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82

抑制剂 & 化合物

17

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T5427	GSK1940029 SCD inhibitor 1	Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Metabolism
	GSK1940029 (SCD inhibitor 1) 是酰基-辅酶A 去饱和酶 (SCD) 抑制剂。
T50029	2-((2,2-Dibenzylhydrazineylidene)methyl)pyridine 2-[(1E)-(dibenzylhydrazin-1-ylidene)methyl]pyridine	Others	Others
	2-((2,2-Dibenzylhydrazineylidene)methyl)pyridine (2-[(1E)-(dibenzylhydrazin-1-ylidene)methyl]pyridine) 是一种杂环化合物。它可以抑制单胺氧化酶，导致体内单胺水平升高；也可以抑制腺苷脱氨酶，导致体内腺苷水平升高；还可以可以增加某些神经递质的活性，包括血清素和多巴胺。
T22466	Adenosine receptor A1 antagonist 5	cAMP	GPCR/G Protein
	Adenosine receptor A1 antagonist 5 可作为一种腺苷拮抗剂，是一种氧嘌呤，可作为杀虫剂和虫害防治剂，对血压升高有抑制作用。
T23097	O-1602 O1602,O 1602	Cannabinoid Receptor; Calcium Channel	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism
	O-1602 是一种新型 GPR55 激动剂，是一种非典型大麻素，与中枢神经系统和肥胖有关，是治疗膀胱炎的候选化合物。O-1602通过小鼠GPR55 的 PI3激酶/ Akt / SREBP-1c信号传导促进肝脂肪变性。O-1602以GPR3非依赖性方式诱导Hep55B细胞中的细胞内钙升高。
T38240	2,6-Dichlorodiphenylamine	Antibacterial	Microbiology/Virology
	2,6-Dichlorodiphenylamine 是双氯芬酸钠的一种结构类似物，显示出抗白色念珠菌活性。2,6-Dichlorodiphenylamine 是非选择性抗炎剂，为COX 的抑制剂，在 CHO 细胞中，对人 COX-1 和 COX-2 的IC50分别为 4 和 1.3 nM。
T12593	Pyrithione 1-hydroxyl-1H-pyridine-2-thione,吡啶硫酮	Others	Others
	Pyrithione (1-hydroxyl-1H-pyridine-2-thione) 是一种锌离子载体，过渡金属配合物，可引起哺乳动物细胞内锌水平的升高，有杀菌和抗真菌作用。
T8773	MID-1	Others; IGF-1R	Others; Tyrosine Kinase/Adaptors
	MID-1 是 MG53-IRS-1 相互作用的抑制剂，能够破坏 MG53 与 IRS-1 的分子缔合，并消除 MG53 诱导的 IRS-1 泛素化和骨骼肌降解，升高 IRS-1 表达水平，增加胰岛素信号传导和葡萄糖摄取。
T3647	HTHQ HX 1171,HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone),1-O-hexyl-2,3,5-trimethylhydroquinone	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	HTHQ (HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone)) 是一种强力的亲脂性酚类抗氧化剂。它通过与活性氧直接反应，清除 ROS，从而形成更稳定的自由基，具有很强的抗氧化活性。
T4121	Bicyclol SY801,双环醇	HBV; Autophagy	Autophagy; Microbiology/Virology
	Bicyclol (SY801) 是一种抗肝炎 HBV 和 HCV 药物。
T3527	TRC051384 TRC 051384	HSP	Cytoskeletal Signaling; Metabolism
	TRC051384 是一种热休克蛋白70 (HSP70) 诱导剂，可减少中风相关的神经元损伤并增加短暂性缺血性中风大鼠模型的存活率，激活热休克因子-1 并导致分子伴侣和抗炎活性升高，增强神经元和神经胶质细胞中 Hsp72 的表达。
T3625	Bempedoic acid ETC1002,ESP-55016,ETC 1002,ETC-1002	ATP Citrate Lyase; AMPK	Chromatin/Epigenetic; Metabolism; PI3K/Akt/mTOR signaling
	Bempedoic acid (ETC1002) 是一种 ATP-柠檬酸裂解酶抑制剂，可激活AMPK。它是脂质和碳水化合物代谢的调节剂。
T8845	UTL-5g 3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-,GBL-5g	TNF	Apoptosis
	UTL-5g (3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-) 是一种抗炎性TNF-α抑制剂，可通过抑制 TNF-α 等因子降低顺铂引起的肝毒性、肾毒性和骨髓毒性，具有化学保护和肝脏放射保护作用。
T16342	KL1333 NQO1 activator 1	NADPH; Mitochondrial Metabolism	Metabolism
	KL1333 (NQO1 activator 1) 是口服NAD+调节剂，与 NAD(P)H: 醌氧化还原酶 1 作为底物反应。它改善线粒体脑肌病、乳酸酸中毒和中风样发作成纤维细胞的能量代谢和线粒体功能障碍。它对顺铂诱导的小鼠耳蜗培养耳毒性的保护作用。
T0755	Carglumic Acid Carbaglu,N-Carbamylglutamate,N-Carbamyl-L-glutamic acid,氨甲酰谷氨酸,Carbamylglutamic acid,Carbamino-L-glutamic acid,Ureidoglutaric acid	Others	Others
	Carglumic Acid (Ureidoglutaric acid) 是一种 N-乙酰谷氨酸 (NAG) 的功能类似物和氨甲酰磷酸合成酶 1(CPS1)的活化剂，可用于与 N-乙酰谷氨酸合成酶 (NAGS) 缺陷相关的急性和慢性高氨血症的研究。
T36983	Cyclic-di-GMP disodium Cyclic diguanylate,5GP-5GP disodium,3',5'-Cyclic diguanylic acid,Cyclic di-GMP (sodium salt),cyclic diguanylate disodium,c-di-GMP,c-di-GMP disodium	STING; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	Cyclic-di-GMP disodium (5GP-5GP disodium) 是细菌的第二信使，也是一种 STING 激动剂，参与原核生物的多种过程，包括生物膜的形成、运动、和细胞周期的进展。Cyclic-di-GMP disodium 对癌细胞显示出抗增殖活性，可诱导 CD4 受体表达升高和细胞周期停滞。Cyclic-di-GMP disodium 可用于癌研究癌症。
TP1293	Jagged-1 (188-204) TFA(219127-21-6 free base) Jagged-1 (188-204) TFA	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Jagged-1 (188-204) TFA(219127-21-6 free base) 是 JAG-1 蛋白的一个片段。 JAG-1 是 Notch 配体，是一种在皮肤中表达最明显的肽。 JAG-1 诱导表皮成熟。将淹没的角质形成细胞单层暴露于钙浓度升高的 JAG-1 会产生具有 loricrin 表达和 NF-alphaB 激活的分层。
T31264	Deanol acetamidobenzoate Deanol p-acetamidobenzoate,Elevan,Diforene,Cervoxan,Deaner
	Deanol acetamidobenzoate is CNS stimulant. It can be caused elevated blood choline levels, can be used in Treatment of Choreiform Movement Disorders.
T37531	Glycerophosphorylethanolamine (sodium salt)
	Glycerophosphorylethanolamine is an active phosphodiester metabolite of phosphatidylethanolamine.1,2It promotes aggregation of amyloid-β (1-40) (Aβ40)in vitro, and levels of glycerophosphorylethanolamine are elevated in postmortem brains isolated from patients with Alzheimer’s disease. 1.Klunk, W.E., Xu, C.J., McClure, R.J., et al.Aggregation of β-amyloid peptide is promoted by membrane phospholipid metabolites elevated in Alzheimer’s disease brainJ. Neurochem.69(1)266-272(1997) 2.Blusztajn, J.K...
T29223	ZK110841 ZK-110841,ZK 110841
	ZK110841 is an agonist of prostaglandin DP-receptors on human platelet. ZK110841 elevated the cyclic AMP level in EBTr cells dose-dependently, being more than 100 fold over the basal level at 1 microM.
T37845	Taurocholic Acid 3-sulfate (sodium salt)
	Taurocholic acid 3-sulfate (TCA3S) is a metabolite of the conjugated bile acid taurocholic acid .1Plasma levels of TCA3S are elevated in wild-type andSortilin 1(Sort1) knockout mice at 6 hours following bile duct ligation (BDL) and are further elevated inSort1knockout mice at 24 hours post-BDL.2 1.Lefebvre, P., Cariou, B., Lien, F., et al.Role of bile acids and bile acid receptors in metabolic regulationPhysiol. Rev.89(1)147-191(2009) 2.Li, J., Woolbright, B.L., Zhao, W., et al.Sortilin 1 loss-o...
T39162	1,1,1,3-Tetrachloroacetone
	1,1,1,3-Tetrachloroacetone, a halogenated compound, is known to form ozone-chlorine and ozone-chloramine disinfection byproducts (DBPs) when elevated bromide levels are present in water treated with chlorine or chloramine as secondary disinfectants.
T81927	Lithium citrate Litarex
	锂柠檬酸用于降低卡纳万病患者脑内过量的N-乙酰天冬氨酸含量。
T37925	7-Biopterin
	7-Biopterin is a 7-substituted pterin.1It is formed by non-enzymatic rearrangement of 4a-hydroxy-tetrahydropterin in the absence of pterin-4a-carbinolamine dehydratase (PCD)in vitroand levels are elevated in the urine of hyperphenylalaninemia patients carrying heterozygous mutations in the PCBD gene encoding PCD.1,2
T61672	MAT2A-IN-7
	MAT2A-IN-7, a potent inhibitor of the enzyme MAT2A, demonstrates efficacy in targeting the abnormally elevated expression of MAT2A observed in gastric, colon, liver, and pancreatic cancers. Furthermore, MAT2A-IN-7 effectively reduces the proliferative activity specifically in MTAP-deficient cancer cells, thus highlighting its potential for cancer research applications [1].
T61065	Lisuride
	Lisuride is an orally active agonist of dopamine D2 receptors, classified as an ergot derivative. It is utilized for research purposes relating to Parkinson's disease, migraine, and elevated prolactin levels [1] [2].
T31189	Dads-E DadsE
	Dads-E can be used to label small molecule technetium 99M with diaminodimercaptan. DADT-FA was marked at room temperature and DADT-E was marked at elevated temperature in ethanol, both of which were reduced by stannous.
T36453	1-Myristoyl-2-hydroxy-sn-glycero-3-PE
	1-Myristoyl-2-hydroxy-sn-glycero-3-PE is a naturally occurring lysophospholipid. It induces transient increases in intracellular calcium in PC12 cells. Serum levels of 1-myristoyl-2-hydroxy-sn-glycero-3-PE are elevated in patients with malignant breast cancer compared to healthy controls.
T40724	1,1-Dibromo-3,3-dichloroacetone
	1,1-Dibromo-3,3-dichloroacetone is a chemical compound that can be formed as a disinfection byproduct (DBP) when elevated levels of bromide are present during the use of chlorine or chloramine as secondary disinfectants, leading to the halogenation of ozone-chlorine and ozone-chloramine compounds.
T40639	1,1,3-Tribromo-3-chloroacetone
	1,1,3-Tribromo-3-chloroacetone is a chemical compound that acts as a halogenated disinfection byproduct (DBP) when elevated bromide levels are present during the use of chlorine or chloramine as a secondary disinfectant. Its formation is attributed to the reaction between ozone-chlorine and ozone-chloramine.
T35807	C18 dihydro Ceramide (d18:0/18:0) C18 dihydro Ceramide (d18:0/18:0),Cer(d18:0/18:0)
	C18 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C18 ceramide that lacks the 4,5-trans double bond. [1] Increased C18 dihydroceramide lipid levels lead to increased triacylglycerol storage and autophagosome accumulation as well as upregulation of the fibrosis markers α-SMA and FGF2 in Chang and LX-2 liver cells. C18 dihydro Ceramide is elevated in the plasma of pre-diabetics up to 9 years prior to the onset of type 2 diabetes. [2] It is also elevated in...
T35603	Oleic Acid-2,6-diisopropylanilide
	AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol. Oleic acid-2,6-diisopropylanilide is an inhibitor of acylCoA:cholesterol acyltransferase with an IC50 of 7 nM. When co-administered to rabbits or rats fed a high fat, high cholesterol diet, oleic acid-2,6-diisopropylanilide decreased low density lipoproteins and elevated high density lipoprotein levels when administered at 0.05%.
T73261	C5aR-IN-1
	C5aR-IN-1 是一种有效的C5aR 抑制剂。C5a 水平升高与自身免疫性疾病和炎症性疾病等疾病有关。C5aR-IN-1 具有研究炎症性疾病的潜力。
T73647	Boc-MLF TFA
	Boc-MLF (TFA) 是甲酰肽受体(FPR)的一种多肽拮抗剂，同时在高浓度下也能对甲酰肽样受体1FPRL1起到拮抗效果。
T37477	L-858,051 (hydrochloride)
	L-858,051 is a water-soluble analog of forskolin , a cell-permeant activator of adenylate cyclase. L-858,051 activates adenylate cyclase (EC50 = 3 μM), inhibits glucose transport, and blocks cytochalasin B binding in rat adipocyte membranes. L-858,051 is used to activate adenylate cyclase and initiate signaling through elevated cAMP synthesis in a variety of cell types in culture.
T35665	Pregnanetriol
	Pregnanetriol is a metabolite of 17α-hydroxyprogesterone .1,2It is formed from 17α-hydroxyprogesterone by reduction of the C-20 ketone.2Urinary levels of pregnanetriol are elevated in patients with 21-hydroxylase deficiency and congenital adrenal hyperplasia.3,4 1.Kamrath, C., Hartmann, M.F., Boettcher, C., et al.Diagnosis of 21-hydroxylase deficiency by urinary metabolite ratios using gas chromatography-mass spectrometry analysis: Reference values for neonates and infantsJ. Steroid Biochem. Mol...
T29062	UNC3133 UNC 3133,UNC-3133
	UNC3133 is a potent and selective Mer tyrosine kinase (MerTK) inhibitor with IC50 Mer 3.0 nM; Axl 17nM; Tyro 3.31 nM; FLT3 6.6 nM; PO Cmax = 0.023; IV T1/2 = 1.59 h, %F = 16. Mer tyrosine kinase (MerTK) is aberrantly elevated in various tumor cells and ha
T35442	1-Amino-1-deoxy-D-fructose (hydrochloride)
	1-Amino-1-deoxy-D-fructose is an amino monosaccharide.1It induces site-specific DNA damage at pyrimidine residues in cell-free assays. 1-Amino-1-deoxy-D-fructose moieties have been found as a component of fructosamines, glycated serum proteins that are elevated in patients with conditions such as diabetes.2,3
T70312	AZ1366
	AZ1366 is a potent tankyrase inhibitor that enhances irinotecan activity in tumors that exhibit elevated tankyrase and irinotecan resistance. Combination AZ1366 and irinotecan achieved greater anti-tumor effects compared to monotherapy. Activity was limited to CRC explants that displayed irinotecan resistance and increased protein levels of tankyrase and NuMA.
T35808	C18:1 Ceramide (d18:1/18:1(9Z)) Cer(d18:1/18:1(9Z))
	C18:1 Ceramide is a naturally occurring ceramide.[1][2][3] Levels of C18:1 ceramide are elevated in overweight and insulin-resistant mice and cattle.[1][2] C18:1 Ceramide is also increased in the plasma and ovarian tissue of patients with advanced ovarian cancer. [3]
T61243	MAT2A-IN-5
	MAT2A-IN-5, a potent inhibitor of MAT2A, effectively targets the abnormally elevated expression of MAT2A found in various tumor types such as gastric, colon, liver, and pancreatic cancers. By reducing the proliferative activity of MTAP-deficient cancer cells, MAT2A-IN-5 exhibits potential in cancer research applications [1].
T25234	CH5447240 CH 5447240,CH-5447240
	CH5447240 is an effective Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist for the treatment of Hypoparathyroidism. CH5447240 showed a potent in vitro hPTHR1 agonist effect (EC20: 3.0 nM; EC50: 12 nM). It showed 55% oral bioavailability and a signifi
T35873	C19 Ceramide (d18:1/19:0) C19 Ceramide (d18:1/19:0)
	C19 Ceramide is a naturally occurring ceramide that has been found in J. juncea extracts as well as rat brain and mouse heart.[1],[2],[3] It is elevated in adult and decreased in juvenile whole rat brain extracts by 114 and 37%, respectively, following chronic ethanol exposure.[2] C19 Ceramide is also increased in mouse hearts following administration of angiotensin II.[3]
T68317	VJ115
	VJ115 is a novel chemical entity that inhibits the enzyme ENOX1, a NADH oxidase. Genetic and small molecule inhibition of ENOX1 inhibits endothelial cell tubule formation and tumor-mediated neo-angiogenesis. Inhibition of ENOX1 radiosensitizes tumor vasculature, a consequence of enhanced apoptosis. VJ115 inhibition of ENOX1 can impact expression of proteins involved in cytoskeletal reorganization and support a hypothesis in which ENOX1 activity links elevated cellular NADH concentrations with cy...
T73774	(S)-3,4-Dihydroxybutyric acid lithium hydrate
	(S)-3,4-Dihydroxybutyric acid (lithium hydrate) 为一种在人体尿液中自然出现的代谢物，其在琥珀酸半醛脱氢酶（SSADH）缺乏症患者体内的浓度会出现上升。
T74364	SDOX	Topoisomerase	DNA Damage/DNA Repair
	SDOX为Doxorubicin的前体药物，通过脂质体递送至肿瘤细胞内，在GSH过量释放条件下，触发DOX释放。该机制在不损害抗癌效果的同时，极大地降低了对正常组织的毒副作用。
T75706	Ac-DEVD-CMK TFA
	Ac-DEVD-CMK (Caspase-3 Inhibitor III) TFA 是一种选择性且不可逆的caspase-3抑制剂。Ac-DEVD-CMK TFA 显着抑制由高水平葡萄糖或 3,20-dibenzoate (IDB) 诱导的凋亡。Ac-DEVD-CMK TFA 可以用于多种实验方法以抑制细胞凋亡。
T35804	C16 Lactosylceramide (d18:1/16:0)
	C16 Lactosylceramide is an endogenous bioactive sphingolipid. It forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors (GPCRs), suggesting a role in cell signaling. Plasma levels of C16 lactosylceramide are elevated in insulin-resistant cattle. C16 Lactosylceramide is also upregulated in a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder.
T78199	S07-1066	Others	Others
	S07-1066为AKR1C3醛酮还原酶抑制剂，增强阿霉素(DOX)细胞毒性作用。该化合物选择性抑制AKR1C3催化的DOX还原反应，逆转AKR1C3高表达细胞的DOX耐药性。
T37905	Hexanoyl Glycine
	Hexanoyl glycine is an acylated amino acid that is used as a urinary biomarker for several indications. It is normally biosynthesized from hexanoyl-CoA and glycine by the mitochondrial enzyme glycine N-acyltransferase. Increased urinary excretion of hexanoyl glycine in humans is indicative of a deficiency in medium-chain acyl-CoA dehydrogenase. Increased urinary hexanoyl glycine can also be used as a biomarker for exposure to gamma radiation. Levels of hexanyl glycine can also be elevated during...
T26868	BMS-986118 BMS 986118
	BMS-986118 is a full agonist of GPR40, is a G-protein-coupled receptor expressed primarily in pancreatic islets and intestinal L-cells that has been a target of significant recent therapeutic interest for type II diabetes. Activation of GPR40 by partial a

化合物

Cat.No: T5427

Synonym: SCD inhibitor 1

Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

2-((2,2-Dibenzylhydrazineylidene)methyl)pyridine

Cat.No: T50029

Synonym: 2-[(1E)-(dibenzylhydrazin-1-ylidene)methyl]pyridine

Target: Others

Adenosine receptor A1 antagonist 5

Cat.No: T22466

Target: cAMP

Cat.No: T23097

Synonym: O1602,O 1602

Target: Cannabinoid Receptor, Calcium Channel

2,6-Dichlorodiphenylamine

Cat.No: T38240

Target: Antibacterial

Cat.No: T12593

Synonym: 1-hydroxyl-1H-pyridine-2-thione,吡啶硫酮

Target: Others

Cat.No: T8773

Target: Others, IGF-1R

Cat.No: T3647

Synonym: HX 1171,HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone),1-O-hexyl-2,3,5-trimethylhydroquinone

Target: Reactive Oxygen Species

Cat.No: T4121

Synonym: SY801,双环醇

Target: HBV, Autophagy

Cat.No: T3527

Synonym: TRC 051384

Target: HSP

Cat.No: T3625

Synonym: ETC1002,ESP-55016,ETC 1002,ETC-1002

Target: ATP Citrate Lyase, AMPK

Cat.No: T8845

Synonym: 3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-,GBL-5g

Target: TNF

Cat.No: T16342

Synonym: NQO1 activator 1

Target: NADPH, Mitochondrial Metabolism

Cat.No: T0755

Synonym: Carbaglu,N-Carbamylglutamate,N-Carbamyl-L-glutamic acid,氨甲酰谷氨酸,Carbamylglutamic acid,Carbamino-L-glutamic acid,Ureidoglutaric acid

Target: Others

Cyclic-di-GMP disodium

Cat.No: T36983

Synonym: Cyclic diguanylate,5GP-5GP disodium,3',5'-Cyclic diguanylic acid,Cyclic di-GMP (sodium salt),cyclic diguanylate disodium,c-di-GMP,c-di-GMP disodium

Target: STING, Endogenous Metabolite

Jagged-1 (188-204) TFA(219127-21-6 free base)

Cat.No: TP1293

Synonym: Jagged-1 (188-204) TFA

Target: Gamma-secretase

Deanol acetamidobenzoate

Cat.No: T31264

Synonym: Deanol p-acetamidobenzoate,Elevan,Diforene,Cervoxan,Deaner

Glycerophosphorylethanolamine (sodium salt)

Cat.No: T37531

Cat.No: T29223

Synonym: ZK-110841,ZK 110841

Taurocholic Acid 3-sulfate (sodium salt)

Cat.No: T37845

1,1,1,3-Tetrachloroacetone

Cat.No: T39162

Lithium citrate

Cat.No: T81927

Synonym: Litarex

Cat.No: T37925

Cat.No: T61672

Cat.No: T61065

Cat.No: T31189

Synonym: DadsE

1-Myristoyl-2-hydroxy-sn-glycero-3-PE

Cat.No: T36453

1,1-Dibromo-3,3-dichloroacetone

Cat.No: T40724

1,1,3-Tribromo-3-chloroacetone

Cat.No: T40639

C18 dihydro Ceramide (d18:0/18:0)

Cat.No: T35807

Synonym: C18 dihydro Ceramide (d18:0/18:0),Cer(d18:0/18:0)

Oleic Acid-2,6-diisopropylanilide

Cat.No: T35603

Cat.No: T73261

Cat.No: T73647

L-858,051 (hydrochloride)

Cat.No: T37477

Cat.No: T35665

Cat.No: T29062

Synonym: UNC 3133,UNC-3133

1-Amino-1-deoxy-D-fructose (hydrochloride)

Cat.No: T35442

Cat.No: T70312

C18:1 Ceramide (d18:1/18:1(9Z))

Cat.No: T35808

Synonym: Cer(d18:1/18:1(9Z))

Cat.No: T61243

Cat.No: T25234

Synonym: CH 5447240,CH-5447240

C19 Ceramide (d18:1/19:0)

Cat.No: T35873

Synonym: C19 Ceramide (d18:1/19:0)

Cat.No: T68317

(S)-3,4-Dihydroxybutyric acid lithium hydrate

Cat.No: T73774

Cat.No: T74364

Target: Topoisomerase

Ac-DEVD-CMK TFA

Cat.No: T75706

C16 Lactosylceramide (d18:1/16:0)

Cat.No: T35804

Cat.No: T78199

Target: Others

Hexanoyl Glycine

Cat.No: T37905

Cat.No: T26868

Synonym: BMS 986118

Cat. No.	Product Name	Target	Signaling Pathways
T5289	N-Acetyl-L-arginine dihydrate N-Ac-L-arg-OH,乙酰精氨酸	Others; Endogenous Metabolite	Metabolism; Others
	N-Acetyl-L-arginine dihydrate (N-Ac-L-arg-OH) 是内源性代谢产物的一种。
T5229	DL -3,4-Dihydroxymandelic acid	Others	Others
	DL -3,4-Dihydroxymandelic acid 是去甲肾上腺素在人体中的次要代谢物。神经母细胞瘤患者的 3,4-二羟基扁桃酸水平升高。
T4734	Suberic acid Octanedioic acid,1,8-Octanedioic acid,辛二酸	Others; Endogenous Metabolite	Metabolism; Others
	Suberic acid (1,8-Octanedioic acid) 被发现和肉毒碱-甲酰基-丙氨酸转位酶缺乏(丙二醇-羧基酶缺乏症)有关。
T13979	(S)-3-Hydroxybutanoic acid L-β-Hydroxybutyric acid,(S)-β-Hydroxybutanoic acid,L-(+)-3-Hydroxybutyric acid,(S)-3-羟基丁酸	Endogenous Metabolite	Metabolism
	(S)-3-Hydroxybutanoic acid (L-(+)-3-Hydroxybutyric acid) 是一种正常的人体代谢产物，在患有抑郁症的老年患者中升高。它在人类的肝脏中由乙酰-CoA 合成，当血糖低时能够被脑用作能量来源。
T5280	3-Chloro-L-Tyrosine 3-氯-L-酪氨酸,3-Chlorotyrosine,Chlorotyrosine	Others; Endogenous Metabolite	Metabolism; Others
	3-Chloro-L-Tyrosine (Chlorotyrosine) 是一种髓过氧化物酶催化氧化的特异性标志物，在从人动脉粥样硬化内膜分离的低密度脂蛋白中显著升高。
T2S2362	Dehydrocorydaline nitrate 去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱	BCL; Others; PARP; p38 MAPK; Caspase; Parasite; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Others; Proteases/Proteasome
	Dehydrocorydaline nitrate 是生物碱。Dehydrocorydaline 调节 Bax，Bcl-2蛋白表达，激活 caspase-7，caspase-8，并使 PARP 失活。它能增强 p38 MAPK 活化，具有抗炎、抗癌、抗疟疾等功效。
T8053	N-Acetyl-L-arginine N-Α-乙酰-L-精氨酸,Ac-Arg-OH	Endogenous Metabolite	Metabolism
	N-Acetyl-L-arginine (Ac-Arg-OH) 是一种胍基诺化合物，被发现存在于血液渗析性肾不足儿童患者血清中的。
T4877	L-Homocystine	Endogenous Metabolite	Metabolism
	L-Homocystine 是一种 L-homocysteine 的氧化物。其中 L-homocysteine 是抗血栓因子、血管舒张损害剂、促炎因子，也是研究心血管疾病发生机制的内质网应激反应的诱导剂。
T4858	4-Hydroxyphenylpyruvic acid 4-羟苯基丙酮酸,4-Hydroxyphenylpyruvic acid	Endogenous Metabolite	Metabolism
	4-Hydroxyphenylpyruvic acid 是一种苯丙氨酸代谢的中间产物，是一种酶抑制剂。
T4881	Phosphorylethanolamine O-Phosphorylethanolamine,乙醇胺磷酸酯	Others; Endogenous Metabolite	Metabolism; Others
	Phosphorylethanolamine (O-Phosphorylethanolamine) 是磷脂代谢的一种磷酸单酯代谢物。Phosphorylethanolamine 是磷脂合成的前体，也是磷脂分解的产物。与其他器官相比，大脑中磷酸单酯的含量要高得多。在大脑发育过程中，磷单酯通常在神经增生期间升高。这也与大脑发育过程中正常的程序性细胞死亡和突触修剪的发生相吻合。这些发现与磷酸单酯在膜生物合成中的作用是一致的。Phosphorylethanolamine 与抑制性神经递质GABA和GABAB受体部分激动剂 3-氨基丙基膦酸具有很强的结构相似性。Phosphorylethanolamine 是一种磷单酯，在阿尔茨海默病患者的大脑中减少。
T19164	8-Dehydrocholesterol	Others	Others
	8-Dehydrocholesterol is a compound whose elevated concentration is a diagnostic biochemical hallmark of classical Smith-Lemli-Opitz syndrome.
T36472	Tetrahydro-11-deoxy Cortisol
	Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol. Urinary excretion of THS is elevated in patients with 11β-hydroxylase deficiency, a condition resulting from mutations in the cytochrome P450 (CYP) isoform CYP11B1. Urinary levels of THS are also elevated in patients with adrenocortical carcinoma (ACC) and adrenocortical adenoma (ACA) but are higher in patients with ACC compared to ACA.
T82300	Gluconasturtiin
	Gluconasturtiin 作为P. maculipennis幼虫的摄食诱导剂，但其高浓度会对幼虫产生毒害效应。
T2905	5α-Cholestan-3-one 5-Α-胆甾烷-3-酮,Coprostanone,5alpha-Cholestan-3-one	Others; Endogenous Metabolite	Metabolism; Others
	5α-Cholestan-3-one (Coprostanone) 是内源性代谢产物的一种。
TN2257	Tanshinone IIB 丹参酮ⅡB	BCL; Caspase; P-gp	Apoptosis; Membrane transporter/Ion channel; Neuroscience; Proteases/Proteasome
	Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a concentration-dependent manner; TSB also suppresses the elevated Bax protein and decreased bc
T36915	21-Deoxycortisol
	21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal glandvia11-hydroxylation by 11β-hydroxylase.1,2Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations inCYP2A21, the gene encoding steroid 21-hydroxylase, and have been used as a biomarker for the detection of 21-hydroxylase deficiencies. 1.Fiet, J., Villette, J.-M., Galons, H., et al.The application of a new highly-sensitive...
T78490	Polygalacturonic acid Galacturonic acid polymer
	Polygalacturonic acid（Galacturonic acid polymer）为透明胶状物，构成细胞壁关键组分。该酸应用于制备银纳米颗粒（AgNPs），充当抗氧化剂与抗炎剂，防护细胞遭受ROS增高引起的损伤，并促进伤口愈合。Polygalacturonic acid纳米颗粒亦显示抗菌性能。

天然产物

N-Acetyl-L-arginine dihydrate

Cat.No: T5289

Synonym: N-Ac-L-arg-OH,乙酰精氨酸

Target: Others, Endogenous Metabolite

DL -3,4-Dihydroxymandelic acid

Cat.No: T5229

Target: Others

Cat.No: T4734

Synonym: Octanedioic acid,1,8-Octanedioic acid,辛二酸

Target: Others, Endogenous Metabolite

(S)-3-Hydroxybutanoic acid

Cat.No: T13979

Synonym: L-β-Hydroxybutyric acid,(S)-β-Hydroxybutanoic acid,L-(+)-3-Hydroxybutyric acid,(S)-3-羟基丁酸

Target: Endogenous Metabolite

3-Chloro-L-Tyrosine

Cat.No: T5280

Synonym: 3-氯-L-酪氨酸,3-Chlorotyrosine,Chlorotyrosine

Target: Others, Endogenous Metabolite

Dehydrocorydaline nitrate

Cat.No: T2S2362

Synonym: 去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱

Target: BCL, Others, PARP, p38 MAPK, Caspase, Parasite, Autophagy

N-Acetyl-L-arginine

Cat.No: T8053

Synonym: N-Α-乙酰-L-精氨酸,Ac-Arg-OH

Target: Endogenous Metabolite

Cat.No: T4877

Target: Endogenous Metabolite

4-Hydroxyphenylpyruvic acid

Cat.No: T4858

Synonym: 4-羟苯基丙酮酸,4-Hydroxyphenylpyruvic acid

Target: Endogenous Metabolite

Phosphorylethanolamine

Cat.No: T4881

Synonym: O-Phosphorylethanolamine,乙醇胺磷酸酯

Target: Others, Endogenous Metabolite

8-Dehydrocholesterol

Cat.No: T19164

Target: Others

Tetrahydro-11-deoxy Cortisol

Cat.No: T36472

Gluconasturtiin

Cat.No: T82300

5α-Cholestan-3-one

Cat.No: T2905

Synonym: 5-Α-胆甾烷-3-酮,Coprostanone,5alpha-Cholestan-3-one

Target: Others, Endogenous Metabolite

Cat.No: TN2257

Synonym: 丹参酮ⅡB

Target: BCL, Caspase, P-gp

21-Deoxycortisol

Cat.No: T36915

Polygalacturonic acid

Cat.No: T78490

Synonym: Galacturonic acid polymer

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