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抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T39461	MT1
	MT1, a bivalent chemical probe targeting BET bromodomains, demonstrates an IC50 value of 0.789 nM for BRD4(1).
T1463	Ramelteon 雷美替胺,TAK-375	Melatonin Receptor; MT Receptor	GPCR/G Protein; Neuroscience
	Ramelteon (TAK-375) 是强效高选择性和可口服的 MT1/MT2激动剂，Ki 值分别为 14 和 112 pM，有用于失眠症的研究潜力。
T3495	Tasimelteon 他司美琼,VEC-162,BMS-214778	Melatonin Receptor; MT Receptor	GPCR/G Protein; Neuroscience
	Tasimelteon (BMS-214778) 是一种褪黑激素受体激动剂，用于治疗盲人的非 24 小时睡眠-觉醒障碍。
T1445	Agomelatine Thymanax,S-20098,Valdoxan,阿戈美拉汀	Melatonin Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Agomelatine (Valdoxan) 是褪黑激素受体的强效激动剂和 5-羟色胺-2C (5-HT2C) 受体的拮抗剂，在猪和人 5-HT2C 克隆受体中pKi 分别为 6.4 和 6.2。
T8841	IMT1 Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1)	Others; DNA/RNA Synthesis; Mitochondrial Metabolism	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) 是一种非竞争特异性人类线粒体 RNA 聚合酶(POLRMT) 抑制剂，可引起 POLRMT 的构象变化，以剂量依赖性方式阻断底物结合和转录。它可降低脱氧核苷三磷酸水平和柠檬酸循环中间体，导致细胞氨基酸水平显著消耗，有用于线粒体转录等相关疾病的研究潜力。
T11063	DMT1 blocker 1	Others	Others
	DMT1 blocker 1 是二价金属转运蛋白1 (DMT1) 的阻断剂，IC50 为 0.64 μM，可以阻断体内肠细胞的铁摄取。
T11064	DMT1 blocker 2	Others	Others
	DMT1 blocker 2 是一种二价金属转运蛋白 1 的直接抑制剂(IC50:0.83 μM)。它可以阻断体内肠细胞的铁摄取。
T8842	IMT1B 3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-,LDC203974	Others; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	IMT1B (LDC203974) 是一种特异性的、具有口服活性的、非竞争性的线粒体 RNA 聚合酶 (POLRMT) 别构抑制剂，能够抑制线粒体 DNA (mtDNA) 的表达，具有抗肿瘤活性。
T60129	MT189 Antiproliferative agent-14	Microtubule Associated	Cytoskeletal Signaling
	MT189 (Antiproliferative agent-14)是一种有效的微管蛋白聚合 (tubulin polymerization) 抑制剂，IC50 为 3.41 μM。MT189 具有优异的抗增殖活性。Antiproliferative agent-14 具有在细胞周期的 G2/M 期阻滞细胞的能力。
T71739	PTPMT1-IN-1
	PTPMT1-IN-1 is a PTEN-like mitochondrial phosphatase PTPMT1 inhibitor.
T38421	PRMT1-IN-1 PRMT1-IN-1
	PRMT1-IN-1 is a PRMT1 inhibitor.
T15795	Luzindole N-乙酰-2-苄基色胺,N-0774	Melatonin Receptor; MT Receptor	GPCR/G Protein; Neuroscience
	Luzindole (N-0774) 是一种选择性褪黑素受体拮抗剂，可抑制实验性自身免疫性脑脊髓炎，有抗抑郁样活性。它优先靶向 MT2 (Mel1b)，对于人 MT2 和 MT1 的 Ki 值分别为 10.2 和 158 nM。
T16834	S26131 N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide	MT Receptor	Neuroscience
	S26131 (N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide) 是一种选择性的褪黑激素配体 MT1 和 MT2 拮抗剂，对 MT1 和 MT2 的 Ki 值分别为 0.5 和 112 nM。
T9193	ACH-000143	Melatonin Receptor; MT Receptor	GPCR/G Protein; Neuroscience
	ACH-000143 是一种可口服的褪黑素受体激动剂，对 MT1 和 MT2 的EC50值分别为0.06 和0.32 nM。
T1891	NSC 405020	MMP	Proteases/Proteasome
	NSC 405020 是一种 MT1-MMP 的非催化抑制剂，可特异地靶向 MT1-MMP 的 PEX 结构域，不会抑制 MT1-MMP 和 MMP-2的催化活性。
T10198	8-M-PDOT 8-Methoxy-2-propionamidotetralin,AH-002	MT Receptor	Neuroscience
	8-M-PDOT (AH-002) 是一种具有选择性和有效性的褪黑激素 MT2 受体激动剂，对 MT1 受体也具有抑制作用。8-M-PDOT 具有抗焦虑活性，可用于研究由 MT2 诱导的神经疼痛。
T10073	2-Iodomelatonin	Melatonin Receptor	GPCR/G Protein
	2-Iodomelatonin 是褪黑激素受体 1 (MT1) 的强效激动剂，Ki 为 28 pM，对 MT1的选择性是 MT2 的 5 倍以上。2-Iodomelatonin 可用于鉴定，表征和定位脑和周围组织的褪黑激素结合位点。
T28145	ND-322 HCl ND 322 Hydrochloride,ND322 Hydrochloride,ND-322 Hydrochloride,ND322 HCl	MMP	Proteases/Proteasome
	ND-322 HCl (ND 322 Hydrochloride) 是 MT1-MMP 和 MMP2 的选择性抑制剂，可减少体外黑色素瘤细胞的生长、迁移和侵袭。
T4093	Fabomotizole hydrochloride Afobazole hydrochloride,CM346 hydrochloride	MAO	Metabolism; Neuroscience
	Fabomotizole hydrochloride (CM346 hydrochloride) 是一种具有抗焦虑和神经保护作用的化合物。
T34081	Piromelatine NEU-P-11,NEU-P 11,NEU-P11	P2X Receptor; 5-HT Receptor; MT Receptor; Sodium Channel; TRP/TRPV Channel	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Piromelatine 是褪黑激素 MT1/MT2 受体、5-HT1A 和 5-HT1D 的激动剂，也是 5-HT2B 的拮抗剂。Piromelatine 具有抗痛觉活性，对 P2X3、TRPV1 和 Nav1.7 通道有抑制作用，可用于促进睡眠、缓解疼痛、抗神经退行性疾病和抗抑郁疾病的研究。
T60523	Agomelatine hydrochloride S-20098 hydrochloride	MT Receptor	Neuroscience
	Agomelatine hydrochloride (S-20098 hydrochloride) (S-20098 hydrochloride) 是特异性的MT1和MT2受体激动剂，对 CHO-hMT1的Ki 值为0.1 nM，对HEK-hMT1的Ki 值为0.06 nM，对CHO-hMT2的Ki 值为0.12 nM，对HEK-hMT2 的Ki 值为0.27 nM。Agomelatine hydrochloride 是选择性的5-羟色胺2C(5-HT2C)受体拮抗剂，对天然 (猪) 和克隆的人 5-HT2C 受体的pKi 值分别为 6.4 和 6.2。
T14042	4-P-PDOT 4-phenyl-2- propionamidotetralin	Melatonin Receptor; MT Receptor	GPCR/G Protein; Neuroscience
	4-P-PDOT (4-phenyl-2- propionamidotetralin) 是一种选择性和亲和性的褪黑激素受体拮抗剂，可显著抵消褪黑激素介导的抗氧化作用。它对MT2的选择性是 MT1 的 300 倍以上。
T17095	TIK-301 PD-6735,LY-156735	5-HT Receptor	GPCR/G Protein; Neuroscience
	TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM, respectively). TIK-301 is also a 5-HT2B/5-HT2C receptor antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment.
T22530	6-Chloromelatonin	Melatonin Receptor; Dopamine Receptor	GPCR/G Protein; Neuroscience
	6-Chloromelatonin 是一种有效的褪黑素受体 (melatonin receptor) 激动剂，是一种5-甲氧基吲哚化合物，可竞争兔视网膜中相同的突触前褪黑激素受体位点，可抑制[3H]多巴胺的钙依赖性释放具有比褪黑素更高的代谢稳定性。6-Chloromelatonin 竞争 [3H] 褪黑素与 MT2 受体结合 (pKi=9.77)，可能用于研究与抑郁症相关的失眠和睡眠障碍。
T27430	GR 196429 GR-196429,GR 196,429,GR-196,429,GR196429,GR196,429
	GR 196429, a melatonin receptor agonist, exhibits selectivity for the MT1 subtype. This compound not only promotes sleep and alters circadian rhythms but also stimulates melatonin release in mice.
T80217	BT1718	MMP	Proteases/Proteasome
	BT1718是一种针对MT1-MMP的双功能抗癌肽，通过MT1-MMP靶向肿瘤来传递细胞毒性有效载荷Mertansine。作为一种多肽-毒素偶联物，其KD值为3 nM。MT1-MMP在多种晚期实体肿瘤如三阴性乳腺癌(TNBC)和非小细胞肺癌中呈现过表达。
T10266	Agomelatine-d6 Agomelatine D6,S-20098 D6	Others	Others
	Agomelatine D6 (S-20098 D6) is a deuterium-labeled Agomelatine. Agomelatine is a specific agonist of MT1 and MT2 receptors.
T70035	Tasimelteon-d5
	Tasimelteon-d5 is intended for use as an internal standard for the quantification of tasimelteon by GC- or LC-MS. Tasimelteon is a melatonin (MT) receptor agonist. It selectively binds MT1 and MT2 receptors over a panel of 160 additional receptors and enzymes at 10 µM. Tasimelteon inhibits forskolin-induced cAMP accumulation with EC50 values of 0.79 and 1 nM in NIH3T3 cells expressing the MT1 or MT2 receptor, respectively. Formulations containing tasimelteon have been used in the treatment of no...
T10267	Agomelatine (L(+)-Tartaric acid) 阿戈美拉汀 L(+)-酒石酸,S-20098 L(+)-Tartaric acid	5-HT Receptor	GPCR/G Protein; Neuroscience
	Agomelatine (S-20098) L(+)-Tartaric acid is a specific agonist of MT1 and MT2 receptors (Kis: 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2). It also is a selective 5-HT2C receptor antagonist (pKis: 6.4 and 6.2 at native (porcine) and cloned (human) 5-HT2C receptors).
T12689	Ramelteon metabolite M-II	Others	Others
	Ramelteon metabolite M-II is the major Ramelteon metabolite(human melatonin receptors (MT1 or MT2) with IC50s of 208 pM, 1470 pM). Ramelteon is an agonist of selective melatonin.
T10193	7-Desmethyl-agomelatine	Others	Others
	7-Desmethyl-agomelatine is a metabolite of Agomelatine and has less activity than Agomelatine. Agomelatine is a melatonergic (MT1 and MT2) agonist and 5-HT2C antagonist.
T10192	7-Desmethyl-3-hydroxyagomelatine 3-Hydroxy-7-desmethyl agomelatine	5-HT Receptor	GPCR/G Protein; Neuroscience
	7-Desmethyl-3-hydroxyagomelatine is a metabolite of Agomelatine and has less activity than Agomelatine. Agomelatine is a melatonergic (MT1 and MT2) agonist and 5-HT2C antagonist.
T78436	Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2	MMP	Proteases/Proteasome
	Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) 是一种用于实时定量测定基质金属蛋白酶(MMP)酶活性的猝灭荧光肽底物。该化合物是MMP底物(FS-1)的衍生物，对胶原酶MMP-1、MMP-8、MMP-13及MT1-MMP的特异性常数更高，具备较强的底物特异性。荧光激发与发射波长分别为325 nm和400 nm。
T70073	Fabomotizole dihydrochloride
	Fabomotizole, also known as Afobazole, Obenoxazine and CM346, is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions. Its mechanism of action remains poorly defined however, with GABAergic, NGF- and BDNF-release-promoting, MT1 receptor agonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Fabomotizole was shown to inhibit MAO-A reversibly and there might be al...
T71963	(−)-WIN 55,212-3 mesylate
	(−)-WIN 55,212-3 mesylate is an aminoalkylindole derivative which acts as a competitive neutral antagonist of the human cannabinoid CB2 receptor, blocking both the stimulating action of CP 55,940 and the inverse agonism of SR 144528. (−)-WIN 55,212-3 neither antagonizes nor mimics the effects of Δ9-THC on rat cerebellar membranes, which presumably express the CB1 receptor. (−)-WIN 55,212-3 also weakly antagonizes the melatonin MT1 and muscarinic M4 receptors but has no effect on several other G ...
T60490	Melatonin receptor agonist 1
	Melatonin receptor agonist 1 (compound 20c) 是褪黑激素受体 (MT) 的有效激动剂，对MT2的Ki 值为 108 nM，对MT1的Ki 值为 1140 nM。
T28645	S-22153
	S22153 is an antagonist of melatonin receptor.

化合物

Cat.No: T39461

Cat.No: T1463

Synonym: 雷美替胺,TAK-375

Target: Melatonin Receptor, MT Receptor

Cat.No: T3495

Synonym: 他司美琼,VEC-162,BMS-214778

Target: Melatonin Receptor, MT Receptor

Cat.No: T1445

Synonym: Thymanax,S-20098,Valdoxan,阿戈美拉汀

Target: Melatonin Receptor, 5-HT Receptor

Cat.No: T8841

Synonym: Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1)

Target: Others, DNA/RNA Synthesis, Mitochondrial Metabolism

Cat.No: T11063

Target: Others

Cat.No: T11064

Target: Others

Cat.No: T8842

Synonym: 3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-,LDC203974

Target: Others, DNA/RNA Synthesis

Cat.No: T60129

Synonym: Antiproliferative agent-14

Target: Microtubule Associated

Cat.No: T71739

Cat.No: T38421

Synonym: PRMT1-IN-1

Cat.No: T15795

Synonym: N-乙酰-2-苄基色胺,N-0774

Target: Melatonin Receptor, MT Receptor

Cat.No: T16834

Synonym: N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide

Target: MT Receptor

Cat.No: T9193

Target: Melatonin Receptor, MT Receptor

Cat.No: T1891

Target: MMP

Cat.No: T10198

Synonym: 8-Methoxy-2-propionamidotetralin,AH-002

Target: MT Receptor

2-Iodomelatonin

Cat.No: T10073

Target: Melatonin Receptor

Cat.No: T28145

Synonym: ND 322 Hydrochloride,ND322 Hydrochloride,ND-322 Hydrochloride,ND322 HCl

Target: MMP

Fabomotizole hydrochloride

Cat.No: T4093

Synonym: Afobazole hydrochloride,CM346 hydrochloride

Target: MAO

Cat.No: T34081

Synonym: NEU-P-11,NEU-P 11,NEU-P11

Target: P2X Receptor, 5-HT Receptor, MT Receptor, Sodium Channel, TRP/TRPV Channel

Agomelatine hydrochloride

Cat.No: T60523

Synonym: S-20098 hydrochloride

Target: MT Receptor

Cat.No: T14042

Synonym: 4-phenyl-2- propionamidotetralin

Target: Melatonin Receptor, MT Receptor

Cat.No: T17095

Synonym: PD-6735,LY-156735

Target: 5-HT Receptor

6-Chloromelatonin

Cat.No: T22530

Target: Melatonin Receptor, Dopamine Receptor

Cat.No: T27430

Synonym: GR-196429,GR 196,429,GR-196,429,GR196429,GR196,429

Cat.No: T80217

Target: MMP

Cat.No: T10266

Synonym: Agomelatine D6,S-20098 D6

Target: Others

Cat.No: T70035

Agomelatine (L(+)-Tartaric acid)

Cat.No: T10267

Synonym: 阿戈美拉汀 L(+)-酒石酸,S-20098 L(+)-Tartaric acid

Target: 5-HT Receptor

Ramelteon metabolite M-II

Cat.No: T12689

Target: Others

7-Desmethyl-agomelatine

Cat.No: T10193

Target: Others

7-Desmethyl-3-hydroxyagomelatine

Cat.No: T10192

Synonym: 3-Hydroxy-7-desmethyl agomelatine

Target: 5-HT Receptor

Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2

Cat.No: T78436

Target: MMP

Fabomotizole dihydrochloride

Cat.No: T70073

(−)-WIN 55,212-3 mesylate

Cat.No: T71963

Melatonin receptor agonist 1

Cat.No: T60490

Cat.No: T28645

Cat. No.	Product Name	Target	Signaling Pathways
T2O2728	glycine 2-Aminoacetic acid,Glycolixir,Aminoacetic acid,Glycosthene,Glycocoll,甘氨酸	MT Receptor; Endogenous Metabolite; iGluR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	glycine (2-Aminoacetic acid) 是中枢神经系统的抑制性神经递质，也是谷氨酸的联合激动剂，有促进谷氨酸能NMDA 受体兴奋的潜力。它主要存在于明胶和丝素蛋白中，并在治疗上用作营养物质。

天然产物

Cat.No: T2O2728

Synonym: 2-Aminoacetic acid,Glycolixir,Aminoacetic acid,Glycosthene,Glycocoll,甘氨酸

Target: MT Receptor, Endogenous Metabolite, iGluR

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