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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T22830 |
GYY4137
GYY 4137 morpholine salt |
Others | Others |
GYY4137 (GYY 4137 morpholine salt) 是一种缓释H2S 供体,具有抗炎和抗癌作用,也具有血管扩张和抗高血压活性。 | |||
T36848 |
Combretastatin A-1
Combretastatin A1 |
Akt; Microtubule Associated | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
Combretastatin A-1 是一种有效的微管抑制剂,具有抗肿瘤和抗血管活性,通过微管蛋白解聚介导的 AKT 失活抑制 Wnt/β-catenin 通路发挥作用,可用于研究肝癌。 | |||
T37425 |
FGFR4-IN-5
FGFR4-IN-5 |
||
FGFR4-IN-5, a covalent FGFR4 inhibitor, demonstrates potency and selectivity with an IC50 value of 6.5 nM. Exhibiting significant in vivo anti-tumor activity, it is applicable for research in hepatocellular carcinoma [1]. | |||
T77102 | Nofazinlimab | ||
Nofazinlimab (CS1003) 是一种人源 IgG4抗PD-1单克隆抗体。Nofazinlimab 可用于不可切除肝细胞癌 (uHCC) 的研究。 | |||
T62704 | HBV-IN-23 | ||
HBV-IN-23 (Compound 5k) 是一种 HBV DNA 复制抑制剂 (IC50: 0.58 μM)。HBV-IN-23 能够抑制药物敏感和耐药株。HBV-IN-23 可以诱导 HepG2 细胞凋亡,表现出抗肝癌细胞 (HCC) 效果。 | |||
T63634 | Palbociclib dihydrochloride | ||
Palbociclib (PD 0332991) dihydrochloride 是口服具有活力的、选择性的 CDK4 (IC50: 11 nM) 和 CDK6 (IC50: 16 nM) 抑制剂。Palbociclib dihydrochloride 对癌细胞具有抗增殖活性,并阻滞细胞周期,能够用于 HR 阳性和 HER2 阴性乳腺癌,以及肝细胞癌的相关研究。 | |||
T79143 |
MS934
|
MEK | MAPK |
MS934是一种VHL招募MEK1/2降解剂,能够有效抑制HT-29细胞生长,表现出抗增殖效果,其GI50值达到0.023 μM。该化合物适用于包括黑色素瘤、非小细胞肺癌(NSCLC)、结直肠癌、原发性脑肿瘤和肝细胞癌在内的多种人类癌症研究。 | |||
T72507 |
Palbociclib orotate
PD 0332991 orotate |
CDK | Cell Cycle/Checkpoint |
Palbociclib (PD 0332991) orotate 是一种口服活性的CDK4和CDK6选择性抑制剂,其IC50值分别为11 nM和16 nM。该化合物对癌细胞展示出抗增殖效果,并促使细胞周期处于阻滞状态。该药物适用于HR阳性、HER2阴性乳腺癌以及肝细胞癌的研究。 | |||
T63576 | Palbociclib hydrochloride | ||
Palbociclib (PD 0332991) hydrochloride 是一种选择性的、有效的 CDK4 (IC50: 11 nM) 和 CDK6 (IC50: 16 nM)抑制剂。Palbociclib hydrochloride 对癌细胞具有抗增殖作用,并诱导细胞周期阻滞,能够用于 HR 阳性和 HER2 阴性乳腺癌,以及肝细胞癌的相关研究。 | |||
T68875 |
Xylocydine
|
||
Xylocydine is a novel Cdk inhibitor, which is an effective inducer of apoptosis in hepatocellular carcinoma cells in vitro and in vivo. Xylocydine also strongly inhibits the activity of Cdk7 and Cdk9, in vitro as well as in cell cultures, that is temporally associated with apoptotic cell death in xylocydine-induced HCC cells. Xylocydine can effectively suppress the growth of HCC xenografts in Balb/C-nude mice by preferentially inducing apoptosis in the xenografts, whereas the drug did not cause... | |||
T36713 |
Streptochlorin
|
||
Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp. SF2583 that has diverse biological activities, including antiangiogenic, antiproliferative, and anti-allergic properties. It inhibits TNF-α-induced NF-κB transcriptional activity and decreases proliferation of human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 5 to 20 μM. Streptochlorin (12 μg/ml) decreases viability of, as well as induces apoptosis and increases the productio... | |||
T35573 | Adenosine 5’-methylenediphosphate (hydrate) | ||
Adenosine 5’-methylenediphosphate is an inhibitor of ecto-5’-nucleotidase, also known as CD73, with a Kivalue of 37 nM.1It inhibits cAMP accumulation induced by adenosine 5’-monophosphate , adenosine 5’-diphosphate , or adenosine 5’-triphosphate but not adenosine in VA-13 human fibroblasts when used at a concentration of 100 μM. Adenosine 5’-methylenediphosphate reduces proliferation of U138MG glioma cells, as well as inhibits the invasion and migration of MHCC97H hepatocellular carcinoma (HCC) ... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3673 |
Mollugin
大叶茜草素,Rubimaillin |
HER; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Mollugin (Rubimaillin) 是Rubia cordifolia L.中主要的生物活性成分。它能通过 p38-Smad 信号通路增强 BMP-2 的成骨作用。它通过抑制 TNF-α 诱导的 NF-κB 激活起抗癌疗效。 | |||
T6S0117 |
Avicularin
Fenicularin,扁蓄苷 |
ERK | MAPK |
Avicularin (Fenicularin) 具有抗过敏、抗炎、保肝、抗氧化、抗肿瘤等活性。它能通过调节 NF-κB(p65)、COX-2 和 PPAR-γ 的活性来改善人类肝细胞癌。在 LPS 刺激的 RAW 264.7 巨噬细胞中,它通过抑制 ERK 信号通路产生抗炎活性。 | |||
TN6694 |
5,6-Benzoflavone
β-Naphthoflavone,beta-NF |
Antioxidant | oxidation-reduction |
5,6-Benzoflavone (β-Naphthoflavone) 是芳烃受体的外源配体,可破坏人肝癌 HepG2 细胞中的锌稳态。5,6-Benzoflavone (β-Naphthoflavone) 具有抗炎和抗氧化活性,抑制通过 AKT/Nrf-2/HO-1-NF-kappaB 信号转导轴,抑制 LPS 诱导的炎症,抑制TNF-α诱导的ICAM-1和VCAM-1表达,可用于研究神经退行性疾病。 | |||
T6S1699 |
Shogaol
[6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol |
Lipoxygenase; Autophagy | Autophagy; Metabolism |
6-Shogaol (6-Shogaol) 是从生姜中分离的一种天然产物,具有抗癌、抗炎和抗氧化的多种生物活性。 | |||
TN1549 |
Damnacanthal
丹宁卡 |
IL Receptor; Akt; Syk | Angiogenesis; Cytoskeletal Signaling; Immunology/Inflammation; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
Damnacanthal possesses anti-cancer, immunomodulatory, antinociceptive and anti-inflammatory actions, it can treat or prevent hepatocellular carcinoma through its inhibitory effects on the HGF/c-Met axis. | |||
TN3931 |
ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid
|
ERK; BCL; p38 MAPK; NF-κB; Caspase; JNK; p53 | Apoptosis; MAPK; NF-κB; Proteases/Proteasome |
Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular carcinoma in vitro and in vivo via stabilizing IkBα. | |||
T28122 |
Myrtenal
NSC-54384,NSC 54384,NSC54384,Benihinal |
||
Myrtenal is a natural monoterpene. It is found to attenuate diethylnitrosamine-induced hepatocellular carcinoma in rats by stabilizing intrinsic antioxidants and modulating apoptotic and anti-apoptotic cascades. Myrtenal also inhibits acetylcholinesterase | |||
TN1728 |
Hellebrigenin
|
PARP; Akt; CDK | Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
Hellebrigenin has anti-hepatoma activities, it induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. Hellebrigenin exhibites moderate to strong activity against human HL-60, SF-295, MDA-MB-435, and HCT-8 cancer cell strains without hemolysis of mouse erythrocytes. | |||
TN5050 |
Sprengerinin C
|
NADPH-oxidase; VEGFR; p38 MAPK; ROS; Akt; PI3K; mTOR; p53 | Angiogenesis; Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can strongly suppress tumor angiogenesis in human umbilical vein endothelial cells, it blocks vascul |