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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

81

抑制剂 & 化合物

14

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T21593	AAL-993	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	AAL-993 是口服有效的VEGFR 选择性抑制剂，抑制 VEGFR1、VEGFR2 和 VEGFR3 的IC50分别为 130 nM、23 nM 和 18 nM，对其他酪氨酸激酶的抑制作用较弱。AAL-993 具有抗血管生成和抗肿瘤的活性。
T60025	Eciruciclib	CDK	Cell Cycle/Checkpoint
	Eciruciclib 是一种具有抗肿瘤特性的 CDK 抑制剂。
T0704	Cyanoacetohydrazide Cyanoacetic hydrazide,2-Cyanoacetohydrazide,氰乙酰肼	GSK-3; Antibacterial	Microbiology/Virology; PI3K/Akt/mTOR signaling; Stem Cells
	Cyanoacetohydrazide (Cyanoacetic hydrazide) 是抗结核药物。
T67877	2-(2-fluoro-6-methoxyphenyl)pyrimidine-4-carboxylic acid	Others	Others
	2-(2-fluoro-6-methoxyphenyl)pyrimidine-4-carboxylic acid 常用来合成具有抗癌抗肿瘤作用的化合物。
T67762	2-Oxo-6-phenyl-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid	Others	Others
	2-Oxo-6-phenyl-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid 属于嘧啶家族，已被证明具有抗炎、抗惊厥和抗肿瘤的特性。
T7538	Tetraethylammonium chloride	Potassium Channel	Membrane transporter/Ion channel
	Tetraethylammonium chloride 是非选择性钾通道阻滞剂。它是有机阳离子转运蛋白的良好底物，并具有抗肿瘤特性。
T73593	PDS-0330	Others	Others
	PDS-0330是一种 claudin-1小分子抑制剂抑制。PDS-0330抑制 claudin-1依赖性 CRC 进展，以微摩尔亲和力直接和特异性地与claudin-1结合。PDS-0330通过抑制与转移性癌基因Src 的关联，表现出具有良好药代动力学特性的抗肿瘤和化学增敏活性。PDS-0330干扰claudin-1 / Src 关联以抑制CRC 进展和转移。
T27883	LY 181984 LY181984,LY-181984,MPCU
	LY 181984 is an sulfonylurea with antitumor properties.
T26587	Alazopeptin AA223 Lederle,AA-223 Lederle,AA 223 Lederle
	Alazopeptin is an antitumor antibiotic. It has trypanocidal properties.
T28185	Nogalamycin Nogalamycinum,U 15167,Nogalamyicn,U-15167,Nogalamycine,Nogalomycin
	Nogalamycin is an anthracycline antibiotic with antitumor properties produced by soil bacteria Streptomyces nogalater.
TQ0142	10-Oxo Docetaxel Docetaxel Impurity 1,10-氧多西他赛	Others	Others
	10-Oxo Docetaxel is a Docetaxel intermediate having remarkable antitumor properties.
T24572	OSI-7904L free acid OSI 7904,OSI-7904L,OSI7904,OSI 7904L,OSI7904L,OSI-7904
	OSI-7904L is a folate-based thymidylate synthase inhibitor. It also has antimalarial and antitumor properties.
T38522	Aminohexylgeldanamycin hydrochloride AHGDM hydrochloride,Aminohexylgeldanamycin hydrochloride
	Aminohexylgeldanamycin (AHGDM) hydrochloride is a Geldanamycin derivative and a powerful inhibitor of HSP90. It exhibits significant antiangiogenic and antitumor properties.
T72571	Antitumor agent-84
	Antitumor agent-84 是一种G-quadruplex(G4) 配体，具有稳定不同 G4-DNA 结构的能力。Antitumor agent-84 具有高效的抗肿瘤特性。
T83004	Antitumor agent-39
	Antitumor agent-39 是抗肿瘤肽类化合物。
T61346	Ph-Ph+
	Ph-Ph+ is a hemiprotonic compound derived from the dimerization of phenanthroline (ph). It exhibits remarkable antitumor, antibacterial, and antifungal properties [1].
T72572	Antitumor agent-85
	Antitumor agent-85 是一种 G-quadruplex(G4) 配体，具有稳定不同 G4-DNA 结构的能力。Antitumor agent-85 具有高效的抗肿瘤特性。
T37377	Aminohexylgeldanamycin
	Aminohexylgeldanamycin (AHGDM), a derivative of Geldanamycin, is a highly effective inhibitor of HSP90. It exhibits considerable antiangiogenic and antitumor properties[1].
T40713	Dihydro-5-azacytidine DHAC,NSC264880,Dihydro-5-azacytidine
	Dihydro-5-azacytidine (DHAC) is a nucleoside analog that interrupts DNA methylation by integrating into DNA. It also exhibits notable antitumor properties.
T61803	p38 MAPK-IN-3
	p38 MAPK-IN-3 (Compound 2c) is a potent inhibitor of p38α MAPK, displaying antitumor properties by promoting apoptosis and increasing reactive oxygen species (ROS) production [1].
T61561	VEGFR-2-IN-18
	VEGFR-2-IN-18 (Compound 15d) is a high-potency inhibitor of VEGFR-2, with an IC 50 value of 60 nM. This compound effectively initiates cell apoptosis and demonstrates significant antitumor properties [1].
T61248	HDAC-IN-32
	HDAC-IN-32 is a highly effective HDAC inhibitor presenting IC50 values of 5.2, 11, and 28 nM for HDAC1, HDAC2, and HDAC6, respectively. This compound demonstrates notable anti-proliferative properties against tumor cells, as well as significant in vivo antitumor efficacy, which can elicit antitumor immunity [1].
T83611	(-)-15-Deoxyspergualin trihydrochloride
	(-)-15-Deoxyspergualin trihydrochloride，一种抗肿瘤剂，对小鼠白血病L-1210显示出显著抑制效果。
T74327	Antitumor agent-41
	Antitumor agent-41 (compound N-12)，一种具有卓越抗迁移及抗侵袭能力的抗肿瘤剂。通过坏死和炎症通路实现其抗肿瘤作用。
T11333	Fulvene-5	Others	Others
	Fulvene-5 is a chemical compound that exhibits antitumor activity. It functions as a potent inhibitor of NADPH oxidase 4 (NOX4) and possesses antioxidant properties. Additionally, Fulvene-5 acts as a reactive oxygen species (ROS) modifying agent and a powerful radioprotector.
T61542	VEGFR-2-IN-17
	VEGFR-2-IN-17 (Compound 15a) is a highly potent inhibitor of Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2), with an IC50 value of 67.25 nM. This compound exhibits significant antitumor properties [1].
T73606	Bleomycin B4
	Bleomycin B4 (Phleomycin F)，一种具有抗肿瘤活性的抗生素，常用于癌症研究。
T18326	MC-Val-Cit-PAB-MMAF	Others	Others
	MC-Val-Cit-PAB-MMAF is an antibody-drug conjugate (ADC) component that exhibits antitumor properties through the action of the tubulin inhibitor, monomethyl auristatin F (MMAF), which is connected by a cathepsin-cleavable linker, MC-Val-Cit-PAB.
T61412	Anticancer agent 47
	Anticancer agent 47 (compound 4j) exhibits potent anticancer properties, demonstrating antiproliferative activities and inducing apoptosis as well as cell cycle arrest at G0/G1 phase. Moreover, Anticancer agent 47 has exhibited significant in vivo antitumor activities [1].
T74146	Ecubectedin
	Ecubectedin (PM14), 作为一种海鞘素衍生物，属于四氢异喹啉类生物碱，展现出广泛的抗肿瘤及抗菌活性。
T18322	MC-Val-Cit-PAB-clindamycin	Others	Others
	MC-Val-Cit-PAB-clindamycin is an antibody-drug conjugate (ADC) linker that combines the potent antitumor properties of clindamycin, a protein synthesis inhibitor, with the ADC linker MC-Val-Cit-PAB, to enhance its ability to target and kill cancer cells effectively.
T25000	Acetylaleuritolic acid NSC 266221,NSC-266221,NSC266221
	Acetylaleuritolic acid 是一种从小花加西亚叶中分离得到的一种五环三萜类化合物，植物代谢产物。它具有抗肿瘤特性，对P-388淋巴细胞白血病测试中显示出肿瘤抑制活性。
T78312	Cifurtilimab SEA-CD40
	Cifurtilimab（SEA-CD40）是一种具有抗癌活性的人源化抗CD40 IgG1单克隆抗体。
T74411	PROTAC IRAK4 degrader-7
	PROTACIRAK4 degrader-7 (Compound I-417) 是一种具有口服活性的 PROTACIRAK4降解剂，具有抗肿瘤效果。
T75990	Cyclo(Arg-Gly-Asp-D-Phe-Val)
	Cyclo(Arg-Gly-Asp-D-Phe-Val) 为一种整合素αvβ3抑制剂，具有抗肿瘤活性，并可用于急性髓系白血病的研究。
T79582	Antitumor agent-116	MELK	PI3K/Akt/mTOR signaling
	Antitumor agent-116 (compound 6C) 是一种显示出对MELK受体具有结合亲和力的抗肿瘤剂，它具有抗增殖活性并能诱导细胞凋亡(apoptosis)。
T61099	Mycophenolic acid sodium
	Mycophenolic acid sodium is a potent uncompetitive inhibitor of inosine monophosphate dehydrogenase (IMPDH), exhibiting an EC50 of 0.24 μM. It has broad antiviral activity against RNA viruses, including influenza. Additionally, mycophenolic acid sodium possesses immunosuppressive properties and exerts antiangiogenic and antitumor effects [1][2].
T82997	Antitumor photosensitizer-2
	Antitumor photosensitizer-2（Compound 11）是一款高效光敏剂，表现出显著的光动力学抗肿瘤活性，并且不具有明显的皮肤光毒性，是光动力学治疗领域新药开发的候选物。
T9665	Esuberaprost Sodium
	Famitinib (SHR1020) is a potent orally active multi-targeted kinase inhibitor that effectively inhibits the activity of c-kit, VEGFR-2, and PDGFRβ with IC50 values of 2.3 nM, 4.7 nM, and 6.6 nM, respectively [1]. It demonstrates remarkable antitumor properties in human gastric cancer cells and xenografts, inducing apoptosis [2].
T72765	EphA2 agonist 2
	EphA2agonist 2 (Lead compound) 为一种选择性EphA2激动剂，展现出抗肿瘤活性，并能透过血脑屏障。
T36647	Trastuzumab emtansine	Others	Others
	Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that combines the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of DM1, a microtubule-inhibitory derivative of maytansine. This compound is utilized in the investigation of advanced breast cancer[1][2].
T71752	Metoprolol fumarate Lopressor OROS,CGP 2175C,CGP 2175C ; Lopressor OROS
	Metoprolol fumarate (CGP 2175C)，为一种具口服活性、选择性β1-肾上腺素受体 (β1-adrenoceptor) 拮抗剂，展现抗炎、抗肿瘤及抗血管生成特性。
T82998	Antitumor photosensitizer-1
	Antitumor photosensitizer-1（Compound 8）是一种高效的光敏化合物，展现出显著的光动力治疗肿瘤能力，且没有显著的皮肤光毒性反应，是一个潜在的光动力疗法新候选药物。
T79434	Antitumor agent-103	Apoptosis	Apoptosis
	Antitumor agent-103（compound 24l）是一种诱导凋亡（apoptosis）的化合物，具备抗增殖及抗克隆形成的特性。该化合物能够导致细胞周期在G0/G1期发生阻滞，并且刺激NO的产生，表现出显著的抗肿瘤活性。
T72604	Multi-kinase-IN-1
	Multi-kinase-IN-1 是一种具有抗肿瘤活性的激酶 (kinase) 抑制剂。Multi-kinase-IN-1 诱导细胞凋亡 (apoptosis)，可用于结直肠癌的研究。
T73909	Abemaciclib metabolite M18 LSN3106729	Ligands for Target Protein for PROTAC	PROTAC
	Abemaciclibmetabolite M18 (LSN3106729) 是一种CDK抑制剂，具有抗肿瘤活性。作为Abemaciclib的代谢物，Abemaciclibmetabolite M18 能与CRBN配体结合，用于设计PROTAC CDK4/6降解剂。
T79840	Bocodepsin hydrochloride OKI-179 hydrochloride	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Bocodepsin hydrochloride (OKI-179) 是一种口服活性的选择性HDAC抑制剂，具抗肿瘤特性，适用于治疗实体瘤和血液系统恶性肿瘤。
T83002	Antitumor agent-49
	Antitumor agent-49 (Compound 10) 是一款 Harmine 和呋喃杂化的衍生物，带有 NO 供体且表现出抗肿瘤特性。该化合物对 HepG2 细胞线展现出显著的细胞毒性，其 IC50 值为 1.79 µM，并且能在体外产生大量的 NO。
T77070	Loncastuximab
	Loncastuximab (RB4v1.2)，一种针对CD19的单克隆抗体，主要具有抗肿瘤活性，尤其在非霍奇金淋巴瘤（NHL），包括弥漫性大B细胞淋巴瘤（DLBCL）中展现出潜在应用价值。
T81280	Rha-PEG3-SMCC
	Rha-PEG3-SMCC（compound 13）作为一种构成部分，集成了蛋白质交联剂SMCC与不可降解的ADC linker Rha-PEG3，用于抗体-活性分子偶联物的构建。

化合物

Cat.No: T21593

Target: VEGFR

Cat.No: T60025

Target: CDK

Cyanoacetohydrazide

Cat.No: T0704

Synonym: Cyanoacetic hydrazide,2-Cyanoacetohydrazide,氰乙酰肼

Target: GSK-3, Antibacterial

2-(2-fluoro-6-methoxyphenyl)pyrimidine-4-carboxylic acid

Cat.No: T67877

Target: Others

2-Oxo-6-phenyl-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid

Cat.No: T67762

Target: Others

Tetraethylammonium chloride

Cat.No: T7538

Target: Potassium Channel

Cat.No: T73593

Target: Others

Cat.No: T27883

Synonym: LY181984,LY-181984,MPCU

Cat.No: T26587

Synonym: AA223 Lederle,AA-223 Lederle,AA 223 Lederle

Cat.No: T28185

Synonym: Nogalamycinum,U 15167,Nogalamyicn,U-15167,Nogalamycine,Nogalomycin

10-Oxo Docetaxel

Cat.No: TQ0142

Synonym: Docetaxel Impurity 1,10-氧多西他赛

Target: Others

OSI-7904L free acid

Cat.No: T24572

Synonym: OSI 7904,OSI-7904L,OSI7904,OSI 7904L,OSI7904L,OSI-7904

Aminohexylgeldanamycin hydrochloride

Cat.No: T38522

Synonym: AHGDM hydrochloride,Aminohexylgeldanamycin hydrochloride

Antitumor agent-84

Cat.No: T72571

Antitumor agent-39

Cat.No: T83004

Cat.No: T61346

Antitumor agent-85

Cat.No: T72572

Aminohexylgeldanamycin

Cat.No: T37377

Dihydro-5-azacytidine

Cat.No: T40713

Synonym: DHAC,NSC264880,Dihydro-5-azacytidine

Cat.No: T61803

Cat.No: T61561

Cat.No: T61248

(-)-15-Deoxyspergualin trihydrochloride

Cat.No: T83611

Antitumor agent-41

Cat.No: T74327

Cat.No: T11333

Target: Others

Cat.No: T61542

Cat.No: T73606

MC-Val-Cit-PAB-MMAF

Cat.No: T18326

Target: Others

Anticancer agent 47

Cat.No: T61412

Cat.No: T74146

MC-Val-Cit-PAB-clindamycin

Cat.No: T18322

Target: Others

Acetylaleuritolic acid

Cat.No: T25000

Synonym: NSC 266221,NSC-266221,NSC266221

Cat.No: T78312

Synonym: SEA-CD40

PROTAC IRAK4 degrader-7

Cat.No: T74411

Cyclo(Arg-Gly-Asp-D-Phe-Val)

Cat.No: T75990

Antitumor agent-116

Cat.No: T79582

Target: MELK

Mycophenolic acid sodium

Cat.No: T61099

Antitumor photosensitizer-2

Cat.No: T82997

Esuberaprost Sodium

Cat.No: T9665

EphA2 agonist 2

Cat.No: T72765

Trastuzumab emtansine

Cat.No: T36647

Target: Others

Metoprolol fumarate

Cat.No: T71752

Synonym: Lopressor OROS,CGP 2175C,CGP 2175C ; Lopressor OROS

Antitumor photosensitizer-1

Cat.No: T82998

Antitumor agent-103

Cat.No: T79434

Target: Apoptosis

Multi-kinase-IN-1

Cat.No: T72604

Abemaciclib metabolite M18

Cat.No: T73909

Synonym: LSN3106729

Target: Ligands for Target Protein for PROTAC

Bocodepsin hydrochloride

Cat.No: T79840

Synonym: OKI-179 hydrochloride

Target: HDAC

Antitumor agent-49

Cat.No: T83002

Cat.No: T77070

Cat.No: T81280

Cat. No.	Product Name	Target	Signaling Pathways
T4S1848	Tubeimoside II Tubeimoside-B,土贝母苷乙	Others	Others
	Tubeimoside II (Tubeimoside-B) 是一种齐墩果烷型三萜皂甙天然类似物，具有抗炎症和抗癌等生物特性。
T3321	Oleanonic acid 3-Oxooleanolic acid,3-Oxoolean-12-en-28-oic Acid,Oleanonic Acid,齐墩果酮酸,3-Ketooleanolic Acid	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Oleanonic acid (3-Ketooleanolic Acid) 是一种三萜，可以抑制 HIV-1 对细胞的感染。它具有保肝作用，并具有抗肿瘤和抗病毒特性。
T6S2038	Ziyuglycoside II	Apoptosis; Antioxidant; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Ziyuglycoside II 是从地榆中提取的一种三萜皂苷，可诱导活性氧产生和凋亡，具有抗炎和抗癌作用。
T5853	Rubitecan RFS 2000,鲁比特康,9-Nitrocamptothecin	Topoisomerase	DNA Damage/DNA Repair
	Rubitecan (9-Nitrocamptothecin) 是一种与喜树碱相关的半合成药物，具有有效的抗肿瘤和抗病毒特性。它是一种 DNA 拓扑异构酶 I 抑制剂，以浓度依赖性方式抑制 DNA 拓扑异构酶 I 并在无细胞试验中增加超螺旋 DNA 的比例。
T40803	Isoanthricin (Rac)-Deoxypodophyllotoxin
	Isoanthricin, also known as (Rac)-Deoxypodophyllotoxin, is the racemate form of Deoxypodophyllotoxin, a powerful compound with noteworthy antitumor and anti-inflammatory properties.
T82037	Isocucurbitacin D
	Isocucurbitacin D为一种抗癌剂，展现出针对多种癌症细胞类型的抑制效果。
T40641	Crocin-4
	Crocin-4, a carotenoid compound found in saffron, possesses potent antioxidant properties and can penetrate the brain. It effectively inhibits the aggregation and deposition of Aβ fibrils, making it useful for Alzheimer's Disease research. Additionally, Crocin-4 demonstrates antitumor and anti-inflammatory activities.
TN6732	Oenothein B	Apoptosis; HCV Protease; Antibacterial; Antifungal	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Oenothein B 是一种聚（ADP-核糖）糖水解酶的特异性抑制剂。 Oenothein B 具有抗氧化、抗炎、抗真菌、抗 HCV 和抗肿瘤特性。
T83345	3-O-α-L-Rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl hederagenin28-O-β-D-xylopyranosyl-(1→6)-β-D-glucopyranosyl ester
	3-O-α-L-Rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl hederagenin 28-O-β-D-xylopyranosyl-(1→6)-β-D-glucopyranosyl ester 是一种皂苷化合物，具备抗肿瘤与抗炎特性。
T75424	(±)-Evodiamine
	(±)-Evodiamine，一种天然生物碱，作为Top1的抑制剂，展现了抗炎、抗肥胖及抗肿瘤特性。(±)-Evodiamine能够通过诱导细胞凋亡来抑制多种肿瘤细胞的增殖。
T83437	18-O-Demethylpederin
	18-O-Demethylpederin 是 pederin 的一种类似物，原先自隐翅虫科昆虫中分离得到。作为一种天然聚酮化合物，pederin 是非蛋白质昆虫毒素，展现了包含抗菌、抗病毒和抗肿瘤在内的广泛生物活性。
T81689	Neohelmanthicin A
	Neohelmanthicin A（compound 3A）是具抗肿瘤活性的苯丙素类化合物。该化合物对EL4白血病细胞系、S180乳腺癌细胞系和MCF7乳腺癌细胞系表现出显著的抑制作用，其IC50s分别为0.13 μM, 7 μM和23 μM。
TN1875	Liriodenine 鹅掌揪碱	BCL; Caspase; p53	Apoptosis; Proteases/Proteasome
	Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can suppress ventricular arrhythmias induced by myocardial ischaemia reperfusion, through inhibiti
TN4411	Lappaol F	CDK; P-gp; JNK	Cell Cycle/Checkpoint; MAPK; Membrane transporter/Ion channel; Neuroscience
	1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. <br/> 2. Lappaol F has potential chemosensitizing activity, it may be candidates for developing novel adju

天然产物

Cat.No: T4S1848

Synonym: Tubeimoside-B,土贝母苷乙

Target: Others

Cat.No: T3321

Synonym: 3-Oxooleanolic acid,3-Oxoolean-12-en-28-oic Acid,Oleanonic Acid,齐墩果酮酸,3-Ketooleanolic Acid

Target: HIV Protease

Ziyuglycoside II

Cat.No: T6S2038

Target: Apoptosis, Antioxidant, Reactive Oxygen Species

Cat.No: T5853

Synonym: RFS 2000,鲁比特康,9-Nitrocamptothecin

Target: Topoisomerase

Cat.No: T40803

Synonym: (Rac)-Deoxypodophyllotoxin

Isocucurbitacin D

Cat.No: T82037

Cat.No: T40641

Cat.No: TN6732

Target: Apoptosis, HCV Protease, Antibacterial, Antifungal

3-O-α-L-Rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl hederagenin28-O-β-D-xylopyranosyl-(1→6)-β-D-glucopyranosyl ester

Cat.No: T83345

(±)-Evodiamine

Cat.No: T75424

18-O-Demethylpederin

Cat.No: T83437

Neohelmanthicin A

Cat.No: T81689

Cat.No: TN1875

Synonym: 鹅掌揪碱

Target: BCL, Caspase, p53

Cat.No: TN4411

Target: CDK, P-gp, JNK

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