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Search Results for " t-lymphocytes "

47

抑制剂 & 化合物

6

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Cat. No.	Product Name	Target	Signaling Pathways
T10765	Eragidomide CC-90009,Cereblon modulator 1	Apoptosis; Ligand for E3 Ligase; Molecular Glues	Apoptosis; PROTAC
	Eragidomide (CC-90009; Cereblon modulator 1) 是一种 GSPT1 选择性 cereblon (CRBN)E3 连接酶调节剂，以分子胶的方式作用。Eragidomide 通过 CRL4CRBN 选择性靶向 GSPT1 进行泛素化和蛋白酶体降解。
T25705	Imupedone LF1695,LF-1695,LF 1695	Others	Others
	Imupedone (LF 1695) 是一种合成免疫调节剂，可调节 T 淋巴细胞和巨噬细胞，诱导骨髓前体细胞的 T 细胞分化，增加淋巴细胞对有丝分裂原、抗原和同种异体细胞的增殖反应。
T10565	BMS-1001 hydrochloride	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	BMS-1001 hydrochloride 是一种人 PD-L1/PD-1免疫检查点的抑制剂，具有口服活性且细胞毒性低。
TP1758L	LCMV gp33-41 acetate LCMV gp33-41 acetate（151705-84-9 Free base）	Others	Others
	LCMV gp33-41 acetate 是淋巴细胞性脉络丛脑膜炎病毒的序列，受主要组织相容性复合体 I 类 H-2Db 限制，呈递给细胞毒性 T 淋巴细胞。
T6964	Resiquimod R848,雷西莫特,S28463	HCV Protease; TLR	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Resiquimod (R848) 是一种 Toll 样受体7/8的激动剂，可诱导细胞因子上调。
TP1527	CEF8, Influenza Virus NP (383-391) CEF8, Influenza Virus NP 383-391	Others	Others
	CEF8, Influenza Virus NP (383-391) 是一种甲型流感病毒核蛋白，含有 383-391 残基，是甲型流感病毒核蛋白中重要的 HLA-B*2705 限制性表位，与细胞毒性 T 淋巴细胞介导的免疫逃逸有关。
T7739	L-Leucyl-L-Leucine methyl ester hydrochloride Leu-Leu-ome hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	L-Leucyl-L-Leucine methyl ester hydrochloride (Leu-Leu-ome hydrochloride) 是一种人单核细胞或多形核白细胞产生的 L-亮氨酸甲酯的二肽缩合产物，能够选择性消除具有细胞毒性潜能的淋巴细胞，也能够诱导溶酶体途径应激。
TP1543L	G280-9 acetate(156761-76-1 free base)	Others	Others
	G280-9 acetate(156761-76-1 free base) 是一种常见的黑色素瘤 gp100 表位，受 MHC 相关 HLA-A2 限制。 G280-9 序列是独特的，因为它可以在非常低的浓度下被细胞毒性 T 淋巴细胞识别，但是它显示出低的总免疫原性，这可能是由于该肽对 HLA-A2 的亲和力相对较低。
T9919	Alemtuzumab	Others	Others
	Alemtuzumab 是人源化抗 CD52单克隆抗体， CD52是一种表达于大多数淋巴细胞以及少数的髓细胞类型的糖蛋白。Alemtuzumab 与能够特异性作用于 CD52 抗原，诱导淋巴细胞深度耗竭，恢复具有调节表型的 T 细胞和 B 细胞。
T7055	Bz-RS-ISer(3-Ph)-Ome Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Bz-RS-ISer(3-Ph)-Ome (Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate) 是紫杉醇衍生物，在低细胞毒性下抑制 HSV 复制周期，阻断 Vero 细胞的有丝分裂，影响 M-MSV 诱导的肿瘤大小，并通过抑制 PHA 诱导的 T 淋巴细胞增殖而影响免疫应答。
T16132	MRE3008F20	cAMP; Adenosine Receptor	GPCR/G Protein; Neuroscience
	MRE3008F20 是一种具有种属选择性和高效性的腺苷 A3 受体（AA3R）拮抗剂，抑制 Cl-IB-MECA 诱导的 cAMP 的产生，可用于研究青光眼和哮喘。
T2548	Diflorasone	Glucocorticoid Receptor	Endocrinology/Hormones
	Diflorasone 是一种皮质类固醇激素受体激动剂，具有抗炎和免疫抑制作用。它可通过细胞膜扩散进入细胞，并与细胞质中的糖皮质激素受体结合。它用于研究湿疹、牛皮癣等皮肤病。
T28408	Phosphostim Sodium IPH1101,Phosphostim,IPH 1101,IPH-1101
	Phosphostim, a gamma9deta2 T lymphocytes agonist, is used potentially for the treatment of renal cell carcinoma, HCV infection.
T70307	POM2-C-HMBP
	POM2-C-HMBP is a potent Activator of Vγ9Vδ2 T-Lymphocytes. It is also an HMBPP ananlog prodrug.
T30136	Armepavine hydrochloride, (+/-)- DL-Armepavine hydrochloride
	Armepavine hydrochloride, (+/-)- is a compound which has been shown to exert immunosuppressive effects on T lymphocytes and on lupus nephritic mice.
T69723	Taminadenant mesylate
	Taminadenant, also known as PBF-509 and NIR-178, is a potent and orally active adenosine A2A receptor antagonist with potential antineoplastic activity. PBF-509 selectively binds to and inhibits A2AR expressed on T lymphocytes. This abrogates the adenosine/A2AR-mediated inhibition of T-lymphocytes and activates a T-cell-mediated immune response against tumor cells, thereby reducing proliferation of susceptible tumor cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell sur...
T39014	KSPWFTTL
	KSPWFTTL is an immunodominant epitope derived from the p15E transmembrane protein. It is Kb-restricted and can enhance the susceptibility of a tumor cell line to cytotoxic T lymphocytes targeting anti-AKR/Gross MuLV.
T27192	DMI-9523 DA-DKP,Ampion,DMI 9523,DM-9523
	DMI-9523 is nuclear factor NF-κB activation inhibitor. Antigen-stimulated human T lymphocytes produce significantly lower quantities of interferon-gamma and tumor necrosis factor-alpha after stimulation in vitro in the presence of DA-DKP. DA-DKP can modul
T14909	CCX140 3-三氟甲基-4-氯-N-[2-[7H-吡咯并[2,3-D]嘧啶-4-羰基]-5-甲基-3-吡啶基]苯磺酰胺,CCX140-B	CCR	Immunology/Inflammation; Microbiology/Virology
	CCX140 (CCX140-B) 是 CCR2 的拮抗剂。
T81697	NBI-6024
	NBI-6024 是一种变构肽配体(APL)，可被1型糖尿病患者中产生炎症性干扰素-γ的T辅助淋巴细胞识别的表位。
TP1629	LCMV gp33-41 (TFA) (151705-84-9 free base) LCMV gp33-41 (TFA)
	LCMV gp33-41 (TFA), the carboxyl-extended 11-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes[1].
T38039	(E)-C-HDMAPP (ammonium salt)
	Synthetic and natural alkyl phosphates, also known as phosphoantigens, stimulate the proliferation of γδ-T lymphocytes. Isopentenyl pyrophosphate, and related derivatives including (E)-hydroxy-dimethyl-allyl pyrophosphate ((E)-HDMAPP), are particularly effective activators of γδ-T cells. (E)-C-HDMAPP is the pyrophosphonate form of (E)-HDMAPP. The pyrophosphonate moiety in (E)-C-HDMAPP is much less susceptible to chemical or enzymatic hydrolysis than its pyrophosphate counterpart. As a result, (E...
TP1583L	HER2/neu (654-662) GP2 acetate	HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	HER2/neu (654-662) GP2 acetate 来源于人表皮生长因子受体 2 (HER2-Neu, 654-662)。 HER2/neu (654-662) GP2 acetate 诱导对各种上皮癌有反应的 HLA-A2 限制性细胞毒性 T 淋巴细胞。
T35906	Padanamide A
	Padanamide A is a bacterial metabolite originally isolated from a marine Streptomyces species. It is active against five strains of P. falciparum (EC50s = 160-340 nM), is not cytotoxic to HEK293 or HepG2 human cell lines, but is cytotoxic to Jurkat T lymphocytes with an IC50 value of approximately 60 μg/ml.
T82882	Binetrakin
	Binetrakin (Interleukin 4 (human)) 是一种多效性细胞因子，源自T淋巴细胞，具有影响包括B细胞和T细胞在内的多种细胞类型的能力。它促进Th0细胞向Th2细胞的分化，广泛应用于各类生物学研究。
T82708	Clenoliximab IDEC-151
	Clenoliximab (IDEC-151)为一种猕猴-人嵌合型单克隆抗体（immunoglobulin G4），特异性结合于T淋巴细胞表面CD4分子。该化合物主要用于类风湿性关节炎的科研领域。
T69830	GSK2239633
	GSK2239633 is a potent CC-chemokine receptor 4 antagonist with pIC50 of 7.9. The CC-chemokine receptor 4 (CCR4) is thought potentially to play a critical role in asthma pathogenesis due to its ability to recruit type 2 T-helper lymphocytes to the inflamed airways. Therefore, CCR4 provides an excellent target for anti-inflammatory therapy.
T61356	CXCR2 antagonist 3
	CXCR2 antagonist 3 (compound 11h) is a highly effective antagonist of CXC chemokine receptor 2 (CXCR2). It displays potent activity in inhibiting neutrophil infiltration into the air pouch, with double-digit nanomolar potencies against CXCR2. Moreover, CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs, while enhancing the infiltration of CD3+ T lymphocytes into Pan02 tumor tissues [1].
T79445	KV1.3-IN-1	Potassium Channel	Membrane transporter/Ion channel
	KV1.3-IN-1 (Compound trans-18) 作为KV1.3通道抑制剂，表现出对Ltk 细胞和PHA激活的T淋巴细胞的IC50值分别为230 nM和26.12 nM。该化合物干扰了细胞内Ca2+信号传导，并能够抑制T细胞的活化、增殖与集落形成。
TP2193	Myelopeptide-2 (MP-2)	Others	Others
	Myelopeptide-2 (MP-2) with the sequence Leu-Val-Val-Tyr-Pro-Trp is originally isolated from the supernatant of porcine bone marrow cell culture and is able to restore the mitogen responsiveness of human T lymphocytes inhibited by conditioned medium from H
T75982	LCMV gp33-41 TFA
	LCMV gp33-41 (TFA)是一种带有羧基延伸的11-aa长肽，作为淋巴细胞脉络丛脑膜炎病毒序列，在MHC I类H-2Db分子的限制下，能够被呈递给细胞毒性T淋巴细胞。
T69944	NLG802 HCl
	NLG802 is an orally bioavailable prodrug of indoximod, a methylated tryptophan, with immune checkpoint inhibitory and antineoplastic activities. Upon oral administration, the indoximod prodrug NLG802 is converted to indoximod. Indoximod targets, binds to and inhibits the enzyme indoleamine 2,3-dioxygenase (IDO; IDO1), which converts the essential amino acid tryptophan into the immunosuppressive metabolite kynurenine. By increasing tryptophan levels and decreasing kynurenine levels, indoximod res...
T37052	Tetranactin
	Tetranactin is a macrotetrolide and a monovalent cation ionophore that has been found in S. aureus and has antibacterial, insecticidal, and mitogenic activities. It exhibits an equilibrium permeability ratio 1,000-fold greater for lithium than sodium or cesium ions accross bilayer membranes at low voltages. Tetranactin inhibits the growth of Gram-positive bacteria and C. miyabeanus and R. solani fungi when used at concentrations less than 0.9 μg/ml. Tetranactin (0.5-1.5 μg per insect) dose-depen...
T78586	Ac-IETD-CHO	Apoptosis	Apoptosis
	Ac-IETD-CHO是一种针对granzyme B和caspase 8的有效可逆抑制剂，能够阻止Fas介导的(Apoptosis)、出血和肝衰竭，并且能够抑制细胞毒性T淋巴细胞引发的细胞死亡。
TP1543	G280-9
	The G280-9 peptide, a common melanoma gp100 epitope restricted by MHC-associated HLA-A2. The G280-9 sequence is unique because it could be recognized by cytotoxic T lymphocytes at very low concentrations, however it shows low total immunogenicity that may
T39067	MAGE-3 (271-279)
	MAGE-3 (271-279) is a peptide consisting of 271-279 amino acid residues that is derived from melanoma antigens encoded by the MAGE-3 gene. It is specifically recognized by cytolytic T lymphocytes (CTLs) and binds to the human leukocyte antigen (HLA)-A2 molecule. MAGE-3 is highly expressed in various human tumor types, such as malignant melanoma, but not in normal tissues, except for the testis and placenta.
T73194	DOCK2-IN-1
	DOCK2-IN-1 是 CPYPP 类似物，也是DOCK2的抑制剂 (IC50=19.1 μM)。DOCK2-IN-1 以可逆方式结合DOCK2DHR-2 结构域以抑制其催化活性。DOCK2-IN-1 阻断淋巴细胞中趋化因子受体和抗原受体介导的 Rac 的激活。DOCK2-IN-1 显着抑制趋化反应和 T 细胞活化。
T36116	Concanamycin B
	Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases, also known as V-ATPases (IC50 = 5 nM). In this way, it blocks the acidification of vacuolar organelles as well as early to late endosomal transport. Concanamycin B interferes with bone resorption and maturation of CD8 T lymphocytes. It also prevents processing of major histocompatibility complex (MHC) class II precursors in human B cells, inhibiting the expression of MHC class II molecules on the cell su...
T37722	Diprovocim-1
	Diprovocim-1 is an agonist of the toll-like receptor 1/2 heterodimer.1It induces TNF-α release in THP-1 cells (EC50= 110 pM), an effect that can be inhibited by anti-TLR1 or anti-TLR2 antibodies. Diprovocim-1 (10 mg/kg) increases the production of ovalbumin-specific IgG1 in wild-type, but notTLR2-/-, mice sensitized to ovalbumin.2It also enhances anti-PD-L1 antibody-induced activation of cytotoxic T lymphocytes, reduction of tumor growth, and increases in survival in a B16/F10 murine melanoma mo...
T35979	Benastatin C
	Benastatin C is a polyketide synthase-derived benastatin that has been found inStreptomycesand has diverse biological activities.1,2It inhibits glutathione S-transferase (GST; IC50= 24 μg/ml for the rat liver enzyme).2Benastatin C also inhibits the esterase activity of isolated porcine pancreatic lipase (IC50= 10 μg/ml). It increases LPS- or concanavalin A-induced blastogenesis of isolated mouse spleen lymphocytes in a concentration-dependent manner. 1.Xu, Z., Schenk, A., and Hertweck, C.Molecul...
T76379	Myelopeptide-2
	Myelopeptide-2 分离于猪骨髓细胞培养上清，能够恢复 HL-60 白血病细胞或麻疹病毒条件抑制下人 T 淋巴细胞的丝裂原反应活性、白细胞介素-2 (IL-2) 合成水平和白细胞介素-2受体 (IL-2R) 表达水平。Myelopeptide-2 参与免疫稳态调节，在抗肿瘤和抗病毒研究中具有广阔的应用前景。
T83852	EGFRvIII Peptide TFA PEGFRvIII (9-mer),Epidermal Growth Factor Receptor Variant III Peptide
	EGFRvIII peptide是一种合成肽，对应于特异性肿瘤、具有持续激活性的EGFR变体EGFRvIII的融合接头，该变体缺少野生型EGFR的第6至273个氨基酸。在25 µg/ml的浓度下，它能与MHC I类亚型HLA-A*0201阳性的T2细胞结合。在用于分离的人外周血单个核细胞（PBMCs）衍生的树突状细胞中，EGFRvIII peptide可诱导抗原呈递，进而刺激CD8+细胞毒性T淋巴细胞的激活和IFN-γ产生。与toll样受体5（TLR5）激动剂鞭毛蛋白B共同免疫EGFRvIII peptide（15 µg/动物），在正交GL261胶质母细胞瘤小鼠异种移植模型中，增加了CD8+ T细胞数量，减少了调节性T细胞（Tregs）数量，减少了肿瘤体积，并提高了生存率。
T63902	XP-524
	XP-524 是 BET 和 EP300 的有效抑制剂。 XP-524 在体内具有显著的杀肿瘤作用，能够阻止 KRAS 诱导的体内肿瘤转化，并延长两种侵袭性 PDAC 转基因小鼠模型的存活时间。XP-524 也提高了自身肽的表达及将肿瘤细胞向细胞毒性 T 淋巴细胞的募集。XP-524 对胰腺导管腺癌（PDAC）表现出研究潜力。
T81431	Pol (476-484), HIV-1 RT Epitope
	Pol (476-484),HIV-1RT Epitope 是具有生物活性的肽，对应逆转录酶 (RT) 的主要HLA A*0201限制性表位（Pol 残基 476-484）。其在HIV-1 RT中的角色涉及分析CTL逃逸机制。实际表位IV9在HIV-1感染的细胞系中被加工和呈现。
T37548	azido-FTY720 azido-FTY720
	FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5). Down-regulation of S1P1 recept...
T35904	O-11
	O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killingTrypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50of less than 1 μM in a cell culture assay.1,2The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface gl...
T83829	2'-Deoxy-1,N6-ethenoadenosine-5'-O-triphosphate sodium ε-dATP
	ε-dATP是一种具有荧光性的嘌呤核苷酸2’-脱氧腺苷-5’-O-三磷酸（dATP）衍生物。它能在50至150µM的浓度范围内诱导初级小鼠脾脏T细胞和B细胞在脂多糖(LPS)或刀豆蛋白A刺激下发生姊妹染色单体交换。ε-dATP已被用于研究乙烯氯诱导的突变过程中模糊碱基配对的情况。相关的ATP衍生物ε-ATP，在300 nm激发下显示415 nm的发射峰值。

化合物

Cat.No: T10765

Synonym: CC-90009,Cereblon modulator 1

Target: Apoptosis, Ligand for E3 Ligase, Molecular Glues

Cat.No: T25705

Synonym: LF1695,LF-1695,LF 1695

Target: Others

BMS-1001 hydrochloride

Cat.No: T10565

Target: PD-1/PD-L1

LCMV gp33-41 acetate

Cat.No: TP1758L

Synonym: LCMV gp33-41 acetate（151705-84-9 Free base）

Target: Others

Cat.No: T6964

Synonym: R848,雷西莫特,S28463

Target: HCV Protease, TLR

CEF8, Influenza Virus NP (383-391)

Cat.No: TP1527

Synonym: CEF8, Influenza Virus NP 383-391

Target: Others

L-Leucyl-L-Leucine methyl ester hydrochloride

Cat.No: T7739

Synonym: Leu-Leu-ome hydrochloride

Target: Others, Endogenous Metabolite

G280-9 acetate(156761-76-1 free base)

Cat.No: TP1543L

Target: Others

Cat.No: T9919

Target: Others

Bz-RS-ISer(3-Ph)-Ome

Cat.No: T7055

Synonym: Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate

Target: Others, HIV Protease

Cat.No: T16132

Target: cAMP, Adenosine Receptor

Cat.No: T2548

Target: Glucocorticoid Receptor

Phosphostim Sodium

Cat.No: T28408

Synonym: IPH1101,Phosphostim,IPH 1101,IPH-1101

Cat.No: T70307

Armepavine hydrochloride, (+/-)-

Cat.No: T30136

Synonym: DL-Armepavine hydrochloride

Taminadenant mesylate

Cat.No: T69723

Cat.No: T39014

Cat.No: T27192

Synonym: DA-DKP,Ampion,DMI 9523,DM-9523

Cat.No: T14909

Synonym: 3-三氟甲基-4-氯-N-[2-[7H-吡咯并[2,3-D]嘧啶-4-羰基]-5-甲基-3-吡啶基]苯磺酰胺,CCX140-B

Target: CCR

Cat.No: T81697

LCMV gp33-41 (TFA) (151705-84-9 free base)

Cat.No: TP1629

Synonym: LCMV gp33-41 (TFA)

(E)-C-HDMAPP (ammonium salt)

Cat.No: T38039

HER2/neu (654-662) GP2 acetate

Cat.No: TP1583L

Target: HER

Cat.No: T35906

Cat.No: T82882

Cat.No: T82708

Synonym: IDEC-151

Cat.No: T69830

CXCR2 antagonist 3

Cat.No: T61356

Cat.No: T79445

Target: Potassium Channel

Myelopeptide-2 (MP-2)

Cat.No: TP2193

Target: Others

LCMV gp33-41 TFA

Cat.No: T75982

Cat.No: T69944

Cat.No: T37052

Cat.No: T78586

Target: Apoptosis

Cat.No: TP1543

MAGE-3 (271-279)

Cat.No: T39067

Cat.No: T73194

Cat.No: T36116

Cat.No: T37722

Cat.No: T35979

Cat.No: T76379

EGFRvIII Peptide TFA

Cat.No: T83852

Synonym: PEGFRvIII (9-mer),Epidermal Growth Factor Receptor Variant III Peptide

Cat.No: T63902

Pol (476-484), HIV-1 RT Epitope

Cat.No: T81431

Cat.No: T37548

Synonym: azido-FTY720

Cat.No: T35904

2'-Deoxy-1,N6-ethenoadenosine-5'-O-triphosphate sodium

Cat.No: T83829

Synonym: ε-dATP

Cat. No.	Product Name	Target	Signaling Pathways
T5S0777	Phellodendrine chloride	Others	Others
	Phellodendrine chloride 是一种Phellodendron amurense 中的生物碱。它通过巨胞饮抑制营养物质的吸收，进而抑制 KRAS 突变的胰腺癌细胞的增殖。
T0798	Triamcinolone Fluoxyprednisolone,曲安西龙,Aristocort,Rodinolone	Glucocorticoid Receptor; COX	Endocrinology/Hormones; Immunology/Inflammation; Neuroscience
	Triamcinolone (Aristocort) 是一种皮质类固醇激素受体激动剂，也是一种合成的长效糖皮质激素，具有抗炎活性。
T6S0781	Phellodendrine 黄柏碱,Phallodendrin	Others; NF-κB; Akt	Cytoskeletal Signaling; NF-κB; Others; PI3K/Akt/mTOR signaling
	Phellodendrine (Phallodendrin) 是异喹啉生物碱，是黄柏皮层中的重要特征成分之一。它具有良好的抗氧化，抗炎作用。它通过调节AKT/NF-κB 途径抵抗 AAPH 诱导的氧化应激。
T20879	Tacrolimus monohydrate FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506	Phosphatase; Others; Antibacterial; Antibiotic; Autophagy	Autophagy; Metabolism; Microbiology/Virology; Others
	Tacrolimus monohydrate (LCP-Tacro) 是大环内酯类化合物，它与 FK506 结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶，从而抑制 T 淋巴细胞信号转导和 IL-2 转录。具有强免疫抑制特性。
T2563	Acetyl-L-carnitine hydrochloride Acetyl L-carnitine hydrochloride,O-Acetylcarnitine,乙酰-L-肉(毒)碱盐酸盐,O-acetyl-L-carnitine,O-Acetyl-L-carnitine hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	Acetyl-L-carnitine hydrochloride (Acetyl L-carnitine hydrochloride) 是一种由内源性左旋肉碱的乙酰化形式的盐酸盐组成的营养补充剂，具有潜在的神经保护、认知增强、抗抑郁和免疫调节活性。还可缓解化疗、糖尿病或其他疾病引起的周围神经病变。此外，乙酰左旋肉碱可能通过增加T淋巴细胞成熟来调节免疫反应，并可能下调促炎细胞因子对病毒(如SARS-CoV-2)的反应。它还可能破坏ACE2信号通路并抑制活性氧(ROS)的产生。
T70221	Dibefurin
	Dibefurin is a metabolite that inhibits the activity of calcineurin, a calcium/calmodulin-dependent protein phosphatase involved in the activation of T lymphocytes.

天然产物

Phellodendrine chloride

Cat.No: T5S0777

Target: Others

Cat.No: T0798

Synonym: Fluoxyprednisolone,曲安西龙,Aristocort,Rodinolone

Target: Glucocorticoid Receptor, COX

Cat.No: T6S0781

Synonym: 黄柏碱,Phallodendrin

Target: Others, NF-κB, Akt

Tacrolimus monohydrate

Cat.No: T20879

Synonym: FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506

Target: Phosphatase, Others, Antibacterial, Antibiotic, Autophagy

Acetyl-L-carnitine hydrochloride

Cat.No: T2563

Synonym: Acetyl L-carnitine hydrochloride,O-Acetylcarnitine,乙酰-L-肉(毒)碱盐酸盐,O-acetyl-L-carnitine,O-Acetyl-L-carnitine hydrochloride

Target: Others, Endogenous Metabolite

Cat.No: T70221

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