78
13
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T40004 |
Pomalidomide-C7-NH2 hydrochloride
|
Others | Others |
Pomalidomide-C7-NH2 hydrochloride 是一种合成的 E3 连接酶配体-接头偶联物,它结合了 PROTAC 技术中使用的基于 Pomalidomide 的 CRBN 配体和接头。 | |||
T39701 |
Pomalidomide-C7-COOH
Pomalidomide-C7-COOH |
||
Pomalidomide-C7-COOH is a chemically synthesized E3 ligase cereblon ligand-linker conjugate, utilized as an intermediate compound for the synthesis of PROTAC BCL-XL degraders. | |||
T39645 |
Thalidomide-O-C7-acid
Thalidomide-O-C7-acid |
||
Thalidomide-O-C7-acid is a compound created through the synthesis of an E3 ligase ligand-linker conjugate. It consists of a cereblon ligand derived from Thalidomide, combined with a linker that is commonly employed in PROTAC technology. | |||
T39838 |
(S,R,S)-AHPC-C7-amine
VH032-C7-amine,(S,R,S)-AHPC-C7-amine |
||
(S,R,S)-AHPC-C7-amine, also known as VH032-C7-amine, is a chemically synthesized conjugate that functions as an E3 ligase ligand-linker. This compound combines the VH032-based VHL ligand with a specific linker designed for the degradation of estrogen-related receptor α (ERRα) PROTAC. | |||
T39511 |
Thalidomide-O-C7-NH2
Thalidomide-O-C7-NH2 |
||
Thalidomide-O-C7-NH2 is a synthesized conjugate compound comprising an E3 ligase ligand-linker conjugate. This compound incorporates a cereblon ligand based on Thalidomide and a linker that is commonly employed in PROTAC technology. | |||
T18671 |
(S,R,S)-AHPC-Me-C7 ester
|
Others | Others |
(S,R,S)-AHPC-Me-C7 ester is a E3 ligase ligand-linker conjugate used to synthesise BCL-XL PROTAC degraders[1]. | |||
T82988 |
AP-C7
|
||
AP-C7是一种特异性的cGMP依赖性蛋白激酶II (cGKII) 抑制剂,pIC50值为5.0。该化合物对cGKII依赖的阴离子分泌仅表现出弱抑制作用。 | |||
T83954 |
VH 032 amide-alkylC7-acid
(S,R,S)-AHPC-amido-C7-acid |
||
VH 032 amide-alkylC7-acid 是一种用于PROTAC研究与开发的功能化Von-Hippel-Lindau蛋白配体(VHL),结合了E3连接酶配体和具有末端羧酸的alkylC7连接物,便于与目标蛋白配体偶联。该化合物是为PROTAC研发设计的一系列功能化工具分子之一。 | |||
T77954 |
Thalidomide-5-O-C7-NH2 hydrochloride
|
||
Thalidomide-5-O-C7-NH2 hydrochloride 是 Thalidomide 衍生的 cereblon 配体,能够募集 CRBN 蛋白。该化合物可以利用 linker 结构与靶蛋白配体相连,用于构建 PROTAC 分子,如 THAL-SNS-032。 | |||
T77917 |
Thalidomide-4-O-C7-NH2 hydrochloride
|
||
Thalidomide-4-O-C7-NH2 hydrochloride是一种Thalidomide衍生的CRBN配体,能够招募cereblon蛋白。该化合物能通过linker与目标蛋白配体结合,用于构建PROTAC分子,如THAL-SNS-032。 | |||
T19663 |
Triheptanoin
UX 007,IND106011,三庚酸甘油脂,UX007,UX-007,IND 106011,IND-106011 |
Others | Others |
Triheptanoin (IND 106011) 是合成的中链甘油三酯 (MCT),由甘油主链上的三个奇数链 7-碳(庚酸)脂肪酸组成,可以用于研究遗传代谢紊乱。 | |||
TQ0235 |
AC710
|
FLT; PDGFR; c-Kit | Angiogenesis; Tyrosine Kinase/Adaptors |
AC710是一种 PDGFR 抑制剂,能够作用于 FLT3 (Kd:0.6),CSF1R (Kd:1.57),KIT (Kd:1),PDGFRα (Kd:1.3) 和 PDGFRβ (Kd:1.0)。 | |||
T15648 |
KDM5-C70
|
Histone Demethylase | Chromatin/Epigenetic |
KDM5-C70 是 KDM5-C49 的乙酯衍生物,是一种有效的细胞渗透性泛 KDM5 组蛋白去甲基化酶抑制剂。它在骨髓瘤细胞中具有抗增殖作用,可诱导全基因组 H3K4me3 水平升高。 | |||
T11828 |
LDC7559
|
Pyroptosis | Apoptosis; Immunology/Inflammation |
LDC7559 通过在晚期阻断中性粒细胞胞外陷阱 (NET)来抑制gasdermin D (GSDMD)。 | |||
T3463 |
NVP-ACC789
ACC-789,ZK202650 |
VEGFR; PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
NVP-ACC789 (ZK202650) 是一种人VEGFR-1,VEGFR-2(鼠VEGFR-2),VEGFR-3 和 PDGFR-β 的抑制剂,它们的 IC50 值分别为 0.38,0.02 (0.23),0.18 和 1.4 μM。 | |||
T16355 |
NSC781406
|
PI3K; mTOR | PI3K/Akt/mTOR signaling |
NSC781406是一种高效PI3K 和mTOR 抑制剂,其PI3Kα的IC50值为2 nM。 | |||
T60164 |
UNC7467
|
Others | Others |
UNC7467 是一种有效的IP6K 抑制剂,IP6K2、IP6K1 和 IP6K6 的IC50值分别为 4.9、8.9 和1320 nM。UNC7467 可降低肌醇焦磷酸盐的水平,而不会显着干扰其他肌醇磷酸盐的水平。UNC7467 可用于肥胖研究。 | |||
T24557 |
NSC756093
NSC-756093,NSC 756093 |
Others | Others |
NSC756093 可能抑制 GBP1:PIM1 相互作用。 NSC756093 可用于卵巢癌研究。 | |||
T3084 |
SGC707
|
Histone Methyltransferase | Chromatin/Epigenetic |
SGC707 是 PRMT3化学探针,是一种有效的、选择性的、细胞活性的 PRMT3 变构抑制剂,IC50值为 31 nM。 | |||
T6661 |
SC75741
|
Influenza Virus; NF-κB | Microbiology/Virology; NF-κB |
SC75741 是NF-κB 抑制剂,对p65的IC50为 200 nM。它可阻断流感病毒复制。它通过损害NF-κB 亚基 p65 的 DNA 结合,导致细胞因子,趋化因子和促凋亡因子的表达降低,抑制 caspase 活化和阻断 caspase 介导的病毒核糖核蛋白的核输出。 | |||
T11372 |
GC7 Sulfate
|
Autophagy | Autophagy |
GC7 Sulfate 是 deoxyhypusine synthase(DHS)有效抑制剂。真核翻译起始因子5A2 (eIF5A2)是DHS 已知的底物,因此GC7通过抑制DHS 活性来抑制eIF5A2的激活。 | |||
T50125 |
Compound C749
|
||
Compound C749 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T50125,CAS号为 57-03-4。 | |||
T10729 |
Cdc7-IN-7
|
CDK | Cell Cycle/Checkpoint |
Cdc7-IN-7 (compound I-E) 是一种有效的 Cdc7 激酶抑制剂。 | |||
T2274 |
SC79
SC 79,2-氨基-6-氯-alpha-氰基-3-(乙氧羰基)-4H-1-苯并吡喃-4-乙酸乙酯 |
Akt | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
SC79 是一个 AKT 激动剂,具有特异性和血脑屏障渗透性。SC79 可以特异性结合 AKT 的 PH 结构域,激活胞质中 AKT,并抑制 AKT 膜转位。SC79 具有神经保护活性。 | |||
TP1166 |
ZINC77292789
Fmoc-Thr[GalNAc(Ac)3-α-D]-OH,Fmoc-Thr(Ac₃AcNH-α-Gal)-OH |
Others | Others |
ZINC77292789 (Fmoc-Thr[GalNAc(Ac)3-α-D]-OH) 是制备基于三聚体 MUC1 免疫显性基序抗原的候选抗癌疫苗的起始材料,可制备含有 βGalNAc-Thr 作为 Tn 抗原异构体的合成 MUC1 糖肽,可诱导针对肿瘤细胞的抗体产生。 | |||
T23867 |
Cdc7-IN-7c
Cdc7 inhibitor-7c,Cdc7 inhibitor 7c,Cdc7 IN 7c |
CDK | Cell Cycle/Checkpoint |
Cdc7-IN-7c (Cdc7 inhibitor-7c) 具有抗肿瘤活性,对肝癌,肺癌,肾癌,脑癌,宫颈癌有抑制作用。 | |||
T10656 |
trans-C75
(±)-C75,反-4-羧基-5-辛基-3-甲基-丁内酯 |
Others; Fatty Acid Synthase | Metabolism; Others |
trans-C75 ((±)-C75) 是一种 C75 的对映异构体。其中 C75 是一种脂肪酸合成酶 (FASN) 的抑制剂。 | |||
T3169 |
KC7F2
|
HIF/HIF Prolyl-Hydroxylase; HIF | Angiogenesis; Chromatin/Epigenetic; Metabolism |
KC7F2 是缺氧诱导因子HIF-1通道抑制剂,在 LN229-HRE-AP 细胞中的IC50=20 μM,可用作抗癌试剂。 | |||
T10727 |
Cdc7-IN-5
|
CDK | Cell Cycle/Checkpoint |
Cdc7-IN-5 是一种有效的 Cdc7 激酶抑制剂。Cdc7 是一种丝氨酸苏氨酸蛋白激酶酶,在细胞周期中对 DNA 复制的启动至关重要。 | |||
T10657 |
C75
C-75 |
Fatty Acid Synthase | Metabolism |
C75 是一种合成脂肪酸合酶 (FASN) 抑制剂,可抑制前列腺癌细胞 PC3 (IC50: 35 μM)。 | |||
T62921 | EBNA1-IN-SC7 | ||
EBNA1-IN-SC7 (compound SC7) 是一种 Epstein-Barr nuclear antigen 1 (EBNA1) 的选择性抑制剂,能够干扰 EBNA1-DNA 结合活性 (IC50: 23 μM)。EBNA1-IN-SC7 能够用于研究 EBV (Epstein-Barr virus) 相关癌症。 | |||
T75168 | Homo-BacPROTAC7 | ||
Homo-BacPROTAC7 是一个 ClpC1NTDBacPROTAC 降解剂,可以靶向 ClpC2。Homo-BacPROTAC7 能有效杀死 M. tuberculosis。 | |||
T61223 |
Cdc7-IN-19
|
||
Cdc7-IN-19 (compound 1-1) 是一种有效的CDC7抑制剂,对 Cdc7/DBF4 酶的IC50为 1.49 nM。 | |||
T71762 |
TLSC702
|
||
TLSC702 is a novel Inhibitor of Human Glyoxalase I, Inducing Apoptosis in Tumor Cells. | |||
T61289 |
Cdc7-IN-14
|
||
Cdc7-IN-14 (compound 82) is a highly potent inhibitor of CDC7, demonstrating an IC50 value of less than 1 nM. This compound, Cdc7-IN-14, exhibits promising potential for cancer research [1]. | |||
T74514 |
HD-TAC7
|
PROTACs | PROTAC |
HD-TAC7 是一种有效的 PROTACHDAC 降解剂,对 HDAC1、HDAC2 和 HDAC3的 IC50分别为 3.6 μM、4.2 μM 和 1.1 μM。HD-TAC7 可降低 RAW 264.7 巨噬细胞NF-κBp65 表达。HD-TAC7 可用于哮喘和慢性阻塞性肺病(COPD)等炎症性疾病的研究。 | |||
T80408 |
Bac7(1-35)
|
||
Bac7(1-35)是一种选择性针对革兰氏阴性菌的脯氨酸富集型抗菌肽,在经过膜易位作用后在细胞内发挥效能。 | |||
T78271 |
Anti-Mouse TCR gamma/delta Antibody (UC7-13D5)
|
||
Anti-Mouse TCR gamma/delta Antibody为针对小鼠TCR gamma/delta的IgG类免疫抑制抗体,其宿主为亚美尼亚仓鼠。 | |||
T79616 |
UNC7096
|
Histone Methyltransferase | Chromatin/Epigenetic |
UNC7096为一种选择性NSD2-PWWP1抑制剂,其Kd为46 nM,拥有潜在治疗NSD2相关疾病的能力。 | |||
T70151 |
MeTC7
|
||
MeTC7 is a VDR antagonist, which can be synthesized from 7-dehydrocholesterol (6) in two steps, inhibits VDR selectively, suppresses the viability of cancer cell-lines, and reduces the growth of the spontaneous transgenic TH-MYCN neuroblastoma and xenografts in vivo. | |||
T24135 |
HEC72702
HEC-72702,HEC 72702 |
||
HEC72702 is a novel Hepatitis B virus capsid inhibitor, based on clinical candidate GLS4. HEC72702 was found to display no induction of the CYP1A2, CYP3A4, or CYP2B6 enzyme at the high concentration of 10 μM. | |||
T10228 |
AC710 Mesylate
|
PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
AC710 Mesylate is a potent PDGFR inhibitor (Kds: 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ). | |||
T16354 |
NSC745885
|
Others | Others |
NSC745885 is an effective down-regulator of EZH2 via proteasome-mediated degradation. NSC745885 is also an effective anti-tumor agent that displays selective toxicity against multiple cancer cell lines but not normal cells. NSC745885 offers possibilities | |||
T29542 |
AC708
AC 708,AC-708 |
||
AC708 is a small molecule CSF1R inhibitor that effectively inhibits CSF1R phosphorylation mediated by CSF-1 (IC50 = 26 nM) and IL-34 (IC50 = 33 nM). It also inhibited the activity of growth factor-dependent cells cultured in CSF-1 (IC50 = 38 nM) or IL-34 | |||
T61224 | Cdc7-IN-8 | ||
Cdc7-IN-8, a potent inhibitor, targets Cdc7, a serine/threonine kinase responsible for activating MCM promotion through phosphorylation of the microchromosome maintenance protein (MCM protein). MCM protein, an essential component of DNA replication initiation, plays a crucial role. Cdc7-IN-8 holds promise in cancer disease research (WO2021032170A1, compound 1-1/1-2) [1]. | |||
T61435 | (S)-Cdc7-IN-18 | ||
(S)-Cdc7-IN-18, a potent CDC7 inhibitor, effectively impedes the overactivation of MCM2, a crucial tumor cell marker, induced by huCdc7 overexpression. Consequently, it inhibits the aberrant proliferation of tumor cells. This compound, exhibits promise for cancer disease research [1]. | |||
T78423 |
ARC7
|
||
ARC7是一种用于探测S. coelicolor次生代谢的化合物,同时也被作为研究次生代谢和链霉菌生命周期的实用工具。 | |||
T10726 |
Cdc7-IN-4
|
Others | Others |
Cdc7-IN-4 is a potent inhibitor of Cdc7 kinase. | |||
T24682 |
PTC725
PTC-725,PTC 725 |
||
PTC725 is a selective HCV 1b replicons inhibitor. It has been shown to target the nonstructural protein 4B. | |||
T61288 |
Cdc7-IN-13
|
||
Cdc7-IN-13 (compound 84) is a highly potent CDC7 inhibitor, exhibiting an IC50 value of <1 nM. This compound holds promise for cancer research [1]. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02892 |
Complement C7 Protein, Human, Recombinant (His)
Complement C7,complement component 7 |
Human | HEK293 Cells |
Complement C7 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 92.6 kDa and the accession number is P10643. | |||
TMPY-03012 |
Complement C7 Protein, Human, Recombinant (hFc)
complement component 7,Complement C7 |
Human | HEK293 Cells |
Complement C7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 118 kDa and the accession number is P10643. | |||
TMPY-02970 |
CXCL10 Protein, Human, Recombinant
IFI10,IP-10,chemokine (C-X-C motif) ligand 10,gIP-10,crg-2,<... |
Human | E. coli |
CXCL10 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 8.8 kDa and the accession number is P02778. | |||
TMPK-01269 |
CXCL10 Protein, Cynomolgus, Recombinant (His)
IFI10,gIP-10,CXCL10,IP-10,SCYB10,C-X-C motif chemokine 10,cr... |
Cynomolgus | E. coli |
C-X-C motif ligand 10 (CXCL10), or interferon-inducible protein-10, is a small chemokine belonging to the CXC chemokine family. Its members are responsible for leukocyte trafficking and act on tissue cells, like endothelial and vascular smooth muscle cells. CXCL10 is secreted by leukocytes and tissue cells and functions as a chemoattractant, mainly for lymphocytes. | |||
TMPH-03750 |
SLC7A11 Protein, Human, Recombinant (His)
|
Human | E. coli |
Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. | |||
TMPY-04118 |
Livin/BIRC7 Protein, Human, Recombinant (His)
MLIAP,baculoviral IAP repeat containing 7,RNF50,KIAP,ML-IAP,... |
Human | E. coli |
BIRC7, a new member of inhibitor of the apoptosis protein family, is expressed in fetal tissues and most solid tumors in humans. BIRC7/livin expression is a novel prognostic marker in adult acute leukemia. Livin/BIRC7 is a member of the inhibitors of apoptosis proteins family, which are involved in tumor development through the inhibition of caspases. Livin/BIRC7 is specifically over-expressed in ACC, suggesting that it might be involved in adrenocortical tumorigenesis and represent a new molecu... | |||
TMPY-02217 |
HSC70 Protein, Human, Recombinant (His)
HSP73,HSC54,HSP71,NIP71,LAP-1,HEL-33,HSPA10,HSC71,L... |
Human | E. coli |
HSPA8, also known as HSC70, is a member of the heat shock protein family due to homology with other heat shock proteins. The heat shock protein 70 family is comprised of both heat-inducible and constitutively expressed members. The latter are called heat-shock cognate proteins. HSPA8 belongs to the heat-shock cognate subgroup. Members of the human heat-shock protein multigene family have several highly conserved proteins with structural and functional properties in common but vary in the extent ... | |||
TMPK-01049 |
CLEC7A Protein, Mouse, Recombinant (hFc)
CLECSF12,DC-associated C-type lectin 1,Dectin-1,Beta-glucan ... |
Mouse | HEK293 Cells |
Dendritic cell-associated C-type lectin-1 (Dectin-1), also known as β-glucan receptor is an emerging pattern recognition receptor (PRR) which belongs to the family of C-type lectin receptor (CLR). Dectin-1 signaling axis has been suggested to be targeted as an effective therapeutic strategy for cancers. Dectin-1 has also been elucidated ascetically in the heart, respiratory, intestinal, neurological and developmental disorders. | |||
TMPH-01475 |
HDAC7 Protein, Human, Recombinant (His)
|
Human | E. coli |
N/A. HDAC7 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 26 kDa and the accession number is Q8WUI4 (BC064840). | |||
TMPH-01604 |
SLC7A5 Protein, Human, Recombinant (His & Myc & SUMO)
|
Human | E. coli |
SLC7A5 Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 19.7 kDa and the accession number is Q01650. | |||
TMPY-04061 |
HIV-2 (subtype CRF01_AB, strain 07JP_NMC716_clone_01) gp36 Protein (His & MBP)
GP36 |
HIV | E. coli |
HIV-2 (subtype CRF01_AB, strain 07JP_NMC716_clone_01) gp36 Protein (His & MBP) is expressed in E. coli expression system with His and MBP tag. The predicted molecular weight is 58.8 kDa and the accession number is L8B302. | |||
TMPH-02528 |
SLC7A10 Protein, Mouse, Recombinant (His & SUMOstar)
|
Mouse | P. pastoris (Yeast) |
Sodium-independent, high affinity transport of small neutral D- and L-amino acids and amino acid-related compounds. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse. SLC7A10 Protein, Mouse, Recombinant (His & SUMOstar) is expressed in yeast with N-His tag. The predicted molecular weight is 22.5 kDa and the accession number is P63115. | |||
TMPH-00218 |
DHCR7 Protein, Bovine, Recombinant (His)
DHCR7,7-dehydrocholesterol reductase,Sterol Delta(7)-reducta... |
Bovine | E. coli |
7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway. DHCR7 Protein, Bovine, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 55.8 kDa and the accession number is Q5E9J5. |