性霉素B |
Antibiotic; Antifungal | Microbiology/Virology |
Amphotericin B (NSC-527017) 是一种多烯类抗真菌剂,对许多真菌物种具有广谱活性。Amphotericin B 不可逆地结合麦角甾醇,破坏细胞膜完整性,从而起到抗真菌活性。 | |||
T38036 | Lumisterol | ||
Lumisterol (9β,10α-Ergosterol), a steroid compound, is the (9β,10α)-stereoisomer of Ergosterol. Lumisterol is a photoprotective agent against UVB-induced DNA damage and anti-proliferative activities[1]. [1]. Anyamanee Chaiprasongsuk, et al. Protective Effects of Novel Derivatives of Vitamin D 3 and Lumisterol Against UVB-induced Damage in Human Keratinocytes Involve Activation of Nrf2 and p53 Defense Mechanisms. Redox Biol. 2019 Jun;24:101206. | |||
T28379 |
PF-1163B
PF1163B,(-)-PF1163B,PF 1163B |
||
PF-1163B is an antifungal agent form Penicillium sp. II. PF-1163B inhibits ergosterol (ERG) synthesis with IC50 value of 34 ng/ml. PF-1163B showed potent growth inhibitory activity against pathogenic fungal strain Candida albicans but did not show cytotox | |||
T80777 |
Withaphysalin R
|
||
Withaphysalin R (化合物 5),一种可从茄科植物中提取的睡茄内酯 (Withanolide),具有麦角固醇框架的甾体内酯。其活性包括细胞毒性、免疫抑制、抗肿瘤、抗炎、抗惊厥及抗氧化等显著生物活性。 |