35
4
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10096L |
Voruciclib
|
CDK | Cell Cycle/Checkpoint |
Voruciclib 是一种具有口服活性和选择性 CDK 抑制剂,Ki 为 0.626 nM-9.1 nM。它在多种弥漫性大 B 细胞淋巴瘤模型中抑制 MCL-1 的表达。它有效阻断 MCL-1 的转录调节子 CDK9。 | |||
T16040 |
Mepazine
甲哌啶嗪,Pecazine |
Apoptosis; MALT | Apoptosis; Immunology/Inflammation |
Mepazine (Pecazine) 是一种有效的特异性 MALT1 抑制剂。 Mepazine 抑制 GSTMALT1 全长和 GSTMALT1 325-760,IC50 为 0.83 μM 和 0.42 μM。 Mepazine 增强细胞凋亡并影响细胞活力。 | |||
T14367 |
AZ1495
|
IRAK; CDK; Haspin Kinase | Cell Cycle/Checkpoint; Immunology/Inflammation; NF-κB |
AZ1495 是一种口服有活性的白介素-1受体相关激酶 4(IRAK4)抑制剂,能够作用于 IRAK4 (IC50:5 nM)和 IRAK1 (IC50:23 nM)。可用于研究突变型 MYD88L265P 弥漫性 B 细胞淋巴瘤 (DLBCL) 。 | |||
T3549 |
Avadomide
CC 122 |
Apoptosis; E1/E2/E3 Enzyme; Ligand for E3 Ligase | Apoptosis; PROTAC; Ubiquitination |
Avadomide (CC 122) 是口服有效的cereblon 调节剂,可以调节 cereblon E3 连接酶活性,诱导弥漫性大 B 细胞淋巴瘤细胞凋亡,具有抗肿瘤和免疫调节活性。 | |||
T1944 |
LDN-214117
|
ALK; TGF-beta/Smad | Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors |
LDN214117 是一种高效的 ALK2 选择性抑制剂(IC50:22nM),也是一种 BMP6 抑制剂(IC50:100nM),对ALK5抑制力弱100倍。 | |||
T5354 |
IRAK4-IN-7
CA-4948 |
IRAK | Immunology/Inflammation; NF-κB |
IRAK4-IN-7 (CA-4948) 是白介素 1 受体相关激酶 4 (IRAK4) 的选择性抑制剂,口服有活性。它可用于研究癌症以及炎症疾病。 | |||
T60008 |
BCL6-IN-6
|
BCL | Apoptosis |
BCL6-IN-6 是 Bcl-6 的抑制剂,可用于关于弥漫性大 B 细胞淋巴瘤的研究。 BCL6-IN-6 阻断 Bcl-6 与其辅阻遏物的相互作用,并以剂量依赖性方式重新激活 Bcl-6 靶基因。 | |||
T77135 |
Tafasitamab
MOR00208,XmAb5574,Tafasitamab-cxix |
Apoptosis; Immunology/Inflammation related | Apoptosis; Immunology/Inflammation |
Tafasitamab (XmAb5574) 是一种 Fc 修饰的人源化单克隆抗体,靶向人 B 细胞表面抗原 CD19 ,可用于研究弥漫性大B细胞淋巴瘤。 | |||
T77367 |
Urelumab
BMS-663513,BMS-66513 |
Others | Others |
Urelumab(BMS-66513) 是一种人源化的 IgG4 单克隆抗体,常被当作 CD137 激动剂使用。Urelumab 具有潜在的抗肿瘤活性,可增强 T 细胞和自然杀伤细胞对肿瘤细胞的杀伤作用,并增强 Rituximab 的细胞毒性。Urelumab 可用于研究弥漫性大B细胞淋巴瘤 (DLBCL)合滤泡性淋巴瘤 (FL) 等实体瘤相关疾病。 | |||
T9969 |
EZM0414
|
Histone Methyltransferase | Chromatin/Epigenetic |
EZM0414 是一种有效、选择性、口服生物利用度高的SETD2抑制剂,在 SETD2 生化分析中,IC50值为18 nM;在细胞分析中,IC50值为34 nM。EZM0414可用于复发或难治性多发性骨髓瘤和弥漫性大 B 细胞淋巴瘤的研究。 | |||
T23409 |
FM4-64
SynaptoRedTM C2 |
Others | Others |
FM4-64 (SynaptoRedTM C2) 是一种苯乙烯类染料,染色效果稳定,但在在水溶液中基本不发荧光。FM4-64与质膜双层结合后不能被动扩散进入细胞内部,必须通过主动运输的方式进行跨膜运输。FM4-64 可用于研究胞吞胞吐和囊泡运输。 | |||
T76776 |
Emactuzumab
RO 5509554,RG 7155 |
c-Fms; TAM Receptor | Tyrosine Kinase/Adaptors |
Emactuzumab(RG 7155) 是一种针对集落刺激因子-1 受体的单克隆抗体,靶向肿瘤相关巨噬细胞 (TAM)。Emactuzumab 具有抗肿瘤活性,可抑制集落刺激因子 1 受体 (CSF1R) 的激活。Emactuzumab 对 CSF-1R 具有高亲和力,Ki 值为 0.2 nM。Emactuzumab 可阻断 CSF-1R 二聚化,可用于研究如弥漫型腱鞘巨细胞瘤(dt-GCT)类的癌症。 | |||
T25400 |
EZH2-IN-3
EZH2 inhibitor 3,EZH2-inhibitor-3 |
||
EZH2-IN-3 is an inhibitor of EZH2 and EZH1 with selective impact on diffuse large B cell lymphoma cell growth. | |||
T10529 |
BF-168
|
Others | Others |
BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42). | |||
T76946 | Zuberitamab | ||
Zuberitamab (HS006)为针对CD20的单克隆抗体,适用于包括弥漫性大B细胞淋巴瘤在内的癌症研究。 | |||
T73093 | Z-VRPR-FMK | ||
Z-VRPR-FMK 是一种不可逆地 MALT1蛋白抑制剂。Z-VRPR-FMK 可通过抑制 MALT1诱导的 NF-κB 活化和 MMP 表达来抑制弥漫性大 B 细胞淋巴瘤的生长和侵袭。 | |||
T77070 | Loncastuximab | ||
Loncastuximab (RB4v1.2),一种针对CD19的单克隆抗体,主要具有抗肿瘤活性,尤其在非霍奇金淋巴瘤(NHL),包括弥漫性大B细胞淋巴瘤(DLBCL)中展现出潜在应用价值。 | |||
T40901 |
Aderbasib
INCB007839,INCB7839 |
||
Aderbasib (INCB007839) is a highly potent and orally active hydroxamate-based inhibitor of ADAM10 and ADAM17, with low nanomolar affinity. This compound demonstrates strong antineoplastic activity and holds potential for cancer research in various areas, such as diffuse large B-cell non-Hodgkin lymphoma, HER2-positive breast cancer, gliomas, and more. | |||
T11674 |
IRAK4-IN-6
|
Others | Others |
IRAK4-IN-6 是一种选择性的、口服有效的IRAK 抑制剂,IC50为 4 nM,靶向 MyD88 L265P 突变型弥漫性大 B 细胞淋巴瘤。 | |||
T81696 |
NBI-961
|
||
NBI-961为高效NEK2抑制剂,能阻断蛋白酶体降解作用。该化合物在弥漫性大B细胞淋巴瘤(DLBCL)细胞中诱导G2/有丝分裂停滞及细胞凋亡(apoptosis)。 | |||
T79485 |
IRAK4-IN-27
|
IRAK | Immunology/Inflammation; NF-κB |
IRAK4-IN-27(Compound 22)为高效选择性IRAK4抑制剂,具IC50值8.7 nM。该化合物能够抑制含MYD88L265P突变的DLBCL细胞系生长并促进其细胞凋亡(apoptosis),适用于弥漫大B细胞淋巴瘤(DLBCL)的研究。 | |||
T62403 | DM-01 | ||
DM-01 是一种强效的、选择性的 EZH2 抑制剂。DM-01 能够用于研究弥漫性大 B 细胞淋巴瘤 (DLBCL),滤泡性淋巴瘤 (FL) 和 SNF5/INI-1/SMARCB1 基因相关实体瘤。 | |||
T80981 |
Tisagenlecleucel
CTL019 |
||
Tisagenlecleucel (CTL019) 是一种自体抗CD19嵌合抗原受体 (CAR) T 细胞治疗,专门针对并消除表达CD19的 B 细胞。该疗法主要用于研究治疗难治性侵袭性弥漫性大 B 细胞淋巴瘤。 | |||
T78877 |
MTX-241F
|
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
MTX-241F是一种选择性小分子抑制剂,针对EGFR和PI3激酶家族。其具备穿透血脑屏障的能力,能够持续控制肿瘤生长。在来源于患者的DIPG神经球中,MTX-241F展示了与放射疗法协同增效的特性,适用于研究弥漫性内源性桥脑胶质瘤(DIPG)。 | |||
T77940 |
Tazemetostat de(methyl morpholine)-COOH
|
Ligands for Target Protein for PROTAC | PROTAC |
Tazemetostat de(methyl morpholine)-COOH(化合物7)是针对EZH2的PROTAC靶向配体,适用于合成EZH2降解剂(PROTACs)。这些降解剂在治疗弥漫性大B细胞淋巴瘤(DLBCL)及其他淋巴瘤亚型中显示出显著的细胞毒性作用。 | |||
T26688 |
Avadomide HCl
Avadomide hydrochloride,CC122, Avadomide HCl,CC-122,CC 122 HCl |
||
Avadomide is an orally available pleiotropic pathway modulator with potential antineoplastic activity. CC-122 mimics an interferon response and has antitumor activity in DLBCL CC-122 binds Cereblon (CRBN) and promotes degradation of Ikaros and Aiolos in d | |||
T76854 | Loncastuximab tesirine | ||
Loncastuximab tesirine 是一种人簇分化 19 (CD19) 靶向的抗体-活性分子偶联物 (ADC)。一旦与细胞膜上的 CD19结合,Loncastuximab tesirine 被迅速内化,引发细胞死亡。Loncastuximab tesirin 诱导细胞凋亡,可用于弥漫型 B 细胞淋巴瘤的研究。 | |||
T73869 | BCL6 PROTAC 1 | ||
BCL6PROTAC1 是一种选择性的 B 细胞淋巴瘤 6 (BCL6)PROTAC。BCL6PROTAC1 抑制 BCL6 细胞报告,IC50值为 8.8 µM。BCL6PROTAC1 在弥漫性大 B 细胞淋巴瘤 (DLBCL) 细胞系中显著降解 BCL6。BCL6PROTAC1 可用于肿瘤相关研究。 | |||
T76393 |
Amyloid 17-42
|
||
Amyloid 17-42 (Aβ(17-42)),作为阿尔茨海默病中弥漫性斑块与唐氏综合症小脑前区的主要淀粉样蛋白成分,源于淀粉样蛋白前体蛋白(APP)经α与γ分泌酶的裂解作用。此外,Amyloid 17-42能通过Fas样/caspase-8途径促使神经细胞发生凋亡。 | |||
T62109 | HDAC-IN-31 | ||
HDAC-IN-31 是一种选择性的、有效的、口服具有活力的 HDAC 抑制剂,能够作用于 HDAC1 (IC50: 84.90 nM)、HDAC2 (IC50: 168.0 nM)、HDAC3 (IC50: 442.7 nM)、HDAC8 (IC50>10000 nM)。 HDAC-IN-31 能够将细胞周期阻滞在 G2/M 期,并诱导细胞凋亡 (apoptosis)。HDAC-IN-31 具有良好的抗肿瘤效果。HDAC-IN-31 对弥漫性大 B 细胞淋巴瘤表现出潜在的研究价值。 | |||
T60488 |
Ganciclovir hydrate
|
||
Ganciclovir (BW 759) hydrate 是一种核苷类似物,是具有口服活性的抗病毒剂,显示出抗巨细胞病毒活性。Ganciclovir hydrate 对疱疹病毒和其他一些 DNA 病毒也具有体外抗病毒活性。Ganciclovir hydrate 在体外抑制人类疱疹病毒 (HSV 1 型和 2 型,CMV) 和腺病毒血清型1、2、4、6、8、10、19、22 和 28 的复制。Ganciclovir hydrate 对猫疱疹病毒 1 型 (FHV-1) 的 IC50为 5.2 μM,可扩散到大脑。 | |||
TP2182 |
Lamin fragment
|
Others | Others |
Lamin fragment has a peptide sequence of Lys-Ala-Gly-Gln-Val-Val-Thr-Ile-Trp. Lamin polypeptides have an almost complete α-helical conformation with multiple α-helical domains separated by non-α-helical linkers that are highly conserved in length and amin | |||
T79801 |
TCIP 1
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
TCIP 1是一款转录/表观遗传CIPs(TCIP)小分子,结构上为能够分别与BCL6和BRD4结合的小分子共价连接而成。该分子通过募集内源性癌症驱动因子或下游转录因子至细胞死亡基因的启动子,促进胞死亡基因的表达。TCIP 1能形成功能性三元复合物,特异性地与BCL6和BRD4作用,从而取消BCL6对凋亡基因的抑制,增强促凋亡基因的转录活性,并触发细胞凋亡。此外,TCIP 1有效降低致癌基因MYC的表达,并抑制弥漫大B细胞淋巴瘤(DLBCL)的增长。 | |||
T37743 |
N-octadecanoyl-L-Homoserine lactone
|
||
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gener... | |||
T37741 |
N-hexadecanoyl-L-Homoserine lactone
C16-HSL,N-palmitoyl-L-Homoserine,N-hexadecanoyl-L-Homoserine lactone |
||
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.[2] Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5598 |
cis-3-Hexenyl hexanoate
|
Others | Others |
cis-3-Hexenyl hexanoate 存在于某些水果中,具有强烈的弥漫果香。 | |||
T19281L |
Dihydroxyacetone phosphate hemimagnesium salt hydrate
Dihydroxyacetone phosphate hemimagnesium salt hydrate(57-04-5 free base) |
Others | Others |
Dihydroxyacetone phosphate hemimagnesium salt hydrate 也称为磷酸二羟基丙酮或 3-羟基-2-氧代丙基磷酸。 Dihydroxyacetone phosphate hemimagnesium salt hydrate 存在于从细菌到人类的所有生物中。在人类体内, Dihydroxyacetone phosphate hemimagnesium salt hydrate参与许多酶促反应。 Dihydroxyacetone phosphate hemimagnesium salt hydrate 已被研究用于治疗淋巴瘤、大细胞淋巴瘤、弥漫性淋巴瘤。 | |||
T20173 |
Noradrenaline tartrate
NSC 169106,NSC-169106,l-Noradrenaline d-bitartrate,NSC169106,Norepinephrine bitartrate |
||
Norepinephrine bitartrate is a precursor of epinephrine. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. | |||
T40634 |
Perilla ketone
|
||
Perilla ketone is a naturally occurring xenobiotic compound that undergoes activation by pulmonary P450 cytochrome enzymes within the lung. This activation leads to the manifestation of severe pulmonary damage and the development of diffuse pulmonary edema. |