70
17
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5519 |
Bivalirudin
BG-8967,比伐卢定,Hirulog-1 |
Thrombin | Proteases/Proteasome |
Bivalirudin (BG-8967) 是一种直接凝血酶(thrombin)抑制剂,是一种肽类抗凝剂,可在侵入性心脏病,特别是在经皮冠状动脉介入中用于抗凝。 | |||
T20470 |
Edetic acid
Ethylenediaminetetraacetic acid,乙二胺四乙酸,EDTA |
Others | Others |
Edetic acid (Ethylenediaminetetraacetic acid) 是 Edetate 的酸形式,是一种具有抗高钙血症和抗凝血特性的螯合剂。它与钙和重金属离子结合后,会形成可溶的稳定复合体,使血清钙水平降低。它也可用作血液样本的抗凝剂,并用于治疗铅中毒。 | |||
T31206 |
Darexaban
YM 150,Darexaban, Tanexaban,YM150 |
Factor Xa | Metabolism |
Darexaban (Tanexaban, YM-150) 是选择性的、口服具有活力的 Xa 因子 (FXa) 抑制剂,IC50=54.6 nM。它对其他相关丝氨酸蛋白酶(如胰蛋白酶、凝血酶和激肽释放酶)具有高选择性。它具有抗凝和抗血栓形成作用。 | |||
T0389 |
Dabigatran etexilate
达比加群酯,BIBR 1048 |
Thrombin | Proteases/Proteasome |
Dabigatran etexilate (BIBR 1048) 是一种 Dabigatran 前药,具有口服活性。它具有抗凝作用,能够预防心房颤动引起的静脉血栓栓塞和中风。 | |||
T5133 |
Dabigatran Etexilate Mesylate
甲磺酸达比加群酯,BIBR 1048MS,Dabigatran etexilate methanesulfonate |
Thrombin | Proteases/Proteasome |
Dabigatran Etexilate Mesylate (BIBR 1048MS) 是一种口服具有活性的 Dabigatran 前药,具有抗凝作用,能够预防心房颤动引起的静脉血栓栓塞和中风。 | |||
T2368 |
Edoxaban Tosylate Monohydrate
DU-176b,DU-176b tosylate Monohydrate,Lixiana,Edoxaban,依度沙班对甲苯磺酸盐一水化合物 |
Factor Xa; Thrombin | Metabolism; Proteases/Proteasome |
Edoxaban Tosylate Monohydrate (DU-176b tosylate Monohydrate) 是口服具有活力的 factor Xa 选择性抑制剂。它是一种抗凝剂,可用于预防中风,是一种凝血酶和凝血因子 IXaβ (FIXa) 的弱抑制剂,对 FXa 的选择性超过 10000 倍。它具有抗血栓形成的特性,可用于血栓栓塞性疾病的研究。 | |||
T1515 |
Bromindione
溴茚二酮,溴茚二酮(INN),Fluidane,Halinone |
Others | Others |
Bromindione (Fluidane) 是强效且长效的 Inandione 衍生口服抗凝化合物。 | |||
T0360 |
Chlorindione
chlophenadione,Indaliton,氯苯茚二酮,G-25766 |
||
Chlorindione (chlophenadione) 是一种维生素 K1 的拮抗剂,也是一种有效的抗凝剂。 | |||
T9153 |
Picotamide
|
Others | Others |
Picotamide 具有抗凝和纤维蛋白溶解特性。 | |||
T77690 |
L-Cyclohexylalanine
L-3-Cyclohexylalanine,H-Cha-OH,3-Cyclohexyl-L-alanine |
||
L-Cyclohexylalanine (L-3-Cyclohexylalanine) 是一种氨基酸类似物,与短杆菌肽S合成酶的重酶硫酯结合。L-Cyclohexylalanine 可用来合成抗凝血十肽。 | |||
TP1628L |
Activated Protein C (390-404), human acetate
Activated Protein C (390-404), human acetate(146340-20-7 Free base) |
APC | Cell Cycle/Checkpoint |
Activated Protein C (390-404), human acetate (Activated Protein C ) 抑制 APC 抗凝活性。 | |||
T30191L |
Atecegatran TFA
Atecegatran TFA(917904-13-3 Free base),AR-H067637 TFA |
Others | Others |
Atecegatran TFA 常被当作一种抗凝血剂,可用来治疗心血管疾病。 | |||
T0155 |
Argatroban
MCI-9038,阿加曲班,MD-805,Argipidine |
Thrombin | Proteases/Proteasome |
Argatroban (MCI-9038) 是一种选择性的凝血酶抑制剂。 | |||
T22246 |
Argatroban Monohydrate
阿加曲班一水合物,阿加曲班 |
Thrombin | Proteases/Proteasome |
Argatroban Monohydrate 是一种 thrombin 选择性抑制剂。 | |||
T80792 |
WAY-639228
|
Others | Others |
WAY-639228-A 具有潜在的抗血栓和抗凝活性,可用于研究脑血栓。 | |||
T50001 |
Tinoridine
ethyl 2-amino-6-benzyl-4H,5H,6H,7H-thieno[2,3-c]pyridine-3-carboxylate,替诺立定 |
P450 | Metabolism |
Tinoridine 通过抑制环氧合酶-2(COX-2)的产生来发挥作用,具有抗炎、抗过敏和抗凝血等活性。 | |||
T0372 |
Gabexate mesylate
甲磺酸加贝酯,FOY |
Factor Xa; Serine Protease; Proteasome | Metabolism; Proteases/Proteasome; Ubiquitination |
Gabexate mesylate (FOY) 是一种非抗原的类胰蛋白酶丝氨酸蛋白酶抑制剂。 | |||
T26240 |
Surfen dihydrochloride
Aminokinuride dihydrochloride,Aminoquinuride dihydrochloride,NSC-12155,Aminokinuride 2HCl,Aminoquinuride 2HCl |
FGFR; Antiviral; Antibiotic | Angiogenesis; Immunology/Inflammation; Microbiology/Virology; Tyrosine Kinase/Adaptors |
Surfen dihydrochloride (Aminoquinuride dihydrochloride) 是一种有效的硫酸肝素小分子拮抗剂,具有抗菌和抗病毒活性,抑制炭疽致死因子、凝血因子 X 和致死因子。Surfen dihydrochloride 可抑制普通肝素和低分子量肝素的抗凝活性,抑制肝素的硫酸化和肝素裂解酶的降解。Surfen dihydrochloridn 抑制阻断硫酸乙酰肝素介导的 FGF2 结合和信号转导。Surfen 抑制 SEVI 和精液介导的 HIV 1 型感染增强。 | |||
T0514 |
Phenindione
Rectadione,phenylindandione,苯茚二酮,Phenylindione |
||
Phenindione (Rectadione) 是一种茚满二酮,已被用作抗凝剂,可作为维生素 K 拮抗剂。它的作用类似于华法林,但由于其严重不良反应的发生率较高,现在很少使用。 | |||
T4980 |
Betrixaban maleate
|
Factor Xa | Metabolism |
Betrixaban maleate 是一种非维生素 K 口服抗凝剂,其作用是由 Xa 因子的竞争性和可逆抑制作用驱动的。 | |||
T1736 |
Apixaban
阿哌沙班,BMS-562247-01 |
Factor Xa | Metabolism |
Apixaban (BMS-562247-01) 是一种高度选择性,可逆的、口服具有活力的凝血因子 Xa (Factor Xa) 抑制剂,抑制人和兔凝血因子 Xa 的 Ki 分别为 0.08 nM 和 0.17 nM。它可以用于研究各种血栓栓塞疾病。 | |||
T10820L1 |
Ciraparantag acetate
Ciraparantag acetate(1438492-26-2 Free base) |
Others | Others |
Ciraparantag acetate 是一种抗凝逆转剂,是一种小分子,专门设计用于通过电荷-电荷相互作用与普通肝素和低分子量肝素非共价结合。它显示出与直接口服抗凝剂 (DOAC) 相似的结合特性。 | |||
T6531 |
Heparin sodium salt
肝素钠,Sodium heparinate,Heparin sodium |
Factor Xa; Thrombin; Autophagy | Autophagy; Metabolism; Proteases/Proteasome |
Heparin sodium salt (Sodium heparinate) 是一种抗凝剂,可与抗凝血酶 III 可逆地结合,使凝血酶因子 IIa 和 Xa 的失活速度加快,显着抑制外泌体-细胞相互作用。 | |||
T1184 |
Rivaroxaban
BAY 59-7939,利伐沙班 |
Factor Xa; Thrombin | Metabolism; Proteases/Proteasome |
Rivaroxaban (BAY 59-7939) 是高效选择性的凝血因子 Xa (FXa) 直接抑制剂,IC50=0.7 nM,Ki 为 0.4 nM。 | |||
T77124 |
Osocimab
BAY 1213790 |
FXR | Metabolism |
Osocimab (BAY 1213790) 是一种高效的抗 FXIa 抗体,Ki 值为 2.4 nM,EC50 值为 0.2 nM。Osocimab 可能通过 FXI 抑制降低血栓形成。Osocimab 常被当作 XI 因子抑制剂,对凝血酶生成有抑制作用,有抗凝血作用,可用于研究血栓栓塞性疾病。 | |||
T4341 |
Betrixaban
贝曲西班,PRT054021 |
Factor Xa | Metabolism |
Betrixaban (PRT054021) 是一种口服具有活力的选择性factor Xa(fXa) 抑制剂,IC50=1.5 nM。 | |||
T2368L |
Edoxaban
Lixiana,依杜沙班 |
Factor Xa; Thrombin | Metabolism; Proteases/Proteasome |
Edoxaban (Lixiana) (DU-176) 是一种选择性的,口服有效的 factor Xa (FXa)抑制剂。Edoxaban 对游离 FXa 和凝血酶原的 Ki 分别为 0.561 nM 和 2.98 nM。Edoxaban 是一种抗凝剂,可用于预防中风。Edoxaban 还是一种凝血酶和凝血因子 IXaβ (FIXa) 的弱抑制剂,Ki 值分别为 6.00 μM 和 41.7 μM,对 FXa 的选择性超过 10000 倍。由于具有抗血栓形成的特性,Edoxaban 可用于预防血栓栓塞性疾病的研究。 | |||
T24930 |
Valone
AI300366,AI3-00366,AI3 00366 |
||
Valone is an anticoagulant. | |||
T27545 |
Hirugen
BG 8865,Hirudin dodecapeptide |
||
Hirugen is a derivative of hirudin, which is an anticoagulant protein found in leeches. | |||
T28404 |
Phenyramidol Hydrochloride
Vazalmin,Analexin,Firmalgil,Phenyramidol HCl,Betapirin |
||
Phenyramidol Hydrochloride is an anticoagulant and analgesic. | |||
T76561 |
Anpocogin
|
||
Anpocogin 是 Ancyclostoma canium 线虫的抗凝蛋白 c2 变体(添加了 C 末端 P85)。Anpocogin 在Pichia pastoris 中产生,用作抗凝剂。 | |||
T25909 |
Oxazidione
LD 4610,Transidione,LD4610,LD-4610,Amplidione |
||
Oxazidione 是一种抗凝血化合物,也是一种有用的医药中间体。 | |||
T25835 |
Moxicoumone
|
||
Moxicoumone is an anticoagulant agent. | |||
T30191 |
Atecegatran
metabolite of AZD0837,atecegatran metoxil |
||
Atecegatran 常被当作一种抗凝血剂属于,可用来治疗心血管疾病。 | |||
T62662 |
Tioclomarol
|
||
Tioclomarol 是一种香豆素抗凝剂,维生素 K 拮抗剂。 | |||
TP1628 |
Activated Protein C (390-404), human
|
||
Activated Protein C (390-404), human, a peptide derived from the vitamin K-dependent serine protease, effectively suppresses the anticoagulant activity of APC[1]. | |||
T82197 |
Hirudin (54-65) (TFA)
|
||
Hirudin (54-65) TFA,是一种具有抗凝血活性的Hirudin 65残基蛋白片段。 | |||
T16377 |
Odiparcil
SB-424323 |
Thrombin | Proteases/Proteasome |
Odiparcil is an orally active beta-d-thioxyloside analog. Odiparcil is an indirect thrombin inhibitor that exerts its anticoagulant effect through activation of antithrombin II (heparin cofactor II). It also has an antithrombotic activity associated with a reduced risk of adverse bleeding events. | |||
T71601 | CU-2010 | ||
CU-2010 is a synthetic serine protease inhibitor with antifibrinolytic and anticoagulant properties. CU-2010 dose-dependently reduces postoperative blood loss and improves postischemic recovery after cardiac surgery in a canine model. | |||
T20616 |
Coumachlor
G-23133,Ratilan,G23133,Tomorin,G 23133 |
||
Coumachlor, a first-generation anticoagulant rodenticide, blocks the formation of prothrombin and inhibits blood coagulation causing internal haemorrhage. | |||
T23052 |
Nafamostat
|
Others | Others |
Nafamostat is a synthetic serine protease inhibitor and is an anticoagulant. | |||
T82521 |
D-Val-Leu-Lys-chloromethylketone
|
||
D-Val-Leu-Lys-chloromethylketone,一种含D-Val、Leu和Lys三种氨基酸的多肽类化合物,具有抗凝血功能。 | |||
T19708 |
(S)-Warfarin
|
||
(S)-Warfarin is a more effective enantiomer of Warfarin. It is used as a vitamin K antagonist, with anticoagulant. | |||
T23755 |
AS1468240
AS 1468240,AS-1468240 |
||
AS1468240 is a factor Xa inhibitor. It has significant oral anticoagulant activity. | |||
T23051 |
Nafamostat hydrochloride
|
Others | Others |
Nafamostat hydrochloride is a synthetic serine protease inhibitor and is an anticoagulant. | |||
T72448 |
Thrombin inhibitor 6
|
||
Thrombin inhibitor6为高效的凝血酶抑制剂,IC50值为1 nM,表现出显著的抗凝作用。 | |||
T23898 |
Clocoumarol
Clocoumarolum,BRN 1264788,DB 112 |
||
Clocoumarol is an anticoagulant that prevents blood clotting. It also can inhibit the dilatation of the spleen and the congestion of lymph nodes. | |||
T71543 |
Difethialone
|
||
Difethialone is an anticoagulant rodenticide and a vitamin K antagonist. | |||
T70184 |
YM-60828 dihydrochloride
|
||
YM-60828 dihydrochloride is a Factor Xa (FXa) inhibitor and anticoagulant used in the treatment of venous thromboembolic disease. | |||
T71532 | Fondaparinux free base | ||
Fondaparinux Free Base is a synthetic pentasaccharide that mediates the interaction of HEPARIN with ANTITHROMBINS and inhibits FACTOR Xa; it is used for prevention of VENOUS THROMBOEMBOLISM after surgery. Fondaparinux is a clinically approved anticoagulant pentasaccharide for the treatment of thrombotic diseases, displays better efficacy and biosafety than other heparin-based anticoagulant drugs. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7544 |
Fucoidan
岩藻多糖 |
Others | Others |
Fucoidan 是一种 α-淀粉酶和 α-葡萄糖苷酶的有效抑制剂,是一种生物特性多糖。 它具有抗凝血,抗肿瘤,抗氧化和抗脂肪特性。 | |||
TQ0197 |
Acenocoumarol
醋硝香豆素,新抗凝 |
||
Acenocoumarol 是一种抗凝血剂,与 Vitamin K 拮抗剂的功能相似。 | |||
TN6444 |
Cyclo(Tyr-Leu)
|
Antifungal | Microbiology/Virology |
Cyclo(Tyr-Leu) 是一种来自马齿苋 Portulaca oleracea Linn 的环状二肽,具有细胞毒性、抗真菌和抗凝血活性。 | |||
T14291 |
Anisindione
|
Others | Others |
Anisindione 是合成的抗凝血剂,对活性促凝因子II,VII,IX 和X 的形成具有抑制作用。 | |||
T5725 |
Salvianolic acid B
丹酚酸B,lithospermic acid B,Dan Shen Suan B |
Sirtuin; Autophagy | Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair |
Salvianolic acid B (Dan Shen Suan B) 是一种来自丹参提取物的水溶性抗氧化剂,具有抗血小板聚集、抗凝和抗血栓作用。它常用来研究微循环疾病。 | |||
T41031 |
Protamine sulfate
|
Thrombin | Proteases/Proteasome |
Protamine sulfate is a polycationic peptide that serves as an antiheparin agent. This compound can neutralize the anticoagulant action of heparin and enhance lipid-mediated gene transfer. | |||
T12952 |
Sodium citrate dihydrate
Citric acid trisodium salt dihydrate,Trisodium citrate dihydrate,二水合柠檬酸钠 |
Antibacterial | Microbiology/Virology |
Sodium citrate dihydrate (Trisodium citrate dihydrate) 是一种抗凝血剂,也用为缓冲剂和食品防腐剂。 | |||
TL0013 |
Heraclenin
独活内酯 |
Anti-infection; Immunology/Inflammation related | Immunology/Inflammation; Microbiology/Virology |
Heraclenin 是一种天然呋喃香豆素。它浓度依赖性的靶向激活的 T 细胞核因子 (NFAT) ,抑制人原代 T 细胞中 T 细胞受体介导的增殖。 | |||
T5795 |
Suberosin
软木花椒素 |
Others; NF-κB | NF-κB; Others |
Suberosin 可分离自Plumbago zeylanica 中,通过调节NF-AT 和NF-κB,抑制PHA-诱导的 PBMC 细胞增殖并捕获细胞周期G1过渡到 S 期,具有抗炎和抗血凝的活性。 | |||
T2727 |
Salvianolic acid B
|
Others | Others |
Salvianolic acid B (Dan Shen Suan B) 是一种来自丹参提取物的水溶性抗氧化剂,具有抗血小板聚集、抗凝和抗血栓作用。它常用来研究微循环疾病。 | |||
T0809 |
Dicoumarol
Dicumarol,双羟香豆素,双香豆素 |
Dehydrogenase; NADPH; PDK | Metabolism; PI3K/Akt/mTOR signaling |
Dicoumarol (Dicumarol) 是一种 NAD(P)H: 醌氧化还原酶 1 和PDK1的抑制剂,它们的IC50值分别为 0.37 和 19.42 μM。 | |||
T2939 |
Forskolin
毛喉素,Coleonol,Colforsin |
FXR; Adenylyl cyclase; AChR; Autophagy | Autophagy; Metabolism; Neuroscience |
Forskolin (Coleonol) 属于天然产物,是一种腺苷酸环化酶激活剂 (EC50=0.5 μM)。Forskolin 可以增加 cAMP 水平,可以激活 PXR 和 FXR,也可以诱导细胞自噬。Forskolin 对心脏产生正性肌力作用,具有血小板抗凝集和降压作用。 | |||
TN6689 |
Cyclo(Tyr-Phe)
|
||
Cyclo-(Phe-Tyr) shows anticoagulant activities. | |||
TN1197 |
19α-Hydroxyasiatic acid
23-羟基委陵菜酸,19 alpha-Hydroxyasiatic acid |
Others | Others |
19 alpha-Hydroxyasiatic acid shows significant anticoagulant effect on the extrinsic pathway. | |||
TN3716 |
Coumurrayin
|
Others | Others |
Coumurrayin may have anticoagulant activity. | |||
T20654 |
Heparin
Certoparin,Bemiparin,Dalteparin,Adomiparin |
Thrombin; Endogenous Metabolite; Antibacterial; Autophagy | Autophagy; Metabolism; Microbiology/Virology; Proteases/Proteasome |
Heparin (Adomiparin) 是硫酸粘多糖,常在临床医学上当抗凝剂使用。Heparin 在体内实验中显示出部分抗炎活性。 | |||
TN5901 |
Cudratricusxanthone A
|
||
Cudratricusxanthone A has potent anti-proliferative, antioxidative, and monoamine oxidase inhibitory effects, it also possesses anti-cancer activities and provide a basis for developing effective therapeutic agents to inhibit growth and metastasis of brea |