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237

抑制剂 & 化合物

33

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T19717	Cyclo-L-Trp-L-Trp	Antifungal	Microbiology/Virology
	Cyclo-L-Trp-L-Trp 是一种广谱抗真菌剂。它还诱导组蛋白的高度乙酰化。
T15457L	H-Lys-Trp-Lys-OH acetate H-Lys-Trp-Lys-OH acetate(38579-27-0 free base)	Antiviral; Antibacterial	Immunology/Inflammation; Microbiology/Virology
	H-Lys-Trp-Lys-OH acetate 是一种具有抗菌和抗病毒活性的肽。
TP1426	His-[D-2-ME-Trp]-Ala	Others	Others
	His-[D-2-ME-Trp]-Ala 是生长激素海沙瑞林的一个片段。
TP2305	pGlu-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val	Others	Others
	pGlu-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val 是一种肽。
T24903	TRP-601 TRP601
	TRP-601 is a caspase inhibitor.
T20540	N-Valyltryptophan 二肽-2,Val-trp,L-Valyl-L-tryptophan	Others	Others
	N-Valyltryptophan (Val-trp) 是蛋白质分解代谢或蛋白质消化的不完全分解产物。
T8318	BNC210 H-Ile-Trp-OH,IW-2143	AChR	Neuroscience
	BNC210 (IW-2143) 是一种α7 nAChR 负变构调节剂，在焦虑和抑郁动物模型中有活性。
T76626	H-Trp-Trp-Trp-OH
	H-Trp-Trp-Trp-OH 是一种三肽，由色氨酸组成。H-Trp-Trp-Trp-OH 具有抗菌活性。
TP1251L	N-terminally acetylated Endomorphin-1 acetate Ac-L-Tyr-L-Pro-L-Trp-L-Phe-CONH2	Others	Others
	N-terminally acetylated Endomorphin-1 acetate (Ac-L-Tyr-L-Pro-L-Trp-L-Phe-CONH2) 是一种修饰的 Endomorphin-1。
T39111	Fmoc-D-Trp(Boc)-OH
	Fmoc-D-Trp(Boc)-OH is a labile ADC linker employed for synthesizing antibody-drug conjugates (ADCs).
T19326	Fmoc-Trp(Me)-OH	Others	Others
	Fmoc-Trp(Me)-OH is synthesized by 1-Methyl-Ltrypthophan and N-(9-Fluorenylmethoxycarbonyloxy)succinimide (Fmoc-ONSu) and can be used for peptide or protein synthesis.
T15457	H-Lys-Trp-Lys-OH	Others	Others
	H-Lys-Trp-Lys-OH is a small molecule peptide that shows antibacterial and antiviral activities.
T33079	Lys-psi(CH2NH)-trp(nps)-ome
	Lys-psi(CH2NH)-trp(nps)-ome peptide bond replaced by CH2NH group.
T41049	Fmoc-Trp(Boc)-Ser(psi(Me,Me)pro)-OH
	Fmoc-Trp(Boc)-Ser(psi(Me,Me)pro)-OH is a dipeptide.
TP1893L1	[D-Trp8]-γ-MSH acetate(321351-81-9 free base)	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	[D-Trp8]-γ-MSH acetate(321351-81-9 free base) 是选择性黑皮质素 3 (MC3) 受体激动剂（对人 MC3、MC5 和 MC4 受体的 IC50 值分别为 6.7、340 和 600 nM）。显示有抗炎功效。
T83748	RW4 TFA (RW)4-NH2,Arg-Trp-Arg-Trp-Arg-Trp-Arg-Trp-NH2
	RW4为一种抗菌肽，对E. coli和S. aureus具有活性（IC50s分别为9.6和5.1 µM）。RW4同时能诱导分离的绵羊红细胞的溶血作用。
T76575	Arg-Trp
	Arg-Trp 是由精氨酸和色氨酸组成的二肽，Arg-Trp 辛酯的类似物显示出抗菌活性。
T39311	Tyrosinase-related Protein 2 (TRP-2) (181-188)
	Tyrosinase-related Protein 2 (TRP-2) (181-188) is a peptide derived from the tyrosinase-related protein 2 (TRP-2), specifically corresponding to residues 180-188. It is the primary epitope within TRP-2 that is recognized by anti-B16 CTLs. Moreover, It is a peptide that conforms to the binding motif of the MHC class I H2-Kb.
T41080	Fmoc-Trp(Boc)-Thr(psi(Me,Me)pro)-OH
	Fmoc-Trp(Boc)-Thr(psi(Me,Me)pro)-OH is a dipeptide.
T7769	Nonapeptide-1 Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-,九胜肽-1,Melanostatine™ 5	Others	Others
	Nonapeptide-1 (Melanostatine™ 5) 可以抑制黑色素的合成，这使得它对治疗某些皮肤病很感兴趣。
T83747	RW3 TFA (RW)3-NH2,Arg-Trp-Arg-Trp-Arg-Trp-NH2
	RW3是一种抗微生物肽，对大肠杆菌(E. coli)和金黄色葡萄球菌(S. aureus)具有活性，其半抑制浓度(IC50s)分别为16 µM和8 µM。RW3还能诱导分离的绵羊红细胞溶解。
TP2460	Lys-phe-phe-phe-ile-ile-trp-och3
	Lys-phe-phe-phe-ile-ile-trp-och3 is a hydrophobic peptide which reacts with lipid vesicles.
T64883	Z-Trp-OH

T24447	Men 10208 Men-10208,Thr-asp-tyr-trp-val-trp-trp-arg-NH2,Men10208
	Men 10208 is an antagonist of the neurokinin A receptor.
T26334	WWamide-1 H-Trp-lys-glu-met-ser-val-trp-NH2
	WWamide-1 is a neuromodulatory peptide isolated from the ganglia of Afrian giant snail, Achatina fulica.
T83746	RW2 TFA (RW)2-NH2,Arg-Trp-Arg-Trp-NH2
	RW2是一种抗微生物肽，对E. coli和S. aureus均有活性（IC50s分别为730和210 µM）。同时，RW2还能诱导分离的绵羊红细胞发生溶血。
T20481	Antagonist G Arg-trp-N-methyl-phe-trp-leu-met-NH2
	Antagonist G is an anticancer peptide and is also a broad spectrum neuropeptide growth factor antagonist.
T34962	Tryptophyl-leucyl-glutamic acid Trp-leu-glu
	Tryptophyl-leucyl-glutamic acid is a tryptophan used for fluorescence spectroscopy.
T25490	Hemorphin 4 Tyr-pro-trp-thr
	Hemorphin 4 is an endogenous opioid peptide of the hemorphin family which has antinociceptive properties and is derived from the β-chain of hemoglobin in the bloodstream.
T76592	H-Lys-Trp-OH
	H-Lys-Trp-OH (KW) 是一种 ACE 抑制肽，IC50为 7.8 μM。
T29466	5-Oxoprolyltryptophan 5-O-Pro-trp
	5-Oxoprolyltryptophan is a bioactive chemical.
T64881	Z-D-Trp-OH

T26336	WWamide-3 H-Trp-lys-gln-met-ser-val-trp-NH2
	WWamide-3 is a neuromodulatory peptide isolated from the ganglia of African giant snail, Achatina fulica.
T26335	WWamide-2 H-Trp-arg-glu-met-ser-val-trp-NH2
	WWamide-2 is used as a neuromodulatory peptide isolated from the ganglia of African giant snail, Achatina fulica.
T82845	Boc-D-Trp(For)-OH
	Boc-D-Trp(For)-OH 是一种含有色氨酸的化合物，其生产过程涉及以 Boc 保护的 D-丙氨酸进行氨解反应，随后通过与茚三酮环化反应合成为二肽。该化合物展现出多种药理学效应，能够抑制生长激素的释放，并具有诱导睡眠及抗炎的功效。
T31915	Gatratet Carbobenzoxy-trp-met-asp-phe-amide
	Gatratet is a tetrapeptide.
TP1261	Alexamorelin Met 1 (D-Mrp)-Ala-Trp-(D-Phe)
	Alexamorelin Met 1 is one of the metabolites of alexamorelin. The heptapeptide Ala-His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2 (Alexamorelin) is a synthetic molecule which inhibits growth hormone secretagogue binding in vitro.
T33323	Methionyltryptophan Met-trp,Methionyl-tryptophan,Methionyl tryptophan
	Methionyl-Tryptophan is a dipeptide composed of methionine and tryptophan. It is an incomplete breakdown product of protein digestion or protein catabolism.
T30084	Antho-rwamide I Glu-ser-leu-arg-trp-NH2
	Antho-rwamide I is an anthozoan neuropeptide.
T32057	Hemorphin 5 Tyr-pro-trp-thr-gln
	Hemorphin 5 is an opioid peptide obtained from bovine hemoglobin.
T34819	Tetragastrin HCl Trp-Met-Asp-Phe hydrochloride,Tetragastrin hydrochloride
	Tetragastrin HCl is the HCl salt of Tetragastrin, the C-terminal tetrapeptide of gastrin. It has the same physiological and pharmacological activity as gastrin.
T76600	Ac-Trp-Glu-His-Asp-Aldehyde
	Ac-Trp-Glu-His-Asp-Aldehyde 是一种有效的选择性 caspase-1抑制剂，Ki 值为 56 pM。
T40850	[D-Trp11]-Neurotensin [D-Trp11]-Neurotensin
	[D-Trp11]-Neurotensin is a compound that functions as a selective antagonist of Neurotensin (NT) in perfused rat hearts, while exhibiting full agonist properties in guinea pig atria and rat stomach strips. Additionally, this compound can inhibit hypotension induced by NT.
T76606	Ac-Trp-Glu-His-Asp-AMC
	Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) 是caspase-1的有效荧光底物。
T37420	Ac-ANW-AMC Ac-ANW-AMC,Ac-Ala-Asn-Trp-AMC
	Ac-ANW-AMC is a fluorogenic substrate for the β5i/LMP7 subunit of the 20S immunoproteasome. [1] Upon cleavage, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify the activity of the β5i/LMP7 subunit of the 20S immunoproteasome. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. Reference[1]. Winter, M.B., La Greca, F., Arastu-Kapur, S., et al. Immunoproteasome functions explained by divergence in cleavage specificity and regulation. ...
T2298	ML204	TRP/TRPV Channel	Membrane transporter/Ion channel
	ML204 是有效的TRPC4/TRPC5通道选择性抑制剂，相比于 TRPC6 ，对TRPC4/TRPC5通道的选择性高出 19 倍，不影响其他的 TRP 通道和电压门控的钠、钾或 Ca2+通道。
T40042	Evifacotrep	TRP/TRPV Channel	Membrane transporter/Ion channel
	Evfacotrep 是一种有效的短期瞬态受体电位通道5 拮抗剂。Evfacotrep 可用于神经系统疾病的研究。
T33516	Msh (5-10), cyclic Cyclic H-asp-his-phe-arg-trp-lys-NH2
	Msh (5-10), cyclic, as a synthetic peptide, can conjugate with fatty acids for enhanced potency.
T32840	Locustakinin Ala-phe-ser-ser-trp-gly-NH2,Lomk peptide,Locustakinn
	Locustakinin is a myotropic peptide.
TP2477	VV-Hemorphin-7 Val-val-tyr-pro-trp-thr-gln-arg-phe
	VV-Hemorphin-7 is a morphinomimetic peptide.

化合物

Cyclo-L-Trp-L-Trp

Cat.No: T19717

Target: Antifungal

H-Lys-Trp-Lys-OH acetate

Cat.No: T15457L

Synonym: H-Lys-Trp-Lys-OH acetate(38579-27-0 free base)

Target: Antiviral, Antibacterial

His-[D-2-ME-Trp]-Ala

Cat.No: TP1426

Target: Others

pGlu-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val

Cat.No: TP2305

Target: Others

Cat.No: T24903

Synonym: TRP601

N-Valyltryptophan

Cat.No: T20540

Synonym: 二肽-2,Val-trp,L-Valyl-L-tryptophan

Target: Others

Cat.No: T8318

Synonym: H-Ile-Trp-OH,IW-2143

Target: AChR

H-Trp-Trp-Trp-OH

Cat.No: T76626

N-terminally acetylated Endomorphin-1 acetate

Cat.No: TP1251L

Synonym: Ac-L-Tyr-L-Pro-L-Trp-L-Phe-CONH2

Target: Others

Fmoc-D-Trp(Boc)-OH

Cat.No: T39111

Fmoc-Trp(Me)-OH

Cat.No: T19326

Target: Others

H-Lys-Trp-Lys-OH

Cat.No: T15457

Target: Others

Lys-psi(CH2NH)-trp(nps)-ome

Cat.No: T33079

Fmoc-Trp(Boc)-Ser(psi(Me,Me)pro)-OH

Cat.No: T41049

[D-Trp8]-γ-MSH acetate(321351-81-9 free base)

Cat.No: TP1893L1

Target: Melanocortin Receptor

Cat.No: T83748

Synonym: (RW)4-NH2,Arg-Trp-Arg-Trp-Arg-Trp-Arg-Trp-NH2

Cat.No: T76575

Tyrosinase-related Protein 2 (TRP-2) (181-188)

Cat.No: T39311

Fmoc-Trp(Boc)-Thr(psi(Me,Me)pro)-OH

Cat.No: T41080

Cat.No: T7769

Synonym: Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-,九胜肽-1,Melanostatine™ 5

Target: Others

Cat.No: T83747

Synonym: (RW)3-NH2,Arg-Trp-Arg-Trp-Arg-Trp-NH2

Lys-phe-phe-phe-ile-ile-trp-och3

Cat.No: TP2460

Cat.No: T64883

Cat.No: T24447

Synonym: Men-10208,Thr-asp-tyr-trp-val-trp-trp-arg-NH2,Men10208

Cat.No: T26334

Synonym: H-Trp-lys-glu-met-ser-val-trp-NH2

Cat.No: T83746

Synonym: (RW)2-NH2,Arg-Trp-Arg-Trp-NH2

Cat.No: T20481

Synonym: Arg-trp-N-methyl-phe-trp-leu-met-NH2

Tryptophyl-leucyl-glutamic acid

Cat.No: T34962

Synonym: Trp-leu-glu

Cat.No: T25490

Synonym: Tyr-pro-trp-thr

Cat.No: T76592

5-Oxoprolyltryptophan

Cat.No: T29466

Synonym: 5-O-Pro-trp

Cat.No: T64881

Cat.No: T26336

Synonym: H-Trp-lys-gln-met-ser-val-trp-NH2

Cat.No: T26335

Synonym: H-Trp-arg-glu-met-ser-val-trp-NH2

Boc-D-Trp(For)-OH

Cat.No: T82845

Cat.No: T31915

Synonym: Carbobenzoxy-trp-met-asp-phe-amide

Alexamorelin Met 1

Cat.No: TP1261

Synonym: (D-Mrp)-Ala-Trp-(D-Phe)

Methionyltryptophan

Cat.No: T33323

Synonym: Met-trp,Methionyl-tryptophan,Methionyl tryptophan

Antho-rwamide I

Cat.No: T30084

Synonym: Glu-ser-leu-arg-trp-NH2

Cat.No: T32057

Synonym: Tyr-pro-trp-thr-gln

Tetragastrin HCl

Cat.No: T34819

Synonym: Trp-Met-Asp-Phe hydrochloride,Tetragastrin hydrochloride

Ac-Trp-Glu-His-Asp-Aldehyde

Cat.No: T76600

[D-Trp11]-Neurotensin

Cat.No: T40850

Synonym: [D-Trp11]-Neurotensin

Ac-Trp-Glu-His-Asp-AMC

Cat.No: T76606

Cat.No: T37420

Synonym: Ac-ANW-AMC,Ac-Ala-Asn-Trp-AMC

Cat.No: T2298

Target: TRP/TRPV Channel

Cat.No: T40042

Target: TRP/TRPV Channel

Msh (5-10), cyclic

Cat.No: T33516

Synonym: Cyclic H-asp-his-phe-arg-trp-lys-NH2

Cat.No: T32840

Synonym: Ala-phe-ser-ser-trp-gly-NH2,Lomk peptide,Locustakinn

Cat.No: TP2477

Synonym: Val-val-tyr-pro-trp-thr-gln-arg-phe

Cat. No.	Product Name	Target	Signaling Pathways
T4833	Ac-DL-Trp-OH N-乙酰-DL-色氨酸,N-Acetyl-DL-tryptophan	Others; Endogenous Metabolite	Metabolism; Others
	Ac-DL-Trp-OH (N-Acetyl-DL-tryptophan) 是内源性代谢产物的一种。
T4806	H-D-Trp-OH D-Tryptophan,D-色氨酸	Others; Endogenous Metabolite	Metabolism; Others
	H-D-Trp-OH (D-Tryptophan) 是一种色氨酸的 D 型异构体。它偶尔也会在自然界多肽中被发现，如海洋毒肽。
T4866	H-Trp-NH2.HCl L-Tryptophanamide hydrochloride,L-色氨酰胺盐酸盐,(2S)-2-amino-3-(1H-indol-3-yl)propanamide hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	H-Trp-NH2.HCl ((2S)-2-amino-3-(1H-indol-3-yl)propanamide hydrochloride) 是一种内源性代谢产物，已在多种生物体液中检测到，如尿液和血液。
T3208	Brevianamide F Cyclo-L-tryptophyl-L-proline,cyclo-(L-Trp-L-Pro),Cyclo(L-Pro-L-Trp)	BCRP; PI3K; Antibacterial	Membrane transporter/Ion channel; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Brevianamide F (Cyclo(L-Pro-L-Trp)) 是一种从Colletotrichum gloeosporioides 中分离得到的真菌毒素，属于天然存在的 2,5-二酮哌嗪类，具有抗菌活性。它具有PI3Kα抑制活性，IC50值为 4.8 µM。
TN6683	Cyclo(Pro-Trp)
	Cyclo(Pro-Trp) and cyclo(Phe-Pro) show broad spectrum antibacterial properties.
T7203	Oglufanide 奥谷法奈,L-Glutamyl-L-tryptophan,H-Glu-Trp-OH	VEGFR; HCV Protease; Endogenous Metabolite	Angiogenesis; Metabolism; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Oglufanide (H-Glu-Trp-OH) 是一种从小牛胸腺中分离出来的二肽免疫调节剂，可抑制血管内皮生长因子，可刺激细胞内细菌感染和对丙型肝炎病毒的免疫反应。
T65245	H-Phe-Trp-OH
	H-Phe-Trp-OH 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 T65245，CAS号为 24587-41-5。
T7177	Capsazepine	Apoptosis; TRP/TRPV Channel	Apoptosis; Membrane transporter/Ion channel
	Capsazepine 是一种 TRPV1 受体的拮抗剂， IC50值为 562 nM。它可阻断由激活 TRPV1 离子通道的辣椒素引起的热痛感，是辣椒素拮抗剂。
T12514	Podocarpic acid	Others; TRP/TRPV Channel	Membrane transporter/Ion channel; Others
	Podocarpic acid 是一种天然产物，是一种新型 TRPA1 激活剂。
T2807	Caffeic Acid	Lipoxygenase; Endogenous Metabolite; TRP/TRPV Channel	Membrane transporter/Ion channel; Metabolism
	Caffeic acid 是5-脂氧合酶和 TRPV1离子通道的双重抑制剂。
T6S1684	8-Gingerol	Antioxidant; Antibacterial; TRP/TRPV Channel	Membrane transporter/Ion channel; Microbiology/Virology; oxidation-reduction
	8-Gingerol 分离自姜的根状茎，是口服有效的 TRPV1激活剂，EC50值为5.0 µM。8-Gingerol 抑制 COX-2，还能抑制体外 H. pylori 的生长。
TN4417	Larixyl acetate	Others	Others
	Larixyl acetate 是一种生物活性化学物质。
TQ0001	1,4-Cineole Isocineole,1,4-桉叶素	Endogenous Metabolite; TRP/TRPV Channel	Membrane transporter/Ion channel; Metabolism
	1,4-Cineole (Isocineole) 是天然广泛分布的含氧单萜烯，存在于桉树油中，可激活人TRPM8和TRPA1。
T3727	Methyl syringate Syringic Acid Methyl Ester,丁香酸甲酯	TRP/TRPV Channel	Membrane transporter/Ion channel
	Methyl syringate (Syringic Acid Methyl Ester) 是水仙花蜜的化学标记物，是有效的细菌和真菌漆酶酚介质。它也是TRPA1激动剂。
TCS0102	Pulegone 胡薄荷酮,(+)-Pulegone,蒲勒酮，胡薄荷酮，长叶薄荷酮	Calcium Channel; Endogenous Metabolite; TRP/TRPV Channel	Membrane transporter/Ion channel; Metabolism
	Pulegone ((+)-Pulegone) 是 Calamintha nepeta (L.) Savi 的精油的主要化学成分，也是禽类驱虫剂之一。它在禽类物种中驱避作用的分子靶点是伤害感受性 TRP 锚蛋 1。它刺激鸡感觉神经元中的 TRPM8 和 TRPA1 通道，并在高浓度下抑制前者但不抑制后者。
T2952	Camphor 樟脑,(±)-Camphor,Bornan-2-one,2-Camphanone,2-Bornanone,Formosa	Influenza Virus; TRP/TRPV Channel	Membrane transporter/Ion channel; Microbiology/Virology
	Camphor (2-Camphanone) 是一种双环单萜酮，广泛存在于植物中，尤其是樟脑。它是一种激动剂，局部用作皮肤止痒剂和抗感染剂，具有抗病毒，镇咳和抗癌活性。
T1407	(-)-Menthol L-Menthol,Levomenthol,(-)-薄荷醇,薄荷冰,Menthomenthol,Menthacamphor	Opioid Receptor; Endogenous Metabolite; TRP/TRPV Channel	Endocrinology/Hormones; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	(-)-Menthol (Levomenthol) 分离自薄荷油，L-Menthol 是瞬时受体电位 M8 (TRPM8)的激活剂，TRPM8 是 Ca2+-可渗透的非选择性阳离子通道，并增加 [Ca2+]i。L-Menthol 具有抗肿瘤活性。
TN1377	α-Spinasterol Α-波菜甾醇,alpha-Spinasterol,菠甾醇	COX; Antibacterial; TRP/TRPV Channel	Immunology/Inflammation; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	α-Spinasterol 是一种从Spinacia oleracea 分离的瞬时受体电位香草酸 1 拮抗剂，具有抗菌、抗炎、抗抑郁、抗氧化和抗伤害作用。它抑制COX-1和COX-2活性，IC50值分别为 16.17 μM 和 7.76 μM。
T8307	Hydroxy-α-sanshool 羟基-α-山椒素,Hydroxy-α-sanshool	Endogenous Metabolite; TRP/TRPV Channel	Membrane transporter/Ion channel; Metabolism
	Hydroxy-α-sanshool 是分离自胡椒的烷基酰胺，作为 TRPA1的共价激动剂和 TRPV1的非共价激动剂，EC50分别为69和 1.1 µM。
T2845	Imperatorin Ammidin,8-Isoamylenoxypsoralen,欧前胡素,8-Isopentenyloxypsoralene,Marmelosin,Pentosalen	TRP/TRPV Channel; AChR; AChE; NOD	Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; NF-κB
	Imperatorin (8-Isopentenyloxypsoralene) 是NO synthesis 和BChE 的抑制剂，IC50分别为 9.2 μmol 和 31.4 μmol。它也是TRPV1的微弱激动剂，EC50为 12.6±3.2 μM。
TN1465	Cannabigerol	NOS; 5-HT Receptor; ROS	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Cannabigerol 是一种植物大麻素，是一种高亲和力 α2-肾上腺素能受体激动剂、中度亲和力 5-HT1A 受体拮抗剂和低亲和力 CB1/CB2受体拮抗剂。它可降低眼压，有潜力治疗青光眼。
T3865	beta-Eudesmol β-桉叶醇,Beta-Selinenol,beta-桉叶醇	TRP/TRPV Channel; AChR	Membrane transporter/Ion channel; Neuroscience
	beta-Eudesmol (Beta-Selinenol) 是天然的含氧倍半萜烯，可激活hTRPA1，EC50值为 32.5 μM。Beta-Eudesmol 有增加食欲的功效。
T23107	Ononetin 芒柄花酚,2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone	TRP/TRPV Channel	Membrane transporter/Ion channel
	Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) 是天然脱氧安息香素，是有效的TRPM3 通道选择性阻断剂，IC50为 0.3 μM。
T1321	Nonivamide Nonanoic acid vanillylamide,Pelargonic acid vanillylamide,辣椒素,Vanillyl-N-nonylamide,Pseudocapsaicin	TRP/TRPV Channel	Membrane transporter/Ion channel
	Nonivamide (Nonanoic acid vanillylamide) 具有激动活性，在静态毒性检测中，4d-EC50为 5.1 mg/L。
T2994	(E)-Cardamonin Alpinetin chalcone,Cardamomin,小豆蔻明,Cardamonin,(E)-Cardamoni,豆蔻明	Apoptosis; TRP/TRPV Channel	Apoptosis; Membrane transporter/Ion channel
	(E)-Cardamonin (Alpinetin chalcone) 是一种新型hTRPA1阳离子通道拮抗剂，IC50值为454 nM。
T0851	Pregnenolone 3β-Hydroxy-5-pregnen-20-one,Arthenolone,孕烯醇酮	Cannabinoid Receptor; Endogenous Metabolite; TRP/TRPV Channel; AChR; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Pregnenolone (Arthenolone) 是一种由胆固醇合成的内源性类固醇激素，用于治疗阿尔茨海默病。它是大麻素 CB1受体的信号传导特异性抑制剂，抑制由 CB1受体介导的四氢大麻酚的作用。它也是 TRPM3通道激活剂，也可弱激活 TRPM1通道。
T2163	Dihydrocapsaicin CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide	Others; TRP/TRPV Channel	Membrane transporter/Ion channel; Others
	Dihydrocapsaicin (CCRIS1589) 是一种天然来源的辣椒素，是TRPV1的选择性激动剂，同时可以增加 p-Akt 水平。它可以增强低温诱导的神经保护。
T14046	Anandamide 花生四烯酸乙醇胺,(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide	Cannabinoid Receptor; Endogenous Metabolite	GPCR/G Protein; Metabolism
	Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide) 是一种免疫调节剂，通过大麻素受体 CB1 和 CB2 起作用，还通过中枢神经系统中的其他靶点起作用，如 GPR18/GPR55。
TN1839	Kumatakenin Jaranol,华良姜素，熊竹素,Kaempferol 3,7-O-dimethyl ether	Apoptosis; Anti-infection	Apoptosis; Microbiology/Virology
	Kumatakenin 是一种从丁香中分离得到的黄酮类天然产物，可诱导卵巢癌细胞凋亡。
T2S0799	Noroxyhydrastinine	Tyrosinase	Proteases/Proteasome
	Noroxyhydrastinine exhibits potent melanogenesis-inhibitory activities, it inhibits melanogenesis, at least in part, by inhibiting the expression of protein levels of tyrosinase, TRP-1, and TRP-2 in α-MSH-stimulated B16 melanoma cells.
TMA0003	Trans-caffeic acid	cAMP; Tyrosinase	GPCR/G Protein; Proteases/Proteasome
	Trans-caffeic acid stearyl ester is posited to inhibit melanogenesis signaling while suppressing cAMP levels and, subsequently, MC1R, MITF, tyrosinase, TRP-2 and TRP-1 down-regulation, resulting in the suppression of tyrosinase activity, DOPA oxidase activity and melanin synthesis.
TN4179	Haginin A	ERK; Tyrosinase; Akt	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Haginin A is an effective inhibitor of hyperpigmentation caused by UV irradiation or by pigmented skin disorders through downregulation via ERK and Akt/PKB activation, MITF, and also by the subsequent downregulation of tyrosinase and TRP-1 production. Hag
T40368	4-Ethylresorcinol
	4-Ethylresorcinol, a derivative of resorcinol, functions as a tyrosinase substrate, possesses hypopigmentary effects, attenuates mRNA and protein expression of tyrosinase-related protein-2 (TRP-2), and exhibits antioxidative properties through inhibition of lipid peroxidation.

天然产物

Cat.No: T4833

Synonym: N-乙酰-DL-色氨酸,N-Acetyl-DL-tryptophan

Target: Others, Endogenous Metabolite

Cat.No: T4806

Synonym: D-Tryptophan,D-色氨酸

Target: Others, Endogenous Metabolite

H-Trp-NH2.HCl

Cat.No: T4866

Synonym: L-Tryptophanamide hydrochloride,L-色氨酰胺盐酸盐,(2S)-2-amino-3-(1H-indol-3-yl)propanamide hydrochloride

Target: Others, Endogenous Metabolite

Cat.No: T3208

Synonym: Cyclo-L-tryptophyl-L-proline,cyclo-(L-Trp-L-Pro),Cyclo(L-Pro-L-Trp)

Target: BCRP, PI3K, Antibacterial

Cyclo(Pro-Trp)

Cat.No: TN6683

Cat.No: T7203

Synonym: 奥谷法奈,L-Glutamyl-L-tryptophan,H-Glu-Trp-OH

Target: VEGFR, HCV Protease, Endogenous Metabolite

Cat.No: T65245

Cat.No: T7177

Target: Apoptosis, TRP/TRPV Channel

Podocarpic acid

Cat.No: T12514

Target: Others, TRP/TRPV Channel

Cat.No: T2807

Target: Lipoxygenase, Endogenous Metabolite, TRP/TRPV Channel

Cat.No: T6S1684

Target: Antioxidant, Antibacterial, TRP/TRPV Channel

Larixyl acetate

Cat.No: TN4417

Target: Others

Cat.No: TQ0001

Synonym: Isocineole,1,4-桉叶素

Target: Endogenous Metabolite, TRP/TRPV Channel

Methyl syringate

Cat.No: T3727

Synonym: Syringic Acid Methyl Ester,丁香酸甲酯

Target: TRP/TRPV Channel

Cat.No: TCS0102

Synonym: 胡薄荷酮,(+)-Pulegone,蒲勒酮，胡薄荷酮，长叶薄荷酮

Target: Calcium Channel, Endogenous Metabolite, TRP/TRPV Channel

Cat.No: T2952

Synonym: 樟脑,(±)-Camphor,Bornan-2-one,2-Camphanone,2-Bornanone,Formosa

Target: Influenza Virus, TRP/TRPV Channel

Cat.No: T1407

Synonym: L-Menthol,Levomenthol,(-)-薄荷醇,薄荷冰,Menthomenthol,Menthacamphor

Target: Opioid Receptor, Endogenous Metabolite, TRP/TRPV Channel

Cat.No: TN1377

Synonym: Α-波菜甾醇,alpha-Spinasterol,菠甾醇

Target: COX, Antibacterial, TRP/TRPV Channel

Hydroxy-α-sanshool

Cat.No: T8307

Synonym: 羟基-α-山椒素,Hydroxy-α-sanshool

Target: Endogenous Metabolite, TRP/TRPV Channel

Cat.No: T2845

Synonym: Ammidin,8-Isoamylenoxypsoralen,欧前胡素,8-Isopentenyloxypsoralene,Marmelosin,Pentosalen

Target: TRP/TRPV Channel, AChR, AChE, NOD

Cat.No: TN1465

Target: NOS, 5-HT Receptor, ROS

Cat.No: T3865

Synonym: β-桉叶醇,Beta-Selinenol,beta-桉叶醇

Target: TRP/TRPV Channel, AChR

Cat.No: T23107

Synonym: 芒柄花酚,2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone

Target: TRP/TRPV Channel

Cat.No: T1321

Synonym: Nonanoic acid vanillylamide,Pelargonic acid vanillylamide,辣椒素,Vanillyl-N-nonylamide,Pseudocapsaicin

Target: TRP/TRPV Channel

Cat.No: T2994

Synonym: Alpinetin chalcone,Cardamomin,小豆蔻明,Cardamonin,(E)-Cardamoni,豆蔻明

Target: Apoptosis, TRP/TRPV Channel

Cat.No: T0851

Synonym: 3β-Hydroxy-5-pregnen-20-one,Arthenolone,孕烯醇酮

Target: Cannabinoid Receptor, Endogenous Metabolite, TRP/TRPV Channel, AChR, Autophagy

Dihydrocapsaicin

Cat.No: T2163

Synonym: CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide

Target: Others, TRP/TRPV Channel

Cat.No: T14046

Synonym: 花生四烯酸乙醇胺,(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide

Target: Cannabinoid Receptor, Endogenous Metabolite

Cat.No: TN1839

Synonym: Jaranol,华良姜素，熊竹素,Kaempferol 3,7-O-dimethyl ether

Target: Apoptosis, Anti-infection

Noroxyhydrastinine

Cat.No: T2S0799

Target: Tyrosinase

Trans-caffeic acid

Cat.No: TMA0003

Target: cAMP, Tyrosinase

Cat.No: TN4179

Target: ERK, Tyrosinase, Akt

4-Ethylresorcinol

Cat.No: T40368

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