265
79
146
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T77730 |
QST4
|
Antifungal | Microbiology/Virology |
QST4 具有抗结核、抗真菌活性,在结核分枝杆菌 Mycobacterium tuberculosis H37Rv 中的 MIC 值为 6.25 μM。 | |||
T27453 |
GSK1733953A
DG70 |
Antibacterial | Microbiology/Virology |
GSK1733953A 可作为一种小分子结核分枝杆菌呼吸抑制剂,对 MenG 活性有抑制作用,IC50 值为 2.6 ± 0.6 μM。GSK1733953A 是一种具有选择性的联苯苯甲酰胺,对结核分枝杆菌去甲基萘醌甲基转移酶的催化甲基化有抑制作用,对结核分枝杆菌H4Rv的MIC为8.37 μg/ml,对耐药菌株的MIC为1.2至9.6 μg/ml。GSK1733953A 是治疗结核病的候选化合物。 | |||
T32490 |
L-161240
L-161,240 |
Antibacterial | Microbiology/Virology |
L-161240 是一种与脂质A生物合成有关的抗菌剂,在DEACET测定IC50值为 30 nM,并且对野生型大肠杆菌的MIC值为1-3μg/ mL。 | |||
T12004 |
Meropenem trihydrate
美罗培南三水合物,SM 7338 trihydrate |
Antibacterial; Antibiotic | Microbiology/Virology |
Meropenem trihydrate (SM 7338 trihydrate) 是一种碳青霉烯抗生素,具有广谱抗菌活性。它对敏感和耐药的杜克氏杆菌 (MIC 值为 0.015-0.12 mg/mL), 淋病奈瑟氏球菌 (MIC 值为 0.02-0.06 mg/mL)和流感嗜血杆菌 (MIC 值为 0.03-0.12 mg/mL) 具有活性。 | |||
T6096 |
Pretomanid
(S)-PA 824,PA-824 |
Antibacterial; Antibiotic | Microbiology/Virology |
Pretomanid ((S)-PA 824) 是一种抗生素,可研究肺部多重耐药性结核病。它对结核病(MTB) 具有亚微摩尔作用活性。它对 MTB 泛敏感和抗 Rifampin 的临床分离株的 MIC 值为 0.015 至 0.25 μg/mL。 | |||
T15500 |
HPi1
|
Others; Antibacterial | Microbiology/Virology; Others |
HPi1 是一种有口服活性的,针对幽门螺杆菌的选择性抗菌剂,IC50为 0.24 μM,MIC 为 0.08-0.16 μg/mL。 | |||
T10586L |
BPH-1358
NSC50460 |
Others; Antibacterial | Microbiology/Virology; Others |
BPH-1358 (NSC-50460) 是一种人 FPPS 和 UPPS 抑制剂,IC50值分别为 1.8 μM 和 110 nM,对金黄色葡萄球菌的 MIC 值大约为 250 ng/mL。 | |||
T1569 |
Tigecycline
替加环素,GAR-936 |
ribosome; Antibacterial; Antibiotic; Autophagy | Autophagy; Microbiology/Virology |
Tigecycline (GAR-936) 是甘氨酰环素抗生素,对 Acinetobacter baumannii(A. baumannii) 的 MIC50和 MIC90分别为 1 和 2 mg/L。它对 E. coli(MG1655 菌株) 的平均抑制浓度 (MIC) 约 125 ng/ mL。 | |||
T78230 |
2,4′-Dichloroacetanilide
2-chloro-N-(4-chlorophenyl)acetamide |
Others | Others |
2,4′-Dichloroacetanilide (2-chloro-N-(4-chlorophenyl)acetamide) 具有抗真菌活性,抑制 T. asteroides,其最小抑菌浓度为 6.25 μg/mL。 | |||
T72358 |
Antimicrobial agent-14
|
Antibacterial | Microbiology/Virology |
Antimicrobial agent-14是一种苄基噻吩磺酰胺衍生物,常作为抗菌剂使用。Antimicrobial agent-14对 Campylobacter coli ATCC33559 的 MIC 值为 200 μM, 可用于研究细菌性食源性胃肠炎。 | |||
T4063 |
Delafloxacin
ABT492,WQ-3034,德拉沙星,RX-3341 |
Antibacterial; Antibiotic | Microbiology/Virology |
Delafloxacin (WQ-3034) 是一种广谱氟喹诺酮类抗生素,抑制耐药性的金黄色葡萄球菌,肺炎链球菌和肺炎克雷伯菌。 | |||
T1526 |
Nifuratel
NF 113,SAP 113,硝呋太尔,Methylmercadone |
Antibacterial; Antibiotic; Parasite | Microbiology/Virology |
Nifuratel (SAP 113) 是广谱抗生素,有抗细菌、真菌和毛滴虫活性。 | |||
T64316 |
VP-4604
1-((4-Nitrophenyl)sulfonyl)piperidine |
||
VP-4604是一种有效的抗耐甲氧西林金黄色葡萄球菌(MRSA)化合物。VP-4604对金黄色葡萄球菌展现出显著的抑制微生物生长的作用,MIC 为4-8μg/mL。VP-4604抑制耐甲氧西林金黄色葡萄球菌的生长,其生长抑制率达到95%以上。 | |||
T38240 |
2,6-Dichlorodiphenylamine
|
Antibacterial | Microbiology/Virology |
2,6-Dichlorodiphenylamine 是双氯芬酸钠的一种结构类似物,显示出抗白色念珠菌活性。2,6-Dichlorodiphenylamine 是非选择性抗炎剂,为COX 的抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的IC50分别为 4 和 1.3 nM。 | |||
T4218 |
Broxaldine
Brobenzoxaldine,溴沙定 |
Antibacterial; Antibiotic; Parasite; Antifungal | Microbiology/Virology |
Broxaldine (Brobenzoxaldine) 是一种具有抗原生动物活性的小分子药物。它抑制艰难梭菌的 MIC 值为 4 µM,并具有抗真菌作用。 | |||
T21831 |
UCM05
G28UCM |
Fatty Acid Synthase | Metabolism |
UCM05 (G28UCM) (G28UCM) 是一种有效的脂肪酸合酶 (FASN) 抑制剂,对 HER2+ 乳腺癌异种移植物具有作用活性,且在抗 HER2 耐药细胞系中具有活性。UCM05 是一种丝状温度敏感蛋白 Z (FtsZ) 抑制剂,可抑制革兰氏阳性菌B. subtilis 生长,MIC 值为 100 μM,但对革兰氏阴性菌E. coli 缺乏活性。 | |||
T2333 |
Efinaconazole
KP-103,艾氟康唑 |
Antifungal | Microbiology/Virology |
Efinaconazole (KP-103) 是一种三唑类抗真菌剂,抑制T. mentagrophytesSM-110和C. albicansATCC 10231菌株的MIC 值分别为 0.0039 μg/mL 和 0.00098 μg/mL | |||
T11227L |
Eravacycline dihydrochloride
TP-434-046,TP-434 dihydrochloride |
Antibacterial | Microbiology/Virology |
Eravacycline dihydrochloride (TP-434-046) 是一种有效的广谱抗菌剂,可对抗六种大肠杆菌(MIC:0.125-0.25 mg/L)。 | |||
T7877 |
Thiacetazone
氨硫脲,Diazam,Thioacetazone,Neustab,Neotibil |
Others; Antibacterial; Antibiotic | Microbiology/Virology; Others |
Thiacetazone (Diazam) 是一种氨基硫脲抗结核剂,也是一种具有口服活性抗生素。它具有抗菌作用,可抑制结核分枝杆菌 H37Rv 的生长,MIC 值为 0.1 μg/mL。 | |||
T3582 |
BTZ043
|
Antibacterial; Antibiotic; DprE1 | Microbiology/Virology; Others |
BTZ043 是一种 DprE1 的抑制剂,它对结核分枝杆菌 H37Rv 和耻垢分枝杆菌具有纳摩尔杀菌活性,MIC 值分别为 2.3 nM 和 9.2 nM。 | |||
T41275 |
PF-04753299
|
Others | Others |
PF-04753299 是一种有效的、选择性的LpxC 抑制剂。PF-04753299 对淋球菌分离株具有杀菌作用,对大肠杆菌、铜绿假单胞菌和肺炎菌株的抑制的MIC90值分别为 2 μg/ml、4 μg/ml 和 16 μg/ml。PF-04753299 用于革兰氏阴性菌感染的研究。 | |||
T0666 |
4-Chlorosalicylic acid
4-Chloro-2-hydroxybenzoic acid, 4-chloro salicylic acid,4-氯水杨酸 |
Tyrosinase; Antibacterial; Antibiotic; Antifungal | Microbiology/Virology; Proteases/Proteasome |
4-Chlorosalicylic acid (4-Chloro-2-hydroxybenzoic acid, 4-chloro salicylic acid) 是一种药物中间体。它抑制单酚酶和二苯酚酶活性,IC50值分别为1.89 mM 和1.10 mM。 它有抗菌活性,抑制大肠杆菌的MIC 为250 μg/mL,MBC 为500 μg/mL。 | |||
T64197 | Antibacterial agent 112 | ||
Antibacterial agent 112 (compound 2) 是一种有效的抗菌剂 (antibacterial)。Antibacterial agent 112 对 P.aeruginosa (MIC: 625 μM)、S.mutans (MIC: 625 μM)、B.subtilis (MIC: 1250 μM)、E.coli (MIC: 1250 μM)、E.faecalis (MIC: 1250 μM)、S.typhimuriumand (MIC: 1250 μM) 和 S.aureus microorganisms (MIC: 1250 μM)具有抗菌活性。 | |||
T62895 | DNA Gyrase-IN-4 | ||
DNA Gyrase-IN-4 (compound 8p) 是一种 DNA 促旋酶的有效抑制剂 (IC50: 0.13 μM)。DNA Gyrase-IN-4 对金黄色葡萄球菌 (MIC: 0.05 μg/ml)、单核增生李斯特菌 (MIC: 0.05 μg/ml)、沙门氏菌 (MIC: 0.05 μg/ml) 和大肠杆菌 (MIC: 8 μg/ml) 具有较好的抗菌作用。 | |||
T40994 | T-2307 | ||
T-2307, a broad-spectrum arylamidine compound, demonstrates potent antifungal properties both in vitro and in vivo. Its activity extends to clinically significant pathogens such as Candida species (MIC range: 0.00025 to 0.0078 μg/ml), Cryptococcus neoformans (MIC range: 0.0039 to 0.0625 μg/ml), and Aspergillus species (MIC range: 0.0156 to 4 μg/mL). | |||
T23947 |
DA-7867
UNII-491MT9GU8K,DA 7867,DA7867 |
||
DA-7867 is a novel oxazolidinone. DA-7867 had the lowest MIC for 90% of the aerobic gram-positive bacterial strains tested (≤0.25 μg/ml) and it was more potent than linezolid. DA-7867 was the most active drug with a MIC(90) of 0.125 μg/ml. | |||
T75019 | Antituberculosis agent-7 | ||
Antituberculosis agent-7 是一种氧杂环丁基喹啉衍生物,对P. mirabilis 具有良好的抗菌活性,MIC 为 31.25 μM。Antituberculosis agent-7 对A. niger 显示出良好的抗真菌活性,MIC 为 62.5 μM。Antituberculosis agent-7 显示出优异的抗分枝杆菌活性,对结核分枝杆菌 H37Rv 的 MIC 为 3.41 μM。 | |||
T72262 | Antituberculosis agent-6 | ||
Antituberculosis agent-6 是一种有效的抗结核分枝杆菌 (antimycobacterial) 剂。Antituberculosis agent-6 对M. tuberculosis 显示出显著的抑制活性,MIC 为 3.49 μM。Antituberculosis agent-6 还对A. niger 表现出良好的抗真菌 (antifungal) 活性,MIC 为 62.50 μM。 Antituberculosis agent-6 表现出高胃肠道吸收。 | |||
T40304 |
Antitubercular agent-10
|
||
Antitubercular agent-10 shows potent antitubercular activity with a MIC value of 30 nM. | |||
T64201 | Antibacterial agent 70 | ||
Antibacterial agent 70 是一种新型二氢嘧啶酮-咪唑杂化抗菌剂 (MIC: 0.5 μg/ml)。 | |||
T29175 |
YKAs3003
YKAs-3003 |
||
YKAs3003, a potent inhibitor of pathogenic KAS III, displays minimal inhibitory concentration (MIC) values in the range 128-256 microg/mL against various bacteria. | |||
T72263 |
Antituberculosis agent-8
|
||
Antituberculosis agent-8 是一种抗结核剂,对M. tuberculosis H37Rv 的 MIC 值为 3.53 μM (1.6 μg/mL)。Antituberculosis agent-8 对A. niger 也显示出良好的抗真菌 (antifungal) 活性,MIC 为 62.50 μM。 | |||
T75279 | Tigecycline tetramesylate | ||
Tigecycline tetramesylate (GAR-936 tetramesylate)为一款广谱甘氨酰环素类抗生素,对E. coli (MG1655菌株)展现出约125 ng/mL的平均抑制浓度(MIC)。针对Acinetobacter baumannii (A. baumannii)的MIC50与MIC90分别达到1 mg/L与2 mg/L。 | |||
T80447 |
Pardaxin P5
|
||
Pardaxin P5,一种抗菌肽,其对大肠杆菌的最小抑制浓度(MIC)为13 μM。 | |||
T35737 |
Emeguisin A
|
||
Emeguisin A is a depsidone fungal metabolite originally isolated fromE. unguis.1It is active against the bacteriaS. aureusand methicillin-resistantS. aureus(MRSA; MIC = 0.5 μg/ml for both), the fungusC. neoformans(MIC = 0.5 μg/ml), and the protozoanP. falciparum(IC50= 2.2 μM).2 1.Kawahara, N., Nozawa, K., Nakajima, S., et al.Isolation and structures of novel fungal depsidones, emeguisins A, B, and C, from Emericella unguisJ. Chem. Soc., Perkin Trans. 12611-2614(1988) 2.Klaiklay, S., Rukachaisiri... | |||
T38874 | Antibacterial agent 35 | ||
Antibacterial Agent 35 (AA35) is a potent antibacterial agent that effectively reduces the minimum inhibitory concentration (MIC) of Ceftazidime, another antibacterial agent. | |||
T40339 | Antitubercular agent-9 | ||
Antitubercular agent-9 shows effective antitubercular activity with a MIC value of 1.03-2.32 μM. | |||
T72387 | MRL-494 hydrochloride | ||
MRL-494 hydrochloride 是一种抗菌剂,是一种BamA 的抑制剂,具有抗外排和外膜渗透性。MRL-494 hydrochloride 可抑制革兰氏阳性细菌 (金黄色葡萄球菌 COL 的 MIC 值为 12.5 μM) 和革兰氏阴性细菌 (大肠杆菌 JCM158 的 MIC 值为 25 μM)。 | |||
T80294 |
GLK-19
|
||
GLK-19是一种具抗大肠杆菌活性的抗菌肽(MIC: 10 μM)。 | |||
T78115 |
Antifungal agent 48
|
||
Antifungalagent 48 (Example 112)是一种针对Cryptococcus neoformans的抗真菌剂,展现出MIC为11 μM的抗菌活性。 | |||
T38876 | Antibacterial agent 33 | ||
Antibacterial Agent 33, a potent antibacterial compound, effectively decreases the minimum inhibitory concentration (MIC) of Ceftazidime, another antibacterial agent. | |||
T61192 | CBR-6672 | ||
CBR-6672, a type II NADH dehydrogenase inhibitor, demonstrates potent antimycobacterial activity against mycobacterium tuberculosis (Mtb) with a minimum inhibitory concentration (MIC) of 0.14 μM [1]. | |||
T61234 |
Stemphyperylenol
|
||
Stemphyperylenol exhibits potent antifungal activity against Alternaria solani, a plant pathogen, with a minimum inhibitory concentration (MIC) value of 1.57 μM. | |||
T80380 |
Cyclopetide 2
|
||
Cyclopeptide 2 (Compound 2) 是中等活性抗菌肽,对B. subtilis的最小抑菌浓度(MIC)为50 μg/mL。 | |||
T75445 | 11-Keto fusidic acid | ||
11-Keto fusidic acid 对金黄色葡萄球菌具有较强的抗菌活性,MIC 值为0.078μg/mL。 | |||
T40301 |
Antibacterial agent 28
|
||
Antibacterial agent 28, with a minimum inhibitory concentration (MIC) range of 0.5-2 μg/mL, exhibits promising potential as an antibacterial candidate targeting MRSA infections. | |||
T38866 |
Antibacterial agent 39
|
||
Antibacterial agent 39 is a potent compound that exhibits antibacterial properties. It effectively reduces the minimum inhibitory concentration (MIC) of Ceftazidime, another antibacterial agent. | |||
T38885 | Antibacterial agent 60 | ||
Antibacterial agent 60 is a potent compound that effectively reduces the minimum inhibitory concentration (MIC) of Ceftazidime, an antibacterial agent. | |||
T38875 |
Antibacterial agent 34
|
||
Antibacterial agent 35 is a compound that effectively reduces the minimum inhibitory concentration (MIC) of Ceftazidime, enhancing its antibacterial activity. | |||
T38870 |
Antibacterial agent 45
|
||
Antibacterial Agent 45 (AA45) exemplifies a potent antibacterial compound that effectively reduces the minimal inhibitory concentration (MIC) value of Ceftazidime, another antibacterial agent. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37267 |
Pachybasin
|
Antibacterial | Microbiology/Virology |
Pachybasin 是一种蒽醌真菌代谢物。 Pachybasin 对大肠杆菌、枯草芽孢杆菌、M. luteus、S. cerevisiae、C. albicans、A. niger 和 A. flavus 具有抗菌活性,MIC 值为 64.0 μg/mL,对金黄色葡萄球菌具有抗菌活性 和尖孢镰刀菌,MIC 值分别为 32.0 和 16.0 μg/mL。 | |||
T8185 |
(+)-Viroallosecurinine
别一叶萩碱,Viroallosecurinine |
Antibacterial | Microbiology/Virology |
(+)-Viroallosecurinine (Viroallosecurinine) 是一种具有抗菌活性的天然生物碱,抑制Ps. Aeruginosa 和Staph. aureus,MIC 为 0.48 μg/mL。 | |||
T2975 |
2,3-Dimethoxybenzaldehyde
5,6-Dimethoxybenzaldehyde,邻藜芦醛,o-Veratraldehyde |
Antifungal | Microbiology/Virology |
2,3-Dimethoxybenzaldehyde (5,6-Dimethoxybenzaldehyde) 是苯甲酸类似物,具有高抗真菌活性(MIC=2.5 mM)。2,3-Dimethoxybenzaldehyde 可用于合成小檗碱。 | |||
TN2281 |
Sinapaldehyde
trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde,TRANS-3,5-二甲氧基-4-羟基肉桂醛,芥子醛 |
Antibacterial | Microbiology/Virology |
Sinapaldehyde (trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde) 对耐甲氧西林的金黄色葡萄球菌和大肠杆菌有抗菌作用,MIC 值都为 128 μg/mL。 | |||
TN2086 |
Piperlotine A
|
Antibacterial | Microbiology/Virology |
Piperlotine A 是一种可从罗洛胡椒中提取得到的生物碱,具有抗血小板聚集活性。Piperlotine A 在体外试验中显示出对结核分枝杆菌的抑制作用,MIC 值为 50 ug/mL。 | |||
T14329 |
Ascamycin
|
Nucleoside Antimetabolite/Analog; Others; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others |
Ascamycin 是一种由链霉菌属产生的 5'-O-磺酰胺核糖核苷抗生素,对黄单胞菌类显示出选择性的抗菌活性,对柠檬黄单胞菌、口蹄疫黄单胞菌和噬菌体具有抑制作用,MIC 值分别为0.4μg/mL、12.5μg/mL 和12.5μg/mL。 | |||
TN1019 |
Beta-mangostin
β-Mangostin,beta-倒捻子素 |
Apoptosis; Antibacterial; Parasite | Apoptosis; Microbiology/Virology |
Beta-mangostin (β-Mangostin) 是存在 Cratoxylum arborescens 中的一种氧杂蒽酮类天然产物,有抗癌和抗菌活性,对结核分枝杆菌的 MIC 值为 6.25 μg/mL。它在体外有抗疟活性,对恶性疟原虫的 IC50值为 3.00 μg/mL。 | |||
T5722 |
Nevadensin
Pedunculin,石吊兰素,5,7-二羟基-6,8,4'-三甲氧基黄酮 |
Anti-infection; Antibacterial | Microbiology/Virology |
Nevadensin 是一种重要的草本成分,可抑制雌二醇的生物活化。 它具有抗结核分枝杆菌、镇咳、抗炎、抗高血压等多种药理作用。 | |||
T3629 |
Gamithromycin
ML-1709460,加米霉素 |
Antibacterial; Antibiotic | Microbiology/Virology |
Gamithromycin (ML-1709460) 是一种可抑制 MmmSC 菌株 B237 和 Tan8 生长的大环内酯类抗菌剂,MIC 值分别为 0.00012 和 0.00006 μg/mL。 | |||
T2979 |
DL-Menthol
DL-薄荷醇,Hexahydrothymol,(±)-Menthol,薄荷醇 |
GABA Receptor; AChE | Membrane transporter/Ion channel; Neuroscience |
DL-Menthol ((±)-Menthol) 是单萜醇 (–)-薄荷醇和 (+)-薄荷醇的外消旋混合物,已在大麻中发现。它与 GABAA 受体的激活有关。 | |||
T5868 |
Methyl indole-3-carboxylate
吲哚-3-甲酸甲酯,Methyl 3-indolecarboxylate,3-吲哚甲酸甲酯 |
Others; Antibacterial | Microbiology/Virology; Others |
Methyl indole-3-carboxylate (Methyl 3-indolecarboxylate) 是一种从Sorangium cellulosumSoce895 菌株中分离出来的天然产物。它对革兰氏阳性诺卡氏菌的MIC 值为 33.3 μg/mL。 | |||
T3822 |
Bellidifolin
Bellidifoline,龙胆山酮酚,Bellidifolium,雏菊叶龙胆酮 |
Others; HIV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Bellidifolin (Bellidifoline) 是从獐牙菜的茎中提取的一种呫吨酮,它能作为病毒蛋白 R 的抑制剂,具有保肝、降血糖、抗炎、抗氧化、抗肿瘤作用。 | |||
T2776 |
Tribuloside
Tiliroside,刺蒺藜皂甙,蒺藜皂甙 |
Others; Antibacterial | Microbiology/Virology; Others |
Tribuloside (Tiliroside) A 是一种可从 Tribulus terrestris L 中分离得到的黄酮,可抑制非致病性分枝杆菌,MIC 值 为5.0 mg/mL。 | |||
T15277 |
Fervenulin
|
Parasite | Microbiology/Virology |
Fervenulin 具有杀灭线虫活性,抑制线虫M. incognita 卵孵化和 J2 的校正死亡率,MIC 分别为 30 μg/mL 和 120 μg/mL。 | |||
T2S1865 |
Octyl gallate
Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯 |
Antioxidant; Influenza Virus; Reactive Oxygen Species; Antibacterial; Antifungal; HSV | Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; oxidation-reduction |
Octyl gallate (Octyl 3,4,5-trihydroxybenzoate) 具有抗菌、抗氧化作用,有选择性和敏感性的荧光特性,广泛用作食品添加剂。它对 HSV-1,水泡性口炎病毒和脊髓灰质炎病毒有显著的抗病毒作用。 | |||
T0224 |
Meropenem
美罗培南,SM 7338 |
Others; Antibacterial; Antibiotic | Microbiology/Virology; Others |
Meropenem (SM 7338) 是一种具有广谱抗菌活性的碳青霉烯抗生素,对敏感和耐药的淋病奈瑟氏球菌,流感嗜血杆菌和杜克氏杆菌的 MIC 值分别为 0.02-0.06 mg/mL,0.03-0.12 mg/mL 和 0.015-0.12 mg/mL。 | |||
T13708 |
Glycol chitosan
羟乙基脱乙酰壳多糖,乙二醇壳聚糖 |
Antibacterial | Microbiology/Virology |
Glycol chitosan 是具有亲水性乙二醇支链的壳聚糖衍生物。它抑制大肠杆菌,金黄色葡萄球菌和肠炎链球菌的生长,MIC 值分别为 4 μg/mL,32 μg/m L 和 <0.5 μg/mL。它可增强 Glycine max Harosoy 63W 细胞的膜通透性和渗漏。 | |||
T5S1285 |
(+)-(3R,8S)-Falcarindiol
Falcarindiol,镰叶芹二醇 |
Others | Others |
(+)-(3R,8S)-Falcarindiol 是一种从胡萝卜中得到的聚乙炔,有抗炎、抗肿瘤和抗脂质过氧化活性。它具有抗分歧杆菌作用,对Mycobacterium tuberculosisH37Ra 的 MIC 和 IC50值分别为 24 μM 和 6 μM。 | |||
T3795 |
Corilagin
|
Apoptosis; TLR; Reverse Transcriptase; Antibacterial; Autophagy | Apoptosis; Autophagy; Immunology/Inflammation; Microbiology/Virology |
Corilagin 是一种鞣酸,有抑制 RNA 肿瘤病毒逆转录酶的活性。它抑制金黄色葡萄球菌的生长,MIC 为 25 μg/mL。它有抗肿瘤活性,可用于肝癌和卵巢癌。 | |||
T13970 | Xinjiachalcone A | Others | Others |
Xinjiachalcone A is a natural product isolated from Glycyrrhiza inflata Batalin. Xinjiachalcone A shows both a low MIC and a strong bactericidal activity against H. pylori(MIC : 12.5 to 50 µM, seventeen H. pylori strains). | |||
T75564 | Pomolic acid 3-acetate | ||
Pomolic acid 3-acetate 是一种抗结核 (antitubercular) 剂,对 Mycobacterium tuberculosisH37Rv 的 MIC 为 32 μM。 | |||
T81051 | Talaroenamine F | ||
Talaroenamine F显示了对蜡样芽胞杆菌的抗菌活性,其最小抑菌浓度(MIC)为0.85μg/mL。 | |||
T75578 | Apigravin | ||
Apigravin 是一种有效的抗菌剂。Apigravin 对 Bacillus subtilis 具有抗菌活性,MIC 值为 61 μM。 | |||
T4131 | Arjunic acid | COX; Antifection | Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Arjunic acid is a strong antioxidant and a free radical scavenger. Arjunic acid shows activity against Gram-positive and Gram-negative bacteria with MIC values ranging between 1.9 and 15.6 microg/mL. | |||
TN2415 |
Mudanpioside H
|
Antibacterial | Microbiology/Virology |
Mudanpioside H 是一种来自芍药根皮部,具有广泛的抗菌活性,MIC值在100到500 microg/mL之间。 | |||
T80347 |
FLGFVGQALNALLGKL-NH2
|
||
FLGFVGQALNALLGKL-NH2 是源自蛙类的抗菌肽,对金黄色葡萄球菌 ATCC 29213 表现出活性(MIC=32 μM)。 | |||
T80331 |
XT-2 peptide
|
||
XT-2 peptide, 源自热带爪蟾(Xenopus tropicalis)皮肤分泌物的抗菌肽,具有强效抗E.coli活性,其最小抑菌浓度(MIC)为8 μM。 | |||
T75476 | Monaschromone | ||
Monaschromone 是一种聚酮代谢物,可显著抑制灰霉病菌、茄病菌、稻瘟病菌和索比内蒂菌的生长,MIC 值在 6.25 至 12.5 μM 之间。 | |||
T80337 |
Maximin 63
|
||
Maximin 63是一种具有强抗金黄色葡萄杆菌活性的蟾蜍大脑来源抗菌肽(MIC为18.8 μg/mL)。 | |||
T80342 |
XT-4
|
||
XT-4,一种抗菌肽,源自热带爪蟾 (Xenopus tropicalis) 皮肤分泌物,对E.coli表现出高效的抑菌作用,最小抑制浓度 (MIC) 为18 μM。 | |||
TN5351 |
Cycloshizukaol A
|
||
Cycloshizukaol A prevents monocyte adhesion to HUVEC through the inhibition of cell adhesion molecules expression stimulated by TNF-alpha, it inhibits PMA-induced homotypic aggregation of HL-60 cells without cytotoxicity with MIC values of 0.9 microM. | |||
T60702 |
Globosuxanthone A
|
||
Globosuxanthone A 是一种具有抗癌活性的二氢黄嘌呤酮。Globosuxanthone A 对禾谷镰刀菌、茄镰刀菌和灰霉病菌表现出显著的抗真菌活性,MIC 值分别为 4、8 和 16 μg/mL。。 | |||
TN4098 | Gancaonin I | GTPase; Antifection | GPCR/G Protein; Microbiology/Virology |
Gancaonin I exhibits anti-BsFtsZ GTPase activities; it also shows significant inhibitory activity against B. subtilis, with a MIC value of 5 uM. | |||
T72805 |
(±)-Hydnocarpin
|
||
(±)-Hydnocarpin 是一种黄酮木脂素。(±)-Hydnocarpin 可以抑制S. aureus 的生长,MIC50值为 3.1 μM。 | |||
T75467 | Asperglaucin A | ||
Asperglaucin A 代表一种不寻常的类苯酞衍生物。Asperglaucin A 对两种植物病原体Pseudomonas syringae pv actinidae(Psa) 和Bacillus cereus 具有有效的抗菌活性,MIC 值为 6.25 μM。 | |||
T75475 | Chaetosemin J | ||
Chaetosemin J,一种对植物病原真菌(如灰霉病菌、番茄交链孢菌、稻瘟病菌和赤霉素)具有抑制活性的抗真菌代谢产物,MIC值在12.5-25 μM范围内。 | |||
TN1099 |
Dihydroevocarpine
|
MAO; P-gp; Antifection | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience |
Dihydroevocarpine shows potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 microg/ml. Dihydroevocarpine is a moderate modulator of p-glycoprotein (p-gp) activity; it shows more potent inhibitory effects against MAO-B compared to MAO-A. | |||
TN4953 |
Sativan
三叶草 |
Antifection | Microbiology/Virology |
Sativan possesses a broad spectrum of antimicrobial activity against bacteria and phytopathogenic fungi, it exhibits antituberculosis activity against Mycobacterium tuberculosis H37Rv, with the MIC value of 50 ug/mL. | |||
TN4023 |
Eucalyptin
|
Antifection | Microbiology/Virology |
Eucalyptin has antioxidant and antimicrobial properties, it exhibits potent antimicrobial activities against seven micro-organisms with minimum inhibitory concentrations (MIC) ranging from 1.0 to 31 mg/L. Eucalyptin A exhibits potent inhibition on HGF/c-M | |||
TN2495 |
1,4,7-Eudesmanetriol
|
Antifection | Microbiology/Virology |
1α,4β,7β-Eudesmanetriol and 1β,4β,7β-Eudesmanetriol can inhibit growth of Pseudomonas stutzeri with a MIC value of 117 uM, they also show remarkable activities against acetylcholinesterase enzyme with IC50 values ranging between 25 and 26 uM. | |||
T75468 | Asperglaucin B | ||
Asperglaucin B 是一种来自真菌Aspergillus chevalieriSQ-8 的烷基化水杨醛衍生物,具有抗菌活性。Asperglaucin B 对两种植物病原体Pseudomonas syringae pv actinidae(Psa)和Bacillus cereus 显示出有效的抗菌活性,MIC 值为 6.25 μM。 | |||
TN1409 |
Asimilobine
|
AChR; Antifection | Microbiology/Virology; Neuroscience |
(-)-Asimilobine shows antioxidative, anti-acetylcholinesterase (AChE), anti-α±-glucosidase, anti-leishmanial and anti-fungal activities; it displays weak inhibition against Streptococcus mutans (ATCC 25175), with a minimum inhibition concentration (MIC) o | |||
T38295 |
Calpinactam
|
||
Calpinactam is a fungal metabolite originally isolated from M. alpina that has antimycobacterial activity. It is active against M. smegmatis (MIC = 0.78 μg/ml) but not a panel of 13 other bacteria and fungi. Calpinactam increases survival in a silkworm model of M. smegmatis infection (ED50 = 5 μg/larva). | |||
TN3995 |
Erythrabyssin II
|
Antifection | Microbiology/Virology |
Erythrabyssin II actives against several strains of Staphylococcus and Streptococcus with an MIC range of 0.78-1.56 microg/ml. It inhibits bacterial neuraminidase in a dose-dependent manner with significant inhibition (IC(50)=0.09-3.25 μM). | |||
T75700 | Longistyline A | ||
Longistyline A (Longistylin A) 是一种天然二苯乙烯,可从木豆中提取。Longistyline A 对耐甲氧西林金黄色葡萄球菌具有抑菌效应,MIC 值为 1.56 μg/mL。Longistyline A 具有神经保护作用,可用于感染和神经系统疾病的研究。 | |||
T75665 | 3-O-Methylellagic acid | ||
3-O-Methylellagic acid 是一种天然产物,从Myrciaria cauliflora 中分离得到,具有抗炎活性。3-O-Methylellagic acid 对葡萄糖转运有抑制作用。3-O-Methylellagic acid 具有抗菌活性,对葡萄球菌 ATCC 25923 菌株作用的 MIC 值为 32 μg/mL。 | |||
TN1991 |
Norchelerythrine
|
Antifection | Microbiology/Virology |
Norchelerythrine shows significant inhibitory activity against Staphylococcus aureus ATCC 6538 with MIC values ranging from 12.5 to 50 ug/mL. It exhibits strong antifeeding activity in a concentration-dependant manner with the EC50 of 62.67 ppm. | |||
T75633 | (22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid | ||
(22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid (compound 15) 为具有抗结核活性的化合物,对结核分枝杆H37Ra的最小抑菌浓度(MIC)为12.5 μg/mL,并展现出对Vero细胞的细胞毒性,其半数抑制浓度(IC50)值为32 μM[1]。 | |||
TN4084 |
Fumitremorgin B
|
Antifection | Microbiology/Virology |
Fumitremorgen B is a mycotoxin, it exhibits a certain degree of genotoxicity, it can cause DNA damage in human lymphocytes; it shows an inhibitory activity on the cell cycle progression of mouse tsFT210 cells in the M phase, with the MIC value of 26.1 mic | |||
TN4776 | Physalin D | TNF; Antifection | Apoptosis; Microbiology/Virology |
Physalin D shows antimalarial activity; it also exhibits a minimum inhibitory concentration value (MIC) against Mycobacterium tuberculosis H(37)Rv strain of 32 microg/mL. Physalin D displays considerable cytotoxicity against several cancer cell lines. It | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02053 |
MICA Protein, Human, Recombinant (His), MICA*018
PERB11.1,MGC21250,MIC-A,MGC111087,FLJ36918... |
Human | HEK293 Cells |
MICA Protein, Human, Recombinant (His), MICA*018 is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34 kDa and the accession number is AAH16929.1. | |||
TMPK-00221 |
MICA alpha 3 Protein, Human, Recombinant (mFc)
MICA alpha 3,MIC |
Human | HEK293 Cells |
MICA (MHC class I chain-related gene A) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. A closely related protein, MICB, shares 85% amino acid identity with MICA. These proteins are distantly related to the MHC class I proteins. They possess three extracellular Ig‑like domains, but they have no capacity to bind peptide or interact with beta 2-microglobulin.. MICA alpha 3 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with N-mFc tag. The predi... | |||
TMPY-05830 |
MICA Protein, Human, Recombinant (hFc), MICA*018
MHC class I polypeptide-related sequence <... |
Human | HEK293 Cells |
MICA Protein, Human, Recombinant (hFc), MICA*018 is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 59.86 kDa and the accession number is AAH16929.1. | |||
TMPY-05469 |
MICA Protein, Human, Recombinant (His), MICA*00801
FLJ36918,MGC111087,DAMA-345G11.2,MHC cl |
Human | HEK293 Cells |
MICA Protein, Human, Recombinant (His), MICA*00801 is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.3 kDa and the accession number is Q96QC4. | |||
TMPJ-01414 |
GDF-15 Protein, Mouse, Recombinant (His & Flag)
Growth Differentiation Factor 15, Ma |
Mouse | HEK293 Cells |
Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1), is a divergent member of the TGF-beta superfamily. GDF15 can be secreted by a wide variety of cell types in response to a broad range of stressors. GDF-15 expression is dramatically upregulated during acute brain injury, cancer, cardiovascular disease, and inflammation, suggesting its potential value as a disease biomarker. GDF15 was shown to inhibit proliferation of primitive hematopoietic progenito... | |||
TMPJ-00131 |
NKG2DL Protein, Human, Recombinant (hFc)
ALCAN-β,NKG2DL1,UL16-binding protein 1,NKG... |
Human | HEK293 Cells |
NKG2D ligand 1, also called ULBP1, is a member of UL16-binding protein (ULBP) family which has also been termed the retinoic acid early transcript 1 (RAET1) family. Unlike the classical MHC class I molecules and the MIC molecules possess α1, α2 and α3 domains, ULBP/RAET1 family members lack α3 domain. ULBP1 is recognized by the activating receptor NKG2D on the surface of cytotoxic natural killer (NK) and T cells, and then promotes the lysis of cells expressing ULBP1 which is important for the im... | |||
TMPK-01426 |
Peptide Ready HLA-A*11:01&B2M Monomer Protein, Human, MHC (His & Avi)
HLA-A*02:01,Peptide Ready,MHC |
Human | HEK293 Cells |
Peptide Ready HLA-A*11:01&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*11:01. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner. | |||
TMPK-01419 |
Peptide Ready HLA-A*03:01&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated
MHC,HLA-A*02:01,Peptide Ready |
Human | HEK293 Cells |
Peptide Ready HLA-A*03:01&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*03:01. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner. | |||
TMPK-01421 |
Peptide Ready HLA-A*02:01&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated
HLA-A*02:01,MHC,Peptide Ready |
Human | HEK293 Cells |
HLA-A*02:01&B2M&Peptide ready Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*02:01. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner. | |||
TMPK-01420 |
Peptide Ready HLA-A*03:01&B2M Monomer Protein, Human, MHC (His & Avi)
Peptide Ready,MHC,HLA-A*02:01 |
Human | HEK293 Cells |
Peptide Ready HLA-A*03:01&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*03:01. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner. | |||
TMPK-01422 |
Peptide Ready HLA-A*02:01&B2M Monomer Protein, Human, MHC (His & Avi)
Peptide Ready,MHC,HLA-A*02:01 |
Human | HEK293 Cells |
Peptide Ready HLA-A*02:01&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*02:01. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner. | |||
TMPK-01425 |
Peptide Ready HLA-A*11:01&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated
MHC,HLA-A*02:01,Peptide Ready |
Human | HEK293 Cells |
Peptide Ready HLA-A*11:01&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*11:01. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner. | |||
TMPK-01410 |
Peptide Ready HLA-A*24:02&B2M Monomer Protein, Human, MHC (His & Avi)
HLA-A,MHC,Peptide Ready |
Human | HEK293 Cells |
Peptide Ready HLA-G&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-G. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner. | |||
TMPK-01409 |
Peptide Ready HLA-A*24:02&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated
Peptide Ready,MHC,HLA-A |
Human | HEK293 Cells |
Peptide Ready HLA-G&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-G. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner. | |||
TMPK-01415 |
APC-equivalent Peptide Ready HLA-A*02:01&B2M Tetramer Protein, Human, MHC (His)
Peptide Ready,HLA-A*02:01,MHC |
Human | HEK293 Cells |
Peptide Ready HLA-A*02:01&B2M Tetramer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*02:01. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner. | |||
TMPK-01403 |
HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Monomer Protein, Human, MHC (E. coli, His & Avi)
K-Ras 2,KI-RAS,CFC2,KRAS1,GTP... |
Human | E. coli |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. | |||
TMPK-01448 |
HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (E. coli, His & Avi)
MHC,LAGE-2,NY-ESO-1,ESO1CTAG,MY-ESO-1,CT |
Human | E. coli |
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy. | |||
TMPK-01427 |
HLA-A*11:01&B2M&KRAS G12D (VVGADGVGK) Monomer Protein, Human, MHC (His & Avi), Biotinylated
C-K-RAS,K-RAS4B,GTPase Kra |
Human | E. coli |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. | |||
TMPK-01399 |
HLA-A*11:01&B2M&KRAS WT (VVGAGGVGK) Monomer Protein, Human, MHC (His & Avi), Biotinylated
K-RAS2A,NS3,KRAS2,CFC2,K-RA |
Human | E. coli |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. | |||
TMPK-01404 |
HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Monomer Protein, Human, MHC (E. coli, His & Avi), Biotinylated
NS,KRAS,KRAS1,KRAS2,MHC,RA |
Human | E. coli |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. | |||
TMPK-01467 |
HLA-A*02:01&B2M&HPV 16 E6 (KLPQLCTEL) Monomer Protein, Human, MHC (His & Avi)
HPV16,E6,Human papillomavirus typ... |
Human | HEK293 Cells |
Human papillomavirus (HPV) 16 infection is a necessary condition for the pathogenesis and development of cervical cancer. The E6 protein is expressed by the HPV16 E6 gene and promotes malignant phenotype transformation, which is an important mechanism for the occurrence and development of cervical cancer. | |||
TMPK-01479 |
HLA-A*11:01&B2M&KRAS WT (VVVGAGGVGK) Monomer Protein, Human, MHC (His & Avi), Biotinylated
NS3,KRAS1,K-Ras 2,K-RAS2A |
Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. | |||
TMPK-01520 |
HLA-A*02:01&B2M&AFP (PLFQVPEPV) Tetramer Protein, Human, MHC (His & Avi)
Alpha-1-fetoprotein,AFP,HPA |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
TMPK-01474 |
HLA-A*24:02&B2M&MAGE-A3 (IMPKAGLLI) Monomer Protein, Human, MHC (His & Avi)
|
Human | HEK293 Cells |
Melanoma antigen gene A3 (MAGE-A3) is one of the most immunogenic cancer testis antigens and is common in various types of cancers. MAGE-A3 can be considered as a predictor for poor prognosis and an option for vaccine immunotherapy in patients with PCa. | |||
TMPK-01444 |
HLA-A*02:01&B2M&MAGE-A1 (KVLEYVIKV) Tetramer Protein, Human, MHC (His & Avi)
MZ2-E,MAGE1A,MAGE-1 anti... |
Human | HEK293 Cells |
MAGE-A1 belongs to the chromosome X-clustered genes of cancer-testis antigen family and is normally expressed in the human germ line but is also overexpressed in various tumors. | |||
TMPK-01461 |
HLA-A*11:01&B2M&KRAS G12S (VVVGASGVGK) Monomer Protein, Human, MHC (His & Avi)
C-K-RAS,KRAS,RASK2,K-Ras... |
Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. | |||
TMPK-01470 |
HLA-A*02:01&B2M&MAGE-A4 or MAGE-A8 (KVLEHVVRV) Monomer Protein, Human, MHC (His & Avi)
MAGE-A4 or MAGE-A8,M... |
Human | HEK293 Cells |
MAGE-A4 and MAGE-A8 are type I membes of the melanoma associated antigen (MAGE) family. The MAGE family is a large, highly conserved group of proteins that share a common MAGE homology domain. Both MAGE-A4 and MAGE-A8 antigen-presenting peptides can be presented by HLA-A*02:01. | |||
TMPK-01525 |
HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Monomer Protein, Human, MHC (His & Avi), Biotinylated
CFC2,RALD,K-Ras 2,MHC,C-K-RAS,NS3... |
Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. | |||
TMPK-01434 |
HLA-A*11:01&B2M&KRAS G12R (VVVGARGVGK) Tetramer Protein, Human, MHC (His & Avi)
RASK2,CFC2,GTPase Kras,KRA |
Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. | |||
TMPK-01417 |
HLA-A*02:03&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled
Alpha-1-fetoprotein,HPAFP,A |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
TMPK-01446 |
HLA-A*02:01&B2M&MAGE-A1 (KVLEYVIKV) Monomer Protein, Human, MHC (His & Avi)
MAGE1,MAGE1A,MAGE-1 ... |
Human | HEK293 Cells |
MAGE-A1 belongs to the chromosome X-clustered genes of cancer-testis antigen family and is normally expressed in the human germ line but is also overexpressed in various tumors. | |||
TMPK-01481 |
HLA-A*24:02&B2M&Survivin 2B (AYACNTSTL) Monomer Protein, Human, MHC (His & Avi), Biotinylated
svn 2B,svn-2B,Survivin-2B |
Human | HEK293 Cells |
Survivin-2B, a known splice variant of survivin, has been reported to promote cell death in some cancer cells, although it keeps prosurvival function in others.survivin-2B promoted autophagy and further regulated cell death by accumulating and stabilizing IKK alpha in the nucleus. | |||
TMPK-01494 |
HLA-A*01:01&B2M&CT83 (NTDNNLAVY) Tetramer Protein, Human, MHC (His & Avi)
HLA-A,HLA-A*0101,HLA... |
Human | HEK293 Cells |
Cancer/testis antigens 83 (CT83), also called KK-LC-1 or CXorf61, recognized by cytotoxic T lymphocytes (CTL), has become a promising target for immunotherapy. | |||
TMPK-01519 |
HLA-A*02:01&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi)
MHC,FETA,AFP,Alpha-feto,... |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
TMPK-01530 |
HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Monomer Protein, Human, MHC (His & Avi), Biotinylated
MHC,LMP-2,PSMB9,LMP2,Macropain cha |
Human | HEK293 Cells |
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of ma... | |||
TMPK-01513 |
HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Monomer Protein, Human, MHC (His & Avi), Biotinylated
CT6.1,LAGE2A,MHC,CTAG1B,CTA |
Human | HEK293 Cells |
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy. | |||
TMPK-01408 |
HLA-A*02:01&B2M&KRAS G12V (KLVVVGAVGV) Monomer Protein, Human, MHC (His & Avi), Biotinylated
RALD,KRAS1,KRAS2,K-RAS2B... |
Human | E. coli |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. | |||
TMPK-01401 |
HLA-A*11:01&B2M&KRAS WT (VVVGAGGVGK) Monomer Protein, Human, MHC (E. coli, His & Avi)
MHC,CFC2,K-Ras 2,RALD,K-RAS4A... |
Human | E. coli |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. | |||
TMPK-01429 |
HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Monomer Protein, Human, MHC (E. coli, His & Avi), Biotinylated
MHC,K-Ras 2,NS,K-RAS4A,KRA |
Human | E. coli |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. | |||
TMPK-01449 |
HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (E. coli, His & Avi)
MHC,CT6.1,CTAG1,LAGE-2,MY-ESO-1,NY-ESO-1,E... |
Human | E. coli |
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy. | |||
TMPK-01473 |
HLA-A*24:02&B2M&MAGE-A3 (IMPKAGLLI) Monomer Protein, Human, MHC (His & Avi), Biotinylated
CT1.3,MAGE-3,MZ2-D,MZ2D,HLA-A2402... |
Human | HEK293 Cells |
Melanoma antigen gene A3 (MAGE-A3) is one of the most immunogenic cancer testis antigens and is common in various types of cancers. MAGE-A3 can be considered as a predictor for poor prognosis and an option for vaccine immunotherapy in patients with PCa. | |||
TMPK-01488 |
HLA-A*11:01&B2M&KRAS WT (VVVGAGGVGK) Monomer Protein, Human, MHC (His & Avi)
K-RAS4A,MHC,GTPase Kras,... |
Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. | |||
TMPK-01445 |
HLA-A*02:01&B2M&MAGE-A1 (KVLEYVIKV) Monomer Protein, Human, MHC (His & Avi), Biotinylated
CT1.1,MAGE1,MAGE-1,MAGE-A |
Human | HEK293 Cells |
MAGE-A1 belongs to the chromosome X-clustered genes of cancer-testis antigen family and is normally expressed in the human germ line but is also overexpressed in various tumors. | |||
TMPK-01529 |
HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Monomer Protein, Human, MHC (His & Avi)
K-RAS4A,KRAS1,MHC,K-RAS2... |
Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. | |||
TMPK-01455 |
HLA-A*02:01&B2M&PRAME (SLLQHLIGL) Monomer Protein, Human, MHC (His & Avi)
OIP4,PRAME,OIP-4,MAPE |
Human | HEK293 Cells |
PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen expressed in cutaneous and ocular melanomas and some other malignant neoplasms, while its expression in normal tissue and benign tumors is limited. | |||
TMPK-01458 |
HLA-A*11:01&B2M&KRAS G12A (VVVGAAGVGK) Monomer Protein, Human, MHC (His & Avi)
K-Ras 2,GTPase Kras,KRAS... |
Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. | |||
TMPK-01463 |
HLA-A*11:01&B2M&KRAS G12C (VVVGACGVGK) Monomer Protein, Human, MHC (His & Avi)
C-K-RAS,KI-RAS,KRAS1,K-RA |
Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. | |||
TMPK-01477 |
HLA-A*02:01&B2M&AFP (FMNKFIYEI) Monomer Protein, Human, MHC (His & Avi), Biotinylated
HPAFP,FETA,Alpha-1-fetop... |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
TMPK-01442 |
HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled
HLA-A,P53,TP53,LFS1,MHC,BCC7,TRP53,FLJ9294... |
Human | HEK293 Cells |
p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein. p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth. | |||
TMPK-01518 |
HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer Protein, Human, MHC (His & Avi)
MHC,NS,KRAS1,K-RAS2A,GTPa |
Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. | |||
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