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Search Results for " ptp "

Targets Recommended: Phosphatase

51

抑制剂 & 化合物

4

天然产物

33

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T7541	PTP inhibitor 1 PTP Inhibitor II,alpha-溴-4-甲氧基苯乙酮	Phosphatase	Metabolism
	PTP inhibitor 1 是蛋白酪氨酸磷酸酶 (PTP) 抑制剂，具有抗血管生成作用。
T22137	PTP Inhibitor IV	Others	Others
	PTP Inhibitor IV 是一种有效的蛋白酪氨酸磷酸酶 (PTP) 抑制剂，可选择性抑制 DUSP14 磷酸酶活性（IC50 ： 5.21 μM）。PTP Inhibitor IV 对 SHP-2、PTP1B、PTP-ε、PTP Meg-2、PTP-σ、PTP-β 和 PTP-μ具有抑制作用，IC50 分别为 1.8 μM、2.5 μM、8.4 μM、13 μM、20 μM、6.4 μM，和 6.7 μM。PTP Inhibitor IV 通过抑制PTP 活性，影响细胞信号传导，并可能调节与PTP 介导的信号传导事件相关的特定途径。
T10927	Cyt-PTPε Inhibitor-1 Cyt-PTP\|A Inhibitor-1	Phosphatase; Src	Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
	Cyt-PTPε Inhibitor-1 (A Inhibitor-1) 是胞质蛋白酪氨酸磷酸酶 ε 的抑制剂。 Cyt-PTPε Inhibitor-1 阻断 c-Src 的去磷酸化并表现出抗破骨活性。
T6667	SF1670 PTP CD45 Inhibitor,PTPase CD45 Inhibitor	Phosphatase; PTEN; Autophagy	Autophagy; Metabolism; PI3K/Akt/mTOR signaling
	SF1670 (PTPase CD45 Inhibitor) 是一种特异性 PTEN 抑制剂，IC50 为 2 μM。
T12577	PTP1B-IN-3	Phosphatase	Metabolism
	PTP1B-IN-3 是一种具有有选择性和高效性的 PTP1B 抑制剂，具有抗癌活性，抑制 PTP1B 和 TCPTP 。PTP1B-IN-3 可用于研究糖尿病。
T4256	PTP1B-IN-2	Phosphatase	Metabolism
	PTP1B-IN-2 是一种蛋白酪氨酸磷酸酶抑制剂，IC50=50 nM。
T7084	2-Bromo-4'-hydroxyacetophenone SHP-1 Inhibitor II,PTP Inhibitor I,α-Bromo-4-hydroxyacetophenone,4-Hydroxyphenacyl bromide,2-溴-4'-羟基苯乙酮	Phosphatase	Metabolism
	2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) 是一种PTP1B 的有效抑制剂，其Ki=42 μM。
T15243	Ertiprotafib PTP 112	Phosphatase; PPAR	DNA Damage/DNA Repair; Metabolism
	Ertiprotafib is a PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist inhibitor ( IC50s: 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ).
T39856	Purine riboside triphosphate PTP,Purine riboside triphosphate
	Purine riboside triphosphate, a derivative of purine riboside, exhibits structural similarity to adenosine. This naturally occurring base analog possesses inhibitory effects on carcinogenic growth, particularly in cancer ascites cells, by strongly impeding RNA and DNA synthesis.
T80870	VE-PTP-IN-1
	VE-PTP-IN-1 (compound 2) 为一种选择性VE-PTP抑制剂，呈弱酸性，涉及调控血管稳态及血管生成。
T40745	PTP1B-IN-13 PTP1B-IN-13
	PTP1B-IN-13, a potent and selective inhibitor of Protein Tyrosine Phosphatase 1B (PTP1B), effectively targets the allosteric site, exhibiting an IC50 value of 1.59 μM.
T40835	PTP1B-IN-14 PTP1B-IN-14
	PTP1B-IN-14 is a selective PTP1B inhibitor ( IC 50 = 0.72 μM) targeting the allosteric site.
T12579	RAMB4 PTP1B-IN-9	Proteasome	Proteases/Proteasome; Ubiquitination
	RAMB4 (PTP1B-IN-9) 是一种泛素-蛋白酶体系统(UPS)应激源，是通过抑制 20S 蛋白酶体催化活性物质上游泛素介导的蛋白质降解而产生。它能够在不影响 20S 蛋白酶体催化活性的情况下触发泛素蛋白酶体系统 (UPS) 应激反应。
T67893	PTP1B-IN-22	Phosphatase	Metabolism
	PTP1B-IN-22是一种蛋白酪氨酸磷酸酶1B (PTP1B)抑制剂，可抑制骨骼肌 L6肌管的葡萄糖摄取。
T4340	SPI-112	Phosphatase	Metabolism
	SPI 112 是一种选择性的、有效的、竞争性的SHP2 (PTPN11)抑制剂，对SHP2，蛋白酪氨酸磷酸酶 (PTP) 和 PTP1B 的IC50分别为 1 μM，18.3 μM 和 14.5 μM。
T7356	PTP1B-IN-1 PTP1B inhibitor,5-苯基-1,2,5-噻二唑烷-3-酮 1,1-二氧化物	Phosphatase	Metabolism
	PTP1B-IN-1 (PTP1B inhibitor) 是一种蛋白质酪氨酸磷酸酶 1B 的有效抑制剂 (IC50 : 1.6 mM)
T24073	PTP1B-IN-4 NUN 17724,PTP1B-inhibitor-2,PTP1B IN 2,PTP1B-IN-2,PTP1B-inhibitor-4,FRJ,PTP1B inhibitor 4,NUN17724,PTP1B inhibitor 2,PTP1BIN2,NUN-17724	Phosphatase	Metabolism
	PTP1B-IN-4 (NUN-17724)是一种 PTP1B 的变构抑制剂，IC50为8μM。PTP1B-IN-4可用于肥胖症和糖尿病的研究。
T61851	PTP1B-IN-3 diammonium
	PTP1B-IN-3 diammonium is a highly effective and orally bioavailable inhibitor of the protein tyrosine phosphatase 1B (PTP1B) enzyme, with an IC50 value of 120 nM for both PTP1B and TCPTP. This compound exhibits potent antidiabetic and anticancer properties, as supported by extensive research [1] [2].
T63739	PTP1B-IN-15
	PTP1B-IN-15 是有效的、选择性的蛋白酪氨酸磷酸酶 1B (PTP1B) 抑制剂，对II 型糖尿病和肥胖症表现出研究潜力。
T80544	PTPσ Inhibitor, ISP	Phosphatase	Metabolism
	PTPσ Inhibitor, ISP 结合并抑制重组人PTPσ的信号传导，具有穿透细胞膜的能力，有助于缓解CSPG介导的脊髓损伤模型中轴突的生长抑制。该抑制剂能增强LPC引起的脊髓脱髓鞘损伤的髓鞘再生，并在MS动物模型中促进OPC的迁移、分化、髓鞘形成及功能恢复。
T63022	PTP1B-IN-18
	PTP1B-IN-18 是一种口服具有活力的完全混合型蛋白酪氨酸磷酸酶 1B (PTP1B) 抑制剂 (Ki: 35.2 μM)。PTP1B-IN-18 能够用于研究 2 型糖尿病。
T22276	Bis(maltolato)oxovanadium(IV) 双(麦芽醇)氧钒(IV),BMOV,Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium,Bis(maltolato)oxovanadium (IV)	Phosphatase; Others	Metabolism; Others
	Bis(maltolato)oxovanadium(IV) (BMOV) 是一种有效的胰岛素增敏剂，也是一种有效的、竞争性的、可逆的、口服具有活性的光谱蛋白酪氨酸磷酸酶 (PTP) 抑制剂。它抑制HCPTPA，PTP1B，HPTPβ和SHP2的IC50分别为 126 nM，109 nM，26 nM 和 201 nM。
T63023	PTP1B-IN-19
	PTP1B-IN-19 (Compound 43) 是一种有潜力的选择性苯并咪唑衍生物，能够作为蛋白质酪氨酸磷酸酶 1B (PTP1B) 抑制剂 (Ki: 23.3 μM)。PTP1B-IN-17 能够用于研究 2 型糖尿病。
T63435	PTP1B-IN-16
	PTP1B-IN-16 是有潜力的、选择性的苯并咪唑衍生物，也是一种蛋白质酪氨酸磷酸酶 1B (PTP1B) 抑制剂 (Ki: 12.6 μM)。PTP1B-IN-16 能够用于研究 2 型糖尿病。
T63021	PTP1B-IN-17
	PTP1B-IN-17 (Compound 45) 是一种有潜力的选择性苯并咪唑衍生物，能够作为蛋白质酪氨酸磷酸酶 1B (PTP1B) 抑制剂 (Ki: 30.2 μM)。PTP1B-IN-17 能够用于研究 2 型糖尿病。
T78703	PTP1B/AKR1B1-IN-2	Phosphatase	Metabolism
	PTP1B/AKR1B1-IN-2（化合物7f）是一种双重PTP1B/AKR1B1抑制剂，具有IC50：3.2和2.1 μM，Ki：4.0和0.9μM。该化合物作为胰岛素模拟剂，能够改善小鼠C2C12肌母细胞的葡萄糖摄取，并可用于2型糖尿病（T2DM）的研究。
T78702	PTP1B/AKR1B1-IN-1	Phosphatase	Metabolism
	PTP1B/AKR1B1-IN-1是一种针对PTP1B和AKR1B1的双重抑制剂，其IC50值分别为0.06 μM和4.3 μM。该化合物也能抑制TC-PTP，IC50为9 μM。在小鼠成肌细胞中，PTP1B/AKR1B1-IN-1作为胰岛素模拟剂使用，并能减少AKR1B1依赖的山梨醇积累，有助于抑制2型糖尿病的发展并控制血糖水平。
T4491	LMPTP INHIBITOR 1 hydrochloride LMPTP INHIBITOR 1 hydrochloride (1908414-82-3(free base))	Phosphatase	Metabolism
	LMPTP INHIBITOR 1 hydrochloride 是一种高选择性的低分子量蛋白酪氨酸磷酸酶 (LMPTP) 抑制剂。LMPTP INHIBITOR 1 (hydrochloride) 能够抑制 LMPTP-A 的活性，IC50值为 0.8 μM。
T41298	LMPTP INHIBITOR 1 dihydrochloride	Phosphatase	Metabolism
	LMPTP INHIBITOR 1 dihydrochloride 是选择性的低分子量蛋白酪氨酸磷酸酶（LMPTP）抑制剂，抑制 LMPTP-A 活性的IC50为 0.8 μM。
T4081	MPTP hydrochloride MPTP-hydrochloride	Apoptosis; Dopamine Receptor	Apoptosis; GPCR/G Protein; Neuroscience
	MPTP hydrochloride 是 MPP+ 的前体，是一种多巴胺神经毒素，具有血脑屏障渗透性。MPTP hydrochloride 对多巴胺能神经元有毒，可以导致帕金森症，被广泛应用于帕金森动物模型的构建。
T71739	PTPMT1-IN-1
	PTPMT1-IN-1 is a PTEN-like mitochondrial phosphatase PTPMT1 inhibitor.
T79160	PROTAC PTPN2 degrader-2	Phosphatase	Metabolism
	PROTACPTPN2 degrader-2（example 187B）作为PTPN2降解剂，展现出对研究癌症和代谢性疾病的有效性。
T73120	MptpB-IN-1
	MptpB-IN-1 是一种有效的、具有口服活性的 MptpB 抑制剂。结核分枝杆菌蛋白-酪氨酸-磷酸酶 B (MptpB) 是一种分泌的毒力因子，可破坏宿主的抗菌活性。MptpB-IN-1 可降低耐多药结核分枝杆菌的存活率和感染负担。
T71195	mPTP-IN-22
	mPTP-IN-22 is a novel mitochondrial permeability transition pore (mptp) inhibitor
T74732	PROTAC PTPN2 degrader-1
	PROTACPTPN2 degrader-1 (compound example 77) 是一种有效的 PTPN2降解剂。PROTACPTPN2 degrader-1 具有研究癌症或代谢性疾病的潜力。
T40216	PTPN22-IN-1 PTPN22-IN-1
	PTPN22-IN-1 is a potent PTPN22 inhibitor ( IC 50 =1.4 μM; K i =0.50 μM). PTPN22-IN-1 exhibits >7-10 fold selectivity for PTPN22 over similar phosphatases. PTPN22-IN-1 augments antitumor immune responses. From WO2021007491A1 compound L-1.
T79161	PROTAC PTPN2 degrader-2 TFA	Phosphatase	Metabolism
	PROTACPTPN2 degrader-2（例187B）TFA 作为PTPN2降解剂，展现出对癌症及代谢性疾病研究的潜在效用。
T79479	MptpB-IN-2	Antibiotic	Microbiology/Virology
	MptpB-IN-2（化合物20）是一种高选择性的结核分枝杆菌蛋白酪氨酸磷酸酶B（MptpB）抑制剂，其对MptpB、MptpA和PTP1B的IC50值分别为0.64 μM、4.06 μM和4.14 μM。此化合物对Mtb H37Rv表现出较低的抗结核活性，MIC为64.9 μM。
T14841	BVT948	Phosphatase; P450; Histone Methyltransferase	Chromatin/Epigenetic; Metabolism
	BVT948 是一种蛋白酪氨酸磷酸酶抑制剂，还可以抑制赖氨酸甲基转移酶 SETD8 (KMT5A) 和几种细胞色素 P450 (P450) 同工型。
T13176	TNO155 Batoprotafib	Phosphatase	Metabolism
	TNO155 是具有口服活性野生型SHP2的选择性变构抑制剂 (IC50= 0.011 µM)。它有研究 RTK 依赖性恶性肿瘤（尤其是晚期实体瘤）的潜力。
T16724	Razuprotafib AKB-9778	Phosphatase; Others	Metabolism; Others
	Razuprotafib (AKB-9778) 是一种 VE-PTP (HPTPß)催化活性的有效选择性抑制剂，抑制结构相关磷酸酶 PTP1B。除 HPTPη 和 HPTPγ 外，它对 VE-PTP 具有良好的选择性。它能够促进 TIE2 活化，增强 ANG1 诱导的 TIE2 活化，并刺激 TIE2 通路中信号分子的磷酸化。
T10594	bpV(phen)	PTEN	PI3K/Akt/mTOR signaling
	bpV(phen) is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor (IC50s: 343 nM, 920 nM, and 38 nM for PTP-β, PTP-1B, and PTEN).
T41339	bpV(phen) trihydrate
	bpV(phen) trihydrate 是一种有效的蛋白酪氨酸磷酸酶 (PTP) 和 PTEN 抑制剂（对于 PTP-β、PTP-1B 和 PTEN，IC50 值：343 nM、920 nM 和 38 nM）。
T62442	MY33-3 hydrochloride
	MY33-3 hydrochloride 是一种有效的、选择性的蛋白酪氨酸磷酸酶 RPTPβ/ζ 抑制剂 (IC50~0.1 μM)。MY33-3 hydrochloride 对 PTP-1B 具有抑制作用 (IC50~0.7 μM)。MY33-3 hydrochloride 能够降低乙醇消耗，缓解 Sevoflurane 引起的神经炎症和认知功能障碍。
T41370	(Rac)-RK-682
	(Rac)-RK-682 是 RK-682 的外消旋体。(Rac)-RK-682 是一种蛋白质酪氨酸磷酸酶 (PTPases) 抑制剂。(Rac)-RK-682 抑制蛋白酪氨酸磷酸酶 1B (PTP-1B)、低分子量蛋白酪氨酸磷酸酶 (LMW-PTP)、细胞分裂周期 25B (CDC-25B)，IC50分别为 8.6 μM、12.4 μM 和 0.7 μM。
T73477	SHP844
	SHP844为一SHP2抑制剂，IC50值为18.9 µM。SHP2为蛋白酪氨酸磷酸酶(PTP)，调控酪氨酸磷酸化水平，影响细胞增殖、分化及存活。
T82056	IP2
	IP2作为免疫调节剂，能增强癌细胞内PTP衍生的抗原呈递，但对癌细胞本身不具有细胞毒性。在小鼠实验中，IP2能诱导肿瘤生长缺陷。
T28901	T-2007 5,5-Diphenylbarbituric acid,DPB
	T-2007 is an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist and gamma-aminobutyric acid (GABA) receptor agonist. T2007 and its analogs upregulates CYP3A4 and MDR1. T-2007 depressed both the degree and the duration of postt
T74980	SPAA-52
	SPAA-52 是一种具有口服活性的、竞争性的和可逆的低分子量蛋白酪氨酸磷酸酶 (LMW-PTP) 抑制剂 (IC50=4 nM,Ki=1.2 nM)。SPAA-52 可用于糖尿病的研究。
T79644	Antidiabetic agent 2	Glucosidase	Metabolism
	Antidiabetic agent 2 (Compound 56) 作为一种葡萄糖摄取促进剂，能有效地抑制DPP-4, PTP-1B, α-淀粉酶和α-葡萄糖苷酶，其IC50s分别达到0.036、0.042、0.241、0.185 μM，表现出显著的降血糖作用。

化合物

PTP inhibitor 1

Cat.No: T7541

Synonym: PTP Inhibitor II,alpha-溴-4-甲氧基苯乙酮

Target: Phosphatase

PTP Inhibitor IV

Cat.No: T22137

Target: Others

Cyt-PTPε Inhibitor-1

Cat.No: T10927

Synonym: Cyt-PTP|A Inhibitor-1

Target: Phosphatase, Src

Cat.No: T6667

Synonym: PTP CD45 Inhibitor,PTPase CD45 Inhibitor

Target: Phosphatase, PTEN, Autophagy

Cat.No: T12577

Target: Phosphatase

Cat.No: T4256

Target: Phosphatase

2-Bromo-4'-hydroxyacetophenone

Cat.No: T7084

Synonym: SHP-1 Inhibitor II,PTP Inhibitor I,α-Bromo-4-hydroxyacetophenone,4-Hydroxyphenacyl bromide,2-溴-4'-羟基苯乙酮

Target: Phosphatase

Cat.No: T15243

Synonym: PTP 112

Target: Phosphatase, PPAR

Purine riboside triphosphate

Cat.No: T39856

Synonym: PTP,Purine riboside triphosphate

Cat.No: T80870

Cat.No: T40745

Synonym: PTP1B-IN-13

Cat.No: T40835

Synonym: PTP1B-IN-14

Cat.No: T12579

Synonym: PTP1B-IN-9

Target: Proteasome

Cat.No: T67893

Target: Phosphatase

Cat.No: T4340

Target: Phosphatase

Cat.No: T7356

Synonym: PTP1B inhibitor,5-苯基-1,2,5-噻二唑烷-3-酮 1,1-二氧化物

Target: Phosphatase

Cat.No: T24073

Synonym: NUN 17724,PTP1B-inhibitor-2,PTP1B IN 2,PTP1B-IN-2,PTP1B-inhibitor-4,FRJ,PTP1B inhibitor 4,NUN17724,PTP1B inhibitor 2,PTP1BIN2,NUN-17724

Target: Phosphatase

PTP1B-IN-3 diammonium

Cat.No: T61851

Cat.No: T63739

PTPσ Inhibitor, ISP

Cat.No: T80544

Target: Phosphatase

Cat.No: T63022

Bis(maltolato)oxovanadium(IV)

Cat.No: T22276

Synonym: 双(麦芽醇)氧钒(IV),BMOV,Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium,Bis(maltolato)oxovanadium (IV)

Target: Phosphatase, Others

Cat.No: T63023

Cat.No: T63435

Cat.No: T63021

PTP1B/AKR1B1-IN-2

Cat.No: T78703

Target: Phosphatase

PTP1B/AKR1B1-IN-1

Cat.No: T78702

Target: Phosphatase

LMPTP INHIBITOR 1 hydrochloride

Cat.No: T4491

Synonym: LMPTP INHIBITOR 1 hydrochloride (1908414-82-3(free base))

Target: Phosphatase

LMPTP INHIBITOR 1 dihydrochloride

Cat.No: T41298

Target: Phosphatase

MPTP hydrochloride

Cat.No: T4081

Synonym: MPTP-hydrochloride

Target: Apoptosis, Dopamine Receptor

Cat.No: T71739

PROTAC PTPN2 degrader-2

Cat.No: T79160

Target: Phosphatase

Cat.No: T73120

Cat.No: T71195

PROTAC PTPN2 degrader-1

Cat.No: T74732

Cat.No: T40216

Synonym: PTPN22-IN-1

PROTAC PTPN2 degrader-2 TFA

Cat.No: T79161

Target: Phosphatase

Cat.No: T79479

Target: Antibiotic

Cat.No: T14841

Target: Phosphatase, P450, Histone Methyltransferase

Cat.No: T13176

Synonym: Batoprotafib

Target: Phosphatase

Cat.No: T16724

Synonym: AKB-9778

Target: Phosphatase, Others

Cat.No: T10594

Target: PTEN

bpV(phen) trihydrate

Cat.No: T41339

MY33-3 hydrochloride

Cat.No: T62442

Cat.No: T41370

Cat.No: T73477

Cat.No: T82056

Cat.No: T28901

Synonym: 5,5-Diphenylbarbituric acid,DPB

Cat.No: T74980

Antidiabetic agent 2

Cat.No: T79644

Target: Glucosidase

Cat. No.	Product Name	Target	Signaling Pathways
T73073	PTP1B-IN-21
	PTP1B-IN-21 是蛋白酪氨酸磷酸酶 1B (PTP1B) 的选择性抑制剂 (IC50=1.56 μM)，抑制力超出高度同源 T 细胞蛋白酪氨酸磷酸酶 (TCPTP；IC50>100 μM)，PTP1B 是抑制 2 型糖尿病的重要靶点。
T73072	PTP1B-IN-20
	PTP1B-IN-20 是蛋白酪氨酸磷酸酶 1B (PTP1B) 的选择性抑制剂 (IC50=1.05 μM)，抑制力超出高度同源 T 细胞蛋白酪氨酸磷酸酶 (TCPTP；IC50=78.0 μM)，PTP1B 是抑制 2 型糖尿病的重要靶点。
T39219	Ficusonolide
	Ficusonolide exhibits significant antidiabetic activity through its interactions with dipeptidyl peptidase-IV (DPP-IV), protein tyrosine phosphatase 1B (PTP-1B), α-glucosidase, and α-amylase.
T3930	Taraxerol acetate 醋酸蒲公英霜,Taraxeryl acetate	Phosphatase; HSV	Metabolism; Microbiology/Virology
	Taraxeryl acetate shows the significant antiviral activity against herpes simplex virus (type II). It has less effect on cell cycle arrest and apoptosis of AGS cells than taraxerol. A. roxburghiana has antidiabetic activity, could be attributed due to PTP

天然产物

Cat.No: T73073

Cat.No: T73072

Cat.No: T39219

Taraxerol acetate

Cat.No: T3930

Synonym: 醋酸蒲公英霜,Taraxeryl acetate

Target: Phosphatase, HSV

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03484	TCPTP Protein, Human, Recombinant TCPTP,protein tyrosine phosphatase, non-receptor ty...	Human	Baculovirus Insect Cells
	TCPTP Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 36.8 kDa and the accession number is P17706-1.
TMPY-02511	PTP alpha/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST) LRP,PTP α/PTPRA Protein, Human, Recombinan...	Human	Baculovirus Insect Cells
	PTPRA is reported to be involved in cancer development and progression through activating the Src family kinase (SFK) signaling pathways. The higher PTPRA level was associated with worse prognosis of SCC patients and PTPRA could promote the cell cycle progression through stimulating the c-Src signaling pathways. The PTPRA gene, which encodes the protein RPTP-alpha, is critical to neurodevelopment. Previous linkage studies, genome-wide association studies, controlled expression analyses and anima...
TMPJ-00908	LMW-PTP Protein, Human, Recombinant (His) Low Molecular Weight Cytosolic Acid Phosphatase,Adipocyte Ac...	Human	E. coli
	Low Molecular Weight Phosphotyrosine Protein Phosphatase (LMW-PTP) is a member of the low molecular weight phosphotyrosine protein phosphatase family. LMW-PTP serves as an acid phosphatase and a protein tyrosine phosphatase (PTPase) by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. LMW-PTP can be detected in all human tissues, including adipocytes. LMW-PTP is a cytosolic enzyme that regulate cell proliferation and growth of leiomyomas during dephosphorylation of t...
TMPK-01132	PRL-1/PTP4A1 Protein, Human, Recombinant (His) PTPCAAX1,PRL1,PRL-1,PTP(CAAXI),PTP	Human	E. coli
	Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1, PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the CNNM magnesium transport regulators. PRL-1 (PTP4A1) is a key molecule that activates tyrosine phosphorylation, which is important for cancer progression and metastasis.
TMPY-02386	PTP4A2 Protein, Human, Recombinant (GST) HNMT-S2,PRL-2,HNMT-S1,protein tyrosine phosphatase type IVA,...	Human	E. coli
	PRL-2 (Protein-tyrosine phosphatase of regenerating liver 2), also known as PTP4A2 (Protein tyrosine phosphatase type IVA, member 2), is a member of PTP family and has an important function in controlling cell growth. PRL-2 phosphatases may be multifunctional enzymes with diverse roles in a variety of tissue and cell types. The phosphatase of regenerating liver (PRL) family, comprising PRL-1, PRL-2 and PRL-3, is a group of prenylated phosphatases that are candidate cancer biomarkers and therapeu...
TMPY-03548	PTPN12 Protein, Human, Recombinant protein tyrosine phosphatase, non-receptor type 12,PTP	Human	Baculovirus Insect Cells
	PTPN12 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 41.8 kDa and the accession number is AAA36529.1.
TMPY-03486	PTPN12 Protein, Human, Recombinant (aa 1-355, His & GST) PTPG1,protein tyrosine phosphatase, non-receptor ty...	Human	Baculovirus Insect Cells
	PTPN12 Protein, Human, Recombinant (aa 1-355, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 69.4 kDa and the accession number is AAA36529.1.
TMPJ-00465	PTP1C Protein, Human, Recombinant (His) HCP,Hematopoietic Cell Protein-Tyrosine Phosphatase,SH-P...	Human	E. coli
	Protein-Tyrosine Phosphatase 1C (PTP1C) belongs to the protein-tyrosine phosphatase family.which is known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1C is highly expressed in leukocyte cell type. It contains two SH2 domains and one tyrosine-protein phosphatase domain. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against inter...
TMPY-02369	TCPTP Protein, Mouse, Recombinant (aa 2-314, His) protein tyrosine phosphatase, non-receptor type 2,TC-PTP...	Mouse	Baculovirus Insect Cells
	TCPTP Protein, Mouse, Recombinant (aa 2-314, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 38.7 kDa and the accession number is Q06180-1.
TMPJ-01141	IA2 Protein, Human, Recombinant (aa 687-979, His) PTP IA-2,PTPRN,ICA3,R-PTP-N,ICA 5...	Human	E. coli
	IA2 Protein, Human, Recombinant (aa 687-979, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 33 KDa and the accession number is Q16849.
TMPY-02173	TCPTP Protein, Human, Recombinant (aa 1-314, His & GST) TCPTP,TC-PTP,protein tyrosine phosphatase,...	Human	Baculovirus Insect Cells
	TCPTP Protein, Human, Recombinant (aa 1-314, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 64.4 kDa and the accession number is P17706-1.
TMPJ-01139	IA2 Protein, Human, Recombinant (aa 576-950, His) Islet cell antigen 512,Islet cell autoantigen 3,ICA3,Recepto...	Human	E. coli
	IA2 Protein, Human, Recombinant (aa 576-950, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 50 KDa and the accession number is Q16849.
TMPJ-01140	IA2 Protein, Human, Recombinant (aa 607-686 & aa 795-888 , His) Islet cell autoantigen 3,PTPRN,Islet cell antigen 5...	Human	E. coli
	IA2 Protein, Human, Recombinant (aa 607-686 & aa 795-888 , His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 26-30 KDa and the accession number is Q16849.
TMPY-02763	DEP-1 Protein, Human, Recombinant (aa 997-1337, His) HPTPeta,SCC1,protein tyrosine phosphatase, receptor...	Human	E. coli
	DEP1 / PTPRJ (Receptor-type tyrosine-protein phosphatase eta) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. DEP1 / PTPRJ possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-...
TMPY-04125	PTP1B Protein, Human, Recombinant (His) protein tyrosine phosphatase, non-receptor type 1,PTP	Human	E. coli
	PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1B contains 1 tyrosine-protein p...
TMPY-01335	REG1A Protein, Human, Recombinant (His) regenerating family member 1 alpha,P19,MGC12447,REG,R EG,PSP...	Human	HEK293 Cells
	REG1A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.7 kDa and the accession number is P05451.
TMPY-05474	REG1A Protein, Human, Recombinant (His), Biotinylated PSPS,R EG,PSPS1,MGC12447,ICRF,REG1A,regenerating family memb...	Human	HEK293 Cells
	REG1A Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.7 kDa and the accession number is P05451.
TMPJ-00053	PRL-2 Protein, Human, Recombinant (His) HU-PP-1,Protein tyrosine phosphatase type IVA 2,OV-1,PTP...	Human	E. coli
	PTP4A2, also known as PRL2 or PTPCAAX2, is short for Protein tyrosine phosphatase type IVA 2. This protein exists in cell membrane, cytoplasm,endosome and membrane. PTP4A2 is often farnesylated during post-translational modification. Farnesylation is required for membrane targeting and for interaction with RABGGTB. The unfarnesylated forms are redirected to the nucleus and cytosol. It can stimulate progression from G1 into S phase during mitosis and promotes tumors. It also inhibits geranylgeran...
TMPK-00742	PRL-3/PTP4A3 Protein, Human, Recombinant (His) PRL-R,PRLR,PRL3,PTP4A3,PRL-3	Human	E. coli
	Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1, PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the CNNM magnesium transport regulators. PTP4A3 (PRL-3) plays an important role in the tumorigenesis and metastasis of multiple tumors.
TMPY-00487	PTPN9 Protein, Human, Recombinant (His & GST) PTPMEG2,protein tyrosine phosphatase, non-receptor ...	Human	Baculovirus Insect Cells
	Protein tyrosine phosphatase non-receptor type 9 (PTPN9), also named PTP-MEG2, is an important member of the protein tyrosine phosphatase family that is involved in variety of human diseases.PTPN9 plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 and ZBP-89, providing new cellular and molecular insights into the role of ptpn9a in developmental hematopoiesis.
TMPY-02602	PTPMT1 Protein, Human, Recombinant (His) protein tyrosine phosphatase, mitochondrial 1,MOSP,FLJ46081,...	Human	E. coli
	PTPMT1 (PTP localized to the Mitochondrion 1) is a member of the protein tyrosine phosphatase superfamily that is localized exclusively to the mitochondrion. It has been recently reported that PTPMT1 dephosphorylates phosphatidylglycerol phosphate, an essential intermediate of cardiolipin biosynthesis. PTPMT1 deficiency in mouse embryonic fibroblasts compromises mitochondrial respiration and results in abnormal mitochondrial morphology. Lipid analysis of PTPMT1-deficient fibroblasts reveals an a...
TMPH-02878	PTPRS Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteo...
TMPH-02011	PTPRB Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	PTPRB Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPH-02277	PTPN11 Protein, Human, Recombinant (T253M & Q257L, His)	Human	E. coli
	Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity. Dephosphorylates CDC73. Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification.
TMPH-02278	PTPN5 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. PTPN5 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 45.5 kDa and the accession number is P54829.
TMPH-02013	PTPRZ1 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades. PTPRZ1 Protein, Human, Recombinant (His) is exp...
TMPH-02987	PTPRS Protein, Mus musculus, Recombinant (His & Myc)	Mouse	Baculovirus Insect Cells
	PTPRS Protein, Mus musculus, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 35.8 kDa and the accession number is B0V2N1.
TMPH-02012	PTPRZ1 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	PTPRZ1 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli.
TMPH-02010	PTPRB Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	PTPRB Protein, Human, Recombinant (His) is expressed in Yeast.
TMPY-02595	DUSP14 Protein, Human, Recombinant (His & MBP) MKP6,MKP-L,dual specificity phosphatase 14	Human	E. coli
	Dual specific phosphatase 14 / MAP-kinase phophatase-6 (DUSP14 / MKP6) is a member of Dual-specificity phosphatases that is a subclass of protein tyrosine phosphatases (PTP) families that can dephosphorylate bothe phosphotyrosine and phosphoserine / phosphothreonine residues in substrates. Unlike many other DUSPs, DUSP14 only contains a catalytic domain within the C-terminal region. In signal transduction, DUSP14 has been considered as negative regulator of the mitogen-activated protein kinase (...
TMPY-02131	Acid Phosphatase/ACP1 Protein, Human, Recombinant (GST) acid phosphatase 1, soluble,HAAP	Human	E. coli
	The low molecular weight phosphotyrosine phosphatase (LMW-PTP), also known as Acid phosphatase 1 (ACP1), belongs to the low molecular weight phosphotyrosine protein phosphatase family are involved in the regulation of important physiological functions, including stress resistance and synthesis of the polysaccharide capsule. ACP1/LMW-PTP is an enzyme involved in platelet-derived growth factor-induced mitogenesis and cytoskeleton rearrangement. LMW-PTP is able to specifically bind and dephosphoryl...
TMPY-03125	SHP-2 Protein, Mouse, Recombinant (His) SAP-2,Syp,PTP1D,SH-PTP2,SH-PTP3,S...	Mouse	HEK293 Cells
	SHP2, also known as PTPN11, belongs to the protein-tyrosine phosphatase(PTP) family, non-receptor class 2 subfamily. PTPs catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation. SHP2 is widely expressed, with highest levels in heart, brain, and skeletal muscle. SHP2 acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participat...
TMPY-03296	SHP-1 Protein, Mouse, Recombinant (aa 207-597, His & GST) SH-PTP1,Hcph,70Z-SHP,Ptp1C,protein tyrosin...	Mouse	Baculovirus Insect Cells
	PTPN6 is an enzyme that belongs to the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of PTPN6 contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of PTPN6 with its substrates. PTPN6 is expressed primarily in hematopoietic cells, and functions as an ...

重组蛋白

TCPTP Protein, Human, Recombinant

Cat.No: TMPY-03484

Species: Human

Expression System: Baculovirus Insect Cells

PTP alpha/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST)

Cat.No: TMPY-02511

Species: Human

Expression System: Baculovirus Insect Cells

LMW-PTP Protein, Human, Recombinant (His)

Cat.No: TMPJ-00908

Species: Human

Expression System: E. coli

PRL-1/PTP4A1 Protein, Human, Recombinant (His)

Cat.No: TMPK-01132

Species: Human

Expression System: E. coli

PTP4A2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-02386

Species: Human

Expression System: E. coli

PTPN12 Protein, Human, Recombinant

Cat.No: TMPY-03548

Species: Human

Expression System: Baculovirus Insect Cells

PTPN12 Protein, Human, Recombinant (aa 1-355, His & GST)

Cat.No: TMPY-03486

Species: Human

Expression System: Baculovirus Insect Cells

PTP1C Protein, Human, Recombinant (His)

Cat.No: TMPJ-00465

Species: Human

Expression System: E. coli

TCPTP Protein, Mouse, Recombinant (aa 2-314, His)

Cat.No: TMPY-02369

Species: Mouse

Expression System: Baculovirus Insect Cells

IA2 Protein, Human, Recombinant (aa 687-979, His)

Cat.No: TMPJ-01141

Species: Human

Expression System: E. coli

TCPTP Protein, Human, Recombinant (aa 1-314, His & GST)

Cat.No: TMPY-02173

Species: Human

Expression System: Baculovirus Insect Cells

IA2 Protein, Human, Recombinant (aa 576-950, His)

Cat.No: TMPJ-01139

Species: Human

Expression System: E. coli

IA2 Protein, Human, Recombinant (aa 607-686 & aa 795-888 , His)

Cat.No: TMPJ-01140

Species: Human

Expression System: E. coli

DEP-1 Protein, Human, Recombinant (aa 997-1337, His)

Cat.No: TMPY-02763

Species: Human

Expression System: E. coli

PTP1B Protein, Human, Recombinant (His)

Cat.No: TMPY-04125

Species: Human

Expression System: E. coli

REG1A Protein, Human, Recombinant (His)

Cat.No: TMPY-01335

Species: Human

Expression System: HEK293 Cells

REG1A Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-05474

Species: Human

Expression System: HEK293 Cells

PRL-2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00053

Species: Human

Expression System: E. coli

PRL-3/PTP4A3 Protein, Human, Recombinant (His)

Cat.No: TMPK-00742

Species: Human

Expression System: E. coli

PTPN9 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-00487

Species: Human

Expression System: Baculovirus Insect Cells

PTPMT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02602

Species: Human

Expression System: E. coli

PTPRS Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02878

Species: Mouse

Expression System: E. coli

PTPRB Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02011

Species: Human

Expression System: E. coli

PTPN11 Protein, Human, Recombinant (T253M & Q257L, His)

Cat.No: TMPH-02277

Species: Human

Expression System: E. coli

PTPN5 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02278

Species: Human

Expression System: E. coli

PTPRZ1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02013

Species: Human

Expression System: P. pastoris (Yeast)

PTPRS Protein, Mus musculus, Recombinant (His & Myc)

Cat.No: TMPH-02987

Species: Mouse

Expression System: Baculovirus Insect Cells

PTPRZ1 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-02012

Species: Human

Expression System: E. coli

PTPRB Protein, Human, Recombinant (His)

Cat.No: TMPH-02010

Species: Human

Expression System: P. pastoris (Yeast)

DUSP14 Protein, Human, Recombinant (His & MBP)

Cat.No: TMPY-02595

Species: Human

Expression System: E. coli

Acid Phosphatase/ACP1 Protein, Human, Recombinant (GST)

Cat.No: TMPY-02131

Species: Human

Expression System: E. coli

SHP-2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03125

Species: Mouse

Expression System: HEK293 Cells

SHP-1 Protein, Mouse, Recombinant (aa 207-597, His & GST)

Cat.No: TMPY-03296

Species: Mouse

Expression System: Baculovirus Insect Cells

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