38
5
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11995 |
Melatonin-d4
N-Acetyl-5-methoxytryptamine D5,Melatonin D5,褪黑素 D5 |
Others | Others |
Melatonin D5, a deuterium-labeled version of melatonin, is a hormone produced by the pineal gland, known for its role as a selective ATF-6 inhibitor that promotes apoptosis in human hepatoma cells via COX-2 downregulation. Additionally, it activates melatonin receptors and exhibits antioxidative and anti-inflammatory properties. | |||
T64745 | Melatonin Biotin | ||
Melatonin Biotin 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T64745。 | |||
T60490 |
Melatonin receptor agonist 1
|
||
Melatonin receptor agonist 1 (compound 20c) 是褪黑激素受体 (MT) 的有效激动剂,对MT2的Ki 值为 108 nM,对MT1的Ki 值为 1140 nM。 | |||
T14042 |
4-P-PDOT
4-phenyl-2- propionamidotetralin |
Melatonin Receptor; MT Receptor | GPCR/G Protein; Neuroscience |
4-P-PDOT (4-phenyl-2- propionamidotetralin) 是一种选择性和亲和性的褪黑激素受体拮抗剂,可显著抵消褪黑激素介导的抗氧化作用。它对MT2的选择性是 MT1 的 300 倍以上。 | |||
T8600 |
N-ACETYLTRYPTAMINE
|
Melatonin Receptor | GPCR/G Protein |
N-Acetyltryptamine 是视网膜褪黑素受体的部分激动剂,可用于 5-羟色胺 N-乙酰转移酶活性的检测。 | |||
T9193 |
ACH-000143
|
Melatonin Receptor; MT Receptor | GPCR/G Protein; Neuroscience |
ACH-000143 是一种可口服的褪黑素受体激动剂,对 MT1 和 MT2 的EC50值分别为0.06 和0.32 nM。 | |||
T15795 |
Luzindole
N-乙酰-2-苄基色胺,N-0774 |
Melatonin Receptor; MT Receptor | GPCR/G Protein; Neuroscience |
Luzindole (N-0774) 是一种选择性褪黑素受体拮抗剂,可抑制实验性自身免疫性脑脊髓炎,有抗抑郁样活性。它优先靶向 MT2 (Mel1b),对于人 MT2 和 MT1 的 Ki 值分别为 10.2 和 158 nM。 | |||
T1463 |
Ramelteon
雷美替胺,TAK-375 |
Melatonin Receptor; MT Receptor | GPCR/G Protein; Neuroscience |
Ramelteon (TAK-375) 是强效高选择性和可口服的 MT1/MT2激动剂,Ki 值分别为 14 和 112 pM,有用于失眠症的研究潜力。 | |||
T3495 |
Tasimelteon
他司美琼,VEC-162,BMS-214778 |
Melatonin Receptor; MT Receptor | GPCR/G Protein; Neuroscience |
Tasimelteon (BMS-214778) 是一种褪黑激素受体激动剂,用于治疗盲人的非 24 小时睡眠-觉醒障碍。 | |||
T1445 |
Agomelatine
Thymanax,S-20098,Valdoxan,阿戈美拉汀 |
Melatonin Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience |
Agomelatine (Valdoxan) 是褪黑激素受体的强效激动剂和 5-羟色胺-2C (5-HT2C) 受体的拮抗剂,在猪和人 5-HT2C 克隆受体中pKi 分别为 6.4 和 6.2。 | |||
T16834 |
S26131
N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide |
MT Receptor | Neuroscience |
S26131 (N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide) 是一种选择性的褪黑激素配体 MT1 和 MT2 拮抗剂,对 MT1 和 MT2 的 Ki 值分别为 0.5 和 112 nM。 | |||
T22530 |
6-Chloromelatonin
|
Melatonin Receptor; Dopamine Receptor | GPCR/G Protein; Neuroscience |
6-Chloromelatonin 是一种有效的褪黑素受体 (melatonin receptor) 激动剂,是一种5-甲氧基吲哚化合物,可竞争兔视网膜中相同的突触前褪黑激素受体位点 ,可抑制[3H]多巴胺的钙依赖性释放 具有比褪黑素更高的代谢稳定性。6-Chloromelatonin 竞争 [3H] 褪黑素 与 MT2 受体结合 (pKi=9.77),可能用于研究与抑郁症相关的失眠和睡眠障碍。 | |||
T10073 |
2-Iodomelatonin
|
Melatonin Receptor | GPCR/G Protein |
2-Iodomelatonin 是褪黑激素受体 1 (MT1) 的强效激动剂,Ki 为 28 pM,对 MT1的选择性是 MT2 的 5 倍以上。2-Iodomelatonin 可用于鉴定,表征和定位脑和周围组织的褪黑激素结合位点。 | |||
T10929L |
D-3263 hydrochloride
EC D-3263 HCl,D3263 HCl salt |
TRP/TRPV Channel | Membrane transporter/Ion channel |
D-3263 hydrochloride (D3263 HCl salt) 是一种具有口服活性的 TRPM8 激动剂。 | |||
T41345 |
AFMK
Formyl-N-acetyl-5-methoxykynurenamine,Acetyl-N-formyl-5-methoxykynurenamine |
Apoptosis; Free radical scavengers; Antioxidant; Endogenous Metabolite | Apoptosis; Metabolism; oxidation-reduction |
AFMK (Formyl-N-acetyl-5-methoxykynurenamine) 是褪黑激素的活性代谢物,具有抗氧化和自由基清除活性。 AFMK 是一种凋亡调节剂,可提高吉西他滨在 PANC-1 细胞中的抗肿瘤作用。 | |||
T10198 |
8-M-PDOT
8-Methoxy-2-propionamidotetralin,AH-002 |
MT Receptor | Neuroscience |
8-M-PDOT (AH-002) 是一种具有选择性和有效性的褪黑激素 MT2 受体激动剂,对 MT1 受体也具有抑制作用。8-M-PDOT 具有抗焦虑活性,可用于研究由 MT2 诱导的神经疼痛。 | |||
T34081 |
Piromelatine
NEU-P-11,NEU-P 11,NEU-P11 |
P2X Receptor; 5-HT Receptor; MT Receptor; Sodium Channel; TRP/TRPV Channel | GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
Piromelatine 是褪黑激素 MT1/MT2 受体、5-HT1A 和 5-HT1D 的激动剂,也是 5-HT2B 的拮抗剂。Piromelatine 具有抗痛觉活性,对 P2X3、TRPV1 和 Nav1.7 通道有抑制作用,可用于促进睡眠、缓解疼痛、抗神经退行性疾病和抗抑郁疾病的研究。 | |||
T27429 |
GR 128107
GR128107,GR-128107 |
||
GR 128107 is an antagonist of melatonin receptor. | |||
T28645 |
S-22153
|
||
S22153 is an antagonist of melatonin receptor. | |||
T13707 |
Pareptide monohydrochloride
|
Others | Others |
Pareptide monohydrochloride is a metabolically stable analog of melatonin inhibitor (MIF). | |||
T27430 |
GR 196429
GR-196429,GR 196,429,GR-196,429,GR196429,GR196,429 |
||
GR 196429, a melatonin receptor agonist, exhibits selectivity for the MT1 subtype. This compound not only promotes sleep and alters circadian rhythms but also stimulates melatonin release in mice. | |||
T22499 |
UCM 608
2-Phenylmelatonin |
Others | Others |
melatonin agonist | |||
T69409 |
DH-97
|
||
DH-97 is a potent MT2 melatonin receptor antagonist (pKi value = 8.03). | |||
T28644 |
S20928
S 20928,S-20928 |
||
S20928 is an antagonist of melatonin receptor. | |||
T29044 |
UCM 765
UCM-765,UCM765 |
||
UCM 765 is a partial agonist of melatonin MT(2) receptor. | |||
T22721 |
DH97
DH 97 |
Others | Others |
MT2 melatonin receptor antagonist | |||
T17095 |
TIK-301
PD-6735,LY-156735 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM, respectively). TIK-301 is also a 5-HT2B/5-HT2C receptor antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment. | |||
T10929 |
D-3263
|
Others | Others |
D-3263 is an agonist of transient receptor potential melatonin member 8 (TRPM8) with potential antitumor activity. | |||
T71182 |
N 0745
|
||
N 0745 inhibits 2-[125I]-iodomelatonin binding to median eminence/pars tuberalis membranes with an affinity similar to that of melatonin. | |||
T12689 |
Ramelteon metabolite M-II
|
Others | Others |
Ramelteon metabolite M-II is the major Ramelteon metabolite(human melatonin receptors (MT1 or MT2) with IC50s of 208 pM, 1470 pM). Ramelteon is an agonist of selective melatonin. | |||
T21366 |
Sapropterin free base
BPH4,Dapropterin,6R-BH4,Tetrahydro-6-biopterin,THB,Phenoptin |
||
Sapropterin is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of dopamine, epinephrine, melatonin, norepinephrine, neurotransmitter | |||
T38112 |
DL-Tryptophan octyl ester (hydrochloride)
|
||
Tryptophan is an amino acid precursor of serotonin and melatonin. DL-Tryptophan octyl ester is a tryptophan derivative with an octyl ester protected COOH group. This addition creates a stable, cell-permeable molecule capable of generating free tryptophan upon hydrolysis of the ester bond. | |||
T36176 |
AMK (hydrochloride)
|
||
AMK is an active metabolite of the neurohormone melatonin .1,2,3,4It is formed from melatoninviathe metabolic intermediate AFMK that is then deformylated by catalase or formamidase.5,6AMK scavenges singlet oxygenin vitrowhen used at a concentration of 200 μM.1It inhibits the epinephrine- and arachidonic acid-induced production of prostaglandin E2and PGD2in ovine seminal vesicle microsomes in a concentration- and time-dependent manner, as well as LPS-induced increases in COX-2 levels in RAW 264.7... | |||
T33450 |
ML 23
ML-23,ML23 |
||
ML 23 is a melatonin analogue in the treatment and management of Parkinson's disease. ML-23 is a potential clinical candidate for the treatment of PD, and the present study has been undertaken to determine the efficacy of ML-23 in the 1-methyl-4-phenyl, 1 | |||
T73832 | Tubulin inhibitor 21 | ||
Tubulin inhibitor 21 (compound 6f) 为基于查尔酮与褪黑激素混合的有效tubulin抑制剂。该化合物对SW480细胞展现显著的细胞毒性活性(IC50=0.26 μM),对非恶性细胞的毒性较低。 | |||
T70035 |
Tasimelteon-d5
|
||
Tasimelteon-d5 is intended for use as an internal standard for the quantification of tasimelteon by GC- or LC-MS. Tasimelteon is a melatonin (MT) receptor agonist. It selectively binds MT1 and MT2 receptors over a panel of 160 additional receptors and enzymes at 10 µM. Tasimelteon inhibits forskolin-induced cAMP accumulation with EC50 values of 0.79 and 1 nM in NIH3T3 cells expressing the MT1 or MT2 receptor, respectively. Formulations containing tasimelteon have been used in the treatment of no... | |||
T71963 |
(−)-WIN 55,212-3 mesylate
|
||
(−)-WIN 55,212-3 mesylate is an aminoalkylindole derivative which acts as a competitive neutral antagonist of the human cannabinoid CB2 receptor, blocking both the stimulating action of CP 55,940 and the inverse agonism of SR 144528. (−)-WIN 55,212-3 neither antagonizes nor mimics the effects of Δ9-THC on rat cerebellar membranes, which presumably express the CB1 receptor. (−)-WIN 55,212-3 also weakly antagonizes the melatonin MT1 and muscarinic M4 receptors but has no effect on several other G ... | |||
T35993 |
Epitalon (acetate)
|
||
Epitalon is a synthetic tetrapeptide with anti-aging properties.1,2,3,4 Dietary administration of epitalon (0.00001% w/w) reduces levels of lipid peroxidation products in aged D. melanogaster tissue homogenates.1 Epitalon (1 μg/animal) delays age-related estrous shutdown and decreases the frequency of bone marrow cell chromosomal aberrations in female mice.2 It decreases spontaneous mammary gland and ovarian tumor development and metastasis in aged female mice.3 Epitalon also stimulates melatoni... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1659 |
Melatonin
Melatonine,松果体素,N-Acetyl-5-methoxytryptamine,褪黑素 |
CaMK; Apoptosis; Mitophagy; Estrogen/progestogen Receptor; Melatonin Receptor; Glutathione Peroxidase; Endogenous Metabolite; ROR; Autophagy | Apoptosis; Autophagy; Endocrinology/Hormones; GPCR/G Protein; Metabolism; Neuroscience |
Melatonin (Melatonine) 是一种由松果体制成的激素,可激活褪黑激素受体。它在睡眠中起作用,有抗氧化和抗炎特性。它是新型选择性ATF-6抑制剂,可诱导细胞凋亡。 | |||
T13520 | 6-Hydroxymelatonin | Others | Others |
6-Hydroxymelatonin is a primary metabolic of Melatonin, which is metabolized by CYP 1A2. | |||
T13513 |
5-Methoxyindole-3-acetic acid
Methoxyindoleacetic acid,5-Methoxyindoleacetic acid,5-甲氧基吲哚-3-乙酸 |
Endogenous Metabolite | Metabolism |
5-Methoxyindole-3-acetic acid (5-Methoxyindoleacetic acid) 是一种 Melatonin 的代谢产物。 | |||
T1354 |
N-Acetyl-5-hydroxytryptamine
Normelatonin,N-乙酰-5-羟色胺,O-Demethylmelatonin,N-Acetylserotonin |
Trk receptor; Endogenous Metabolite | Metabolism; Tyrosine Kinase/Adaptors |
N-Acetyl-5-hydroxytryptamine (O-Demethylmelatonin) 是褪黑激素的直接前体,能够有效激活TrkB 受体。 | |||
T8181 |
Poricoic acid A
Poricoic acid A(F),茯苓新酸 A |
Others | Others |
Poricoic acid A (Poricoic acid A(F)) 是提取于 Poria cocos 中,拥有抗肿瘤作用。它通过调节Gas6/AxlNFκB/Nrf2 轴提高AKI-to-CKD 的褪黑激素抑制。 |