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Search Results for " mrsa "

103

抑制剂 & 化合物

35

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T62577	Anti-MRSA agent 5
	Anti-MRSA agent 是一种 MRSA 的有效拮抗剂 (MIC50: 0.38 μg/mL)，hERG 活性较低 (IC50: 40 μM)。Anti-MRSA agent 对哺乳动物细胞的毒性也很低，几乎不可能获得细菌的耐药性。
T60546	Anti-MRSA agent 6
	Anti-MRSA agent 6 (compound 3q6) 是一种有效的抗耐甲氧西林金黄色酿脓葡萄球菌(anti-MRSA)剂，对 MCF-7、A549 细胞具有低细胞毒性。
T79778	Anti-MRSA agent 8
	Anti-MRSA agent 8（Compound 7g）为DAPG衍生物，展现出显著的抗菌活性，主要通过作用于细菌细胞膜以发挥效能。此化合物可应用于耐甲氧西林Staphylococcus aureus（MRSA）的研究领域。
T63775	Anti-MRSA agent 1
	Anti-MRSA agent 1 是 MRSA 抑制剂，其 MIC 值为 0.5 μg/mL，能够有效的缓解 MRSA 抵抗作用。
T63632	Anti-MRSA agent 3
	Anti-MRSA agent 3 能够明显的抑制耐甲氧西林金黄色葡萄球菌 (MRSA) 的活性 (MIC: 0.098 μg/ml)，并且对正常细胞毒性较低。Anti-MRSA agent 3 对细菌基因组 DNA 具有较高的结合亲和力，对细菌细胞壁和细胞膜具有较强的破坏能力。
T62383	Anti-MRSA agent 2
	Anti-MRSA agent 2 (compound 14) 能够较好的抑制耐甲氧西林金黄色葡萄球菌 (MRSA) (MIC: 0.098 μg/ml)，对正常细胞的毒性相对较低。Anti-MRSA agent 2 能够较强的破坏细菌膜，并具有较好的与细菌基因组DNA 结合的能力。
T74527	Anti-MRSA agent 4
	Anti-MRSA agent 4 (compound 7a) 为针对耐甲氧西林金黄色葡萄球菌 (MRSA) 的革兰氏阳性菌强效选择性生长抑制剂，具有MIC≤ 0.26 µM的显著效力。此外，该化合物在HEK293细胞中未显示细胞毒性和溶血活性。
T74810	Anti-MRSA agent 7
	Anti-MRSA agent 7 (Compound 12)作为一种抗菌剂，具有针对S. aureus DNA gyrase、E. coli DNA gyrase、S. aureus topo IV和E. coli topo IV的显著抑制效果，其IC50值分别为0.185 μM、0.365 μM、0.341 μM和0.059 μM。
T7897	PK150	Others; Antibacterial	Microbiology/Virology; Others
	PK150 是一种 Sorafenib 类似物，具有抗菌活性。它抑制甲氧西林敏感金黄色葡萄球菌，耐甲氧西林金黄色葡萄球菌，万古霉素中介金黄色葡萄球菌的 MIC 分别为 0.3，0.3-1，0.3 µM。
T22269	Benzyldodecyldimethylammonium Chloride Dihydrate	Antibacterial	Microbiology/Virology
	Benzyldodecyldimethylammonium chloride dihydrate 可以用作杀虫试剂，可以靶向耐药性细菌，如耐甲氧西林金黄色葡萄球菌、耐多药铜绿假单胞菌等，且具有浓度依赖性。
T8507	MAC-545496	Antibacterial	Microbiology/Virology
	MAC-545496 是一种抗毒剂，可逆转耐甲氧西林的菌株中的 β-内酰胺耐药性。它是糖肽抗性相关蛋白 R 的纳摩尔抑制剂，对全长 GraR 蛋白具有很强的结合亲和力。
T40475	Ceftobiprole medocaril BAL5788,头孢比普酯	Antibacterial	Microbiology/Virology
	Ceftobiprole medocaril (BAL5788) 是 Ceftobiprole 的前药。Ceftobiprole 是一种广谱的头孢菌素，对耐甲氧西林金黄色葡萄球菌具有活性。
TQ0077	Ceftobiprole Ro 63-9141,BAL 9141,头孢吡普	Antibacterial	Microbiology/Virology
	Ceftobiprole (Ro 63-9141) 是一种广谱头孢菌素，对甲氧西林耐受的金黄色葡萄球菌的MIC90值为 2 μg/mL。
T7387	Ceftaroline fosamil TAK-599,头孢罗林酯,PPI0903	Antibacterial; Antibiotic	Microbiology/Virology
	Ceftaroline fosamil (TAK-599) 是一种头孢菌素衍生物，是抗甲氧西林金黄色葡萄球菌 (MRSA) T-91825 的 N-膦酰基前药，可研究 MRSA 感染。
T21358	Dalbavancin BI 397,BI-397,VER 001,A-A 1,BI397,VER-001,Dalbavancin HCl,达巴万星	Antibacterial; Antibiotic	Microbiology/Virology
	Dalbavancin (BI-397) HCl 是一种半合成的脂糖肽抗生素，对革兰氏阳性细菌有杀菌活性。Dalbavancin 抑制金黄色葡萄球菌和炭疽芽孢杆菌的 MIC90分别为 0.06 μg/mL 和 0.25 μg/mL。
T4208	Targocil	Antibacterial	Microbiology/Virology
	Targocil 是一种磷壁酸生物合成的抑菌抑制剂，可抑制甲氧西林敏感金黄色葡萄球菌 (MSSA) 和耐甲氧西林金黄色葡萄球菌 (MRSA) 的生长，对于 MRSA 和 MSSA 的MIC90值都为 2 μg/mL。
T2549	Robenidine hydrochloride Rasexinium,Dexium,氯苯胍盐酸盐,Robenidine Hydrochoride,Toraxine,盐酸氯苯胍,Nugatex	Antibacterial; Antibiotic; Parasite	Microbiology/Virology
	Robenidine hydrochloride (Robenidine Hydrochoride) 是一种主要用于家禽的抗球虫剂, 对 MRSA 和 VRE 有抑制活性，其 MIC50值分别为 8.1 和 4.7 μM。
T3114	Povidone iodine Betadine,聚乙烯吡酮磺,Povidone-iodine,聚乙烯吡咯烷酮碘,Isodine,PVP iodine,iodopovidone,PVP-I	Antibacterial; Antibiotic	Microbiology/Virology
	Povidone iodine (Povidone-iodine) 有很强的抗细菌活性, 可杀死 MRSA 和 MSSA 菌株，其 MICs 值分别为 31.25 mg/L 和7.82 mg/L。
T61037	Glycosyltransferase-IN-1	Others	Others
	Glycosyltransferase-IN-1 是一种糖基转移酶 (glycosyltransferase) 抑制剂，具有抑菌活性，抑制 MSSA、MRSA 、枯草杆菌和肠杆菌。
T36033	DETA NONOate NOC-18,Diethylamine NONOate	NO Synthase	Immunology/Inflammation
	DETA NONOate (NOC 18)是外源性一氧化氮 (NO) 供体，具有血管舒张和抗抑郁活性。DETA NONOate 可用于激活神经元中的内向电流，可加速MRSA感染伤口的愈合。
T64316	VP-4604 1-((4-Nitrophenyl)sulfonyl)piperidine
	VP-4604是一种有效的抗耐甲氧西林金黄色葡萄球菌（MRSA）化合物。VP-4604对金黄色葡萄球菌展现出显著的抑制微生物生长的作用，MIC 为4-8μg/mL。VP-4604抑制耐甲氧西林金黄色葡萄球菌的生长，其生长抑制率达到95%以上。
T67826	Alalevonadifloxacin	DNA gyrase; Topoisomerase; Antibacterial	DNA Damage/DNA Repair; Microbiology/Virology
	Alalevonadifloxacin 是一种DNA 回旋酶和DNA 拓扑异构酶抑制剂，是一种喹诺酮类针对Mrsa 的新型抗菌化合物。Alalevonadifloxacin 对治疗细菌性革兰氏阳性、革兰氏阴性和厌氧性感染有潜在作用。
T0391	Linezolid PNU-100766,雷奈佐利	MAO; Antibacterial; Antibiotic	Metabolism; Microbiology/Virology; Neuroscience
	Linezolid (PNU-100766) 是恶唑烷酮类合成抗生素，抑制细菌蛋白质合成的起始阶段，具有抗感染作用。
T4165	Delpazolid LCB01-0371	Antibacterial; Antibiotic	Microbiology/Virology
	Delpazolid (LCB01-0371) 是一种恶唑烷酮类新型抗生素，能抑制MSSA 和MRSA 的生长，对它们的MIC90值都为 2 μg/mL。
T31064	CP-5484 CP 5484,UNII-A53TMV6VUN,CP5484
	Cp-5484 is a new kind of Quaternary carbapenem with strong anti MRSA activity and low acute toxicity.
T39816	Ceftaroline fosamil inner salt TAK-599 free acid,PPI0903freeacid
	Ceftaroline fosamil (TAK-599) inner salt, a cephalosporin derivative, is an N-phosphono prodrug of anti-methicillin-resistant Staphylococcus aureus (MRSA) T-91825. Ceftaroline fosamil inner salt can be used for the research of MRSA infection.
T74269	Antibacterial agent 83
	Antibacterial agent 83 (compound 17h) 对各种耐万古霉素 Enterococcus faecalis(VRE) 和耐甲氧西林 Staphylococcus aureus(MRSA) 显示出有效的抗菌活性。Antibacterial agent 83 可以显着减少 MRSA 的生物膜形成，并表现出良好的选择性。Antibacterial agent 83 在人肝微粒体中代谢稳定。
T30767	CB-181963 CB 181963,CB181963,UNII-6784994L0W,CAB 175
	CB-181963, a new cephalosporin, is an effective antistaphylococcal drug, showing excellent activity against the resistance of MRSA strains to other cephalosporins in planktonic and biofilm cultures.
T40301	Antibacterial agent 28
	Antibacterial agent 28, with a minimum inhibitory concentration (MIC) range of 0.5-2 μg/mL, exhibits promising potential as an antibacterial candidate targeting MRSA infections.
T80390	HG4
	HG4为快速作用的抗菌多肽，具有抗生物膜和抗炎活性。特别是针对MRSA菌株（MIC: 32-64 μg/mL），它对革兰氏阳性病原体表现出显著活性。此外，HG4能够与细菌脂质结合，并能减少S. aureus MRSA USA300细菌的ATP浓度。
T35064	Viquidacin NXL101,NXL-101,NXL 101
	Viquidacin ( NXL-101) is an oral/intravenous antibiotic that targets Gram-positive bacteria such as MRSA. In 2008, Novexel announced it had discontinued the development of Viquidacin (NXL 101).
T61121	NusB-IN-1
	NusB-IN-1 (Compound 22r) is a highly effective bacterial rRNA synthesis inhibitor, administered orally. It exhibits potent antimicrobial activity against MRSA and VRSA [1].
T82761	CDFI
	CDFI为MurJ（脂质II翻转酶）的抑制剂，能够提升β-内酰胺类对抗MRSA的活性。
T83097	Antibacterial agent 165
	Antibacterialagent 165 (compound 3) 是一种有效针对细菌 (bacterial) 的羟基喹啉衍生物抑制剂，具备抗耐甲氧西林金黄色葡萄球菌 (MRSA) 的能力。
T39230	Contezolid acefosamil MRX-4,Contezolid acefosamil
	Contezolid acefosamil (MRX-4), an orally active prodrug, is metabolized into Contezolid (MRX-I), an oxazolidinone derivative with potent in vitro efficacy against multidrug-resistant Gram-positive bacteria, including MRSA.
T73127	C16-K-cBB1
	C16-K-cBB1 是一种对 MRSA(甲氧西林耐药金黄色葡萄球菌)有效且选择性的抗菌剂，其 MIC 为 1 μg/mL。C16-K-cBB1 具有很好的选择性，由于其溶血活性较弱。在 12.5 μg/mL 浓度下，C16-K-cBB1 能够在 120 分钟内杀死 MRSA 细胞。
T80387	HG2
	HG2 是一種具有快速抗菌效能的肽類化合物，展現了顯著的抗生物膜及抗炎特性。該化合物對革兰氏阳性病原体有效，特別是對 MRSA (最小抑菌浓度：16-32μg/mL) 有良好活性。HG2 能夠結合至细菌脂質，并且有效降低 S. aureus MRSA USA300株中的 ATP 濃度。
T74715	Antibacterial agent 136
	Antibacterial agent 136 (compound 3) 是恶二唑酮类抗生素。Antibacterial agent 136 对 Staphylococcus aureus(MRSA) 具有很高的抗菌效力，MIC50值为 0.8 μM。
T64054	Antibacterial agent 88
	Antibacterial agent 88 是一种有效的抗细菌剂，能够作用于 B. subtilis (MIC: 4 μg/ml)，对 MRSA、MRSE 和 S. aureus 的 MIC 值均为 ≤0.0156 μg/mL。
T83098	Antibacterial agent 163
	Antibacterialagent 163 (compound 1) 是一种羟基喹啉衍生物，能有效抑制细菌 (bacterial)。该化合物特别针对耐甲氧西林金黄色葡萄球菌 (MRSA) 表现出抑制作用。
T63224	Antibacterial agent 104
	Antibacterial agent 104 是有效的抗细菌 (antibacterial) 剂，体外具有显著的抗细菌作用，体内表现出良好的抗 MRSA 效果。
T64069	Antibacterial agent 87
	Antibacterial agent 87 是一种有效的抗细菌剂，能够作用于 MRSA (MIC: 0.125 μg/ml)、MRSE (MIC: 0.0625 μg/ml) 和 S. aureus (MIC: 0.0625 μg/ml)。
T74502	Antibacterial agent 108
	Antibacterial agent 108 (Compound 1h) 是一种有效的抗细菌剂，对 MRSA 和一些抗生素抗性菌的 MIC 值均为 3 μM。
T64315	VP-4509
	VP-4509 是一种抗耐甲氧西林金黄色葡萄球菌 (MRSA) 剂 (MIC: 49.3 μM)。VP-4509 对革兰氏阴性细菌铜绿假单胞菌 (ATCC9027) 表现出高抗菌效果。
T80391	LCI peptide
	LCI peptide为具备抗细菌特性的抗菌肽。该肽对多种细菌株显示活性，包括植物病原体、黄单胞菌、假单胞菌，以及大肠杆菌、Gentamicin抗性 MRSA和Xoo。
T74776	Antibacterial agent 139
	Antibacterial agent 139 对革兰氏阳性菌具有抗菌活性。Antibacterial agent 139 具有抗 MRSA、抗 VISA 和抗 LRSE 活性。Antibacterial agent 139 去极化细菌细胞膜。
T37464	CAY10711
	CAY10711 is a substituted diamine that produces rapid bactericidal activity against both Gram-positive and Gram-negative bacteria, including methicillin-resistant S. aureus (MRSA) and stationary-phase bacteria. It displays MIC99 values of 2.9, 11.5, 2.9, and 2.9 μM against S. aureus RN4220, P. aeruginosa PAO1, E. coli ANS1, and MRSA 10082B, respectively. CAY10711 reduces biofilm formation and promotes biofilm dispersal in P. aeruginosa. It is synergistic with kanamycin and has limited adverse ef...
T80414	ASP-1
	ASP-1是一种活性强的抗葡萄球菌肽，其对金黄色葡萄球菌及耐甲氧西林金黄色葡萄球菌(MRSA)的最低抑制浓度(mic)范围为2μg/mL至64μg/mL。
T80275	Lynronne-2
	Lynronne-2是抗菌肽，对革兰氏阳性细菌，包含MDR菌株具有活性（耐甲氧西林MRSA菌株MIC: 32-256 μg/mL）。该化合物亦对P. aeruginosa感染展现效用。
T74803	Levonadifloxacin
	Levonadifloxacin ((S)-(-)-Nadifloxacin; WCK 771)，作为一种宽谱抗葡萄球菌药物，对甲氧西林敏感金黄色葡萄球菌(MSSA)及对甲氧西林耐药金黄色葡萄球菌(MRSA)显示出显著的抗菌活性，并能有效减少THP-1单核细胞对MRSA和MSSA菌株的吞噬。

化合物

Anti-MRSA agent 5

Cat.No: T62577

Anti-MRSA agent 6

Cat.No: T60546

Anti-MRSA agent 8

Cat.No: T79778

Anti-MRSA agent 1

Cat.No: T63775

Anti-MRSA agent 3

Cat.No: T63632

Anti-MRSA agent 2

Cat.No: T62383

Anti-MRSA agent 4

Cat.No: T74527

Anti-MRSA agent 7

Cat.No: T74810

Cat.No: T7897

Target: Others, Antibacterial

Benzyldodecyldimethylammonium Chloride Dihydrate

Cat.No: T22269

Target: Antibacterial

Cat.No: T8507

Target: Antibacterial

Ceftobiprole medocaril

Cat.No: T40475

Synonym: BAL5788,头孢比普酯

Target: Antibacterial

Cat.No: TQ0077

Synonym: Ro 63-9141,BAL 9141,头孢吡普

Target: Antibacterial

Ceftaroline fosamil

Cat.No: T7387

Synonym: TAK-599,头孢罗林酯,PPI0903

Target: Antibacterial, Antibiotic

Cat.No: T21358

Synonym: BI 397,BI-397,VER 001,A-A 1,BI397,VER-001,Dalbavancin HCl,达巴万星

Target: Antibacterial, Antibiotic

Cat.No: T4208

Target: Antibacterial

Robenidine hydrochloride

Cat.No: T2549

Synonym: Rasexinium,Dexium,氯苯胍盐酸盐,Robenidine Hydrochoride,Toraxine,盐酸氯苯胍,Nugatex

Target: Antibacterial, Antibiotic, Parasite

Povidone iodine

Cat.No: T3114

Synonym: Betadine,聚乙烯吡酮磺,Povidone-iodine,聚乙烯吡咯烷酮碘,Isodine,PVP iodine,iodopovidone,PVP-I

Target: Antibacterial, Antibiotic

Glycosyltransferase-IN-1

Cat.No: T61037

Target: Others

Cat.No: T36033

Synonym: NOC-18,Diethylamine NONOate

Target: NO Synthase

Cat.No: T64316

Synonym: 1-((4-Nitrophenyl)sulfonyl)piperidine

Alalevonadifloxacin

Cat.No: T67826

Target: DNA gyrase, Topoisomerase, Antibacterial

Cat.No: T0391

Synonym: PNU-100766,雷奈佐利

Target: MAO, Antibacterial, Antibiotic

Cat.No: T4165

Synonym: LCB01-0371

Target: Antibacterial, Antibiotic

Cat.No: T31064

Synonym: CP 5484,UNII-A53TMV6VUN,CP5484

Ceftaroline fosamil inner salt

Cat.No: T39816

Synonym: TAK-599 free acid,PPI0903freeacid

Antibacterial agent 83

Cat.No: T74269

Cat.No: T30767

Synonym: CB 181963,CB181963,UNII-6784994L0W,CAB 175

Antibacterial agent 28

Cat.No: T40301

Cat.No: T80390

Cat.No: T35064

Synonym: NXL101,NXL-101,NXL 101

Cat.No: T61121

Cat.No: T82761

Antibacterial agent 165

Cat.No: T83097

Contezolid acefosamil

Cat.No: T39230

Synonym: MRX-4,Contezolid acefosamil

Cat.No: T73127

Cat.No: T80387

Antibacterial agent 136

Cat.No: T74715

Antibacterial agent 88

Cat.No: T64054

Antibacterial agent 163

Cat.No: T83098

Antibacterial agent 104

Cat.No: T63224

Antibacterial agent 87

Cat.No: T64069

Antibacterial agent 108

Cat.No: T74502

Cat.No: T64315

Cat.No: T80391

Antibacterial agent 139

Cat.No: T74776

Cat.No: T37464

Cat.No: T80414

Cat.No: T80275

Levonadifloxacin

Cat.No: T74803

Cat. No.	Product Name	Target	Signaling Pathways
T5724	Neogambogic acid neo-gambogic acid,新藤黄酸	Apoptosis; Others; Antibacterial	Apoptosis; Microbiology/Virology; Others
	Neogambogic acid 是藤黄的有效成分，可诱导细胞凋亡并具有抗癌作用。它有效抑制耐甲氧西林的金黄色葡萄球菌。
T1465	Mupirocin Pseudomonic acid,莫匹罗星,BRL-4910A	DNA/RNA Synthesis; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Mupirocin (BRL-4910A) 是从Pseudomonas fluorescens 中分离得到的一种有口服活性的抗生素。它可逆地抑制异亮氨酸转移RNA，并抑制细菌蛋白和RNA 的合成起抗菌作用。
T8148	Mupirocin calcium hydrate 莫匹罗星钙,Mupirocin calcium	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Mupirocin calcium hydrate 是从Pseudomonas fluorescens 中分离得到的，一种有口服活性的抗生素。它可逆地抑制异亮氨酸转移RNA，并抑制细菌蛋白和RNA 的合成起到抗菌作用。
TN4943	Sanguisorbigenin 地榆皂苷元,Tomentosolic acid,3β-Hydroxyurs-12,19-dien-28-oic acid,19-Dehydroursolic acid,Ursa-12,19-dien-28-oic acid	Antibacterial	Microbiology/Virology
	Sanguisorbigenin (Tomentosolic acid) 抑制耐甲氧西林金黄色葡萄球菌，是一种天然抗菌剂。
TN2281	Sinapaldehyde trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde,TRANS-3,5-二甲氧基-4-羟基肉桂醛,芥子醛	Antibacterial	Microbiology/Virology
	Sinapaldehyde (trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde) 对耐甲氧西林的金黄色葡萄球菌和大肠杆菌有抗菌作用，MIC 值都为 128 μg/mL。
T8724	6-Methoxydihydrosanguinarine	Others	Others
	6-Methoxydihydrosanguinarine 是一种从M. cordata 果实中分离出的生物碱，它对 MCF-7 细胞系(IC50:0.61 μM)和 SF-268 细胞系(IC50:0.54 μM)具有强的细胞毒性。
TN1524	Continentalic acid	NOS; COX; Antibacterial; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Continentalic acid 是来自 Aralia continentalis 的，对金黄色葡萄球菌的 MIC 约为 8-16 µg/mL，包括对甲氧西林敏感的金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌标准菌株。
T3S0153	Xanthatin 苍耳亭,叶黄制菌素	Apoptosis; VEGFR; Lipoxygenase; Wnt/beta-catenin; Antibacterial	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Metabolism; Microbiology/Virology; Stem Cells; Tyrosine Kinase/Adaptors
	Xanthatin 是一种从Xanthium strumarium 叶子中提取的天然产物，可诱导细胞凋亡。它抑制布鲁氏菌的IC50值为 2.63 μg/ mL，对寄生虫特异性锥虫硫磷还原酶具有不可逆的弱抑制作用。它通过抑制PGE2的合成和 5-脂氧合酶的活性而显示出抗炎活性。
TJS1779	Protosappanin A 原苏木素A,PTA	NADPH-oxidase; IL Receptor; IκB/IKK; TNF; NF-κB; TLR; ROS; COX; HIV Protease; JAK; NO Synthase; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome; Stem Cells
	Protosappanin A (PTA) 是从苏木中分离得到的免疫抑制成分和主要联苯化合物，通过下调 JAK2和 STAT3的磷酸化，抑制 JAK2/STAT3依赖的炎症通路。
T10838	Closthioamide	Antibacterial	Microbiology/Virology
	Closthioamide is a potent inhibitor of bacterial DNA gyrase and highly active against MRSA, Ec, VRE, and Mv (MICs: 0.58 μM, 9.00 μM, 0.58 μM and 72.03 μM).
T74200	Glicophenone
	Glicophenone 作为一种抗细菌(antibacterial)剂，对MRSA OM481、MRSA OM505、MRSA OM584、MRSA OM623 以及MSSA 209P的MIC值均为32 μg/mL。
TN4308	Isolupalbigenin	Antifection	Microbiology/Virology
	Isolupalbigenin shows promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 uM), it also shows in vitro inhibitory activity toward human glyoxalase I. Isolupalbigenin shows two different antibacterial activities against MRSA: direct growth inhibition and intensification of methicillin sensitivity, it could lead to the development of compounds for new approaches against MRSA infection.
TN3216	(3R)-7,4’-Dihydrohomoisoflavanone 7,4'-Dihydroxyhomoisoflavanone	Antibacterial	Microbiology/Virology
	(3R)-7,4’-Dihydrohomoisoflavanone 是一种天然化合物，对金黄色葡萄球菌和耐甲氧西林金黄色葡萄菌（MRSA）都具有强大的抗菌性能。
TN4097	Gancaonin G	Antifection	Microbiology/Virology
	Gancaonin G shows antibacterial effects on the MRSA strains with MIC values of 16 microg/ml, it also shows more moderate antibacterial activity against Streptococcus mutans.
T2S0058	6-Ethoxychelerythrine 乙氧基白屈菜红碱,Ethoxychelerythrin	Antibacterial	Microbiology/Virology
	6-Ethoxychelerythrine (Ethoxychelerythrin) 具有抗菌活性，对烟曲霉和耐甲氧西林金黄色葡萄球菌 (MRSA) 表现出很强的活性。
TN3450	Artanin	Antifection	Microbiology/Virology
	Artanin displays promising inhibition against both MSSA and MRSA with minimal inhibitory concentrations (MICs) of 8-64 ug/ml, but very weak against Gram-negative pathogen and yeast with MICs of 256 to ≥1024 ug/ml.
T38349	Talaromycesone A
	Talaromycesone A is a fungal metabolite originally isolated fromTalaromyces.1It is active againstS. epidermidisand methicillin-resistantS. aureus(MRSA) bacteria (IC50s = 3.70 and 5.48 μM, respectively). Talaromycesone A inhibits acetylcholinesterase (AChE) in a cell-free assay (IC50= 7.49 μM for the human enzyme). 1.Wu, B., Ohlendorf, B., Oesker, V., et al.Acetylcholinesterase inhibitors from a marine fungus Talaromyces sp. strain LF458Mar. Biotechnol. (NY)17(1)110-119(2015)
TN2524	1-Acetyl-β-carboline 1-Acetyl-beta-carboline	Antifection	Microbiology/Virology
	Combination of 1-acetyl-beta-carboline with ampicillin exhibits synergistic antibacterial activity against MRSA.
T73207	Laburnetin
	Laburnetin 是一种异黄酮类抗菌剂 (antibacterial agent)。Laburnetin 对真菌、S. vesicarium 具有抗菌活性。Laburnetin 增强了耐甲氧西林 (Methicillin) 金黄色葡萄球菌 (MRSA) 菌株对甲氧西林的敏感性。Laburnetin 可用于控制栽培物种的虫害。
TN3907	Pinosylvin monomethyl ether (E)-3-Hydroxy-5-methoxystilbene	Antifection	Microbiology/Virology
	(E)-3-Hydroxy-5-methoxystilbene possesses inhibitory activity against several Gram-positive bacteria, including isolates of methicillin-resistant Staphylococcus aureus (MRSA), Mycobacterium bovis BCG, and avirulent Bacillusanthracis (Sterne strain), among
TN1444	Bis(dihydrochelerythrinyl)amine bis[6-(5,6-dihydrochelerythrinyl)]amine	Antifection	Microbiology/Virology
	BIS-[6-(5,6-dihydro-chelerythrinyl)] ether shows strong activity against Aspergillus fumigatus and methicillin-resistant Staphylococcus aureus (MRSA).
T75273	Teicoplanin sodium
	Teicoplanin sodium (Antibiotic MDL-507 sodium) 是一种有效的脂糖肽类抗生素。Teicoplanin sodium 对 HIV-1、SARS-CoV1 和 SARS-CoV2 显示出抗病毒活性。Teicoplanin sodium 具有抗 MRSA 活性。
TN4319	Isopimaric acid	Antifection	Microbiology/Virology
	Isopimaric acid is active against MDR and MRSA strains of S. aureus which are becoming increasingly resistant to antibiotics, the minimum inhibitory concentrations (MIC) are 32-64 microg/mL . Isopimaric acid is also possible that an antagonistic interacti
T79943	6-C-Methylquercetin-3,4'-dimethyl ether	Antibiotic	Microbiology/Virology
	6-C-Methylquercetin-3,4'-dimethyl etheris 是一种黄酮醇衍生物，提取自Bauhinia thonningii Schum叶。本化合物对多重耐药的革兰氏阴性细菌及耐甲氧西林金黄色葡萄球菌（MRSA）表现出抗菌活性。
T75560	4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl-
	4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl- (化合物2) 是一种从蛇床子提取的喹诺酮类生物碱。该化合物对耐甲氧西林金黄色葡萄球菌(MRSA)表现出活性，其最小抑制浓度(MIC)值对ATCC 33591和ATCC 25923株分别为32 μg/mL和16 μM/mL。
T74206	Kalimantacin A
	Kalimantacin A是具有针对葡萄球菌（包括耐甲氧西林金黄色葡萄球菌）抗菌活性的有效抗生素。
T73673	Thiomarinol A
	Thiomarinol A (4-Hydroxythiomarinol C) 是一种有效的抗生素。Thiomarinol A 是二硫代吡咯酮和海藻酸的混合物。Thiomarinol A 显示出抗菌活性。Thiomarinol A 以剂量依赖性方式抑制 MRSA IleRS，Kiapp 值为 19 nM。
T75278	Pristinamycin
	Pristinamycin, 一种 Streptomyces pristinaespiralis 产生的口服活性链霉素样抗生素，由化学上不相关的两部分组成：Pristinamycin I (PI) 与 Pristinamycin II (PII)。该药物对包括耐甲氧西林金黄色葡萄球菌 (MRSA)、万古霉素耐药金黄色葡萄球菌 (VRSA) 和粪肠球菌 (VREF) 在内的多种抗生素耐药革兰氏阳性菌表现出强大活性。
T75555	(6E,12E)-Tetradecadiene-8,10-diyne-1,3-diol
	'(6E,12E)-Tetradecadiene-8,10-diyne-1,3-diol' 是从白术根中分离出的一种具有抗菌活性的化合物，对 MRSA 显示出 4 - 32 μg/mL 的最小抑菌浓度（MIC），表现出对抗性细菌感染研究的潜力。
TN1814	Juncusol 6-甲基灯心草二酚,灯心草酚	Caspase; Antifection	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Juncusol shows anxiolytic and sedative activities, it shows anxiolytic activity at dosages of 10 mg/kg; it can induce caspase-3-mediated cytotoxicity in HT22 cells. Juncusol has anti-microbial activity, it shows significant activity against MRSA strains.
TN6010	Picrasidine S
	Picrasidine S shows the potent cytotoxicity against human HeLa cervical, gastric MKN-28, and mouse melanoma B-16 cancer cells, it also shows the potent antibacterial activity against two strains of pathogenic bacteria methicillin-resistant Staphylococcus
T38394	PSMα3
	PSMα3 is a peptide compound that can be utilized to induce tolerance in dendritic cells (DCs) for DC vaccination strategies. It effectively penetrates and modulates human monocyte-derived DCs by modifying the maturation process induced by TLR2 or TLR4. Additionally, PSMα3 inhibits the production of both pro- and anti-inflammatory cytokines and decreases antigen uptake. Notably, PSMα3 is a significant virulence factor released by the most pathogenic strains of methicillin-resistant Staphylococcus...
T75700	Longistyline A
	Longistyline A (Longistylin A) 是一种天然二苯乙烯，可从木豆中提取。Longistyline A 对耐甲氧西林金黄色葡萄球菌具有抑菌效应，MIC 值为 1.56 μg/mL。Longistyline A 具有神经保护作用，可用于感染和神经系统疾病的研究。
T36417	Nargenicin Antibiotic 47444
	Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S. aureus, methicilin resistant S. aureus (MRSA), and M. luteus (MICs = 0.6, 0.3, and 2.5 μg/ml, respectively) over a panel of 11 Gram-positive and Gram-negative bacteria (MICs = >80 μg/ml). [1] It dose-dependently inhibits S. aureus DnaE in the presence of DNase I-activated DNA and E. coli DnaE when used at concentrations of 0.00001-0.1 and 0.01-100 μg/mL, respectively. [2] In murine BV-2 microglial cells, nargenicin (...
T36000	3-Hydroxyterphenyllin
	3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methi...

天然产物

Neogambogic acid

Cat.No: T5724

Synonym: neo-gambogic acid,新藤黄酸

Target: Apoptosis, Others, Antibacterial

Cat.No: T1465

Synonym: Pseudomonic acid,莫匹罗星,BRL-4910A

Target: DNA/RNA Synthesis, Antibacterial, Antibiotic

Mupirocin calcium hydrate

Cat.No: T8148

Synonym: 莫匹罗星钙,Mupirocin calcium

Target: Others, Antibacterial, Antibiotic

Sanguisorbigenin

Cat.No: TN4943

Synonym: 地榆皂苷元,Tomentosolic acid,3β-Hydroxyurs-12,19-dien-28-oic acid,19-Dehydroursolic acid,Ursa-12,19-dien-28-oic acid

Target: Antibacterial

Cat.No: TN2281

Synonym: trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde,TRANS-3,5-二甲氧基-4-羟基肉桂醛,芥子醛

Target: Antibacterial

6-Methoxydihydrosanguinarine

Cat.No: T8724

Target: Others

Continentalic acid

Cat.No: TN1524

Target: NOS, COX, Antibacterial, Prostaglandin Receptor

Cat.No: T3S0153

Synonym: 苍耳亭,叶黄制菌素

Target: Apoptosis, VEGFR, Lipoxygenase, Wnt/beta-catenin, Antibacterial

Protosappanin A

Cat.No: TJS1779

Synonym: 原苏木素A,PTA

Target: NADPH-oxidase, IL Receptor, IκB/IKK, TNF, NF-κB, TLR, ROS, COX, HIV Protease, JAK, NO Synthase, STAT

Cat.No: T10838

Target: Antibacterial

Cat.No: T74200

Isolupalbigenin

Cat.No: TN4308

Target: Antifection

(3R)-7,4’-Dihydrohomoisoflavanone

Cat.No: TN3216

Synonym: 7,4'-Dihydroxyhomoisoflavanone

Target: Antibacterial

Cat.No: TN4097

Target: Antifection

6-Ethoxychelerythrine

Cat.No: T2S0058

Synonym: 乙氧基白屈菜红碱,Ethoxychelerythrin

Target: Antibacterial

Cat.No: TN3450

Target: Antifection

Talaromycesone A

Cat.No: T38349

1-Acetyl-β-carboline

Cat.No: TN2524

Synonym: 1-Acetyl-beta-carboline

Target: Antifection

Cat.No: T73207

Pinosylvin monomethyl ether

Cat.No: TN3907

Synonym: (E)-3-Hydroxy-5-methoxystilbene

Target: Antifection

Bis(dihydrochelerythrinyl)amine

Cat.No: TN1444

Synonym: bis[6-(5,6-dihydrochelerythrinyl)]amine

Target: Antifection

Teicoplanin sodium

Cat.No: T75273

Isopimaric acid

Cat.No: TN4319

Target: Antifection

6-C-Methylquercetin-3,4'-dimethyl ether

Cat.No: T79943

Target: Antibiotic

4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl-

Cat.No: T75560

Cat.No: T74206

Cat.No: T73673

Cat.No: T75278

(6E,12E)-Tetradecadiene-8,10-diyne-1,3-diol

Cat.No: T75555

Cat.No: TN1814

Synonym: 6-甲基灯心草二酚,灯心草酚

Target: Caspase, Antifection

Cat.No: TN6010

Cat.No: T38394

Cat.No: T75700

Cat.No: T36417

Synonym: Antibiotic 47444

3-Hydroxyterphenyllin

Cat.No: T36000

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