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123

抑制剂 & 化合物

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Cat. No. Product Name Target Signaling Pathways
T5210 BAI1

Apoptosis; BCL Apoptosis
BAI1 是一种选择性凋亡因子BAX 变构抑制剂。它结合 BAX 并变构抑制其激活,具有潜力研究 BAX 依赖性细胞死亡介导的疾病。
T2199 Myclobutanil

Systhane,腈菌唑

Antifungal Microbiology/Virology
Myclobutanil (Systhane) 是康唑类抗真菌剂,可用作农药。
T24212 XX-650-23

XX65023,XX 650 23

Apoptosis; Epigenetic Reader Domain Apoptosis; Chromatin/Epigenetic
XX-650-23 是一种小分子 CREB 抑制剂,阻断 CREB 与其所需的共激活因子 CBP(CREB 结合蛋白)之间的关键相互作用,诱导AML细胞凋亡和细胞周期停滞,可用于研究急性髓系白血病 (AML)。
T3940 CID5721353

BCL6 inhibitor

Apoptosis; BCL Apoptosis
CID5721353 (BCL6 inhibitor) 是一种 B 细胞淋巴瘤 6 抑制剂,IC50为 212 μM,Ki 值为 147 μM。它可在体内外破坏 BCL6/辅助阻遏物复合物,并显示与 BTB 沟内的关键位点结合。
T4647 M2I-1

M2I 1

Others Others
M2I-1 是Mad2抑制剂,靶向的 Mad2 与 Cdc20 的结合,该结合是纺锤体装配检查点内必不可少的蛋白-蛋白相互作用。
T6904 Necrosulfonamide

(E)-Necrosulfonamide

MLK MAPK
Necrosulfonamide ((E)-Necrosulfonamide) 是一种坏死性凋亡抑制剂,通过选择性靶向(MLKL),可阻止 MLKL-RIP1-RIP3 坏死小体复合体与其下游效应子相互作用。MLKL 是诱导坏死过程中 RIP3 的重要底物。
T6386 Ampicillin sodium

氨苄西林钠,Domicillin,D-(-)-α-Aminobenzylpenicillin sodium salt,Penialmen,Citteral

Antibacterial; Antibiotic Microbiology/Virology
Ampicillin sodium (Domicillin) 是Ampicillin 的钠盐形式,是Ampicillin 的广谱半合成衍生物。它通过与青霉素结合蛋白结合来抑制细菌细胞壁的合成,从而抑制肽聚糖的合成,肽聚糖是细菌细胞壁的关键成分。
T1433 Ritodrine hydrochloride

DU21220,盐酸利托君,Ritodrine HCl,NSC 291565

Adrenergic Receptor GPCR/G Protein; Neuroscience
Ritodrine hydrochloride (NSC 291565) 是一种 β-2肾上腺素受体激动剂。
T2170 SKF-96365 hydrochloride

1-[2-(4-甲氧基)-2-[3-(4-甲氧基苯基)丙氧基]乙基]咪唑,SKF96365

Apoptosis; Potassium Channel; Calcium Channel; TRP/TRPV Channel; Autophagy Apoptosis; Autophagy; Membrane transporter/Ion channel; Metabolism
SKF-96365 hydrochloride (SKF96365) 是store-operated Ca2+entry 抑制剂,也是TRP channel 阻滞剂。它显著抑制豚鼠离体心脏 hERG、hKCNQ1/hKCNE1、hKir2.1 和 hKv4.3 电流,延长QTc 间期。它通过诱导结直肠癌细胞的细胞周期阻滞和凋亡起抗肿瘤作用。
T9574 PF-07304814

Lufotrelvir,卢夫特韦

Lufotrelvir (PF-07304814) 是 PF-00835231 的磷酸盐前药,是一种有效的3CLpro 蛋白酶 (Mpro) 抑制剂,具有 抗SARS-CoV-2 病毒活性。Lufotrelvir 结合并抑制 SARS-CoV-2 3CLpro 活性,Ki 为 174nM。Lufotrelvir 是一种很有前途的单一抗病毒试剂,也可用于与针对冠状病毒生命周期其他关键阶段的其他抗病毒试剂的联合研究。
T4013 SGC2085 HCl

Histone Methyltransferase Chromatin/Epigenetic
SGC2085 HCl 是一种有效的选择性辅激活剂相关的精氨酸甲基转移酶 1 (CARM1) 抑制剂,IC50 为 50 nM,选择性比其他 PRMT 高出数倍。 CARM1 是结直肠癌中 Wnt/β-catenin 转录和肿瘤转化的重要正调节因子,也是雌激素刺激的乳腺癌生长的关键因素,其耗竭导致体内髓性白血病细胞增殖减少。
T14134 Afabicin

AFN-1720,Debio 1450

Antibacterial Microbiology/Virology
Afabicin is the prodrug of Debio1452. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci.
T28808 SLUPP-417

SLUPP417

SLUPP-417 is an efflux pump inhibitor (EPI) by interacting with the membrane fusion protein AcrA, a critical component of the AcrAB-TolC efflux pump in Escherichia coli.
T34458 Ryanodol

Ryanodol is a complex diterpenoid that modulates intracellular calcium-ion release at ryanodine receptors, ion channels critical for skeletal and cardiac muscle excitation-contraction coupling and synaptic transmission.
T10046 16,16-Dimethyl prostaglandin E2

16,16-dimethyl PGE2

Prostaglandin Receptor GPCR/G Protein; Immunology/Inflammation
16,16-Dimethyl prostaglandin E2 is an orally active vertebrate Hematopoietic stem cells homeostasis critical regulator. It can act through EP2/EP4 and has an interaction with the Wnt pathway.
T68291 APSR-IN-8

APSR-IN-8 is a first-in-class inhibitor of APS reductase (APSR), which is a critical enzyme in the assimilation of sulfate for the biosynthesis of cysteine and other essential sulfur-containing molecules.
T38614 TLR7 agonist 3

TLR7 agonist 3 (Compound 2), a potent activator of toll-like receptor 7 (TLR7), plays a critical role in initiating immune responses, positioning it as a promising target for immunomodulator development.
T75410 Ganglioside sialidase (AuSialidase S)

Ganglioside sialidase (AuSialidase S)为一种内源性代谢物,与神经元分化过程有关,涉及神经突生长。
T40781 Geranylgeranyl pyrophosphate

Geranylgeranyl pyrophosphate, a key metabolite in protein geranylgeranylation, serves as the universal precursor for diterpenoids, such as Paclitaxel. Its role in cancer research stems from this critical function.
T28807 SLUPP-225

SLUPP 225

SLUPP-225 is an efflux pump inhibitor (EPI) by interacting with the membrane fusion protein AcrA, a critical component of the AcrAB-TolC efflux pump in Escherichia coli.
T73107 RAD51-IN-4

RAD51-IN-4 是一种有效的RAD51抑制剂。RAD51是一种真核生物基因。RAD51-IN-4 具有研究线粒体缺陷病症的潜力。
T80055 Beta-glucuronidase (bovine liver)

Beta-glucuronidase是一种关键溶酶体酶,主要功能是参与糖胺聚糖中含有葡萄糖醛酸成分的降解过程。
T27068 CPI098

CPI-098,CPI 098

CPI098 is a potent and selective inhibitors for the bromodomains of CREBBP/EP300. CREBBP/EP300 bromodomains play a critical role in regulatory T cell biology. T cell recruitment to tumors is a major mechanism of immune evasion by cancer cells.
T18618 Bis-NH2-C1-PEG3

PROTAC Linker 24

Others Others
Bis-NH2-C1-PEG3 (PROTAC Linker 24) is a polyethylene glycol (PEG)-based linker compound utilized in the synthesis of PROTACs. This compound serves as a critical component in constructing PROTAC molecules, facilitating the targeted degradation of specific proteins[1].
T7459 Abametapir

5 5'-二甲基-2,2-联吡啶,HA-44,BRN 0123183

MMP; Others; Parasite Microbiology/Virology; Others; Proteases/Proteasome
Abametapir (BRN 0123183) 是一种金属蛋白酶抑制剂,能够靶向对卵孵化和虱子发育至关重要的金属蛋白酶。
T16592 Propargyl-PEG1-SS-PEG1-propargyl

Others Others
Propargyl-PEG1-SS-PEG1-propargyl refers to a cleavable di-functional polyethylene glycol (PEG) linker composed of two units. This specific linker is employed in the synthesis of antibody-drug conjugates (ADCs), where it plays a critical role in linking the antibody to the drug. [1]
T18630 Tos-PEG3-NH-Boc

PROTAC Linker 9

Others Others
Tos-PEG3-NH-Boc (PROTAC Linker 9) is a PEG-based linker utilized for the synthesis of PROTACs. It plays a critical role in facilitating the connection between a target protein and an E3 ubiquitin ligase, ultimately leading to the degradation of the target protein.
T74122 Deoxythymidine-5'-triphosphate sodium hydrate

Deoxythymidine-5'-triphosphate (dTTP) sodium hydrate 是四种核苷三磷酸之一,可以合成 DNA。
T68755 NZ-28

NZ28, also known as NSC134754, is potent HSF1 inhibitor, which induced inhibition of HSF1, SP1 and NF-κB triggers the loss of the natural killer cell-activating ligands MICA/B on human tumor cells. Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis.
T69830 GSK2239633

GSK2239633 is a potent CC-chemokine receptor 4 antagonist with pIC50 of 7.9. The CC-chemokine receptor 4 (CCR4) is thought potentially to play a critical role in asthma pathogenesis due to its ability to recruit type 2 T-helper lymphocytes to the inflamed airways. Therefore, CCR4 provides an excellent target for anti-inflammatory therapy.
TD0053 Fluo-3, pentapotassium salt

Calcium measurement is critical for numerous biological investigations. Fluorescent probes that show spectral responses upon binding calcium have enabled researchers to investigate changes in intracellular free calcium concentrations by using fluorescence microscopy, flow cytometry, fluorescence spectroscopy and fluorescence microplate readers. Fluo-3, pentapotassium salt is most commonly used among the visible light-excitable calcium indicators.
T18268 Mal-PEG1-Val-Cit-PABC-OH

Others Others
Mal-PEG1-Val-Cit-PABC-OH is a 1 unit polyethylene glycol (PEG) ADC linker that possesses cleavable properties. This linker, commonly utilized in the synthesis of antibody-drug conjugates (ADCs), serves as a critical component facilitating the conjugation of drugs to antibodies[1].
T40456 8-Bromoadenosine 5'-triphosphate tetrasodium

8-Br-ATP tetrasodium,8-Bromoadenosine 5'-triphosphate tetrasodium

8-Bromoadenosine 5'-triphosphate tetrasodium (8-Br-ATP tetrasodium) is a tetrasodium ATP analogue, serving as a vital element for energy storage and metabolic processes in living organisms. ATP, a central component in vivo, plays a critical role in these functions.
T82589 Delpacibart

Delpacibart为针对TFRC的人源化小鼠IgG1κ抗体,TFRC作为关键膜蛋白负责调控细胞铁元素转运。
T25749 L-NIL dihydrochloride

L-NIL HCl,N-Iminoethyl-L-lysine dihydrochloride

L-NIL HCl is a relatively selective iNOS inhibitor (IC50s: 0.4-3.3, 8-38, and 17-92 µM for iNOS, eNOS, and nNOS). L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response
TD0052 Fluo-3, pentasodium salt

Calcium measurement is critical for numerous biological investigations. Fluorescent probes that show spectral responses upon binding calcium have enabled researchers to investigate changes in intracellular free calcium concentrations by using fluorescence microscopy, flow cytometry, fluorescence spectroscopy and fluorescence microplate readers. Fluo-3, pentasodium salt is most commonly used among the visible light-excitable calcium indicators.
TD0054 Fluo-3, pentaammonium salt

Calcium measurement is critical for numerous biological investigations. Fluorescent probes that show spectral responses upon binding calcium have enabled researchers to investigate changes in intracellular free calcium concentrations by using fluorescence microscopy, flow cytometry, fluorescence spectroscopy and fluorescence microplate readers. Fluo-3, pentaammonium salt is most commonly used among the visible light-excitable calcium indicators.
T60363 Nitrefazole

Nitrefazole 是一种4-nitroimidazole 衍生物,对醛脱氢酶(ALDH)具有强烈而持久的抑制作用,醛脱氢酶是一种参与酒精代谢的酶。
T81578 p60c-src substrate II, phosphorylated

p60c-src substrate II, phosphorylated 是磷酸化的五肽,为 p60c-src substrate II 的磷酸化形式。其代表了蛋白质翻译后修饰的一种,对生物调控具有重要作用。
T78356 Fructosyl amino acid oxidase

Fructosyl amino acid oxidase是测量糖化蛋白的重要试剂,特别是用于评估糖尿病指标糖化血红蛋白A1c。
T74435 Alicaforsen sodium

Alicaforsen sodium为20个碱基长度的反义寡核苷酸,主要通过抑制ICAM-1的产生发挥作用,ICAM-1作为关键粘附分子,参与白细胞向炎症部位的迁移和转运。
T80397 Darobactin

Antibiotic Microbiology/Virology
Darobactin为一种有效的抗生素,其针对多种重要革兰氏阴性病原体展现出显著的抑制作用,无论是在体外实验还是动物感染模型中均有证实。
T37715 Galactosylcerebrosides (bovine)

Galactosylcerebrosides (SGal-CB) 在髓鞘形成的早期阶段可由周围神经系统 (PNS) 中的 Schwann 细胞 (SC) 表达,在鞘中的持续存在对于长期维持其结构完整性至关重要。
T82123 ICMT-IN-21

ICMT-IN-21(化合物6ag)是一种具有8.8 μM IC50值的ICMT抑制剂,属于磺胺修饰法尼基半胱氨酸(SMFC)。该化合物以其特有的法尼基和羧酸基序列对ICMT活性起抑制作用。
T74318 18:0 EPC chloride

18:0 EPC chloride为合成阳离子磷脂,(在临界协同浓度2.34-2.93 μM)可显著增强丁香酚对大肠杆菌的灭活效能。
T36365 KAPA (hydrochloride)

KAPA (hydrochloride),7-keto-8-Aminopelargomic Acid

Biotin is a growth factor that plays an important role in numerous reactions that are critical to microorganisms, plants, and animals. Biotin has a strong affinity for the protein avidin, a trait that has been utilized for many assay reporter applications. KAPA is a key intermediate in the biotin biosynthetic pathway.[1]
T75971 γ-1-Melanocyte Stimulating Hormone (MSH), amide

γ-1-Melanocyte Stimulating Hormone (MSH), amide为含11个氨基酸的多肽,主要通过激活黑皮质素受体3 (MC3-R) 调节钠 (Na+) 平衡及血压。
T80189 Hainantoxin-IV

HNTX-IV

Sodium Channel Membrane transporter/Ion channel
Hainantoxin-IV是针对河豚毒素敏感(TTX-S)电压门控钠通道的特异性拮抗剂。该化合物以His28和Lys32为主要残基与靶标结合,并采用了抑制剂胱氨酸结基序。
T82403 Fibronectin Type III Connecting Segment Fragment 1-25

Fibronectin Type III Connecting Segment Fragment 1-25,一种多肽,主要作用于黑色素瘤细胞的粘附,并在鸡的周围神经系统发育中扮演关键角色。
T61554 CSF1R-IN-13

CSF1R-IN-13 is a powerful CSF1R inhibitor with potential applications in researching cancer diseases [1]. CSF1R, also known as colony stimulating factor 1 receptor, is a critical growth factor that regulates various cell types, including bone marrow progenitor cells, monocytes, macrophages, and giants [1]. CSF1R-IN-13 shows promise in furthering our understanding of cancer-related disorders (WO2019134661A1, compound 32) [1].

化合物

BAI1
Cat.No: T5210
Synonym:
Target: Apoptosis, BCL
Myclobutanil
Cat.No: T2199
Synonym: Systhane,腈菌唑
Target: Antifungal
XX-650-23
Cat.No: T24212
Synonym: XX65023,XX 650 23
Target: Apoptosis, Epigenetic Reader Domain
CID5721353
Cat.No: T3940
Synonym: BCL6 inhibitor
Target: Apoptosis, BCL
M2I-1
Cat.No: T4647
Synonym: M2I 1
Target: Others
Necrosulfonamide
Cat.No: T6904
Synonym: (E)-Necrosulfonamide
Target: MLK
Ampicillin sodium
Cat.No: T6386
Synonym: 氨苄西林钠,Domicillin,D-(-)-α-Aminobenzylpenicillin sodium salt,Penialmen,Citteral
Target: Antibacterial, Antibiotic
Ritodrine hydrochloride
Cat.No: T1433
Synonym: DU21220,盐酸利托君,Ritodrine HCl,NSC 291565
Target: Adrenergic Receptor
SKF-96365 hydrochloride
Cat.No: T2170
Synonym: 1-[2-(4-甲氧基)-2-[3-(4-甲氧基苯基)丙氧基]乙基]咪唑,SKF96365
Target: Apoptosis, Potassium Channel, Calcium Channel, TRP/TRPV Channel, Autophagy
PF-07304814
Cat.No: T9574
Synonym: Lufotrelvir,卢夫特韦
Target:
SGC2085 HCl
Cat.No: T4013
Synonym:
Target: Histone Methyltransferase
Afabicin
Cat.No: T14134
Synonym: AFN-1720,Debio 1450
Target: Antibacterial
SLUPP-417
Cat.No: T28808
Synonym: SLUPP417
Target:
Ryanodol
Cat.No: T34458
Synonym:
Target:
16,16-Dimethyl prostaglandin E2
Cat.No: T10046
Synonym: 16,16-dimethyl PGE2
Target: Prostaglandin Receptor
APSR-IN-8
Cat.No: T68291
Synonym:
Target:
TLR7 agonist 3
Cat.No: T38614
Synonym:
Target:
Ganglioside sialidase (AuSialidase S)
Cat.No: T75410
Synonym:
Target:
Geranylgeranyl pyrophosphate
Cat.No: T40781
Synonym:
Target:
SLUPP-225
Cat.No: T28807
Synonym: SLUPP 225
Target:
RAD51-IN-4
Cat.No: T73107
Synonym:
Target:
Beta-glucuronidase (bovine liver)
Cat.No: T80055
Synonym:
Target:
CPI098
Cat.No: T27068
Synonym: CPI-098,CPI 098
Target:
Bis-NH2-C1-PEG3
Cat.No: T18618
Synonym: PROTAC Linker 24
Target: Others
Abametapir
Cat.No: T7459
Synonym: 5 5'-二甲基-2,2-联吡啶,HA-44,BRN 0123183
Target: MMP, Others, Parasite
Propargyl-PEG1-SS-PEG1-propargyl
Cat.No: T16592
Synonym:
Target: Others
Tos-PEG3-NH-Boc
Cat.No: T18630
Synonym: PROTAC Linker 9
Target: Others
Deoxythymidine-5'-triphosphate sodium hydrate
Cat.No: T74122
Synonym:
Target:
NZ-28
Cat.No: T68755
Synonym:
Target:
GSK2239633
Cat.No: T69830
Synonym:
Target:
Fluo-3, pentapotassium salt
Cat.No: TD0053
Synonym:
Target:
Mal-PEG1-Val-Cit-PABC-OH
Cat.No: T18268
Synonym:
Target: Others
8-Bromoadenosine 5'-triphosphate tetrasodium
Cat.No: T40456
Synonym: 8-Br-ATP tetrasodium,8-Bromoadenosine 5'-triphosphate tetrasodium
Target:
Delpacibart
Cat.No: T82589
Synonym:
Target:
L-NIL dihydrochloride
Cat.No: T25749
Synonym: L-NIL HCl,N-Iminoethyl-L-lysine dihydrochloride
Target:
Fluo-3, pentasodium salt
Cat.No: TD0052
Synonym:
Target:
Fluo-3, pentaammonium salt
Cat.No: TD0054
Synonym:
Target:
Nitrefazole
Cat.No: T60363
Synonym:
Target:
p60c-src substrate II, phosphorylated
Cat.No: T81578
Synonym:
Target:
Fructosyl amino acid oxidase
Cat.No: T78356
Synonym:
Target:
Alicaforsen sodium
Cat.No: T74435
Synonym:
Target:
Darobactin
Cat.No: T80397
Synonym:
Target: Antibiotic
Galactosylcerebrosides (bovine)
Cat.No: T37715
Synonym:
Target:
ICMT-IN-21
Cat.No: T82123
Synonym:
Target:
18:0 EPC chloride
Cat.No: T74318
Synonym:
Target:
KAPA (hydrochloride)
Cat.No: T36365
Synonym: KAPA (hydrochloride),7-keto-8-Aminopelargomic Acid
Target:
γ-1-Melanocyte Stimulating Hormone (MSH), amide
Cat.No: T75971
Synonym:
Target:
Hainantoxin-IV
Cat.No: T80189
Synonym: HNTX-IV
Target: Sodium Channel
Fibronectin Type III Connecting Segment Fragment 1-25
Cat.No: T82403
Synonym:
Target:
CSF1R-IN-13
Cat.No: T61554
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T4912 Jatrorrhizine chloride

盐酸药根碱,Yatrorhizine chloride,Neprotine chloride

Others; 5-HT Receptor; OCT; Antibacterial; AChE GPCR/G Protein; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Others
Jatrorrhizine chloride (Neprotine chloride) 是从黄连中分离得到的生物碱,具有神经保护、抗菌、抗氧化和抗疟原虫活性。它通过抑制摄取2转运蛋白的活性减少血清素和去甲肾上腺素的摄取。它是具有口服活性的乙酰胆碱酯酶抑制剂。
T3909 Pulsatilla saponin D

白头翁皂苷D,Hederacolchiside A,SB365

Apoptosis; Others Apoptosis; Others
Pulsatilla saponin D (Hederacolchiside A) 是从朝鲜白头翁根部分离得到的一种天然产物,具有抗癌活性。
T5S0527 Rhodojaponin III

闹羊花素 Ⅲ,闹羊花毒素III

Others Others
Rhodojaponin III 是二萜类化合物,提取于Rhododendron molle 叶子,具有抗炎作用。
T19316 Ethyl oleate

Others Others
Ethyl oleate 是由油酸和乙醇的缩合形成的脂肪酸酯。它是纳米结构脂质载体 (NLC) 中的液体脂质成分。其中 NLC 是一种口服有活性的反式阿魏酸的给药载体。
T36585 Isodeoxycholic Acid

isoDCA

Chloride channel; Antibacterial Membrane transporter/Ion channel; Microbiology/Virology
Isodeoxycholic Acid 是一种胆汁酸,由肠道细菌通过脱氧胆酸的表聚作用形成。Isodeoxycholic acid 的临界胶束浓度高于二氯苯甲醚,这表明它的去污活性降低了,而且在抑制七种肠道共生细菌生长方面的活性低于二氯苯甲醚。Isodeoxycholic Acid(0.1%)能抑制几种艰难梭菌菌株在牛磺胆酸诱导下的孢子萌发,并能降低艰难梭菌培养上清对 Vero 细胞的细胞毒性。在高脂饮食诱发肥胖的大鼠模型中,血浆中的Isodeoxycholic acid 水平比正常饮食的大鼠低。
T3S0027 Picropodophyllotoxin

AXL 1717,Picropodophyllin,苦鬼臼毒素

IGF-1R Tyrosine Kinase/Adaptors
Picropodophyllotoxin (AXL 1717) 是一种环木脂素生物碱,存在于五月树(Podophyllum peltatum) 中,是一种具有潜在抗肿瘤活性的胰岛素样生长因子 1 受体 (IGF1R) 的小分子抑制剂。它特异性抑制 IGF1R 的活性并下调细胞表达,而不干扰其他生长因子受体的活性,例如胰岛素受体、表皮生长因子、血小板衍生生长因子、成纤维细胞生长因子和肥大/干细胞生长因子 (KIT) )。该药剂在抑制肿瘤细胞增殖和诱导肿瘤细胞凋亡方面显示出有效的活性。 IGF1R 是一种在多种人类癌症中过度表达的受体酪氨酸激酶,在多种癌细胞的生长和存活中起关键作用。
T3794 Pentagalloylglucose

Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖

Influenza Virus Microbiology/Virology
1,2,3,4,6-O-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) 存在于多种植物中,具有重要的药理作用。Pentagalloylglucose 表现出显著的抗狂犬病病毒 (RABV) 活性。
T82636 Cyclosporin U

Cyclosporin U (SMP0V32C6L)为一种细胞免疫抑制剂,关键用于防止移植器官的排斥反应。
TN2655 17alpha-Neriifolin

Others Others
17alpha-Neriifolin and 17alpha-Deacetyltanghinin have little anti-proliferative activity, indicating that the 17beta configuration is critical for the anti-proliferative activity of these compounds.
T80020 UDP-3-O-acyl-GlcNAc diammonium

UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine diammonium

Endogenous Metabolite Metabolism
UDP-3-O-acyl-GlcNAc diammonium 是一种E. coli代谢产物,涉及3-deoxy-D-manno-octulosonate (KDO) 生物合成途径。
T74191 Tanshinol borneol ester

Tanshinol borneol ester 是一种血管生成刺激剂,通过 Akt 和 MAPK 信号通路促进血管生成的多个关键步骤。Tanshinol borneol ester 具有抗缺血和抗动脉粥样硬化作用。
T73812 Phosphatidylinositol 4,5-bisphosphate

Phosphatidylinositol 4,5-bisphosphate(L-alpha-Phosphatidylinositol-4,5-bisphosphate)为细胞膜磷脂成分,主要作为磷脂酶C(PLC)与磷酸肌醇3-激酶(PI3K)的底物,充当重要信使。
T73073 PTP1B-IN-21

PTP1B-IN-21 是蛋白酪氨酸磷酸酶 1B (PTP1B) 的选择性抑制剂 (IC50=1.56 μM),抑制力超出高度同源 T 细胞蛋白酪氨酸磷酸酶 (TCPTP;IC50>100 μM),PTP1B 是抑制 2 型糖尿病的重要靶点。
T4448 NADP

NADP,也称为烟酰胺腺嘌呤二核苷酸磷酸,是各种代谢过程中电子转移所必需的重要氧化还原辅因子。 它在促进细胞能量产生和维持细胞内氧化还原平衡方面发挥着关键作用。

天然产物

Jatrorrhizine chloride
Cat.No: T4912
Synonym: 盐酸药根碱,Yatrorhizine chloride,Neprotine chloride
Target: Others, 5-HT Receptor, OCT, Antibacterial, AChE
Pulsatilla saponin D
Cat.No: T3909
Synonym: 白头翁皂苷D,Hederacolchiside A,SB365
Target: Apoptosis, Others
Rhodojaponin III
Cat.No: T5S0527
Synonym: 闹羊花素 Ⅲ,闹羊花毒素III
Target: Others
Ethyl oleate
Cat.No: T19316
Synonym:
Target: Others
Isodeoxycholic Acid
Cat.No: T36585
Synonym: isoDCA
Target: Chloride channel, Antibacterial
Picropodophyllotoxin
Cat.No: T3S0027
Synonym: AXL 1717,Picropodophyllin,苦鬼臼毒素
Target: IGF-1R
Pentagalloylglucose
Cat.No: T3794
Synonym: Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖
Target: Influenza Virus
Cyclosporin U
Cat.No: T82636
Synonym:
Target:
17alpha-Neriifolin
Cat.No: TN2655
Synonym:
Target: Others
UDP-3-O-acyl-GlcNAc diammonium
Cat.No: T80020
Synonym: UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine diammonium
Target: Endogenous Metabolite
Tanshinol borneol ester
Cat.No: T74191
Synonym:
Target:
Phosphatidylinositol 4,5-bisphosphate
Cat.No: T73812
Synonym:
Target:
PTP1B-IN-21
Cat.No: T73073
Synonym:
Target:
NADP
Cat.No: T4448
Synonym:
Target:
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