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39

抑制剂 & 化合物

36

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T17144	TPA 023	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	TPA 023 是 GABAA α2/α3 亚型的特异性激动剂 (Ki = 0.19 - 0.41 nM)。
T41352	4α-TPA

T13192	TPA-023B	Others	Others
	TPA-023B is an orally active and high-affinity agonist of the GABAA receptor α2/α3 subtype (Kis: 0.73 nM/2 nM) partial and an antagonist α1 subtype (Ki: 1.8 nM), has non-sedating anxiolytic-like properties.
T67967	EOB-DTPA N-((2s)-2-(bis(carboxymethyl)amino)-3-(4-ethoxyphenyl)propyl)-n-(2-(bis(carboxymethyl)amino)ethyl)glycine	Others	Others
	EOB-DTPA 是一种生化试剂，可由其他化合物合成，常用于核磁共振成像。
T12692	RAS GTPase inhibitor 1	Raf	MAPK
	RAS GTPase inhibitor 1 是一种 RAS GTPase 抑制剂，具有潜在的抗肿瘤活性。
T83967	ATPase-IN-3	ATPase	Membrane transporter/Ion channel
	ATPase-IN-3 是一种 ATP 酶 (ATPase) 抑制剂，可用于研究与代谢相关的疾病。
T9882	RUVBL1/2 ATPase-IN-1	Others	Others
	RUVBL1/2 ATPase-IN-1 是一种有效的 RUVBL1/2 ATPase 抑制剂，IC50 值分别为 6.0 和 7.7 μM。 RUVBL1/2 ATPase-IN-1 可用于癌症疾病的研究。
TP2287	Rac GTPase fragment	Others	Others
	Rac GTPase fragment is a peptide with the sequence H2N-Val-Phe-Asp-Glu-Ala-Ile-Arg-Ala-Val-OH, MW= 1019.15. Rac is a subfamily of the Rho family of GTPases, small signaling G proteins (more specifically a GTPase).
T78239	Mergetpa	Carboxypeptidase	Proteases/Proteasome
	Mergetpa作为一种羧肽酶抑制剂，其功能是阻碍激肽及B2受体拮抗剂转变成无c末端精氨酸的代谢物。
T19270	DTPA-DAB2	Others	Others
	DAB2-DTPA is a conjugate of DTPA and two DABs used in the photooxidation experiment.
T81252	RTQLLWTPAAPTAMA TFA
	RTQLLWTPAAPTAMA TFA为肽类抗原，用于免疫应答中的药物传递。
T73237	gTPA2-OMe
	gTPA2-OMe 是潜在的钙钛矿型太阳能电池（PSC）空穴传输层候选材料。
T61553	ATPase-IN-2
	ATPase-IN-2 is a compound that acts as an inhibitor of ATPase, with an IC50 value of 0.9 μM. It also inhibits the glycohydrolase activity of C. difficile toxin B (TcdB) with an AC50 value of 30.91 μM. ATPase-IN-2 is commonly utilized in ATP-related research [1].
TNU0612	S-2-(4-Aminobenzyl)-diethylenetriamine pentaacetic acid TFA salt, p-NH2-Bn-DTPA-TFA
	Super-chelating agent & MRI contrast agent
T82561	di-DTPA TL
	di-DTPA TL，作为一种亲水性的二价DTPA衍生物，主要用于肿瘤学研究中作为半抗原。
T27350	Fosmetpantotenate RE-024,RE024,RE 024
	Fosmetpantotenate, a immunomodulator, is used for treatment of Pantothenate Kinase Associated Neurodegeneration (PKAN).
T10405	ATPA	Others	Others
	ATPA is a selective glutamate receptor GluR5 activator (EC50s: 0.66, 1.4, 9.5, 23, 32, 18, and 14 μM for GluR5wt, GluR5(S721T), GluR5(S741M), GluR5(S721T, S741M), GluR5(S741A), GluR5(S741L), and GluR5(S741V)).
T81433	p-NH2-CHX-A"-DTPA
	p-NH2-CHX-A"-DTPA 是双功能螯合剂。
T7604	Valrubicin Valstar,AD-32,戊柔比星	Antibiotic; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology
	Valrubicin (AD-32) 是一种具有抗炎和抗肿瘤作用的化疗剂，能够抑制 TPA 和 PDBu 诱导的 PKC 活化，IC50值分别为 0.85 和 1.25 μM。
T13408	ZK824190	Others; Serine Protease	Others; Proteases/Proteasome
	ZK824190 是具有口服活性尿激酶型纤溶酶原激活剂 (uPA) 选择性抑制剂，对 uPA，tPA 和 Plasmin 的IC50分别为 237，1600 和 1850 nM。ZK824190在多发性硬化症中有研究价值。
T3560	Desmethylanethol trithione ADT-OH	VEGFR; Akt	Angiogenesis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Desmethylanethol trithione (ADT-OH) 是合成硫化氢的供体。它利用上调 FADD 诱导细胞凋亡，并对体内黑色素瘤的形成具有一定的抑制作用，可用于研究癌症疾病。
T22831	Protein kinase inhibitor H-7 dihydrochloride H-7 dihydrochloride	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	Protein kinase inhibitor H-7 dihydrochloride(H-7 dihydrochloride0) 是一种有效的蛋白激酶 C（PKC）抑制剂。Protein kinase inhibitor H-7 dihydrochloride（100 μM）显著抑制 TPA (皮肤肿瘤启动子，12-O-tetradecanoylphorbol-13-acetate) 和磷脂酶 C 促使的 ODC (鸟氨酸脱羧酶)，抑制 PMA 诱导的混杂细胞溶解活性。
T13409L	ZK824859 hydrochloride (2271122-53-1 free base) ZK824859 hydrochloride	Others	Others
	ZK824859 hydrochloride is an oral available and selective inhibitor of urokinase plasminogen activator (uPA)(IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively).
T13409	ZK824859	Others	Others
	ZK824859 is an oral available and selective inhibitor of urokinase plasminogen activator (uPA)(IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively).
T39029	APC-6860
	APC-6860 is a trypsin-like serine proteases inhibitor with k i values of 0.21, 0.44, 1.5, 16.8, 20, 30 μM for uPA, trypsin, tryptase, tPA, thrombin and factor Xa, respectively. APC-6860 has a selectivity ratio for tPA versus uPA of 80. APC-6860 has k i values of 0.1, 0.082 μM for human and murine urokinases, respectively. APC-6860 can be used for the research of cancer.
T70810	THR-18
	THR-18 is an 18-mer peptide derived from the sequence of human plasminogen activator inhibitor 1 (PAI-1), having the ability to bind to a site of tissue plasminogen activator (tPA) distal to its catalytic site and uncouple the beneficial clot-dissolving properties of tPA from its deleterious non-fibrinolytic effects.
T22451	UK-371804 HCl	Serine Protease	Proteases/Proteasome
	UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (2700-fold versus plasmin and 4000-fold versus tPA).
T35434	β-Cembrenediol
	β-Cembrenediol (β-CBT) is a natural product from tobacco plants that is found in cigarette smoke condensate. β-CBT inhibits induction of the early antigen of Epstein-Barr virus (EA-EBV) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in vitro (IC50 = 21.9 μM). It inhibits tumor promoting effects of TPA on 7,12-demethylbenz[a]anthracene-induced papilloma formation in vivo. β-CBT is also released into soil by flue-cured tobacco plants and exerts autotoxicity as well as phytotoxic activity against L....
TP2482	LCKLSL acetate LCKLSL acetate(533902-29-3 free base)	Annexin A	GPCR/G Protein
	LCKLSL acetate 是一种竞争性膜联蛋白 A2 (AnxA2) 抑制剂。 LCKLSL acetate 有效抑制组织纤溶酶原激活剂 (tPA) 与 AnxA2 的结合和纤溶酶的产生。 LCKLSL acetate 具有抗血管生成作用。
T62961	ZK824859 hydrochloride
	ZK824859 hydrochloride 是一种选择性的、口服具有活力的尿激酶型纤溶酶原激活剂 (uPA) 抑制剂。ZK824859 hydrochloride 对人 uPA，tPA 和纤溶酶的 IC50 值分别为 79 nM，1580 nM 和 1330 nM。
T71126	Allixin
	Allixin is a phytoallexin found in garlic (Allium sativum) bulbs. Allixin has weak antimicrobial activity and exerts an anti-promoting activity against skin tumors induced by the chemical 12-O-tetradecanoylphorbol-13-acetate (TPA). Allixin also demonstrates an inhibitory effect on aflatoxin B1-induced mutagenesis.
T77221	Benzenecarboximidamide, hydrochloride, hydrate (1:1:x)
	Benzenecarboximidamide, hydrochloride, hydrate (1:1:x) (Benzamidine hydrochloride hydrate) 是一种可逆的竞争性胰蛋白酶样丝氨酸蛋白酶 (trypsin-like serine proteases) 抑制剂，对 Tryptase、Trypsin、uPA、Factor Xa、Thrombin 和 tPA 的Ki 值分别为 20、21、97、110、320 和 750 μM。
T62731	ZK824190 hydrochloride
	ZK824190 hydrochloride 是一种选择性的、口服具有活力的尿激酶型纤溶酶原激活剂 (uPA) 抑制剂，能够作用于 uPA (IC50: 237 nM)、tPA (IC50: 1600 nM) 和 Plasmin (IC50: 1850 nM)。ZK824190 hydrochloride 能够用于研究多发性硬化症的研究
T78015	LCKLSL hydrochloride
	LCKLSL hydrochloride为N端六肽，作为膜联蛋白A2（AnxA2）的竞争性抑制剂，有效阻止组织纤溶酶原激活物（tPA）与AnxA2结合。此化合物还能够抑制纤溶酶生成，并表现出抗血管生成活性。
T40614	LCKLSL
	LCKLSL, an N-terminal hexapeptide, acts as a competitive inhibitor of annexin A2 (AnxA2), effectively preventing the binding of tissue plasminogen activator (tPA) to AnxA2 while also inhibiting the generation of plasmin. In addition, LCKLSL exhibits anti-angiogenic properties.
T41085	UK122 UK122
	UK122 is a highly effective and specific inhibitor of urokinase-type plasminogen activator (uPA) with an IC50 value of 0.2 μM. It displays negligible to minimal inhibition towards tissue-type plasminogen activator (tPA), plasmin, thrombin, and trypsin (all IC50 >100 μM). Functioning as a 4-oxazolidinone analogue, UK122 is an anticancer agent that effectively inhibits cancer cell migration and invasion.
T78018	Plasminogen
	Plasminogen是一种可由尿激酶血浆蛋白原激活剂(uPA)或组织血浆蛋白原激活剂(tPA)裂解激活的分泌性蛋白，生成血浆蛋白，该酶可以广泛裂解纤维蛋白及其他ECM成分。作为促炎调节剂，Plasminogen能促进急性及糖尿病相关伤口愈合。该蛋白在伤口愈合、炎症和低纤溶酶原血症的研究中有重要应用。
T69244	Betulonaldehyde
	Betulonaldehyde is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin that has been found in Betula. It is active against P. falciparum (IC50 = 3.36 µg/ml) and cytotoxic to NCI H187 lung cancer cells and non-cancerous Vero cells (IC50s = 19.23 and 17.09 µg/ml, respectively). Topical application of betulonaldehyde (1 mg/ear) reduces ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice. It has also been used a precursor in t...
T37556	CAY10502
	Phospholipase A2 (PLA2) catalyzes the hydrolysis of phospholipids at the sn-2 position leading to the production of lysophospholipids and free fatty acids. Calcium-dependent cytosolic PLA2 (cPLA2α) is a 85 kDa enzyme that plays a key role in the arachidonic cascade and the inflammatory response associated with this metabolic pathway. CAY10502 is a potent inhibitor of calcium-dependent cytosolic PLA2α (cPLA2α) with an IC50 value of 4.3 nM for the purified enzyme from human platelets. It inhibits ...

化合物

Cat.No: T17144

Target: GABA Receptor

Cat.No: T41352

Cat.No: T13192

Target: Others

Cat.No: T67967

Synonym: N-((2s)-2-(bis(carboxymethyl)amino)-3-(4-ethoxyphenyl)propyl)-n-(2-(bis(carboxymethyl)amino)ethyl)glycine

Target: Others

RAS GTPase inhibitor 1

Cat.No: T12692

Target: Raf

Cat.No: T83967

Target: ATPase

RUVBL1/2 ATPase-IN-1

Cat.No: T9882

Target: Others

Rac GTPase fragment

Cat.No: TP2287

Target: Others

Cat.No: T78239

Target: Carboxypeptidase

Cat.No: T19270

Target: Others

RTQLLWTPAAPTAMA TFA

Cat.No: T81252

Cat.No: T73237

Cat.No: T61553

S-2-(4-Aminobenzyl)-diethylenetriamine pentaacetic acid TFA salt, p-NH2-Bn-DTPA-TFA

Cat.No: TNU0612

Cat.No: T82561

Fosmetpantotenate

Cat.No: T27350

Synonym: RE-024,RE024,RE 024

Cat.No: T10405

Target: Others

p-NH2-CHX-A"-DTPA

Cat.No: T81433

Cat.No: T7604

Synonym: Valstar,AD-32,戊柔比星

Target: Antibiotic, PKC

Cat.No: T13408

Target: Others, Serine Protease

Desmethylanethol trithione

Cat.No: T3560

Synonym: ADT-OH

Target: VEGFR, Akt

Protein kinase inhibitor H-7 dihydrochloride

Cat.No: T22831

Synonym: H-7 dihydrochloride

Target: PKC

ZK824859 hydrochloride (2271122-53-1 free base)

Cat.No: T13409L

Synonym: ZK824859 hydrochloride

Target: Others

Cat.No: T13409

Target: Others

Cat.No: T39029

Cat.No: T70810

Cat.No: T22451

Target: Serine Protease

β-Cembrenediol

Cat.No: T35434

Cat.No: TP2482

Synonym: LCKLSL acetate(533902-29-3 free base)

Target: Annexin A

ZK824859 hydrochloride

Cat.No: T62961

Cat.No: T71126

Benzenecarboximidamide, hydrochloride, hydrate (1:1:x)

Cat.No: T77221

ZK824190 hydrochloride

Cat.No: T62731

LCKLSL hydrochloride

Cat.No: T78015

Cat.No: T40614

Cat.No: T41085

Synonym: UK122

Cat.No: T78018

Betulonaldehyde

Cat.No: T69244

Cat.No: T37556

Cat. No.	Product Name	Target	Signaling Pathways
TN1025	3,29-O-Dibenzoyloxykarounidiol	Others	Others
	3,29-O-Dibenzoyloxykarounidiol 是一种苯甲酸三萜烯酯，从 Momordica grosvenori 果实中提取。它能够抑制肿瘤启动子 TPA 诱导的 EB 病毒早期抗原活化。
TQ0198	Phorbol 12-myristate 13-acetate 佛波醇12-十四酸酯13-乙酸酯,PMA	NF-κB; S1P Receptor; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; GPCR/G Protein; NF-κB
	Phorbol 12-myristate 13-acetate (PMA) 属于佛波酯类天然产物，是一种 PKC、SphK、NF-κB 的激活剂。Phorbol 12-myristate 13-acetate 可诱导 THP1 细胞分化。
TN1031	Poricoic acid B 茯苓酸B,茯苓新酸 B	Others	Others
	Poricoic acid B 是提取自 Poria cocos 中，拥有抗肿瘤作用。
TN1111	Arnidiol	Immunology/Inflammation related	Immunology/Inflammation
	Arnidiol 是一种五环三萜烯，从Barleria Longiflora LinnF. 中提取得到。
T2S1086	Nepitrin 假荆芥属苷,Nepetin-7-glucoside	Antioxidant	oxidation-reduction
	Nepitrin (Nepetin-7-glucoside) 分离自Scrophularia striata 中，具有强大的抗炎、抗关节炎作用。
T5603	Phthalic acid 邻苯二甲酸,1,2-Benzenedioic acid	Others	Others
	Phthalic acid (1,2-Benzenedioic acid) 是一种邻苯二甲酸酯 (PAE) 的最终常见代谢形式。它可用于合成试剂，如间苯二甲酸 (IPA) 和对苯二甲酸 (TPA)。它广泛的用于邻苯二甲酸酯增塑剂的制备。
T3889	Platycodin D	Prostaglandin Receptor; AMPK	Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; PI3K/Akt/mTOR signaling
	Platycodin D 是从桔梗中分离得到的一种皂苷类天然产物，是AMPKα的激活剂，具有抗肥胖活性。它可刺激 TNF-α 合成或抑制 TNF-α mRNA 的降解。
TN2500	1,5,15-Tri-O-methylmorindol	Others	Others
	1,5,15-Tri-O-methylmorindol has effects against the Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA.
TN5852	Oleuropeic acid
	(+)-Oleuropeic acid shows potent in vitro antitumor-promoting activity, it also suppresses an in vivo two-stage carcinogenesis induced with nitric oxide and 12-O-tetradecanoyl phorbol 13-acetate (TPA) on mouse skin.
T75567	Cabenoside D
	Cabenoside D（化合物 8）是从苔藓根的甲醇提取物中分离的一种三萜苷，显示出对12-O-十四烷酰基激素-13-乙酸酯（TPA）诱导的小鼠炎症的抗炎活性，并能抑制TPA促使的Epstein-Barr病毒（EBV）早期抗原（EBV-EA）激活。
TN5285	Stigmast-4-ene-3β,6β-diol
	Stigmast-4-ene-3beta,6beta-diol possesses marked inhibitory activity against 12-O- -tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice.
TN5920	Octacosyl (E)-ferulate
	Octacosyl ferulate inhibits the phosphorylation of histon III-S by PK-C in a concentration dependent manner. It markedly inhibits the inflammatory activity induced by TPA in mice.
TN5681	Cypellocarpin C Camaldulenside,桉叶苷
	Cypellocarpin C shows potent in vitro antitumor-promoting activity, it also can suppress an in vivo two-stage carcinogenesis induced with nitric oxide and TPA on mouse skin.
TN4421	Latisxanthone C	Others	Others
	Latisxanthone C shows inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, it may be a valuable antitumor promoter.
TN3321	9-Methoxy-alpha-lapachone	Others	Others
	9-Methoxy-alpha-lapachone has antitumor-promoting effect, it exhibits significant inhibitory activity against 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced Epstein- Barr virus early antigen (EBV-EA) activation in Raji cells.
TN2047	Pendulone	Antifection	Microbiology/Virology
	Pendulone could be a valuable chemopreventive agent, it shows strong inhibition on the effect of the cell cycle induced by TPA and shows potent anti-tumor-promoting activity for an in vivo two-stage carcinogenesis test.
TN3426	Anwuweizonic acid	Others	Others
	Anwuweizonic acid may have inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. Mixture of coccinic acid and anwuweizonic acid has antifertility activity, shows significant inhibitory activity against human decidu
TN4140	Glochidiol	Others	Others
	Glochidiol exhibits strong inhibitory effects against all three human tumor cell lines (MCF-7, NCI-H-460 and SF-268), it exerts its antiproliferative activity through the involvement of apoptosis. It exhibits a strong inhibitory effect on mouse skin tumor
TN4381	Karounidiol	Others	Others
	Karounidiol exhibits cytotoxicity especially against a human renal cancer, it markedly suppresses the promoting effect of TPA (1 microgram/mouse) on skin tumor formation in mice following initiation with 7,12-dimethylbenz[a]anthracene (50 micrograms/mouse
TN4582	Moracin T	c-Myc; COX	Cell Cycle/Checkpoint; Immunology/Inflammation; Neuroscience
	Moracin treatment can inhibit the double 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment-induced morphological changes reflecting inflammatory response, including leucocyte infiltration, hyperplasia and cell proliferation; moracin treatment furthermo
T10042	11-Oxomogroside IIa	Others	Others
	11-Oxomogroside IIa is a cucurbitane glycoside extracted from the fruits of Siraitia grosVenorii. It has inhibitory effects against the EBV-EA activation induced by TPA, shows weak inhibitory effects on activation of NOR 1, a nitric oxide (NO) donor.
TN5068	Stigmastane-3,6-diol	Others	Others
	Stigmastane-3 beta, 6 alpha-diol and stigmastane-3 beta, 6 beta-diol possess marked inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, the 50% inhibitory dose is 0.5--1.0 mg/ear.
TN2839	2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid has anti-HIV activity. It shows an inhibitory effect on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and causes a significant delay o
TN4380	Karavilagenin D	Others	Others
	Karavilagenin D exhibits inhibitory effects on skin-tumor promotion in an in vivo two-stage mouse skin carcinogenesis test based on 7,12-dimethylbenz[a]anthracene (DMBA) as initiator, and with TPA as a promoter. It exhibits inhibition effect against human
TN4185	Hautriwaic acid
	Hautriwaic acid shows anti-inflammatory activity in 12-O-tetradecanoylphorbol 13-acetate (TPA) mice ear edema models, it diminishes the joint edema induced by this mixture of polysaccharides (carrageenan), possibly by acting as immunomodulator of the infl
TN1935	Mogroside III A2 Mogroside III-A2,罗汉果苷IIIA2,罗汉果苷 III A2	Others	Others
	Mogroside III-A2 exhibits inhibitory effects with IC50 values of 346-400 mol ratio/32 pmol TPA. and shows weak inhibitory effects on activation of (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor.
TN3019	4,9-Dihydroxy-alpha-lapachone	Others	Others
	4,9-Dihydroxy-alpha-lapachone has antitumor-promoting effects, it exhibits significant inhibitory activity against 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced Epstein-Barr virus early antigen (EBV-EA) activation in Raji cells. 4,9-Dihydroxy-alpha-l
TN5578	Abieta-8,11,13-triene-7,15,18-triol
	Abieta-8,11,13-triene-7alpha,15,18-triol,7alpha,8alpha,13beta,14beta-diepoxyabietan-18-oic acid, and 18-nor-abieta-8,11,13-triene-4alpha,7alpha,15-triol may have inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tum
TN4652	Niazimicin	NF-κB; PI3K; AChR; Antifection	Microbiology/Virology; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling
	Niazimicin are NF-B and PI3K inhibitors, which shows antimicrobial, hypotensive and spasmolytic activities. Niazimicin has potent antitumor promoting activity in the two-stage carcinogenesis in mouse skin using 7,12-dimethylbenz(a)anthracene (DMBA) as ini
T75566	11-Oxomogroside II A1
	11-Oxomogroside II A1（化合物 7）是一种从罗汉果乙醇提取物中分离的氧化葫芦苷，对12-O-十四烷酰基激素-13-乙酸酯（TPA）诱导的Epstein-Barr病毒（EBV）早期抗原（EBV-EA）活化具有抑制效果，并对一氧化氮（NO）供体（+/-）-(E)-甲基-2-[(E)羟基亚氨基]-5-硝基-6-甲氧基-3-己酰胺（NOR 1）的活化也展示出轻微的抑制作用。
TN4241	Hyptadienic acid
	Hyptadienic acid exhibits moderate cytotoxicity against HepG2 cells.It also shows a marked anti-inflammatory effect, it also exhibits strong antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz
TN3573	Camaric acid	Antifection	Microbiology/Virology
	Camaric acid shows antibacterial activity against Staphylococcus aureus and methicillin resistant S. aureus with IC50 values 8.74 and 8.09 uM, respectively, it also shows moderate antileishmanial activity and highly potent antitrypanosomal activity. Camar
TN3607	Catalpalactone	cAMP	GPCR/G Protein
	Catalpalactone exhibits high antitermitic, and cytotoxic activities, it exhibits potent inhibitory effects on lipopolysaccharide-induced NO synthesis in RAW 264.7 cells , with IC50 values of 9.80 microM. Catalpalactone can inhibit dopamine biosynthesis by
TN4277	Isocupressic acid	cAMP; P450; PKA	GPCR/G Protein; Metabolism; Tyrosine Kinase/Adaptors
	Isocupressic acid induces abortion in pregnant cows when ingested primarily during the last trimester, it decrease affects the angiogenesis of the female reproductive system, the decrease in blood flow and apoptosis of corpus luteum-derived endothelial ce
T35741	Gliovirin
	Gliovirin is a fungal metabolite that has been found inT. harzianumand has fungicidal, antimicrobial and anti-inflammatory activities.1It is active against the plant pathogenic fungusP. ultimum(MIC = 60 ng/ml) and the parasiteT. brucei brucei(IC50= 90 ng/ml), but has no effect on the plant pathogenic fungiR. solani,P. omnivorum,T. basicola,R. arrhizus, andV. dahliaeor the bacteriaB. thuringiensis,P. fluorescens, andX. malvacearumwhen used at concentrations up to 1,000 ng/ml.2,3Gliovirin decrease...
TN2977	3-O-trans-p-Coumaroyltormentic acid	Caspase; Antifection	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	3-O-(E)-p-coumaroyl tormentic acid may be promising lead compound for developing an effective drug for treatment of leukemia, it induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition. 3-O-trans-p-coumaroyltormentic acid shows cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) in vitro, the IC50 values of 13.72, 14.29,14.61, 14.04 uM, respectively. 3beta-O-cis-p-Coumaroyltormentic acid, an...

天然产物

3,29-O-Dibenzoyloxykarounidiol

Cat.No: TN1025

Target: Others

Phorbol 12-myristate 13-acetate

Cat.No: TQ0198

Synonym: 佛波醇12-十四酸酯13-乙酸酯,PMA

Target: NF-κB, S1P Receptor, PKC

Poricoic acid B

Cat.No: TN1031

Synonym: 茯苓酸B,茯苓新酸 B

Target: Others

Cat.No: TN1111

Target: Immunology/Inflammation related

Cat.No: T2S1086

Synonym: 假荆芥属苷,Nepetin-7-glucoside

Target: Antioxidant

Cat.No: T5603

Synonym: 邻苯二甲酸,1,2-Benzenedioic acid

Target: Others

Cat.No: T3889

Target: Prostaglandin Receptor, AMPK

1,5,15-Tri-O-methylmorindol

Cat.No: TN2500

Target: Others

Oleuropeic acid

Cat.No: TN5852

Cat.No: T75567

Stigmast-4-ene-3β,6β-diol

Cat.No: TN5285

Octacosyl (E)-ferulate

Cat.No: TN5920

Cypellocarpin C

Cat.No: TN5681

Synonym: Camaldulenside,桉叶苷

Latisxanthone C

Cat.No: TN4421

Target: Others

9-Methoxy-alpha-lapachone

Cat.No: TN3321

Target: Others

Cat.No: TN2047

Target: Antifection

Anwuweizonic acid

Cat.No: TN3426

Target: Others

Cat.No: TN4140

Target: Others

Cat.No: TN4381

Target: Others

Cat.No: TN4582

Target: c-Myc, COX

11-Oxomogroside IIa

Cat.No: T10042

Target: Others

Stigmastane-3,6-diol

Cat.No: TN5068

Target: Others

2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid

Cat.No: TN2839

Target: HIV Protease

Karavilagenin D

Cat.No: TN4380

Target: Others

Hautriwaic acid

Cat.No: TN4185

Mogroside III A2

Cat.No: TN1935

Synonym: Mogroside III-A2,罗汉果苷IIIA2,罗汉果苷 III A2

Target: Others

4,9-Dihydroxy-alpha-lapachone

Cat.No: TN3019

Target: Others

Abieta-8,11,13-triene-7,15,18-triol

Cat.No: TN5578

Cat.No: TN4652

Target: NF-κB, PI3K, AChR, Antifection

11-Oxomogroside II A1

Cat.No: T75566

Hyptadienic acid

Cat.No: TN4241

Cat.No: TN3573

Target: Antifection

Cat.No: TN3607

Target: cAMP

Isocupressic acid

Cat.No: TN4277

Target: cAMP, P450, PKA

Cat.No: T35741

3-O-trans-p-Coumaroyltormentic acid

Cat.No: TN2977

Target: Caspase, Antifection

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