32
8
Cat. No. | Product Name | Target | Signaling Pathways |
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T12234 |
NMDA-IN-1
|
NMDAR | Neuroscience |
NMDA-IN-1是一种 NR2B 选择性 NMDA 拮抗剂,对NMDA 的Ki 值为 0.85 nM,对NR2B Ca2+ influx 的IC50值为 9.7 nM。 | |||
T63003 |
NMDA receptor potentiator-1
|
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NMDA receptor potentiator-1 (Compound 1368) 是一种亚基选择性的 NMDA receptor 增强剂。NMDA receptor potentiator-1 对 NR2C 和 NR2D 表达的 IC50 值分别为 4 μM 和 5 μM。 | |||
T60612 |
Neboglamine hydrochloride
|
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Neboglamine (CR-2249, XY-2401) hydrochloride 是NMDA 受体甘氨酸位点的正向调节剂,具有口服活性,可用于研究精神分裂症。 | |||
TP1179L |
Porcine dynorphin A(1-13) acetate
Dynorphin A Porcine Fragment 1-13 acetate,Porcine dynorphin A(1-13) acetate(72957-38-1 free base) |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Porcine dynorphin A(1-13) acetate (Dynorphin A Porcine Fragment 1-13 acetate)(72957-38-1 free base) 是一种有效的内源性 κ opioid 受体激动剂,在生理浓度下具有镇痛作用。暴露于强啡肽 A (1-13) 会导致单个神经元中 [Ca2+]i 的急剧增加,类似于急性 NMDA 治疗所见的增加。 | |||
T1751 |
Eliprodil
依利罗地,SL-820715 |
NMDAR; iGluR | Membrane transporter/Ion channel; Neuroscience |
Eliprodil (SL-820715) 是NR2B-NMDA 受体高效选择性抑制剂,IC50值1uM。它对NR2A-和NR2C-NMDA 受体作用较弱,可用于研究帕金森病和运动障碍治疗的试验。 | |||
T3486 |
3-MATIDA
|
GluR; NMDAR | Neuroscience |
3-MATIDA 是一种有效的 mGluR-1 拮抗剂(IC50:6.3 μM,大鼠 mGluR-1a)。显示出 ≥ 40 倍于其他受体的选择性:mGluR-5、mGluR-2、mGluR-4 (mGluR-4a) (IC50 > 300 μM)、NMDA 和 GluR (AMPA) (IC50 = 250 μM)。 3-MATIDA 在体外培养的鼠皮质细胞和大鼠海马切片培养物中充当神经保护剂。 | |||
T0825 |
Ebselen
SPI-1005,PZ-51,依布硒,CCG-39161 |
Phosphatase; Virus Protease; Calcium Channel; COX; HIV Protease | Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Ebselen (CCG-39161) 是一种谷胱甘肽过氧化物酶模拟物,是电压依赖性钙通道阻断剂。它抑制Mpro 和COVID-19病毒,是HIV-1衣壳 CTD 二聚化的抑制剂,具有抗炎、抗癌和抗氧化活性。 | |||
T60513 |
NMDA-IN-2
|
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NMDA-IN-2 (化合物 6b) 是普鲁卡因的衍生物。NMDA-IN-2是 NMDA 受体2B 亚型的抑制剂。 | |||
T61470 | NMDA receptor antagonist 5 | ||
NMDA receptor antagonist 5 (Compound 10e), a potent and non-toxic NMDA receptor antagonist, exhibits brain permeability. It is of significance in studying neurological disorders [1]. | |||
T60685 |
NMDA receptor modulator 3
|
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NMDA receptor modulator 3 (Compound 99) 是一种用于神经障碍研究的,NMDA 受体的调节剂。 | |||
T22734 | DL-AP7 | Others | Others |
DL-AP7 是一种竞争性NMDA 拮抗剂和抗惊厥剂。DL-AP7 阻断 NMDA 诱导的惊厥,并导致小鼠在被动回避任务中的学习表现受损。 | |||
T60695 |
DPQ
|
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DPQ 是PARP-1的有效抑制剂,可用于研究神经保护。DPQ 可降低 N-甲基-D-天冬氨酸(NMDA) 诱导的 PARP 激活,将 ATP 恢复至接近正常水平,并且显著减轻 NMDA 暴露模型中的神经元损伤。 | |||
T60306 | NMDA receptor antagonist 4 | ||
NMDA receptor antagonist 4 (IIc) 是一个非竞争性、电压依赖的、口服活性的 NMDAR 阻断剂,IC50值为1.93 μM。NMDA receptor antagonist 4 可透过血脑屏障,可用于研究阿兹海默症。 | |||
T76358 |
Neuropeptide Y (1-24) (human)
|
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Neuropeptide Y (1-24) (human) 是一种神经肽,它能够抑制大鼠输精管电刺激引发的抽搐反应,同时在体内刺激 N-methyl-D-aspartate (NMDA) 促使大鼠海马背侧 CA3 区神经元激活。 | |||
T60471 | Lanicemine dihydrochloride | ||
Lanicemine (AZD6765) dihydrochloride 是NMDA 通道的低捕获拮抗剂,Ki 值为 0.56-2.1 μM,在CHO 和爪蟾卵母细胞的IC50分别为 4-7 μM 和 6.4 μM。Lanicemine (AZD6765) dihydrochloride 具有持续的抗抑郁功效。 | |||
T78231 | DAO-IN-1 | Others | Others |
DAO-IN-1是高效的D-氨基酸氧化酶(DAO)抑制剂,其IC50值为269 nM。DAO负责d-丝氨酸的代谢,而d-丝氨酸是NMDA受体的共激动剂。 | |||
T60235 |
(Rac)-Lanicemine
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(Rac)-Lanicemine ((Rac)-AZD6765) 是 Lanicemine 的外消旋体。Lanicemine (AZD6765) 是一种低捕获的NMDA 受体拮抗剂,Ki 为 0.56-2.1 μM;在CHO 和非洲爪蟾卵母细胞中,IC50分别为 4-7 μM 和 6.4 μM。Lanicemine 具有抗抑郁作用。 | |||
T79375 |
NMDA receptor antagonist 8
|
iGluR | Membrane transporter/Ion channel; Neuroscience |
NMDA receptor antagonist8 (Compound (R)-10a)为针对GluN2B亚基具有选择性的NMDA受体拮抗剂,拥有Ki值为265 nM及IC50值为62 nM,适用于神经退行性疾病的研究。 | |||
T27269 |
Ensaculin HCl
KA 672,KA672,Ensaculin,Anseculin Hydrochloride,KA-672 HCl |
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Ensaculin is a NMDA antagonist and a 5HT1A agonist potentially for the treatment of Alzheimer's disease (AD). Ensaculin showed memory-enhancing effects in paradigms of passive and conditioned avoidance in both normal and artificially amnesic rodents. It e | |||
T73682 |
(R)-Lanicemine
|
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(R)-Lanicemine ((R)-AZD6765) 是 Lanicemine 的低活性的 R 型异构体。Lanicemine (AZD6765) 是一种低捕获的NMDA 受体拮抗剂,Ki 为 0.56-2.1 μM。CHO 和爪蟾卵母细胞中,IC50分别为 4-7 μM 和 6.4 μM。具有抗抑郁作用。 | |||
T74129 |
L-Homocysteic acid
|
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L-Homocysteic acid (L-HCA) 是一种内源性兴奋性氨基酸,可作为NMDA 受体激动剂 (EC50: 14 μM)。L-Homocysteic acid 具有神经毒性,可用于神经系统疾病的研究。 | |||
T74195 | 4′-Demethylnobiletin | ||
4′-Demethylnobiletin 是一种生物活性代谢物,可以激活PKA/ERK/CREB 信号通路,增强海马神经元中 CRE 介导的转录,并通过刺激ERK 信号逆转与 NMDA 受体拮抗相关的记忆障碍。 | |||
T13112 |
Tat-NR2B9c
Tat-NR2Bct,NA-1 |
NO Synthase; iGluR | Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience |
Tat-NR2B9c (NA-1) 是一种突触后密度-95(PSD-95)抑制剂,具有神经保护和抗癫痫作用。Tat-NR2B9c 可抑制PSD-95d2、 PSD-95d1 和 PSD-95,可阻止NMDA诱导的神经元NADPH氧化酶的激活,从而阻断超氧化物的产生,可减少中风后急性期的缺血性损伤。 | |||
T79569 |
AChE/Aβ-IN-1
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AChE/Aβ-IN-1(compound 32)是一种双功能化合物,既表现出高效的AChE抑制活性,IC50值为86 nM,又能作为NMDA受体(GluN1-1b/GluN2B亚基组合)的拮抗剂,其IC50为3.876 μM。此外,它能够抑制Aβ聚集,且表现出优秀的血脑屏障穿透能力和神经保护效果,能在大鼠模型中显著改善认知和空间记忆障碍。 | |||
T79857 |
Risevistinel
NYX-783 |
iGluR | Membrane transporter/Ion channel; Neuroscience |
Risevistinel (NYX-783),一种N-甲基-D-天冬氨酸 (NMDA) 受体正变构调节剂,旨在缓解与神经退行性疾病相关的认知功能障碍,包括轻度认知障碍、阿尔茨海默病初期、帕金森病及路易体病等病症。 | |||
TP1179 |
Porcine dynorphin A(1-13)
Dynorphin A Porcine Fragment 1-13 |
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Porcine dynorphin A (1-13) is a potent, endogenous κ opioid receptor agonist and is antinociceptive at physiological concentrations. Exposure to dynorphin A (1-13) causes acute increases in [Ca2+]i in individual neurons similar to increases seen with acut | |||
T60578 |
Procyclidine
|
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Procyclidine (Tricyclamol; (±)-Procyclidine) 是一种抗胆碱能剂。它是一种毒蕈碱受体 (muscarinic receptor) 拮抗剂,也是 N-甲基-D-天冬氨酸 (NMDA) 拮抗剂。Procyclidine 可用于帕金森症和相关精神疾病的研究,如Soman 诱发的癫痫。 | |||
TP1910 |
CALP1
|
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Cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site; produces CaM-dependent activation of phosphodiesterase. Also binds to cytoplasmic sites on other Ca2+ channels, including NMDA and HIV-1 gp120-activated channels, inhibit | |||
T79611 |
DQP-26
|
iGluR | Membrane transporter/Ion channel; Neuroscience |
DQP-26,作为一种高效的NMDAR负变构调制剂,展现出对GluN2C和GluN2D亚单位具有显著的选择性,其IC50值分别仅为0.77 μM和0.44 μM。该化合物在针对NMDAR相关神经系统疾病的研究中显示出潜在应用价值。 | |||
T79571 |
AChE/Aβ-IN-2
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AChE/Aβ-IN-2(compound 32)是一种双重功能性化合物,作为乙酰胆碱酯酶(AChE)的有效口服抑制剂,表现出86 nM的IC50,同时也对NMDA受体(GluN1-1b/GluN2B亚基组合)起拮抗作用,其IC50为3.876 μM。该化合物能够抑制Aβ聚集,具有良好的血脑屏障渗透性,并表现出神经保护效果。在大鼠模型中,AChE/Aβ-IN-2展现出改善认知和空间记忆障碍的潜力。 | |||
T36521 |
Alaproclate (hydrochloride)
|
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Alaproclate is a selective serotonin reuptake inhibitor (SSRI).1,2 It inhibits depletion of serotonin (5-HT) induced by 4-methyl-α-ethyl-m-tyramine in rat cerebral cortex, hippocampus, hypothalamus, and striatum (EC50s = 18, 4, 8, and 12 mg/kg, respectively).1 Alaproclate inhibits NMDA-evoked currents and depolarization-induced voltage-dependent potassium currents in rat hippocampal neurons (IC50s = 1.1 and 6.9 μM, respectively) and does not inhibit GABA-evoked currents when used at concentratio... | |||
T36101 |
Psychotridine
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Psychotridine is an alkaloid that has been found inP. forsterianaand has diverse biological activities.1,2,3It inhibits ADP-, collagen-, or thrombin-induced aggregation of washed isolated human platelets with IC50values of 1.4, 1.4, and 3.9 μM, respectively.1Psychotridine (2.5 or 5 μM) is cytotoxic to HTC rat hepatocellular carcinoma cells.2It reduces paw licking induced by capsaicin in mice when administered at doses of 0.5, 2.5, or 5 mg/kg.3 1.Beretz, A., Roth-Georger, A., Corre, G., et al.Pol... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T6S0659 |
Rhynchophylline
钩藤碱,Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin |
Calcium Channel; NF-κB | Membrane transporter/Ion channel; Metabolism; NF-κB |
Rhynchophylline (Mitrinermine) 是一种生物碱类化合物,从钩藤中分离得到,具有很高的生物活性,被广泛用于抗炎、神经保护等方面的研究。 | |||
T2768 |
Saikosaponin A
柴胡皂苷A,柴胡皂苷 A |
NF-κB; Antibacterial; Liver X Receptor | Metabolism; Microbiology/Virology; NF-κB |
Saikosaponin A 是银柴胡中的主要活性成分,有抗炎活性,可上调 LXRα的表达。 | |||
T6S1418 |
Praeruptorin C
|
Antioxidant; Calcium Channel | Membrane transporter/Ion channel; Metabolism; oxidation-reduction |
Praeruptorin C 是白花前胡中的一种主要成分,是钙拮抗剂,pD2′值为 5.7。 | |||
T1589 |
D-Cycloserine
RO-1-9213,D-环丝氨酸 |
Others; Antibacterial; Antibiotic; iGluR | Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Others |
D-Cycloserine (RO-1-9213) 是一种抗生素,靶向细菌细胞壁肽聚糖生物合成酶。它是一种NMDA 部分激动剂,可以改善认知功能,可研究耐多药结核病。 | |||
T3S2259 |
Methyl eugenol
4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether,丁香酚甲醚,丁子香酚甲醚 |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Methyl eugenol (4-allylveratrole) 是一种苯丙类化合物,存在于植物叶子、果实、根茎中,当植物相应的部位因食草动物进食而受损时,就会释放。它可用于消灭雄性东方果蝇。 | |||
T2S2264 |
Linalool
Linalol,(±)-Linalool,Phantol,沉香醇 |
Apoptosis; IL Receptor; TNF; Endogenous Metabolite; iGluR | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Linalool (Linalol) 是存在芫荽等植物中的单萜类天然产物,是竞争性NMDA 受体拮抗剂,具有抗肿瘤和抗心脏毒性的作用。它通过激活 Nrf2 诱导抗氧化防御和通过抑制 NF-κB 减少炎症反应来保护其免受 LPS/GalN 诱导的肝损伤,具有镇痛、抗菌和抗炎的特性。 | |||
T4752 |
1-Aminocyclopropane-1-carboxylic acid
1-Aminocyclopropanecarboxylic acid,1-氨基环丙烷羧酸,1-Amino-1-carboxycyclopropane,ACC |
Endogenous Metabolite; NMDAR | Metabolism; Neuroscience |
1-Aminocyclopropane-1-carboxylic acid (ACC) 是内源性代谢产物的一种。 | |||
T75890 |
Conantokin G TFA
|
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Conantokin G TFA 是一种 17 个氨基酸的肽,是一种有效,选择性和竞争性的 N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂。Conantokin G TFA 抑制鼠皮质神经元中NMDA 诱发的电流,IC50为 480 nM,具有神经保护作用。 |