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Search Results for " myosin "

51

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T72060	Myosin V-IN-1	Myosin	Cytoskeletal Signaling
	Myosin V-IN-1是一种有效且具有选择性的 Myosin V 抑制剂，Ki 值为 6 μM。Myosin V-IN-1 抑制肌动蛋白 V 发生作用，通过选择性抑制肌动球蛋白复合物释放 ADP 来减缓肌动蛋白激活的肌球蛋白 V ATP 酶。
T21550	Blebbistatin (±)-Blebbistatin	ATPase; Myosin	Cytoskeletal Signaling; Membrane transporter/Ion channel
	Blebbistatin ((±)-Blebbistatin) 是一种选择性的非肌肉肌球蛋白 II 抑制剂，可促进角膜内皮细胞 (CEC) 的定向迁移并加速伤口愈合，并保留了细胞连接的完整性和屏障功能。
T6038	(-)-Blebbistatin (S)-(-)-Blebbistatin	ATPase; Myosin	Cytoskeletal Signaling; Membrane transporter/Ion channel
	(-)-Blebbistatin ((S)-(-)-Blebbistatin) 是 blebbistatin 的 S 对映异构体。它是一种有效的选择性肌球蛋白 II 抑制剂，IC50 范围为 0.5 至 5 μM。
T15050	Danicamtiv MYK-491,SAR 440181	Myosin	Cytoskeletal Signaling
	Danicamtiv (MYK-491) 是一种正性肌力药物，也是一种心肌肌球蛋白的选择性变构激活剂，可增加心脏收缩功能并保持机械效率。
T78375	Myosin H Chain Fragment, mouse
	MyosinH Chain Fragment, mouse, 来自α-肌球蛋白重链肽的片段，旨在诱导实验性自身免疫性心肌炎(EAM)小鼠模型。
T2006	Omecamtiv mecarbil CK-1827452	ATPase; Myosin	Cytoskeletal Signaling; Membrane transporter/Ion channel
	Omecamtiv mecarbil (CK-1827452) 是一种心脏特异性的肌球蛋白激活剂，用于研究心脏相关疾病。
T2176	2,3-Butanedione 2-Monoxime Diacetyl monoxime,2,3-Butanedione-2-monoxime	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	2,3-Butanedione 2-Monoxime (Diacetyl monoxime) 是一种肌球蛋白 ATP 酶(myosin ATPase) 抑制剂。它诱导肌质网 Ca2+释放，能够有效抑制骨骼肌和心肌收缩。
T80046	Myosin H Chain Fragment, mouse acetate
	MyosinH Chain Fragment, mouse acetate salt，一种α-肌球蛋白重链肽的肽段，用于诱导实验性自身免疫性心肌炎(EAM)的小鼠模型。
T9258	Aficamten	Others	Others
	Aficamten 是一种可研究肥厚型心肌病的新型心肌肌球蛋白抑制剂，IC50为 1.4 μM。
T16104	ML-9	Myosin; Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	ML-9 是 Akt 激酶的一种选择性强效抑制剂，可抑制肌球蛋白轻链激酶 (MLCK) 和基质相互作用分子1(STIM1) 活性。它通过刺激自噬小体的形成并抑制其降解来诱导自噬。它抑制 MLCK，PKA 和 PKC 活性，Ki 值分别为 4、32 和 54 μM。
T81732	Myosin light chain kinase fragment 11-19 amide MLCK(11-19) amide
	Myosinlight chain kinase fragment 11-19 amide (MLCK(11-19) amide) 为MLCK专一性多肽抑制剂，具抑制低渗透压刺激下Ca2+入细胞的能力，并可应用于人类宫颈癌研究。
T7134	Mavacamten MYK-461,SAR439152	Myosin	Cytoskeletal Signaling
	Mavacamten (MYK-461) 是一种可口服的心肌肌球蛋白 ATP 酶抑制剂，在牛心脏和人心脏中的IC50值分别为 490和711 nM。
T7648	HA-100	Myosin; PKA; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	HA-100 是蛋白激酶和ROCK 抑制剂，抑制PKG，PKA，PKC 和MLC 激酶的IC50值分别为 4、8、12 和 240 μM。
T7144	BTS N-Tosylbenzylamine,N-苄基-对甲苯磺酸胺,N-Benzyl-p-toluenesulfonamide	ATPase; Myosin	Cytoskeletal Signaling; Membrane transporter/Ion channel
	BTS (N-Tosylbenzylamine) 是一种选择性骨骼肌肌球蛋白 II 亚片段 1 (S1) ATPase 活性抑制剂，可特异性抑制骨骼肌快速纤维的收缩。它对肌动蛋白和 Ca2+刺激的肌球蛋白 S1 ATPase 的 IC50值约为 5 µM。
T3050	ML-7 hydrochloride ML-7 HCl,ML-7盐酸盐	Serine/threonin kinase; Myosin; YAP; PKA; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism; Stem Cells; Tyrosine Kinase/Adaptors
	ML-7 hydrochloride (ML-7 HCl) 是一种可渗透细胞的、可逆的、有效的、ATP 竞争性的肌球蛋白轻链激酶(MLCK) 特异性抑制剂，IC50为300 nM。它还抑制平滑肌肌球蛋白轻链激酶、PKA 和 PKC。
T20792	W-7 hydrochloride N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐,W 7 HCl,W7 HCl,W-7 HCl	CaMK; Apoptosis; Myosin; PDE	Apoptosis; Cytoskeletal Signaling; Metabolism; Neuroscience
	W-7 hydrochloride (W-7 HCl) 是一种选择性的钙调蛋白拮抗剂。它抑制Ca2+-钙调蛋白依赖性磷酸二酯酶和肌球蛋白轻链激酶，IC50值分别为 28 μM 和 51 μM。它可诱导细胞凋亡，具有抗癌活性。
T67952	JB062	Myosin	Cytoskeletal Signaling
	JB062是一种针对非肌肉肌球蛋白(nonmusclemyosin)的抑制剂，其IC50值对骨骼肌肌球蛋白为1.6μM、心肌肌球蛋白为5.4μM，而对平滑肌肌球蛋白II大于100μM。此化合物对人类癌细胞显示出细胞毒性，对正常细胞则无此作用。JB062在肌肉痉挛、慢性肌肉骨骼疼痛及肥厚型心肌病研究中有潜在应用价值。
T67951	JB061	Myosin	Cytoskeletal Signaling
	JB061是一种非肌肉肌球蛋白II抑制剂，针对心肌肌球蛋白、骨骼肌肌球蛋白和平滑肌肌球蛋白II的IC50分别为4.4 μM、9.1 μM和>100 μM。其对ATP酶活性的抑制作用较弱（IC50>200 μM）。此外，JB061对COS-7细胞显示出细胞毒性，IC50值为39 μM。
T72023	JB002	Myosin	Cytoskeletal Signaling
	JB002为一种肌球蛋白 II 抑制剂，IC50值不大于10 μM。适用于研究肌肉痉挛、慢性肌肉骨骼疼痛及肥厚型心肌病。
T12360	para-Nitroblebbistatin p-Nitroblebbistatin	Myosin	Cytoskeletal Signaling
	para-Nitroblebbistatin (p-Nitroblebbistatin) 是无细胞毒性、无荧光、光稳定、特异性的肌球蛋白 II (Myosin II) 抑制剂。para-Nitroblebbistatin 可用于肌球蛋白 II 在生理学、发育和细胞生物学中特殊作用的相关研究。
T24612	Pentachloropseudilin PClP
	Pentachloropseudilin is a selective inhibitor of Myosin-1. In target cells, It acts by suppressing transforming growth factor-β activity by accelerating cell-surface type II TGF-β receptor turnover.
T24214	Phenamacril JS39919,苯那普利,JS399 19	Myosin; Antifungal	Cytoskeletal Signaling; Microbiology/Virology
	Phenamacril (JS39919) 是一种氰基丙烯酸酯类杀菌剂，对镰刀菌，特别是禾谷镰刀菌有很强的抑制作用。它是一种特异性镰刀菌肌球蛋白 I 抑制剂。
T12503	(+)-Blebbistatin	Others	Others
	(+)-Blebbistatin 是 (–)-Blebbistatin 的非活性对映异构体。 (–)-Blebbistatin 是一种选择性肌球蛋白 II ATPase 抑制剂。
T26078	Rhodblock 6 Rhodblock6,Rhodblock-6	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Rhodblock 6 是一种 Rho 激酶 (ROCK) 抑制剂，可抑制磷酸化 MRLC（肌球蛋白调节轻链）定位,通过特异性抑制 Rho 激酶的活性发挥作用。
T62447	Paltimatrectinib PBI-200,PPI-5278	Trk receptor; Tyrosine Kinases	Tyrosine Kinase/Adaptors
	Paltimatrectinib (PBI-200) 是一种高效的酪氨酸激酶 (tyrosine kinase) 抑制剂，具有抗癌活性，抑制肌球蛋白相关激酶 A (TrkA) 。Paltimatrectinib 可用于研究膀胱癌、乳腺癌和结直肠癌。
TP1890L1	MLCK inhibitor peptide 18 acetate MLCK inhibitor peptide 18 acetate(224579-74-2 free base)	Serine/threonin kinase	Cell Cycle/Checkpoint; Metabolism
	MLCK inhibitor peptide 18 acetate(224579-74-2 free base) 是肌球蛋白轻链激酶的选择性竞争性抑制剂 (IC50 = 50 nM)。显示出比 CaM 激酶 II 高 4000 倍的选择性，并且不抑制 PKA。细胞可渗透。
T13492	3,5-Diiodothyropropionic acid C082182,Ditpa cpd,3,5-二碘甲腺丙酸	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	3,5-Diiodothyropropionic acid (C082182) 是一种甲状腺激素类似物，能够诱导 α-肌球蛋白重链 mRNA 表达。它可与甲状腺激素受体结合，作用于 TRα1 (Ka:2.40 M-1) 和 TRβ1 (Ka:4.06 M-1) 。
T30778	CCG-257081 MRTF/SRF-IN-1,CCG257081,CCG 257081	Rho; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	CCG-257081 (MRTF/SRF-IN-1) 是心肌素相关转录因子和血清反应因子 (MRTF/SRF) 的抑制剂,通过抑制 Rho/MRTF/SRF 通路来发挥作用。CCG-257081 已在多个小鼠模型中显示出预防博莱霉素诱导的纤维化的功效。CCG-257081 可用于预防癌症和纤维化的研究。
T1613	Hydralazine hydrochloride Hydralazine HCl,Apresoline,盐酸肼屈嗪	MAO; HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism; Neuroscience
	Hydralazine hydrochloride (Apresoline) 是一种直接作用的血管舒张剂，可抗高血压。
T1433	Ritodrine hydrochloride DU21220,盐酸利托君,Ritodrine HCl,NSC 291565	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Ritodrine hydrochloride (NSC 291565) 是一种 β-2肾上腺素受体激动剂。
T0075	Nicorandil SG-75,尼可地尔	Potassium Channel	Membrane transporter/Ion channel
	Nicorandil (SG-75) 是一种有效的钾通道激活剂，靶向血管核苷二磷酸依赖性 K+通道和心脏 ATP 敏感 K+通道 (KATP)。Nicorandil 是一种烟酰胺酯，具有血管舒张和心脏保护作用，并具有治疗心绞痛和缺血性心脏病的潜力。
T14069	A-3 hydrochloride	CaMK; Casein Kinase; PKA; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism; Neuroscience; Stem Cells; Tyrosine Kinase/Adaptors
	A-3 hydrochloride 是一种细胞可渗透的、可逆的、ATP 竞争性非选择性拮抗剂。它抑制 PKA 、酪蛋白激酶 II 和肌球蛋白轻链激酶，Ki 值分别为4.3 µM、5.1 µM 和7.4 µM。它还抑制 PKC 和酪蛋白激酶 I 的活性，Ki 分别为 47 µM 和 80 µM。
T16145	MS-444 BE-34776	Others	Others
	MS-444 suppresses the activity of purified smooth muscle myosin light chain kinase (MLCK) (IC50: 10 μM).
T33451	ML 7 ML7,ML-7
	ML 7 is an inhibitor of myosin light chain kinase that protects cardiac function from ischemia/reperfusion (I/R) injury.
T70626	MS 347a
	MS 347a is a myosin light chain kinase (MLCK) inhibitor; an epoxide analog of sydowinin B (MS-347b).
T69639	Sevasemten
	Sevasemten为骨骼肌肌球蛋白(Myosin)的变构抑制剂，具有选择性抑制作用，其IC50值对骨骼肌球蛋白 ≤ 10 μM，而对心脏肌球蛋白则 >100 μM。
T62804	YQ456
	YQ456 是一种新型的肌球蛋白小分子抑制剂，能够高亲和力的结合肌球蛋白 (KD: 37 nM)，抗侵袭能力强 (IC50: 110 nM) 。
T24272	KT5926 KT 5926,KT-5926
	KT5926 is an effective and selective inhibitor of myosin light chain kinase. KT5926 is an analogue of K-252a, which blocks all responses to NGF. KT5926 selectively inhibits nerve growth factor-dependent neurite elongation.
T23992	Diazobenzenesulfonic acid Diazobenzenesulphonate,diazobenzene sulfonic acid,DASA,Diazobenzene sulfonate,Diazobenzenesulfonate
	Diazobenzenesulfonic acid is a whiter or reddish crystalline acid derivative of sulfanilic acid. It is a desensitizer (inhibitor) of allosteric effect for myosin ATPase 13.
T62833	Myoferlin inhibitor 1
	Myoferlin inhibitor 1 是一种新型抗胰腺癌转移药物，能够肌球蛋白发挥作用。
TP1890	MLCK inhibitor peptide 18
	Selective competitive inhibitor of myosin light chain kinase (IC50 = 50 nM). Displays 4000-fold selectivity over CaM kinase II and does not inhibit PKA. Cell permeable.
TP1710	Calmodulin Binding Peptide 1
	Calmodulin Binding Peptide 1, a potent CaM-binding peptide with picomolar (pM) affinity, originates from smooth muscle myosin light-chain kinase (MLCK peptide). It effectively blocks inositol trisphosphate (IP3)-induced calcium (Ca2+) release [1].
T36400	para-amino-Blebbistatin
	para-amino-Blebbistatin is a more water-soluble form of (S)-4'-nitro-blebbistatin , which is a more stable and less phototoxic form of (-)-blebbistatin .1,2,3 (-)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases that rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM).2,3,4 Through these effects, it blocks ap...
T36335	(S)-nitro-Blebbistatin
	(S)-nitro-Blebbistatin is a more stable form of (-)-blebbistatin , which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (-)-Blebbistatin rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM). Through these effects, it blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. H...
T17189	U-46619 9,11-Methanoepoxy PGH2	Progesterone Receptor; PPAR	DNA Damage/DNA Repair; Metabolism; Others
	U-46619是一种有效的TXA2激动剂，是一种血栓素A2类似物（内过氧化物），有诱导肌球蛋白轻链9 (Myl9)基因缺失小鼠主动脉平滑肌(SM)收缩的功能。
T73439	MPH-220
	MPH-220是一种口服活性的、选择性骨骼肌myosin-2抑制剂，能够促进肌肉松弛。作为一种抗痉挛药物，它用于研究痉挛和肌肉僵硬。
T16103	ML-9 Free Base	Others	Others
	ML-9 (free base) suppresses MLCK, PKA, and PKC activity (Ki: 4, 32, and 54 μM, respectively). ML-9 (free base) is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal interaction molecule 1 (STIM1) acti
T63641	(3S,4R)-PF-6683324
	(3S,4R)-PF-6683324 是原肌球蛋白相关激酶 (Trk) 抑制剂，对疼痛和癌症表现出研究潜力。
T71207	(R)-(+)-Blebbistatin O-Benzoate
	(R)-(+)-Blebbistatin O-Benzoate is a derivative of Blebbistatin. (R)-(+)-Blebbistatin is a 1-phenyl-2-pyrrolidinone derivative and a selective inhibitor of non-muscle myosin II. It blocks cell blebbing rapidly and reversibly and also disrupts directed cell migration and cytokinesis in vertebrate cell. (R)-(+)-Blebbistatin can also inhibit contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. (R)-(+)-Blebbistatin is suitable as a negative control for (S)-(-)-...
T78585	Pentabromopseudilin
	Pentabromopseudilin (PBrP) 为自Pseudomonas bromoutilis与Alteromonas luteoviolaceus两种海洋细菌中提取的海洋抗生素，展现抗菌、抗肿瘤及植物毒性活性。此化合物为肌球蛋白 Va(Myosin Va, MyoVa)的可逆构型抑制剂，并能有效抑制转化生长因子-β(Transforming Growth Factor-β, TGF-β)的活性，适用于纤维化疾病与癌症研究领域。

化合物

Myosin V-IN-1

Cat.No: T72060

Target: Myosin

Cat.No: T21550

Synonym: (±)-Blebbistatin

Target: ATPase, Myosin

(-)-Blebbistatin

Cat.No: T6038

Synonym: (S)-(-)-Blebbistatin

Target: ATPase, Myosin

Cat.No: T15050

Synonym: MYK-491,SAR 440181

Target: Myosin

Myosin H Chain Fragment, mouse

Cat.No: T78375

Omecamtiv mecarbil

Cat.No: T2006

Synonym: CK-1827452

Target: ATPase, Myosin

2,3-Butanedione 2-Monoxime

Cat.No: T2176

Synonym: Diacetyl monoxime,2,3-Butanedione-2-monoxime

Target: Akt

Myosin H Chain Fragment, mouse acetate

Cat.No: T80046

Cat.No: T9258

Target: Others

Cat.No: T16104

Target: Myosin, Akt

Myosin light chain kinase fragment 11-19 amide

Cat.No: T81732

Synonym: MLCK(11-19) amide

Cat.No: T7134

Synonym: MYK-461,SAR439152

Target: Myosin

Cat.No: T7648

Target: Myosin, PKA, PKC

Cat.No: T7144

Synonym: N-Tosylbenzylamine,N-苄基-对甲苯磺酸胺,N-Benzyl-p-toluenesulfonamide

Target: ATPase, Myosin

ML-7 hydrochloride

Cat.No: T3050

Synonym: ML-7 HCl,ML-7盐酸盐

Target: Serine/threonin kinase, Myosin, YAP, PKA, PKC

W-7 hydrochloride

Cat.No: T20792

Synonym: N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐,W 7 HCl,W7 HCl,W-7 HCl

Target: CaMK, Apoptosis, Myosin, PDE

Cat.No: T67952

Target: Myosin

Cat.No: T67951

Target: Myosin

Cat.No: T72023

Target: Myosin

para-Nitroblebbistatin

Cat.No: T12360

Synonym: p-Nitroblebbistatin

Target: Myosin

Pentachloropseudilin

Cat.No: T24612

Synonym: PClP

Cat.No: T24214

Synonym: JS39919,苯那普利,JS399 19

Target: Myosin, Antifungal

(+)-Blebbistatin

Cat.No: T12503

Target: Others

Cat.No: T26078

Synonym: Rhodblock6,Rhodblock-6

Target: ROCK

Paltimatrectinib

Cat.No: T62447

Synonym: PBI-200,PPI-5278

Target: Trk receptor, Tyrosine Kinases

MLCK inhibitor peptide 18 acetate

Cat.No: TP1890L1

Synonym: MLCK inhibitor peptide 18 acetate(224579-74-2 free base)

Target: Serine/threonin kinase

3,5-Diiodothyropropionic acid

Cat.No: T13492

Synonym: C082182,Ditpa cpd,3,5-二碘甲腺丙酸

Target: Thyroid hormone receptor(THR)

Cat.No: T30778

Synonym: MRTF/SRF-IN-1,CCG257081,CCG 257081

Target: Rho, Ras

Hydralazine hydrochloride

Cat.No: T1613

Synonym: Hydralazine HCl,Apresoline,盐酸肼屈嗪

Target: MAO, HIF/HIF Prolyl-Hydroxylase

Ritodrine hydrochloride

Cat.No: T1433

Synonym: DU21220,盐酸利托君,Ritodrine HCl,NSC 291565

Target: Adrenergic Receptor

Cat.No: T0075

Synonym: SG-75,尼可地尔

Target: Potassium Channel

A-3 hydrochloride

Cat.No: T14069

Target: CaMK, Casein Kinase, PKA, PKC

Cat.No: T16145

Synonym: BE-34776

Target: Others

Cat.No: T33451

Synonym: ML7,ML-7

Cat.No: T70626

Cat.No: T69639

Cat.No: T62804

Cat.No: T24272

Synonym: KT 5926,KT-5926

Diazobenzenesulfonic acid

Cat.No: T23992

Synonym: Diazobenzenesulphonate,diazobenzene sulfonic acid,DASA,Diazobenzene sulfonate,Diazobenzenesulfonate

Myoferlin inhibitor 1

Cat.No: T62833

MLCK inhibitor peptide 18

Cat.No: TP1890

Calmodulin Binding Peptide 1

Cat.No: TP1710

para-amino-Blebbistatin

Cat.No: T36400

(S)-nitro-Blebbistatin

Cat.No: T36335

Cat.No: T17189

Synonym: 9,11-Methanoepoxy PGH2

Target: Progesterone Receptor, PPAR

Cat.No: T73439

Cat.No: T16103

Target: Others

(3S,4R)-PF-6683324

Cat.No: T63641

(R)-(+)-Blebbistatin O-Benzoate

Cat.No: T71207

Pentabromopseudilin

Cat.No: T78585

Cat. No.	Product Name	Target	Signaling Pathways
T8274	3-Methyl-L-histidine	Endogenous Metabolite	Metabolism
	3-Methyl-L-histidine 是一种肉类尤其是鸡肉摄入和大豆制品摄入的生物标记。
TN1533	Cucurbitacin A	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-Kinase.

天然产物

3-Methyl-L-histidine

Cat.No: T8274

Target: Endogenous Metabolite

Cat.No: TN1533

Target: ROCK

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